Cdc25b (cell division cycle 25B) - Rat Genome Database

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Gene: Cdc25b (cell division cycle 25B) Rattus norvegicus
Analyze
Symbol: Cdc25b
Name: cell division cycle 25B
RGD ID: 621500
Description: Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle and positive regulation of cell cycle process. Predicted to act upstream of or within female meiosis I and oocyte maturation. Predicted to be located in centrosome and spindle pole. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC25B (cell division cycle 25B); PARTICIPATES IN cell cycle pathway, mitotic; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division cycle 25 homolog B (S. cerevisiae); cell division cycle 25 homolog B (S. pombe); dual specificity phosphatase Cdc25B; M-phase inducer phosphatase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,860,148 - 138,870,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,860,130 - 138,870,492 (+)EnsemblGRCr8
mRatBN7.23118,407,127 - 118,417,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,301,484 - 122,311,583 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,900,852 - 130,910,946 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,557,585 - 128,567,684 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,731,539 - 123,741,696 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,731,539 - 123,741,339 (+)Ensemblrn6Rnor6.0
Rnor_5.03130,229,228 - 130,239,385 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,893,716 - 118,903,516 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,215,222 - 117,225,031 (+)NCBICelera
RGSC_v3.13118,799,288 - 118,809,089 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
busulfan  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carmustine  (EXP)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
endosulfan  (EXP)
equol  (ISO)
ethanol  (ISO)
fangchinoline  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
isosilybin A  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
Licochalcone B  (ISO)
linezolid  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
metformin  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (EXP,ISO)
silibinin  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thiram  (ISO)
tioguanine  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)
spindle pole  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Ito Y, etal., Breast Cancer. 2004;11(3):295-300.
3. Cdc25A is a novel phosphatase functioning early in the cell cycle. Jinno S, etal., EMBO J 1994 Apr 1;13(7):1549-56.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Ngan ES, etal., Oncogene. 2003 Feb 6;22(5):734-9.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer. Wang R, etal., Cancer Res. 2009 May 1;69(9):3810-8. Epub 2009 Apr 21.
10. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. Wang Z, etal., BMC Cancer. 2010 May 25;10:233.
11. Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas. Wu W, etal., Cancer Res. 2003 Oct 1;63(19):6195-9.
Additional References at PubMed
PMID:11912493   PMID:12400006   PMID:15908796   PMID:17332740   PMID:20083600   PMID:22899714   PMID:23326474  


Genomics

Comparative Map Data
Cdc25b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,860,148 - 138,870,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,860,130 - 138,870,492 (+)EnsemblGRCr8
mRatBN7.23118,407,127 - 118,417,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,301,484 - 122,311,583 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,900,852 - 130,910,946 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,557,585 - 128,567,684 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,731,539 - 123,741,696 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,731,539 - 123,741,339 (+)Ensemblrn6Rnor6.0
Rnor_5.03130,229,228 - 130,239,385 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,893,716 - 118,903,516 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,215,222 - 117,225,031 (+)NCBICelera
RGSC_v3.13118,799,288 - 118,809,089 (+)NCBI
Cytogenetic Map3q36NCBI
CDC25B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,786,951 - 3,806,115 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,786,772 - 3,806,730 (+)Ensemblhg38GRCh38
GRCh37203,767,598 - 3,786,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,724,401 - 3,734,762 (+)NCBIBuild 36Build 36hg18NCBI36
Celera203,838,270 - 3,848,633 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,724,986 - 3,735,364 (+)NCBIHuRef
CHM1_1203,776,654 - 3,787,027 (+)NCBICHM1_1
T2T-CHM13v2.0203,817,891 - 3,837,037 (+)NCBIT2T-CHM13v2.0
Cdc25b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,028,356 - 131,040,431 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,028,869 - 131,040,417 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382131,186,436 - 131,198,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,186,949 - 131,198,497 (+)Ensemblmm10GRCm38
MGSCv372131,012,687 - 131,024,233 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362130,878,520 - 130,889,906 (+)NCBIMGSCv36mm8
Celera2132,410,981 - 132,422,509 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.29NCBI
Cdc25b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,629,132 - 14,650,116 (+)Ensembl
ChiLan1.0NW_00495541514,637,295 - 14,647,181 (+)NCBIChiLan1.0ChiLan1.0
CDC25B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,749,003 - 4,769,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,745,828 - 4,765,995 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,877,255 - 3,883,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,626,097 - 3,645,179 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,626,107 - 3,645,179 (+)EnsemblpanPan2panpan1.1
CDC25B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,552,206 - 17,561,791 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,553,316 - 17,561,759 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2417,381,964 - 17,391,536 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02417,971,255 - 17,980,600 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,971,273 - 17,980,568 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,566,166 - 17,575,511 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,676,969 - 17,686,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,004,858 - 18,014,203 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdc25b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,465,682 - 166,482,670 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,897,368 - 14,906,325 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,897,050 - 14,914,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,910,825 - 31,929,242 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11731,910,824 - 31,929,418 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,244,262 - 36,262,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,482,709 - 34,493,737 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,483,771 - 34,494,071 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660719,958,886 - 9,969,775 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc25b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,882,516 - 4,892,925 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247414,871,275 - 4,892,730 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdc25b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15110,914,218 - 110,924,414 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdc25b
197 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:515
Count of miRNA genes:228
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000051064
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH131478  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83138,869,965 - 138,870,280 (+)Marker Load Pipeline
mRatBN7.23118,416,950 - 118,417,265 (+)MAPPERmRatBN7.2
Rnor_6.03123,741,375 - 123,741,689NCBIRnor6.0
Rnor_5.03130,239,064 - 130,239,378UniSTSRnor5.0
RGSC_v3.43118,903,552 - 118,903,866UniSTSRGSC3.4
Celera3117,225,067 - 117,225,381UniSTS
RH 3.4 Map31013.1UniSTS
Cytogenetic Map3q36UniSTS
RH133919  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,416,101 - 118,416,311 (+)MAPPERmRatBN7.2
Rnor_6.03123,740,526 - 123,740,735NCBIRnor6.0
Rnor_5.03130,238,215 - 130,238,424UniSTSRnor5.0
RGSC_v3.43118,902,703 - 118,902,912UniSTSRGSC3.4
Celera3117,224,218 - 117,224,427UniSTS
RH 3.4 Map31013.0UniSTS
Cytogenetic Map3q36UniSTS
Cdc25b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,411,929 - 118,412,755 (+)MAPPERmRatBN7.2
Rnor_6.03123,736,354 - 123,737,179NCBIRnor6.0
Rnor_5.03130,234,043 - 130,234,868UniSTSRnor5.0
RGSC_v3.43118,898,531 - 118,899,356UniSTSRGSC3.4
Celera3117,220,046 - 117,220,871UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000051064   ⟹   ENSRNOP00000051129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,860,164 - 138,870,284 (+)Ensembl
mRatBN7.2 Ensembl3118,407,182 - 118,417,270 (+)Ensembl
Rnor_6.0 Ensembl3123,731,539 - 123,741,339 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101513   ⟹   ENSRNOP00000088213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,860,130 - 138,870,285 (+)Ensembl
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103719   ⟹   ENSRNOP00000096779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,860,133 - 138,870,492 (+)Ensembl
mRatBN7.2 Ensembl3118,407,182 - 118,417,270 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119042   ⟹   ENSRNOP00000091343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,860,133 - 138,870,492 (+)Ensembl
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122290   ⟹   ENSRNOP00000106275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,860,133 - 138,870,492 (+)Ensembl
RefSeq Acc Id: NM_001389213   ⟹   NP_001376142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,173 - 138,870,287 (+)NCBI
mRatBN7.23118,407,157 - 118,417,272 (+)NCBI
RefSeq Acc Id: NM_133572   ⟹   NP_598256
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,173 - 138,870,287 (+)NCBI
mRatBN7.23118,407,157 - 118,417,272 (+)NCBI
Rnor_6.03123,731,539 - 123,741,339 (+)NCBI
Rnor_5.03130,229,228 - 130,239,385 (+)NCBI
RGSC_v3.43118,893,716 - 118,903,516 (+)RGD
Celera3117,215,222 - 117,225,031 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104193   ⟹   XP_038960121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,148 - 138,870,287 (+)NCBI
mRatBN7.23118,407,132 - 118,417,094 (+)NCBI
RefSeq Acc Id: XM_039104195   ⟹   XP_038960123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,861,330 - 138,870,287 (+)NCBI
mRatBN7.23118,408,304 - 118,417,094 (+)NCBI
RefSeq Acc Id: XM_063283040   ⟹   XP_063139110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,860,148 - 138,870,287 (+)NCBI
RefSeq Acc Id: NP_598256   ⟸   NM_133572
- Peptide Label: isoform 1
- UniProtKB: P48966 (UniProtKB/Swiss-Prot),   F1LQS5 (UniProtKB/TrEMBL),   A6HQC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051129   ⟸   ENSRNOT00000051064
RefSeq Acc Id: XP_038960121   ⟸   XM_039104193
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001376142   ⟸   NM_001389213
- Peptide Label: isoform 2
- UniProtKB: A0A8I6GIX5 (UniProtKB/TrEMBL),   A0A8I6A7K8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960123   ⟸   XM_039104195
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000091343   ⟸   ENSRNOT00000119042
Ensembl Acc Id: ENSRNOP00000088213   ⟸   ENSRNOT00000101513
Ensembl Acc Id: ENSRNOP00000096779   ⟸   ENSRNOT00000103719
RefSeq Acc Id: XP_063139110   ⟸   XM_063283040
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000106275   ⟸   ENSRNOT00000122290
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48966-F1-model_v2 AlphaFold P48966 1-574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692446
Promoter ID:EPDNEW_R2971
Type:initiation region
Name:Cdc25b_1
Description:cell division cycle 25B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,731,582 - 123,731,642EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621500 AgrOrtholog
BioCyc Gene G2FUF-47820 BioCyc
Ensembl Genes ENSRNOG00000021248 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000101513 ENTREZGENE
  ENSRNOT00000103719 ENTREZGENE
  ENSRNOT00000119042 ENTREZGENE
  ENSRNOT00000122290 ENTREZGENE
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
InterPro MPI_Phosphatase UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:171103 UniProtKB/Swiss-Prot
NCBI Gene 171103 ENTREZGENE
PANTHER M-PHASE INDUCER PHOSPHATASE 2 UniProtKB/Swiss-Prot
  M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 UniProtKB/Swiss-Prot
Pfam M-inducer_phosp UniProtKB/Swiss-Prot
  Rhodanese UniProtKB/Swiss-Prot
PhenoGen Cdc25b PhenoGen
PRINTS MPIPHPHTASE UniProtKB/Swiss-Prot
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021248 RatGTEx
SMART RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot
UniProt A0A8I6A7K8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AR92_RAT UniProtKB/TrEMBL
  A0A8I6GIX5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKL5_RAT UniProtKB/TrEMBL
  A6HQC8 ENTREZGENE, UniProtKB/TrEMBL
  A6HQC9_RAT UniProtKB/TrEMBL
  A6HQD0_RAT UniProtKB/TrEMBL
  A6HQD1_RAT UniProtKB/TrEMBL
  F1LQS5 ENTREZGENE, UniProtKB/TrEMBL
  MPIP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc25b  cell division cycle 25B  Cdc25b  cell division cycle 25 homolog B (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-01-29 Bsnd  cell division cycle 25 homolog B (S. pombe)  Cdc25b  cell division cycle 25 homolog B (S. cerevisiae)  Name updated 1299863 APPROVED
2005-01-20 Cdc25b  cell division cycle 25 homolog B (S. cerevisiae)    cell division cycle 25B  Name updated 1299863 APPROVED
2002-08-07 Cdc25b  cell division cycle 25B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression predominantly expressed in late G1 724653