Ces1e (carboxylesterase 1E) - Rat Genome Database

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Gene: Ces1e (carboxylesterase 1E) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces1e
Name: carboxylesterase 1E
RGD ID: 621508
Description: Enables retinyl-palmitate esterase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in endoplasmic reticulum lumen and membrane. Predicted to be active in endoplasmic reticulum and lipid droplet; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxyesterase ES-3; carboxylesterase 1; Ces1; egasyn; ES-HTEL; Es22; esterase 22; liver carboxylesterase 3; LOC683107; MGC156521; pI 5.5 esterase; similar to carboxylesterase 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,006,173 - 30,042,628 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1930,006,153 - 30,042,626 (+)EnsemblGRCr8
mRatBN7.21913,833,154 - 13,869,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,796,623 - 13,912,035 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1915,542,278 - 15,571,859 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,737,029 - 20,766,618 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,682,303 - 23,712,070 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_5.01926,347,402 - 26,354,168 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01926,133,775 - 26,134,125 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41914,887,900 - 14,924,363 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1913,766,930 - 13,801,741 (+)NCBICelera
RGSC_v3.11914,892,725 - 14,929,187 (+)NCBI
Cytogenetic Map19p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular cloning and expression of rat hepatic neutral cholesteryl ester hydrolase. Ghosh S, etal., Biochim Biophys Acta 1995 Dec 7;1259(3):305-12.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
5. The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences. Medda S and Proia RL, Eur J Biochem 1992 Jun 15;206(3):801-6.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Cloning and sequencing of rat liver carboxylesterase ES-3 (egasyn). Robbi M and Beaufay H, Biochem Biophys Res Commun 1994 Sep 30;203(3):1404-11.
11. Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum. Robbi M, etal., Biochem J 1990 Jul 15;269(2):451-8.
12. Cloning and sequencing of rat liver carboxylesterase ES-4 (microsomal palmitoyl-CoA hydrolase). Robbi M, etal., Biochem J 1996 Feb 1;313 ( Pt 3):821-6.
13. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
14. Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolase. Yan B, etal., J Biol Chem 1994 Nov 25;269(47):29688-96.
Additional References at PubMed
PMID:12477932   PMID:15825828   PMID:17764701   PMID:19187434   PMID:19225040  


Genomics

Variants

.
Variants in Ces1e
234 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000020775, ENSRNOT00000074479
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
CES2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,837,454 - 13,837,605 (+)MAPPERmRatBN7.2
mRatBN7.21913,926,882 - 13,927,033 (+)MAPPERmRatBN7.2
Rnor_6.01915,294,979 - 15,295,129NCBIRnor6.0
Rnor_6.01915,158,908 - 15,159,058NCBIRnor6.0
Rnor_5.01926,263,742 - 26,263,892UniSTSRnor5.0
Rnor_5.01926,392,061 - 26,392,211UniSTSRnor5.0
RGSC_v3.41914,892,454 - 14,892,604UniSTSRGSC3.4
RGSC_v3.41914,981,939 - 14,982,089UniSTSRGSC3.4
Celera1913,771,227 - 13,771,377UniSTS
Cytogenetic Map19p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
7 2 45 2 1 36 23

Sequence


Ensembl Acc Id: ENSRNOT00000120869   ⟹   ENSRNOP00000098478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1930,006,153 - 30,042,626 (+)Ensembl
RefSeq Acc Id: NM_031565   ⟹   NP_113753
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,006,173 - 30,042,628 (+)NCBI
mRatBN7.21913,833,154 - 13,869,627 (+)NCBI
Rnor_5.01926,133,775 - 26,134,125 (+)NCBI
Rnor_5.01926,347,402 - 26,354,168 (+)NCBI
RGSC_v3.41914,887,900 - 14,924,363 (+)RGD
Celera1913,766,930 - 13,801,741 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113753 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA57158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000098478
GenBank Protein Q63108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113753   ⟸   NM_031565
- Peptide Label: precursor
- UniProtKB: Q63108 (UniProtKB/Swiss-Prot),   A0A8I6AA76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000098478   ⟸   ENSRNOT00000120869

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63108-F1-model_v2 AlphaFold Q63108 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621508 AgrOrtholog
BioCyc Gene G2FUF-6407 BioCyc
Ensembl Genes ENSRNOG00000015438 Ensembl
  ENSRNOG00000071280 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000120869 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Type-B_Carboxylest/Lipase UniProtKB/Swiss-Prot
NCBI Gene 29225 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Ces1e PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015438 RatGTEx
  ENSRNOG00000071280 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A8I6AA76 ENTREZGENE
  A0ABK0L778_RAT UniProtKB/TrEMBL
  EST1E_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Ces1e  carboxylesterase 1E  LOC683107  similar to carboxylesterase 1  Data merged from RGD:1590459 737654 PROVISIONAL
2010-11-18 Ces1e  carboxylesterase 1E  Es22  esterase 22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Es22  esterase 22  Ces1  carboxylesterase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC683107  similar to carboxylesterase 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Ces1  carboxylesterase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains 2 potential N-linked glycosylation sites and a HXEL consensus sequence for retaining proteins to the endoplasmic reticulum 632434
gene_expression mRNA and protein expressed in liver and proximal tubules of the kidney 632432
gene_homology aa sequence shares 90% identity with mouse Es22 632432
gene_protein mature protein consists of 543 aa residues plus an 18 aa signal peptide at the N terminus 632434
gene_protein protein masses 62 kDa 632435