Lifr (LIF receptor subunit alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lifr (LIF receptor subunit alpha) Rattus norvegicus
Analyze
Symbol: Lifr
Name: LIF receptor subunit alpha
RGD ID: 621431
Description: Enables cytokine binding activity and leukemia inhibitory factor receptor activity. Involved in animal organ regeneration; negative regulation of muscle cell apoptotic process; and neuron projection morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leukemia inhibitor factor receptor alpha-chain; leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha; LIF receptor; LIF receptor alpha; LIF-R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,951,787 - 58,020,357 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl257,952,975 - 58,020,364 (+)EnsemblGRCr8
mRatBN7.2256,224,393 - 56,292,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl256,250,120 - 56,286,699 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx263,340,495 - 63,390,488 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0261,410,670 - 61,461,110 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0256,411,932 - 56,462,624 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0256,424,910 - 56,489,346 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,426,367 - 56,489,415 (+)Ensemblrn6Rnor6.0
Rnor_5.0276,165,154 - 76,229,631 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4256,426,058 - 56,477,198 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera251,855,443 - 51,906,055 (+)NCBICelera
RGSC_v3.1256,354,290 - 56,405,431 (+)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atrazine  (EXP)
belinostat  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bromochloroacetic acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glyphosate  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
nevirapine  (EXP)
nickel sulfate  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
pyridaben  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rofecoxib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
starch  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of rat leukemia inhibitory factor receptor alpha-chain gene and its expression during pregnancy. Aikawa J, etal., Biochim Biophys Acta 1997 Sep 12;1353(3):266-76.
2. Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndrome. Dagoneau N, etal., Am J Hum Genet. 2004 Feb;74(2):298-305. Epub 2004 Jan 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS. Kurdi M and Booz GW, J Cell Physiol. 2007 Aug;212(2):424-31.
5. Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats. Kurdi M, etal., Mol Cell Biochem. 2005 Jan;269(1-2):95-101.
6. Characterization of the protective effects of cardiotrophin-1 against non-ischemic death stimuli in adult cardiomyocytes. Lopez N, etal., Cytokine. 2005 Jun 7;30(5):282-92. Epub 2005 Apr 2.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons. Ng YP, etal., J Biol Chem. 2003 Oct 3;278(40):38731-9. Epub 2003 Jul 18.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure. Yoshino J, etal., J Am Soc Nephrol. 2003 Dec;14(12):3090-101.
16. Effect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease. Zhang XG, etal., Hepatobiliary Pancreat Dis Int. 2006 May;5(2):268-72.
Additional References at PubMed
PMID:7957045   PMID:8385113   PMID:8999038   PMID:12643274   PMID:12707266   PMID:15051883   PMID:15716858   PMID:17873291   PMID:21446866   PMID:22291973   PMID:23064267   PMID:23533145  
PMID:24006456   PMID:30937308  


Genomics

Comparative Map Data
Lifr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,951,787 - 58,020,357 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl257,952,975 - 58,020,364 (+)EnsemblGRCr8
mRatBN7.2256,224,393 - 56,292,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl256,250,120 - 56,286,699 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx263,340,495 - 63,390,488 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0261,410,670 - 61,461,110 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0256,411,932 - 56,462,624 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0256,424,910 - 56,489,346 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl256,426,367 - 56,489,415 (+)Ensemblrn6Rnor6.0
Rnor_5.0276,165,154 - 76,229,631 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4256,426,058 - 56,477,198 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera251,855,443 - 51,906,055 (+)NCBICelera
RGSC_v3.1256,354,290 - 56,405,431 (+)NCBI
Cytogenetic Map2q16NCBI
LIFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38538,474,668 - 38,608,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl538,474,668 - 38,608,354 (-)Ensemblhg38GRCh38
GRCh37538,474,770 - 38,595,507 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36538,510,822 - 38,631,253 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34538,515,661 - 38,631,253NCBI
Celera538,361,644 - 38,482,099 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef538,427,081 - 38,547,293 (-)NCBIHuRef
CHM1_1538,476,985 - 38,597,458 (-)NCBICHM1_1
T2T-CHM13v2.0538,723,737 - 38,857,447 (-)NCBIT2T-CHM13v2.0
Lifr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39157,120,091 - 7,226,970 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl157,120,095 - 7,226,970 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38157,090,610 - 7,197,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl157,090,614 - 7,197,489 (+)Ensemblmm10GRCm38
MGSCv37157,079,572 - 7,147,489 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36157,087,757 - 7,138,433 (+)NCBIMGSCv36mm8
Celera156,977,793 - 7,045,762 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.46NCBI
Lifr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542623,047,167 - 23,116,891 (-)Ensembl
ChiLan1.0NW_00495542623,045,867 - 23,093,694 (-)NCBIChiLan1.0ChiLan1.0
LIFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2471,780,323 - 71,863,299 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1569,933,979 - 70,016,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0571,817,431 - 71,899,101 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1576,878,633 - 76,934,893 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl576,878,633 - 76,928,267 (+)EnsemblpanPan2panpan1.1
LIFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1470,328,963 - 70,376,127 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl470,267,514 - 70,376,127 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha470,004,435 - 70,051,591 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0470,845,522 - 70,892,699 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl470,839,649 - 70,893,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1470,593,619 - 70,640,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0470,707,131 - 70,754,284 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0471,245,697 - 71,292,862 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lifr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213227,678,883 - 227,719,656 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365183,652,152 - 3,693,078 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365183,651,630 - 3,693,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC102167255
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1623,634,298 - 23,804,854 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11623,627,700 - 23,672,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21624,852,896 - 24,857,618 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1437,307,753 - 37,385,489 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl437,314,347 - 37,362,137 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607127,670,489 - 27,746,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lifr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475916,410,687 - 16,472,014 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475916,368,390 - 16,478,486 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lifr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13173,282,515 - 173,343,882 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lifr
462 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000016036
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 83 59 6 347 183 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016036   ⟹   ENSRNOP00000016036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl257,952,975 - 58,020,364 (+)Ensembl
mRatBN7.2 Ensembl256,250,120 - 56,286,699 (+)Ensembl
Rnor_6.0 Ensembl256,426,367 - 56,489,415 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102098   ⟹   ENSRNOP00000081114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl257,952,975 - 58,007,791 (+)Ensembl
mRatBN7.2 Ensembl256,250,120 - 56,280,422 (+)Ensembl
RefSeq Acc Id: NM_031048   ⟹   NP_112310
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,963,389 - 58,014,068 (+)NCBI
mRatBN7.2256,236,013 - 56,286,699 (+)NCBI
Rnor_6.0256,436,726 - 56,487,589 (+)NCBI
Rnor_5.0276,165,154 - 76,229,631 (+)NCBI
RGSC_v3.4256,426,058 - 56,477,198 (+)RGD
Celera251,855,443 - 51,906,055 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232027   ⟹   XP_006232089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,952,973 - 58,020,357 (+)NCBI
mRatBN7.2256,225,598 - 56,292,988 (+)NCBI
Rnor_6.0256,426,445 - 56,489,346 (+)NCBI
Rnor_5.0276,165,154 - 76,229,631 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232029   ⟹   XP_006232091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,951,787 - 58,020,357 (+)NCBI
mRatBN7.2256,224,393 - 56,292,988 (+)NCBI
Rnor_6.0256,424,910 - 56,489,346 (+)NCBI
Rnor_5.0276,165,154 - 76,229,631 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103223   ⟹   XP_038959151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,951,791 - 58,020,357 (+)NCBI
mRatBN7.2256,224,393 - 56,292,988 (+)NCBI
RefSeq Acc Id: XM_063282627   ⟹   XP_063138697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,952,973 - 58,020,357 (+)NCBI
RefSeq Acc Id: NP_112310   ⟸   NM_031048
- Peptide Label: precursor
- UniProtKB: O70535 (UniProtKB/Swiss-Prot),   A6KGG5 (UniProtKB/TrEMBL),   G3V7K2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232091   ⟸   XM_006232029
- Peptide Label: isoform X1
- UniProtKB: O70535 (UniProtKB/Swiss-Prot),   G3V7K2 (UniProtKB/TrEMBL),   A6KGG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232089   ⟸   XM_006232027
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000016036   ⟸   ENSRNOT00000016036
RefSeq Acc Id: XP_038959151   ⟸   XM_039103223
- Peptide Label: isoform X1
- UniProtKB: O70535 (UniProtKB/Swiss-Prot),   G3V7K2 (UniProtKB/TrEMBL),   A6KGG5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081114   ⟸   ENSRNOT00000102098
RefSeq Acc Id: XP_063138697   ⟸   XM_063282627
- Peptide Label: isoform X1
- UniProtKB: O70535 (UniProtKB/Swiss-Prot),   A6KGG5 (UniProtKB/TrEMBL),   G3V7K2 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70535-F1-model_v2 AlphaFold O70535 1-1093 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691172
Promoter ID:EPDNEW_R1697
Type:initiation region
Name:Lifr_1
Description:LIF receptor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0256,426,337 - 56,426,397EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621431 AgrOrtholog
BioCyc Gene G2FUF-54147 BioCyc
Ensembl Genes ENSRNOG00000011696 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016036 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  LIF-R-like_Ig-like UniProtKB/Swiss-Prot
  LIFR_D2 UniProtKB/Swiss-Prot
  LIFR_N UniProtKB/Swiss-Prot
  Type-I_Cytokine_Rcpt UniProtKB/Swiss-Prot
KEGG Report rno:81680 UniProtKB/Swiss-Prot
NCBI Gene 81680 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  LEUKEMIA INHIBITORY FACTOR RECEPTOR UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  LIF-R_Ig-like UniProtKB/Swiss-Prot
  LIFR_D2 UniProtKB/Swiss-Prot
  LIFR_N UniProtKB/Swiss-Prot
PhenoGen Lifr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011696 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
UniProt A0A8I5ZRS1_RAT UniProtKB/TrEMBL
  A6KGG5 ENTREZGENE, UniProtKB/TrEMBL
  G3V7K2 ENTREZGENE, UniProtKB/TrEMBL
  LIFR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-29 Lifr  LIF receptor subunit alpha  Lifr  LIF receptor alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-27 Lifr  LIF receptor alpha  Lifr  leukemia inhibitory factor receptor alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Lifr  leukemia inhibitory factor receptor alpha  Lifr  leukemia inhibitory factor receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lifr  leukemia inhibitory factor receptor    leukemia inhibitor factor receptor alpha-chain  Name updated 1299863 APPROVED
2002-08-07 Lifr  leukemia inhibitor factor receptor alpha-chain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and placenta 633290