Dnase2 (deoxyribonuclease 2, lysosomal) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dnase2 (deoxyribonuclease 2, lysosomal) Rattus norvegicus
Analyze
Symbol: Dnase2
Name: deoxyribonuclease 2, lysosomal
RGD ID: 621457
Description: Enables DNA endonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to act upstream of or within DNA catabolic process; enucleate erythrocyte differentiation; and regulation of immune response. Predicted to be located in lysosome. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acid DNase; deoxyribonuclease II; deoxyribonuclease II alpha; deoxyribonuclease II, lysosomal; deoxyribonuclease-2-alpha; DNase II alpha; Dnase2a; lysosomal DNase II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,149,505 - 40,152,225 (-)NCBIGRCr8
mRatBN7.21923,244,656 - 23,247,376 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,244,664 - 23,247,376 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,067,580 - 30,070,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,721,940 - 30,724,660 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,944,628 - 32,947,348 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,022,855 - 26,025,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,022,849 - 26,025,532 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,998,478 - 37,001,146 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,900,949 - 24,903,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,905,774 - 24,908,443 (-)NCBI
Celera1922,801,629 - 22,804,297 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
eugenol  (ISO)
folic acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
O-methyleugenol  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
pyrogallol  (ISO)
resveratrol  (EXP)
Soman  (EXP)
T-2 toxin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
lysosome  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Cloning of a cDNA encoding a rat DNase II-like acid DNase. Tanuma S and Shiokawa D, Biochem Biophys Res Commun 1999 Nov 19;265(2):395-9.
Additional References at PubMed
PMID:12477932   PMID:23376485   PMID:23533145   PMID:25781645  


Genomics

Comparative Map Data
Dnase2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,149,505 - 40,152,225 (-)NCBIGRCr8
mRatBN7.21923,244,656 - 23,247,376 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,244,664 - 23,247,376 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,067,580 - 30,070,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,721,940 - 30,724,660 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,944,628 - 32,947,348 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,022,855 - 26,025,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,022,849 - 26,025,532 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,998,478 - 37,001,146 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,900,949 - 24,903,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,905,774 - 24,908,443 (-)NCBI
Celera1922,801,629 - 22,804,297 (-)NCBICelera
Cytogenetic Map19q11NCBI
DNASE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,875,209 - 12,881,449 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,875,209 - 12,881,595 (-)EnsemblGRCh38hg38GRCh38
GRCh371912,986,023 - 12,992,263 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,847,023 - 12,853,335 (-)NCBINCBI36Build 36hg18NCBI36
Build 341912,847,024 - 12,853,335NCBI
Celera1912,875,733 - 12,882,043 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,557,881 - 12,564,200 (-)NCBIHuRef
CHM1_11912,986,545 - 12,992,854 (-)NCBICHM1_1
T2T-CHM13v2.01912,999,693 - 13,005,938 (-)NCBIT2T-CHM13v2.0
Dnase2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,635,384 - 85,638,332 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,635,189 - 85,649,544 (+)EnsemblGRCm39 Ensembl
GRCm38884,908,755 - 84,911,703 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,908,560 - 84,922,915 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,432,523 - 87,435,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,798,729 - 87,801,566 (+)NCBIMGSCv36mm8
Celera889,208,019 - 89,210,856 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.31NCBI
Dnase2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,936,757 - 31,939,339 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,936,588 - 31,939,540 (-)NCBIChiLan1.0ChiLan1.0
DNASE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,803,952 - 17,811,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,804,533 - 16,811,820 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,436,898 - 12,443,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,180,073 - 13,185,650 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,180,073 - 13,185,650 (-)Ensemblpanpan1.1panPan2
DNASE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,299,236 - 49,301,815 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,299,406 - 49,301,814 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,171,506 - 49,174,081 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,816,184 - 49,818,759 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,816,420 - 49,821,137 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,027,501 - 49,030,074 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,453,986 - 49,456,560 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,696,325 - 49,698,901 (+)NCBIUU_Cfam_GSD_1.0
Dnase2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,408,688 - 208,411,034 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,941,372 - 1,946,087 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,943,673 - 1,945,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,149,862 - 66,152,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,150,071 - 66,152,857 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,447,511 - 66,450,524 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNASE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,557,034 - 11,570,117 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,553,904 - 11,570,244 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,226,718 - 8,233,053 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnase2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901464,223 - 467,161 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901464,211 - 466,979 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnase2
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000014887
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7 48 32 19 32 34 32 30 11
Low 36 9 9 9 8 11 40 3 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014887   ⟹   ENSRNOP00000014887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,244,664 - 23,247,376 (-)Ensembl
Rnor_6.0 Ensembl1926,022,849 - 26,025,532 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115823   ⟹   ENSRNOP00000095960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1923,244,665 - 23,247,328 (-)Ensembl
RefSeq Acc Id: NM_138539   ⟹   NP_612548
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,149,505 - 40,152,225 (-)NCBI
mRatBN7.21923,244,656 - 23,247,376 (-)NCBI
Rnor_6.01926,022,855 - 26,025,523 (+)NCBI
Rnor_5.01936,998,478 - 37,001,146 (+)NCBI
RGSC_v3.41924,900,949 - 24,903,617 (-)RGD
Celera1922,801,629 - 22,804,297 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_612548 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF13597 (Get FASTA)   NCBI Sequence Viewer  
  AAH91124 (Get FASTA)   NCBI Sequence Viewer  
  EDL92190 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014887
  ENSRNOP00000014887.3
  ENSRNOP00000095960.1
  ENSRNOP00055010511
  ENSRNOP00060016451
  ENSRNOP00065013547
GenBank Protein Q9QZK8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_612548   ⟸   NM_138539
- Peptide Label: precursor
- UniProtKB: Q5BKC7 (UniProtKB/Swiss-Prot),   Q9QZK8 (UniProtKB/Swiss-Prot),   A6IY62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014887   ⟸   ENSRNOT00000014887
RefSeq Acc Id: ENSRNOP00000095960   ⟸   ENSRNOT00000115823

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZK8-F1-model_v2 AlphaFold Q9QZK8 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701029
Promoter ID:EPDNEW_R11553
Type:initiation region
Name:Dnase2_1
Description:deoxyribonuclease 2, lysosomal
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01926,022,864 - 26,022,924EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621457 AgrOrtholog
BioCyc Gene G2FUF-6128 BioCyc
Ensembl Genes ENSRNOG00000023830 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007827 UniProtKB/Swiss-Prot
  ENSRNOG00060012300 UniProtKB/Swiss-Prot
  ENSRNOG00065010869 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014887 ENTREZGENE
  ENSRNOT00000014887.6 UniProtKB/Swiss-Prot
  ENSRNOT00000115823.1 UniProtKB/TrEMBL
  ENSRNOT00055013133 UniProtKB/Swiss-Prot
  ENSRNOT00060020870 UniProtKB/Swiss-Prot
  ENSRNOT00065017646 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7375398 IMAGE-MGC_LOAD
InterPro DNase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171575 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108596 IMAGE-MGC_LOAD
NCBI Gene 171575 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE-2-ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10858 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DNase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnase2 PhenoGen
RatGTEx ENSRNOG00000023830 RatGTEx
  ENSRNOG00055007827 RatGTEx
  ENSRNOG00060012300 RatGTEx
  ENSRNOG00065010869 RatGTEx
UniProt A0A8I6ASI3_RAT UniProtKB/TrEMBL
  A6IY62 ENTREZGENE, UniProtKB/TrEMBL
  DNS2A_RAT UniProtKB/Swiss-Prot
  Q5BKC7 ENTREZGENE
  Q9QZK8 ENTREZGENE
UniProt Secondary Q5BKC7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Dnase2  deoxyribonuclease 2, lysosomal  Dnase2  deoxyribonuclease II, lysosomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Dnase2  deoxyribonuclease II, lysosomal  Dnase2a  deoxyribonuclease II alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Dnase2a  deoxyribonuclease II alpha  Dnase2a  deoxyribonuclease II, lysosomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Dnase2a  deoxyribonuclease II, lysosomal  Dnase2  deoxyribonuclease II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dnase2  deoxyribonuclease II      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dnase2  deoxyribonuclease II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 356-amino acids 70721