Tpp2 (tripeptidyl peptidase 2) - Rat Genome Database

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Gene: Tpp2 (tripeptidyl peptidase 2) Rattus norvegicus
Analyze
Symbol: Tpp2
Name: tripeptidyl peptidase 2
RGD ID: 621584
Description: Enables peptide binding activity and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TPP-2; TPP-II; tripeptidyl aminopeptidase; tripeptidyl peptidase II; tripeptidyl-peptidase 2; tripeptidyl-peptidase II; tripeptidylpeptidase II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,538,788 - 53,620,253 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl953,538,313 - 53,620,251 (+)EnsemblGRCr8
mRatBN7.2946,046,712 - 46,128,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,046,632 - 46,128,157 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx954,558,681 - 54,643,682 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,681,484 - 59,766,488 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,961,710 - 58,046,719 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,578,868 - 50,628,943 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0950,664,048 - 50,744,803 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,581,234 - 50,744,803 (+)Ensemblrn6Rnor6.0
Rnor_5.0950,244,904 - 50,293,192 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0950,328,059 - 50,409,442 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4942,984,834 - 43,066,195 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera943,759,380 - 43,840,712 (+)NCBICelera
RGSC_v3.1942,986,247 - 43,067,609 (+)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
propanal  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
vanadyl sulfate  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
nuclear body  (IEA,ISO)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis. Wray CJ, etal., Biochem Biophys Res Commun 2002 Aug 9;296(1):41-7.
Additional References at PubMed
PMID:8602240   PMID:9668046   PMID:11062501   PMID:22483107   PMID:22871113   PMID:25095668  


Genomics

Comparative Map Data
Tpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,538,788 - 53,620,253 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl953,538,313 - 53,620,251 (+)EnsemblGRCr8
mRatBN7.2946,046,712 - 46,128,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,046,632 - 46,128,157 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx954,558,681 - 54,643,682 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,681,484 - 59,766,488 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,961,710 - 58,046,719 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,578,868 - 50,628,943 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0950,664,048 - 50,744,803 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,581,234 - 50,744,803 (+)Ensemblrn6Rnor6.0
Rnor_5.0950,244,904 - 50,293,192 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0950,328,059 - 50,409,442 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4942,984,834 - 43,066,195 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera943,759,380 - 43,840,712 (+)NCBICelera
RGSC_v3.1942,986,247 - 43,067,609 (+)NCBI
Cytogenetic Map9q22NCBI
TPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,596,986 - 102,679,958 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,596,958 - 102,679,958 (+)Ensemblhg38GRCh38
GRCh3713103,249,336 - 103,332,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,047,374 - 102,129,522 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3413102,047,373 - 102,129,522NCBI
Celera1384,091,643 - 84,173,864 (+)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1383,841,839 - 83,924,038 (+)NCBIHuRef
CHM1_113103,218,763 - 103,300,981 (+)NCBICHM1_1
T2T-CHM13v2.013101,812,992 - 101,895,917 (+)NCBIT2T-CHM13v2.0
Tpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,973,130 - 44,042,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl143,972,807 - 44,042,160 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38143,933,970 - 44,003,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,933,647 - 44,003,000 (+)Ensemblmm10GRCm38
MGSCv37143,990,852 - 44,059,816 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36143,878,553 - 43,947,517 (+)NCBIMGSCv36mm8
Celera144,277,065 - 44,346,020 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.5NCBI
Tpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,463,715 - 8,528,784 (-)Ensembl
ChiLan1.0NW_0049554048,465,877 - 8,528,372 (-)NCBIChiLan1.0ChiLan1.0
TPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,113,261 - 104,195,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113102,781,660 - 102,863,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01383,756,757 - 83,838,997 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113102,892,037 - 102,974,974 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13102,892,037 - 102,974,974 (+)EnsemblpanPan2panpan1.1
TPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,105,821 - 52,176,213 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2252,105,886 - 52,175,426 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2251,885,525 - 51,955,929 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02252,556,648 - 52,627,124 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,556,638 - 52,627,381 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,205,955 - 52,276,357 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,222,152 - 52,292,574 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,263,035 - 52,333,679 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,513,772 - 187,581,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,369,736 - 8,438,412 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,370,607 - 8,438,376 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1170,943,141 - 71,009,627 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11170,943,142 - 71,009,381 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,219,920 - 78,323,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,151,769 - 81,234,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,151,801 - 81,236,235 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604637,688,665 - 37,771,717 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,779,967 - 8,848,539 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247938,782,956 - 8,848,547 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tpp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14119,983,358 - 120,056,494 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tpp2
776 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:156
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000015393
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH134792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2946,127,914 - 46,128,118 (+)MAPPERmRatBN7.2
Rnor_6.0950,744,561 - 50,744,764NCBIRnor6.0
Rnor_5.0950,409,200 - 50,409,403UniSTSRnor5.0
RGSC_v3.4943,065,953 - 43,066,156UniSTSRGSC3.4
Celera943,840,470 - 43,840,673UniSTS
RH 3.4 Map9392.19UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015393   ⟹   ENSRNOP00000015393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl953,538,313 - 53,620,251 (+)Ensembl
mRatBN7.2 Ensembl946,046,632 - 46,128,156 (+)Ensembl
Rnor_6.0 Ensembl950,664,150 - 50,744,002 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078220   ⟹   ENSRNOP00000074045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,046,632 - 46,128,157 (+)Ensembl
Rnor_6.0 Ensembl950,581,234 - 50,744,803 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085267   ⟹   ENSRNOP00000074556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,046,734 - 46,127,485 (+)Ensembl
Rnor_6.0 Ensembl950,581,247 - 50,743,999 (+)Ensembl
RefSeq Acc Id: NM_031137   ⟹   NP_112399
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,892 - 53,620,253 (+)NCBI
mRatBN7.2946,046,805 - 46,128,157 (+)NCBI
Rnor_6.0950,664,137 - 50,744,803 (+)NCBI
Rnor_5.0950,328,059 - 50,409,442 (+)NCBI
RGSC_v3.4942,984,834 - 43,066,195 (+)RGD
Celera943,759,380 - 43,840,712 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244852   ⟹   XP_006244914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,788 - 53,620,253 (+)NCBI
mRatBN7.2946,046,712 - 46,128,157 (+)NCBI
Rnor_6.0950,664,048 - 50,744,803 (+)NCBI
Rnor_5.0950,328,059 - 50,409,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244853   ⟹   XP_006244915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,788 - 53,615,206 (+)NCBI
mRatBN7.2946,046,712 - 46,123,161 (+)NCBI
Rnor_6.0950,664,048 - 50,739,548 (+)NCBI
Rnor_5.0950,328,059 - 50,409,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063267773   ⟹   XP_063123843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,788 - 53,606,626 (+)NCBI
RefSeq Acc Id: NP_112399   ⟸   NM_031137
- UniProtKB: Q64560 (UniProtKB/Swiss-Prot),   A6INR9 (UniProtKB/TrEMBL),   A0A8L2R9L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244915   ⟸   XM_006244853
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R9L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244914   ⟸   XM_006244852
- Peptide Label: isoform X1
- UniProtKB: A6INR8 (UniProtKB/TrEMBL),   A0A8L2R9L9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074556   ⟸   ENSRNOT00000085267
Ensembl Acc Id: ENSRNOP00000074045   ⟸   ENSRNOT00000078220
Ensembl Acc Id: ENSRNOP00000015393   ⟸   ENSRNOT00000015393
RefSeq Acc Id: XP_063123843   ⟸   XM_063267773
- Peptide Label: isoform X3
Protein Domains
Peptidase S8   Peptidase S8/S53   Tripeptidyl peptidase II C-terminal   Tripeptidyl peptidase II second Ig-like   Tripeptidyl-peptidase II first Ig-like   Tripeptidyl-peptidase II galactose-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64560-F1-model_v2 AlphaFold Q64560 1-1249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696642
Promoter ID:EPDNEW_R7166
Type:initiation region
Name:Tpp2_1
Description:tripeptidyl peptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0950,664,085 - 50,664,145EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621584 AgrOrtholog
BioCyc Gene G2FUF-27661 BioCyc
Ensembl Genes ENSRNOG00000011194 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015393 ENTREZGENE
Gene3D-CATH 1.25.40.710 UniProtKB/Swiss-Prot
  2.60.40.3170 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
  6.10.250.3080 UniProtKB/Swiss-Prot
InterPro Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-like UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  Peptidase_S8A_TPPII UniProtKB/Swiss-Prot
  TPP_II_domain UniProtKB/Swiss-Prot
  TPPII_C_art UniProtKB/Swiss-Prot
  TPPII_C_sf UniProtKB/Swiss-Prot
  TPPII_GBD UniProtKB/Swiss-Prot
  TPPII_Ig-like-1 UniProtKB/Swiss-Prot
  TPPII_Ig-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:81815 UniProtKB/Swiss-Prot
NCBI Gene 81815 ENTREZGENE
PANTHER PEPTIDASE S8 UniProtKB/Swiss-Prot
  TRIPEPTIDYL-PEPTIDASE 2 UniProtKB/Swiss-Prot
Pfam Peptidase_S8 UniProtKB/Swiss-Prot
  TPPII UniProtKB/Swiss-Prot
  TPPII_C UniProtKB/Swiss-Prot
  TPPII_GBD UniProtKB/Swiss-Prot
  TPPII_Ig-like-1 UniProtKB/Swiss-Prot
PhenoGen Tpp2 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_HIS UniProtKB/Swiss-Prot
  SUBTILASE_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011194 RatGTEx
Superfamily-SCOP SSF52743 UniProtKB/Swiss-Prot
UniProt A0A8L2Q8D6_RAT UniProtKB/TrEMBL
  A0A8L2R9L9 ENTREZGENE
  A6INR8 ENTREZGENE, UniProtKB/TrEMBL
  A6INR9 ENTREZGENE, UniProtKB/TrEMBL
  Q64560 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Tpp2  tripeptidyl peptidase 2  Tpp2  tripeptidyl peptidase II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tpp2  tripeptidyl peptidase II    tripeptidylpeptidase II  Name updated 1299863 APPROVED
2002-08-07 Tpp2  tripeptidylpeptidase II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activity and expression are increased in skeletal muscle during sepsis 634435