![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Kcnk6 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Kcnk6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of KCNK6 mRNA | CTD | PMID:22206623 | Kcnk6 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KCNK6 mRNA | CTD | PMID:22206623 | Kcnk6 | Rat | 1,3-dinitrobenzene | increases expression | EXP | | 6480464 | 3-dinitrobenzene results in increased expression of KCNK6 mRNA | CTD | PMID:21983209 | Kcnk6 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of KCNK6 mRNA | CTD | PMID:17557909 | Kcnk6 | Rat | 17beta-estradiol | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of KCNK6 mRNA and [Estradiol co-treated with TGFB1 protein] results in increased expression of KCNK6 mRNA | CTD | PMID:20404318 and PMID:30165855 | Kcnk6 | Rat | 17beta-estradiol | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Estradiol results in increased expression of KCNK6 mRNA | CTD | PMID:31614463 | Kcnk6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Kcnk6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KCNK6 mRNA | CTD | PMID:19933214 | Kcnk6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KCNK6 mRNA | CTD | PMID:33387578 | Kcnk6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Kcnk6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KCNK6 mRNA | CTD | PMID:21570461 | Kcnk6 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Kcnk6 (Mus musculus) | 6480464 | bisphenol S results in increased expression of KCNK6 mRNA | CTD | PMID:30951980 | Kcnk6 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KCNK6 mRNA | CTD | PMID:24780913 | Kcnk6 | Rat | actinomycin D | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of KCNK6 mRNA | CTD | PMID:38460933 | Kcnk6 | Rat | actinomycin D | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Dactinomycin results in increased expression of KCNK6 mRNA | CTD | PMID:38460933 | Kcnk6 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KCNK6 mRNA | CTD | PMID:16483693 | Kcnk6 | Rat | aristolochic acid A | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KCNK6 mRNA | CTD | PMID:33212167 | Kcnk6 | Rat | arsenous acid | decreases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KCNK6 mRNA | CTD | PMID:22521957 | Kcnk6 | Rat | benzo[a]pyrene | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to KCNK6 promoter] | CTD | PMID:19654925 | Kcnk6 | Rat | benzo[a]pyrene | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of KCNK6 mRNA | CTD | PMID:32234424 | Kcnk6 | Rat | benzo[a]pyrene | decreases methylation | ISO | KCNK6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of KCNK6 promoter | CTD | PMID:27901495 | Kcnk6 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of KCNK6 mRNA | CTD | PMID:31163220 | Kcnk6 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KCNK6 mRNA | CTD | PMID:25181051 | Kcnk6 | Rat | bisphenol A | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of KCNK6 mRNA | CTD | PMID:32387340 | Kcnk6 | Rat | Bisphenol B | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of KCNK6 mRNA | CTD | PMID:32387340 | Kcnk6 | Rat | camptothecin | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Camptothecin results in increased expression of KCNK6 mRNA | CTD | PMID:38460933 | Kcnk6 | Rat | cyclosporin A | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of KCNK6 mRNA | CTD | PMID:27989131 | Kcnk6 | Rat | diarsenic trioxide | decreases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KCNK6 mRNA | CTD | PMID:22521957 | Kcnk6 | Rat | Dibutyl phosphate | affects expression | ISO | KCNK6 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of KCNK6 mRNA | CTD | PMID:37042841 | Kcnk6 | Rat | dibutyl phthalate | increases expression | ISO | Kcnk6 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of KCNK6 mRNA | CTD | PMID:17361019 and PMID:21266533 | Kcnk6 | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of KCNK6 mRNA | CTD | PMID:21266533 | Kcnk6 | Rat | dimethylarsinic acid | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of KCNK6 mRNA | CTD | PMID:34876320 | Kcnk6 | Rat | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of KCNK6 mRNA | CTD | PMID:33729688 | Kcnk6 | Rat | dorsomorphin | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Kcnk6 | Rat | doxorubicin | decreases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of KCNK6 mRNA | CTD | PMID:29803840 | Kcnk6 | Rat | entinostat | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | entinostat results in increased expression of KCNK6 mRNA | CTD | PMID:26272509 and PMID:27188386 | Kcnk6 | Rat | entinostat | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK6 mRNA | CTD | PMID:27188386 | Kcnk6 | Rat | folic acid | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KCNK6 mRNA | CTD | PMID:22206623 | Kcnk6 | Rat | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of KCNK6 gene | CTD | PMID:27387713 | Kcnk6 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of KCNK6 mRNA | CTD | PMID:27387713 | Kcnk6 | Rat | lithium chloride | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Lithium Chloride results in increased expression of KCNK6 mRNA | CTD | PMID:23527032 | Kcnk6 | Rat | methylarsonic acid | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of KCNK6 mRNA | CTD | PMID:34876320 | Kcnk6 | Rat | mono(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of KCNK6 mRNA | CTD | PMID:16809437 | Kcnk6 | Rat | N-methyl-4-phenylpyridinium | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of KCNK6 mRNA | CTD | PMID:24810058 | Kcnk6 | Rat | nickel atom | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Nickel results in increased expression of KCNK6 mRNA | CTD | PMID:24768652 and PMID:25583101 | Kcnk6 | Rat | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of KCNK6 mRNA | CTD | PMID:33484710 | Kcnk6 | Rat | Nutlin-3 | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of KCNK6 mRNA | CTD | PMID:38460933 | Kcnk6 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of KCNK6 mRNA | CTD | PMID:33387578 | Kcnk6 | Rat | perfluorooctanoic acid | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] results in decreased expression of KCNK6 mRNA | CTD | PMID:33325755 | Kcnk6 | Rat | phenobarbital | decreases expression | ISO | Kcnk6 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of KCNK6 mRNA | CTD | PMID:19482888 | Kcnk6 | Rat | phenobarbital | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KCNK6 mRNA] | CTD | PMID:19482888 | Kcnk6 | Rat | phytoestrogen | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] results in decreased expression of KCNK6 mRNA | CTD | PMID:33325755 | Kcnk6 | Rat | picene | decreases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | picene results in decreased expression of KCNK6 mRNA | CTD | PMID:32251684 | Kcnk6 | Rat | progesterone | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Progesterone results in increased expression of KCNK6 mRNA | CTD | PMID:20864642 | Kcnk6 | Rat | propanal | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of KCNK6 mRNA | CTD | PMID:26079696 | Kcnk6 | Rat | rotenone | increases expression | ISO | Kcnk6 (Mus musculus) | 6480464 | Rotenone results in increased expression of KCNK6 mRNA | CTD | PMID:32937126 | Kcnk6 | Rat | SB 431542 | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Kcnk6 | Rat | sodium arsenate | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of KCNK6 mRNA | CTD | PMID:34876320 | Kcnk6 | Rat | sodium arsenite | multiple interactions | ISO | Kcnk6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of KCNK6 mRNA | CTD | PMID:34876320 | Kcnk6 | Rat | testosterone | decreases expression | ISO | Kcnk6 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of KCNK6 mRNA | CTD | PMID:33848595 | Kcnk6 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of KCNK6 mRNA | CTD | PMID:34492290 | Kcnk6 | Rat | trichloroethene | affects expression | EXP | | 6480464 | Trichloroethylene affects the expression of KCNK6 mRNA | CTD | PMID:33387578 | Kcnk6 | Rat | trichostatin A | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of KCNK6 mRNA | CTD | PMID:24935251 | Kcnk6 | Rat | triclosan | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Triclosan results in increased expression of KCNK6 mRNA | CTD | PMID:30510588 | Kcnk6 | Rat | valproic acid | increases methylation | ISO | KCNK6 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KCNK6 gene | CTD | PMID:29154799 | Kcnk6 | Rat | valproic acid | affects expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KCNK6 mRNA | CTD | PMID:25979313 | Kcnk6 | Rat | valproic acid | increases expression | ISO | KCNK6 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KCNK6 mRNA | CTD | PMID:23179753 more ... | Kcnk6 | Rat | valproic acid | multiple interactions | ISO | KCNK6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KCNK6 mRNA | CTD | PMID:27188386 | |