Kcnj4 (potassium inwardly-rectifying channel, subfamily J, member 4) - Rat Genome Database

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Gene: Kcnj4 (potassium inwardly-rectifying channel, subfamily J, member 4) Rattus norvegicus
Analyze
Symbol: Kcnj4
Name: potassium inwardly-rectifying channel, subfamily J, member 4
RGD ID: 621436
Description: Enables inward rectifier potassium channel activity. Involved in cellular response to mechanical stimulus. Located in dendrite and neuronal cell body. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BIR11; brain inwardly rectifying K(+) channel 2; Hirk2; inward rectifier K(+) channel Kir2.3; inward rectifier potassium channel 4; IRK-3; IRK3; potassium channel, inwardly rectifying subfamily J member 4; potassium channel, inwardly rectifying subfamily J, member 4; potassium voltage-gated channel subfamily J member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,927,494 - 112,954,547 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7112,922,532 - 112,954,826 (-)EnsemblGRCr8
mRatBN7.27111,047,097 - 111,074,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,047,094 - 111,074,151 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7112,794,719 - 112,821,776 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,018,256 - 115,045,311 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,987,627 - 115,014,682 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,717,378 - 120,744,602 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,717,375 - 120,744,602 (-)Ensemblrn6Rnor6.0
Rnor_5.07120,710,647 - 120,738,030 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47117,601,723 - 117,616,019 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7107,378,714 - 107,405,561 (-)NCBICelera
RGSC_v3.17117,636,661 - 117,638,055 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
neuron-to-neuron signaling pathway via the chemical synapse  (IEP)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of a family of inward rectifier potassium channels. Bond CT, etal., Receptors Channels 1994;2(3):183-91.
2. Cloning and expression of two brain-specific inwardly rectifying potassium channels. Bredt DS, etal., Proc Natl Acad Sci U S A 1995 Jul 18;92(15):6753-7.
3. Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein. Falk T, etal., FEBS Lett 1995 Jun 26;367(2):127-31.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Pruss H, etal., Brain Res Mol Brain Res. 2003 Feb 20;110(2):203-19.
11. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Pruss H, etal., Brain Res Mol Brain Res. 2005 Sep 13;139(1):63-79.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9.
Additional References at PubMed
PMID:16855024   PMID:17670900   PMID:18619942   PMID:23426663   PMID:23561319  


Genomics

Comparative Map Data
Kcnj4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,927,494 - 112,954,547 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7112,922,532 - 112,954,826 (-)EnsemblGRCr8
mRatBN7.27111,047,097 - 111,074,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,047,094 - 111,074,151 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7112,794,719 - 112,821,776 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,018,256 - 115,045,311 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,987,627 - 115,014,682 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,717,378 - 120,744,602 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,717,375 - 120,744,602 (-)Ensemblrn6Rnor6.0
Rnor_5.07120,710,647 - 120,738,030 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47117,601,723 - 117,616,019 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7107,378,714 - 107,405,561 (-)NCBICelera
RGSC_v3.17117,636,661 - 117,638,055 (-)NCBI
Cytogenetic Map7q34NCBI
KCNJ4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,426,327 - 38,455,199 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,426,327 - 38,455,639 (-)Ensemblhg38GRCh38
GRCh372238,822,332 - 38,851,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,152,278 - 37,181,149 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342237,146,831 - 37,175,703NCBI
Celera2222,627,921 - 22,656,791 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,788,287 - 21,817,034 (-)NCBIHuRef
CHM1_12238,781,129 - 38,809,998 (-)NCBICHM1_1
T2T-CHM13v2.02238,890,595 - 38,919,463 (-)NCBIT2T-CHM13v2.0
Kcnj4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,364,427 - 79,396,712 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,367,915 - 79,389,442 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381579,480,226 - 79,512,511 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,483,714 - 79,505,241 (-)Ensemblmm10GRCm38
MGSCv371579,314,144 - 79,335,671 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361579,310,972 - 79,336,740 (-)NCBIMGSCv36mm8
Celera1581,607,702 - 81,629,675 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.74NCBI
Kcnj4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,605,887 - 24,634,524 (-)Ensembl
ChiLan1.0NW_00495541324,605,887 - 24,634,524 (-)NCBIChiLan1.0ChiLan1.0
KCNJ4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,282,292 - 48,311,156 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,973,769 - 51,002,639 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02219,341,699 - 19,370,666 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,163,293 - 37,165,182 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,163,760 - 37,165,097 (-)EnsemblpanPan2panpan1.1
KCNJ4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,321,274 - 26,348,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,347,140 - 26,348,486 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1026,276,719 - 26,304,778 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01027,112,472 - 27,140,533 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11026,833,697 - 26,861,515 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,163,037 - 27,173,007 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,321,947 - 27,349,562 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnj4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,830,569 - 9,857,540 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,865,879 - 2,867,201 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,865,803 - 2,867,657 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,547,177 - 9,548,520 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.159,526,399 - 9,549,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,808,886 - 6,831,164 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,085,857 - 21,114,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,086,322 - 21,087,659 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045104,652,027 - 104,681,343 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,638,704 - 9,659,523 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247529,633,799 - 9,659,532 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj4
88 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:61
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000018564
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Rat12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,075,397 - 111,075,573 (+)MAPPERmRatBN7.2
Rnor_6.07120,745,849 - 120,746,024NCBIRnor6.0
Rnor_5.07120,739,277 - 120,739,452UniSTSRnor5.0
Celera7107,406,808 - 107,406,983UniSTS
RH 3.4 Map7850.1UniSTS
RH 3.4 Map7850.1RGD
RH 2.0 Map7642.1RGD
SHRSP x BN Map763.5RGD
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 5 37 113 43 44 20 15 20 6 156 72 1 95 52 80 24 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000018564   ⟹   ENSRNOP00000053014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,923,459 - 112,949,485 (-)Ensembl
mRatBN7.2 Ensembl7111,047,094 - 111,074,151 (-)Ensembl
Rnor_6.0 Ensembl7120,717,375 - 120,744,602 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122959   ⟹   ENSRNOP00000104988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,923,165 - 112,954,722 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156013   ⟹   ENSRNOP00000102507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7112,922,532 - 112,954,826 (-)Ensembl
RefSeq Acc Id: NM_053870   ⟹   NP_446322
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,927,494 - 112,954,547 (-)NCBI
mRatBN7.27111,047,097 - 111,074,151 (-)NCBI
Rnor_6.07120,717,378 - 120,744,602 (-)NCBI
Rnor_5.07120,710,647 - 120,738,030 (-)NCBI
RGSC_v3.47117,601,723 - 117,616,019 (-)RGD
Celera7107,378,714 - 107,405,561 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241963   ⟹   XP_006242025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,927,867 - 112,948,431 (-)NCBI
mRatBN7.27111,047,472 - 111,068,034 (-)NCBI
Rnor_6.07120,717,758 - 120,738,434 (-)NCBI
Rnor_5.07120,710,647 - 120,738,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241964   ⟹   XP_006242026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,927,866 - 112,947,283 (-)NCBI
mRatBN7.27111,047,471 - 111,067,298 (-)NCBI
Rnor_6.07120,717,758 - 120,737,998 (-)NCBI
Rnor_5.07120,710,647 - 120,738,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594575   ⟹   XP_017450064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,927,866 - 112,948,184 (-)NCBI
mRatBN7.27111,047,471 - 111,067,802 (-)NCBI
Rnor_6.07120,717,758 - 120,738,341 (-)NCBI
Sequence:
RefSeq Acc Id: NP_446322   ⟸   NM_053870
- UniProtKB: O35752 (UniProtKB/Swiss-Prot),   P52190 (UniProtKB/Swiss-Prot),   G3V9M7 (UniProtKB/TrEMBL),   A6HSS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242025   ⟸   XM_006241963
- Peptide Label: isoform X1
- UniProtKB: P52190 (UniProtKB/Swiss-Prot),   O35752 (UniProtKB/Swiss-Prot),   G3V9M7 (UniProtKB/TrEMBL),   A6HSS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242026   ⟸   XM_006241964
- Peptide Label: isoform X1
- UniProtKB: P52190 (UniProtKB/Swiss-Prot),   O35752 (UniProtKB/Swiss-Prot),   G3V9M7 (UniProtKB/TrEMBL),   A6HSS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450064   ⟸   XM_017594575
- Peptide Label: isoform X1
- UniProtKB: P52190 (UniProtKB/Swiss-Prot),   O35752 (UniProtKB/Swiss-Prot),   G3V9M7 (UniProtKB/TrEMBL),   A6HSS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053014   ⟸   ENSRNOT00000018564
Ensembl Acc Id: ENSRNOP00000102507   ⟸   ENSRNOT00000156013
Ensembl Acc Id: ENSRNOP00000104988   ⟸   ENSRNOT00000122959
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52190-F1-model_v2 AlphaFold P52190 1-446 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621436 AgrOrtholog
BioCyc Gene G2FUF-32759 BioCyc
Ensembl Genes ENSRNOG00000013869 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018564 ENTREZGENE
  ENSRNOT00000122959 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.40.1400 UniProtKB/Swiss-Prot
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir2.3 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
KEGG Report rno:116649 UniProtKB/Swiss-Prot
NCBI Gene 116649 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot
  PTHR11767:SF53 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
PharmGKB KCNJ4 RGD
PhenoGen Kcnj4 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR23CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013869 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A6HSS0 ENTREZGENE, UniProtKB/TrEMBL
  G3V9M7 ENTREZGENE, UniProtKB/TrEMBL
  KCNJ4_RAT UniProtKB/Swiss-Prot
  O35752 ENTREZGENE
  P52190 ENTREZGENE
UniProt Secondary O35752 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-19 Kcnj4  potassium inwardly-rectifying channel, subfamily J, member 4  Kcnj4  potassium voltage-gated channel subfamily J member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Kcnj4  potassium voltage-gated channel subfamily J member 4  Kcnj4  potassium channel, inwardly rectifying subfamily J, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj4  potassium channel, inwardly rectifying subfamily J, member 4  Kcnj4  potassium inwardly-rectifying channel, subfamily J, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnj4  potassium inwardly-rectifying channel, subfamily J, member 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnj4  potassium inwardly-rectifying channel, subfamily J, member 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains two-transmembrane domains 729013
gene_expression expressed in brain, pituitary and GH3/B6 cells 729286