Adam6 (ADAM metallopeptidase domain 6A) - Rat Genome Database

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Gene: Adam6 (ADAM metallopeptidase domain 6A) Rattus norvegicus
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Symbol: Adam6
Name: ADAM metallopeptidase domain 6A
RGD ID: 621472
Description: Orthologous to human ADAM6 (ADAM metallopeptidase domain 6 (pseudogene)); INTERACTS WITH 2-methoxyethanol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: a disintegrin and metallopeptidase domain 6; a disintegrin and metallopeptidase domain 6A; a disintegrin and metalloproteinase domain 6; Adam6a; tMDC IV; TMDCIV
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,488,008 - 138,490,496 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6138,488,008 - 138,490,493 (+)EnsemblGRCr8
mRatBN7.26132,666,974 - 132,669,462 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6132,831,539 - 132,834,027 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06133,230,764 - 133,233,252 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,505,448 - 132,507,936 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06138,432,550 - 138,435,038 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6138,432,550 - 138,435,035 (+)Ensemblrn6Rnor6.0
Rnor_5.06147,426,645 - 147,429,133 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46138,590,268 - 138,592,756 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6130,181,108 - 130,183,596 (+)NCBICelera
RGSC_v3.16138,596,454 - 138,598,940 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, etal., Mol Reprod Dev 1997 Oct;48(2):159-67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
Additional References at PubMed
PMID:19129510   PMID:21339297  


Genomics

Comparative Map Data
Adam6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,488,008 - 138,490,496 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6138,488,008 - 138,490,493 (+)EnsemblGRCr8
mRatBN7.26132,666,974 - 132,669,462 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6132,831,539 - 132,834,027 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06133,230,764 - 133,233,252 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,505,448 - 132,507,936 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06138,432,550 - 138,435,038 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6138,432,550 - 138,435,035 (+)Ensemblrn6Rnor6.0
Rnor_5.06147,426,645 - 147,429,133 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46138,590,268 - 138,592,756 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6130,181,108 - 130,183,596 (+)NCBICelera
RGSC_v3.16138,596,454 - 138,598,940 (+)NCBI
Cytogenetic Map6q32NCBI
ADAM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,969,729 - 105,972,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,969,729 - 105,972,269 (-)Ensemblhg38GRCh38
GRCh38.p14 Ensembl14105,970,168 - 105,971,166 (-)Ensemblhg38GRCh38
GRCh3714106,435,818 - 106,438,358 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,506,864 - 105,509,403 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1486,366,419 - 86,368,958 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,568,723 - 86,571,224 (-)NCBIHuRef
CHM1_114106,306,686 - 106,309,225 (-)NCBICHM1_1
T2T-CHM13v2.014100,240,816 - 100,243,356 (-)NCBIT2T-CHM13v2.0
Adam6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,507,528 - 113,510,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,507,528 - 113,510,085 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812113,543,908 - 113,546,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,543,908 - 113,546,465 (+)Ensemblmm10GRCm38
MGSCv3712114,782,119 - 114,784,625 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612113,991,716 - 113,994,222 (+)NCBIMGSCv36mm8
Celera12114,727,041 - 114,729,547 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.12NCBI

Variants

.
Variants in Adam6
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:78
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000056829
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
7 5 5 25 27 36 12 80 12 2 129 98 10 12 8 30 24

Sequence


Ensembl Acc Id: ENSRNOT00000056829   ⟹   ENSRNOP00000053671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6138,432,550 - 138,435,035 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149852   ⟹   ENSRNOP00000107788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6138,488,008 - 138,490,493 (+)Ensembl
RefSeq Acc Id: NM_138906   ⟹   NP_620261
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,488,008 - 138,490,496 (+)NCBI
mRatBN7.26132,666,974 - 132,669,462 (+)NCBI
Rnor_6.06138,432,550 - 138,435,038 (+)NCBI
Rnor_5.06147,426,645 - 147,429,133 (+)NCBI
RGSC_v3.46138,590,268 - 138,592,756 (+)RGD
Celera6130,181,108 - 130,183,596 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620261 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA70328 (Get FASTA)   NCBI Sequence Viewer  
  EDL97376 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107788
  ENSRNOP00000107788.1
RefSeq Acc Id: NP_620261   ⟸   NM_138906
- Peptide Label: precursor
- UniProtKB: P70535 (UniProtKB/TrEMBL),   A6KC05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053671   ⟸   ENSRNOT00000056829
Ensembl Acc Id: ENSRNOP00000107788   ⟸   ENSRNOT00000149852
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9N4-F1-model_v2 AlphaFold G3V9N4 1-751 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694866
Promoter ID:EPDNEW_R5389
Type:multiple initiation site
Name:Adam6_1
Description:a disintegrin and metallopeptidase domain 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06138,432,534 - 138,432,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621472 AgrOrtholog
BioCyc Gene G2FUF-35741 BioCyc
Ensembl Genes ENSRNOG00000037524 Ensembl
  ENSRNOG00000090919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000149852 ENTREZGENE
  ENSRNOT00000149852.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:192271 UniProtKB/TrEMBL
NCBI Gene 192271 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 6-RELATED UniProtKB/TrEMBL
  ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
PhenoGen Adam6 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037524 RatGTEx
  ENSRNOG00000090919 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0ABK0LPP9_RAT UniProtKB/TrEMBL
  A6KC05 ENTREZGENE, UniProtKB/TrEMBL
  P70535 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Adam6  ADAM metallopeptidase domain 6A  Adam6a  a disintegrin and metallopeptidase domain 6A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-01-07 Adam6a  a disintegrin and metallopeptidase domain 6A  Adam6  a disintegrin and metallopeptidase domain 6  Name and Symbol changed 629549 APPROVED
2005-01-20 Adam6  a disintegrin and metallopeptidase domain 6    a disintegrin and metalloproteinase domain 6  Name updated 1299863 APPROVED
2002-08-07 Adam6  a disintegrin and metalloproteinase domain 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in germ cells and somatic cells 631879