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Gene: Ces2e (carboxylesterase 2E) Rattus norvegicus

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Symbol:

Ces2e

Name:

carboxylesterase 2E

RGD ID:

621563

Description:

Enables retinyl-palmitate esterase activity. Predicted to be involved in retinoid metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human CES2 (carboxylesterase 2); INTERACTS WITH 17beta-estradiol; acetamide; beta-naphthoflavone.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

carboxylesterase 5; carboxylic ester hydrolase; Ces5; Loc192257; phenobarbital-inducible carboxylesterase (liver); pyrethroid hydrolase Ces2e

RGD Orthologs

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Ces2e (carboxylesterase 2E)	RGD	RGD
Other homologs ²
Homo sapiens (human):	CES2 (carboxylesterase 2)	HGNC	Ensembl, Panther, Treefam
Alliance orthologs ³
Homo sapiens (human):	CES2 (carboxylesterase 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Ces2e (carboxylesterase 2E)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Mus musculus (house mouse):	Ces2e (carboxylesterase 2E)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector)
Mus musculus (house mouse):	Ces2f (carboxylesterase 2F)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ces3 (carboxylesterase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ces2 (carboxylesterase 2 (intestine, liver))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC376.3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	B0238.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Caenorhabditis elegans (roundworm):	C52A10.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Drosophila melanogaster (fruit fly):	Jhedup	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Est-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Est-6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Est-P	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Jhe	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	clt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG3841	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA)
Drosophila melanogaster (fruit fly):	CG4382	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	ges-1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4757	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	alpha-Est9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Danio rerio (zebrafish):	ces2b	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces3.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces3.1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ces3.4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces3.4	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ces2.8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.7	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ces2.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	163,899 - 179,274 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	163,859 - 179,308 (+)	Ensembl				GRCr8
mRatBN7.2	19	157,447 - 172,822 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	157,407 - 172,856 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	162,415 - 177,795 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	896,113 - 911,493 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	171,345 - 186,725 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	85,679 - 100,386 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	85,606 - 100,424 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	86,201 - 100,908 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	65,698 - 82,042 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	153,546 - 166,005 (+)	NCBI		Celera
RGSC_v3.1	19	65,705 - 82,042 (+)	NCBI
Cytogenetic Map	19	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-acetamidofluorene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitrophenyl acetate (ISO)

acetamide (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

arsenous acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

Benzo[ghi]perylene (ISO)

beta-naphthoflavone (EXP,ISO)

bifenthrin (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butylated hydroxyanisole (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chrysene (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

cyfluthrin (ISO)

cyhalothrin (ISO)

cypermethrin (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

endosulfan (EXP)

etoposide (ISO)

fenvalerate (ISO)

flutamide (EXP)

folic acid (ISO)

furan (ISO)

genistein (ISO)

hydrazine (EXP)

inulin (ISO)

N-nitrosodiethylamine (EXP,ISO)

ozone (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

permethrin (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

silver atom (ISO)

silver(0) (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

retinoid metabolic process (TAS)

retinol metabolic process (IEA)

Molecular Function

all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity (IEA)

carboxylesterase activity (IBA,ISO)

carboxylic ester hydrolase activity (IEA)

hydrolase activity (IEA)

retinyl-palmitate esterase activity (IBA,IDA)

trans-permethrin hydrolase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate.	Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.

Genomics

Comparative Map Data

Ces2e
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	163,899 - 179,274 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	163,859 - 179,308 (+)	Ensembl				GRCr8
mRatBN7.2	19	157,447 - 172,822 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	157,407 - 172,856 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	162,415 - 177,795 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	896,113 - 911,493 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	171,345 - 186,725 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	85,679 - 100,386 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	85,606 - 100,424 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	86,201 - 100,908 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	65,698 - 82,042 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	153,546 - 166,005 (+)	NCBI		Celera
RGSC_v3.1	19	65,705 - 82,042 (+)	NCBI
Cytogenetic Map	19	p14	NCBI

Ces2e
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	105,652,892 - 105,661,304 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	105,652,892 - 105,661,304 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	104,926,260 - 104,934,672 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	104,926,260 - 104,934,672 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	107,450,160 - 107,458,572 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	107,815,399 - 107,823,796 (+)	NCBI		MGSCv36	mm8
Celera	8	109,148,515 - 109,156,927 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.04	NCBI

Variants

Variants in Ces2e
67 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	48
Interacting mature miRNAs:	49
Transcripts:	ENSRNOT00000015724
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549847	Bss8	Bone structure and strength QTL 8	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	19	1	31969901	Rat
7411590	Foco7	Food consumption QTL 7	6.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	19	1	24694445	Rat
10054132	Srcrt9	Stress Responsive Cort QTL 9	2.87	0.0017	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	27361636	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	3	4	13	57	60	50	50	4	86	12	5	13	22	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D50580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015724 ⟹ ENSRNOP00000015724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	163,859 - 179,308 (+)	Ensembl
mRatBN7.2 Ensembl	19	157,407 - 172,856 (+)	Ensembl
Rnor_6.0 Ensembl	19	85,606 - 100,424 (+)	Ensembl

RefSeq Acc Id:

NM_001100477 ⟹ NP_001093947

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	163,899 - 179,274 (+)	NCBI
mRatBN7.2	19	157,447 - 172,822 (+)	NCBI
Rnor_6.0	19	85,679 - 100,386 (+)	NCBI
Rnor_5.0	19	86,201 - 100,908 (+)	NCBI
RGSC_v3.4	19	65,698 - 82,042 (+)	RGD
Celera	19	153,546 - 166,005 (+)	RGD

Sequence:

show sequence

ATGCCACTGGAAAGTCTTCCTGGCTGGCTGAATGCTGTGGTCTGGGGGCTCCTGCTTCTCTTCT
GCCAAGTGCAGGGCCAGGACTCAGCCAGCCCCATCAGAAACACGCACACGGGTCAAGTGAGAGG
CAGTTTTGTCCATGTGAAGGACACTAAATCTGGTGTCCACACCTTCCTGGGAATTCCCTTTGCC
AAGCCTCCTATAGGACCGCTGCGCTTTGCACCTCCTGAGCCACCTGAGCCATGGAGTGGTGTGA
GAGATGGGACATCCCACCCTGCCATGTGTCTACAGAATATCGATGGACTGAATCTAGAAAATCT
GAAAATTAAGATGAGCAGGTCTCCTGTCTCTATGTCTGAAGACTGCCTATACCTCAGCATCTAC
ACACCAGCCCACACCCATAAGGACTCTAATCTGCCTGTGATGGTATGGATCCATGGAGGTGGGC
TATGTTGGGGCATGGCTTCCACGTATGATGGATCTATGCTGGCAGCCATTGAGGATGTGGTGGT
GGTCACTATCCAGTACCGCCTAGGTATCCTGGGCTTCTTCAGCACTGGAGATGAACATGCCAGA
GGCAACTGGGGATACCTAGACCAAGTGGCTGCCCTACGGTGGGTCCAGCAGAACATCGTCCACT
TTGGAGGCAACCCTGACCGGGTCACTATTTTTGGAGAGTCAGCAGGTGGCATAAGTGTGTCTTC
ACATGTTGTGTCCCCCATGTCCCAAGGGCTCTTCCATGGTGCCATCATGGAGAGTGGAGTGGCA
CTACTACCTAACCTTATCTCCAACACCTCTGAGGTGATCTACACAATGGTAGCCAACCTATCTG
GATGTGAGCCTGTGGATTCAGAGGCCTTGATGAGCTGCCTACGAGAGAAGAGTGAAGAGGAAAT
GCTGGCTATTAACAATATCGTCAGGACCATCTCTGGTGTGGTAGATGGGAAGTTCTTACCCAGG
CACCCCTTGGAGTTGTTGGCCTCTGTGGATTTTCACCCTGTCCCCAGCATCATTGGTATCAATA
GTGATGAATATGGTTGGATAATTCCCATGCTCCACCCTGATAGCACCATGAAGGAAATAAACAG
AGAGACCATGCGGGCTGTTCTGAAGAACACAGCAGTACAGATGATGCTGCCTCCTGAGTGTAGT
GATTTGTTGATGGAAGAGTACATGGGGGACACTGAGGATTCCAAGACTCTCCAAATACAGTTCA
ATGAGATGATGGGGGACTTCATATTTGTGATTCCTGCTCTTCAAGTAGCACACTTTCAGCGTTC
CCATGCTCCTGTCTATTTTTATGAGTTCCAGCATCAGTCCAACTTCCTGAAGGATATCAGGCCA
CCTCATGTGAAGGCTGACCATGGTGATGAGCTTCCTTATGTGATTGGATACTTATTCTGGGACA
TGAAATTTGTCTTCACTGAGGAGGAGAAGCTGCTAAGCAGGAAGATGATAAAGTACTGGGCCAA
TTTTGCACGTCACGGGAATCCCAACAGTGAGGGTCTACCCTACTGGCCTGCATTGGACCATGAT
GAGCAGTACCTGCAGCTGGACATCCAGCCTGTTGTGGGCCGAGCCCTGAAGGCCAGAAGGCTGA
AATTCTGGACCAAGACTCTGCCCCAGAAGATCCAAGAGCTAAAGGGTTCTCAGGACAATCACAC
AGAGCTATAATGTCCTGTGTCAAGAAAACTGTGTAGACTTGAGTACAGGGTTTCTGAAGCCTCT
AAAGTCTACACTTGAATGGATATATCACATCTGTTGGATGACCCTGCAATTAAGGTTGAAGTCG
ACCATGTCTAGATAAGCTCTCTGAACCTGGTGCAAAATGGAAGACTCCCTTTCTCAGTGGGGTT
TCCTCTCCTTTGCCCAATCTTATCTGGAAAGTGTTCTAAGCACAAGTGCCTGACCTTATCTAGA
GAATGGCCTTGCACAAAGCTTCCTGCAAGTGCCGCAAGGTTCAGCACATACATCCCACTCAGTC
CTTCCCACCATATGATAATTAGGTACTGTTATGACCAATCAGCCACTCCTGCCTGTAACCCCAG
AAATCCTCTGAGGAAAGTCACATAACTTATGGCCAGATTACAGATTCAACTTCCTCTTTCAGGA
TATGAACTTGTCCAGCAGGTTCTTGGCATATTCCTCTTCATGTAAATGAAACATTCCCACCCTA
ATAAATAATCTACCTTCACCCTGGAAATCCCTACCCACACCCCAAGATCTACATAGTGCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001093947	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA23607	(Get FASTA)	NCBI Sequence Viewer
	EDL87215	(Get FASTA)	NCBI Sequence Viewer
	EDL87216	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015724
	ENSRNOP00000015724.5
GenBank Protein	G3V7J5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001093947 ⟸ NM_001100477
- Peptide Label:	precursor
- UniProtKB:	O35535 (UniProtKB/Swiss-Prot), G3V7J5 (UniProtKB/Swiss-Prot), A6JXT7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPLESLPGWLNAVVWGLLLLFCQVQGQDSASPIRNTHTGQVRGSFVHVKDTKSGVHTFLGIPFA KPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKMSRSPVSMSEDCLYLSIY TPAHTHKDSNLPVMVWIHGGGLCWGMASTYDGSMLAAIEDVVVVTIQYRLGILGFFSTGDEHAR GNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVA LLPNLISNTSEVIYTMVANLSGCEPVDSEALMSCLREKSEEEMLAINNIVRTISGVVDGKFLPR HPLELLASVDFHPVPSIIGINSDEYGWIIPMLHPDSTMKEINRETMRAVLKNTAVQMMLPPECS DLLMEEYMGDTEDSKTLQIQFNEMMGDFIFVIPALQVAHFQRSHAPVYFYEFQHQSNFLKDIRP PHVKADHGDELPYVIGYLFWDMKFVFTEEEKLLSRKMIKYWANFARHGNPNSEGLPYWPALDHD EQYLQLDIQPVVGRALKARRLKFWTKTLPQKIQELKGSQDNHTEL hide sequence

Ensembl Acc Id:

ENSRNOP00000015724 ⟸ ENSRNOT00000015724

Protein Domains

Carboxylesterase type B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V7J5-F1-model_v2	AlphaFold	G3V7J5	1-567	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700903

Promoter ID:

EPDNEW_R11427

Type:

initiation region

Name:

Ces2e_1

Description:

carboxylesterase 2E

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	85,639 - 85,699	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621563	AgrOrtholog
BioCyc Gene	G2FUF-6674	BioCyc
Ensembl Genes	ENSRNOG00000011635	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015724	ENTREZGENE
	ENSRNOT00000015724.8	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot
	CarbesteraseB	UniProtKB/Swiss-Prot
	Carboxylesterase_B_AS	UniProtKB/Swiss-Prot
	Carboxylesterase_B_CS	UniProtKB/Swiss-Prot
	Type-B_Carboxylest/Lipase	UniProtKB/Swiss-Prot
NCBI Gene	192257	ENTREZGENE
PANTHER	CARBOXYLESTERASE	UniProtKB/Swiss-Prot
Pfam	COesterase	UniProtKB/Swiss-Prot
PhenoGen	Ces2e	PhenoGen
PROSITE	CARBOXYLESTERASE_B_1	UniProtKB/Swiss-Prot
	CARBOXYLESTERASE_B_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011635	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot
UniProt	A6JXT7	ENTREZGENE, UniProtKB/TrEMBL
	EST2E_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	O35535	ENTREZGENE
UniProt Secondary	O35535	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-11-18	Ces2e	carboxylesterase 2E	Ces5	carboxylesterase 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Ces5	carboxylesterase 5	Loc192257	phenobarbital-inducible carboxylesterase (liver)	Symbol and Name updated	1299863	APPROVED
2002-08-07	Loc192257	phenobarbital-inducible carboxylesterase (liver)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in metabolizing tissues, including lung, small intestine, liver, stomach, kidney, skin, and testis	724430

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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