Atp6v0c (ATPase H+ transporting V0 subunit C) - Rat Genome Database

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Gene: Atp6v0c (ATPase H+ transporting V0 subunit C) Rattus norvegicus
Analyze
Symbol: Atp6v0c
Name: ATPase H+ transporting V0 subunit C
RGD ID: 621394
Description: Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of autophagic cell death and positive regulation of ERK1 and ERK2 cascade. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Atp6c; Atp6l; ATPase, H transporting, lysosomal V0 subunit c; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit C; ATPase, H+ transporting, lysosomal 1; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATPase, H+ transporting, lysosomal V0 subunit C; ATPase, H+ transporting, V0 subunit C; V-ATPase 16 kDa proteolipid subunit; V-ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 16 kDa proteolipid subunit; V-type proton ATPase 16 kDa proteolipid subunit c; vacuolar proton pump 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit c
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,700,764 - 13,707,147 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,700,764 - 13,706,245 (-)EnsemblGRCr8
mRatBN7.21013,196,204 - 13,202,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,196,204 - 13,201,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,941,023 - 17,946,085 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,429,860 - 17,434,922 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,928,324 - 12,933,402 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,537,031 - 13,543,407 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,537,033 - 13,542,077 (-)Ensemblrn6Rnor6.0
Rnor_5.01013,352,991 - 13,359,367 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,415,671 - 13,420,715 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1012,882,252 - 12,887,296 (-)NCBICelera
RGSC_v3.11013,415,670 - 13,420,715 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
choline  (ISO)
clobetasol  (ISO)
dextran sulfate  (ISO)
dichlorine  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
Maduramicin  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
miconazole  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
osimertinib  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phenylpropanolamine  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structure of V-ATPase from the mammalian brain. Abbas YM, etal., Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
2. Protective effects of vacuolar H+ -ATPase c on hydrogen peroxide-induced cell death in C6 glioma cells. Byun YJ, etal., Neurosci Lett. 2007 Oct 2;425(3):183-7. doi: 10.1016/j.neulet.2007.08.027. Epub 2007 Aug 19.
3. PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas. Camargo Barros-Filho M, etal., Int J Mol Sci. 2019 Mar 16;20(6). pii: ijms20061334. doi: 10.3390/ijms20061334.
4. The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. Galli T, etal., J Biol Chem. 1996 Jan 26;271(4):2193-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit of vacuolar H(+)-ATPases: organellar and tissue distribution of 16 kDa proteolipids. Nezu J, etal., J Biochem (Tokyo) 1992 Aug;112(2):212-9.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17897319   PMID:18298843   PMID:19056867   PMID:20093472   PMID:21423176   PMID:29476059   PMID:30155790  


Genomics

Comparative Map Data
Atp6v0c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,700,764 - 13,707,147 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,700,764 - 13,706,245 (-)EnsemblGRCr8
mRatBN7.21013,196,204 - 13,202,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,196,204 - 13,201,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,941,023 - 17,946,085 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,429,860 - 17,434,922 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,928,324 - 12,933,402 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,537,031 - 13,543,407 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,537,033 - 13,542,077 (-)Ensemblrn6Rnor6.0
Rnor_5.01013,352,991 - 13,359,367 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,415,671 - 13,420,715 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1012,882,252 - 12,887,296 (-)NCBICelera
RGSC_v3.11013,415,670 - 13,420,715 (-)NCBI
Cytogenetic Map10q12NCBI
ATP6V0C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,513,726 - 2,520,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,513,713 - 2,520,218 (+)Ensemblhg38GRCh38
GRCh37162,563,727 - 2,570,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,503,954 - 2,510,220 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34162,503,953 - 2,510,219NCBI
Celera162,755,525 - 2,785,155 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,489,699 - 2,496,194 (+)NCBIHuRef
CHM1_1162,563,664 - 2,570,161 (+)NCBICHM1_1
T2T-CHM13v2.0162,535,856 - 2,542,340 (+)NCBIT2T-CHM13v2.0
Atp6v0c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,382,839 - 24,388,652 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,382,840 - 24,388,676 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381724,163,865 - 24,169,678 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,163,866 - 24,169,702 (-)Ensemblmm10GRCm38
MGSCv371724,300,833 - 24,306,374 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361723,891,488 - 23,897,029 (-)NCBIMGSCv36mm8
Celera1724,669,200 - 24,674,661 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.29NCBI
Atp6v0c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,791,795 - 14,798,066 (-)Ensembl
ChiLan1.0NW_00495544214,791,795 - 14,798,066 (-)NCBIChiLan1.0ChiLan1.0
ATP6V0C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,015,432 - 3,021,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,796,438 - 6,802,895 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,370,460 - 1,376,775 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,613,096 - 2,619,204 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,613,096 - 2,619,204 (+)EnsemblpanPan2panpan1.1
ATP6V0C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,519,869 - 38,525,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,520,765 - 38,525,062 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha639,758,250 - 39,763,598 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0638,829,102 - 38,834,450 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,829,102 - 38,834,443 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,514,259 - 38,519,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,486,868 - 38,492,219 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,962,951 - 38,968,303 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp6v0c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,167,247 - 105,173,070 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,536,393 - 1,542,221 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,536,393 - 1,542,218 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP6V0C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1339,532,707 - 39,538,704 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,700,733 - 42,706,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP6V0C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,387,891 - 2,394,111 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,387,812 - 2,394,180 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606828,630,936 - 28,637,307 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp6v0c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824267,102 - 272,893 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624824267,102 - 272,893 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp6v0c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v191,461,281 - 1,466,732 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp6v0c
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:179
Interacting mature miRNAs:196
Transcripts:ENSRNOT00000008736
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH143316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,201,346 - 13,201,620 (+)MAPPERmRatBN7.2
Rnor_6.01013,542,174 - 13,542,447NCBIRnor6.0
Rnor_5.01013,358,134 - 13,358,407UniSTSRnor5.0
RGSC_v3.41013,420,812 - 13,421,085UniSTSRGSC3.4
Celera1012,887,393 - 12,887,666UniSTS
RH 3.4 Map10192.2UniSTS
Cytogenetic Map10q12UniSTS
Atp6l  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,196,216 - 13,196,379 (+)MAPPERmRatBN7.2
Rnor_6.01013,537,044 - 13,537,206NCBIRnor6.0
Rnor_5.01013,353,004 - 13,353,166UniSTSRnor5.0
RGSC_v3.41013,415,682 - 13,415,844UniSTSRGSC3.4
Celera1012,882,263 - 12,882,425UniSTS
Cytogenetic Map10q12UniSTS
Atp6c3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,196,216 - 13,196,405 (+)MAPPERmRatBN7.2
Rnor_6.01013,537,044 - 13,537,232NCBIRnor6.0
Rnor_5.01013,353,004 - 13,353,192UniSTSRnor5.0
RGSC_v3.41013,415,682 - 13,415,870UniSTSRGSC3.4
Celera1012,882,263 - 12,882,451UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_130823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008736   ⟹   ENSRNOP00000008736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,700,764 - 13,706,245 (-)Ensembl
mRatBN7.2 Ensembl1013,196,207 - 13,201,206 (-)Ensembl
Rnor_6.0 Ensembl1013,537,033 - 13,542,077 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104238   ⟹   ENSRNOP00000087132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,196,204 - 13,201,500 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113937   ⟹   ENSRNOP00000088542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,196,204 - 13,201,243 (-)Ensembl
RefSeq Acc Id: NM_130823   ⟹   NP_570836
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,700,764 - 13,705,842 (-)NCBI
mRatBN7.21013,196,204 - 13,201,282 (-)NCBI
Rnor_6.01013,537,033 - 13,542,077 (-)NCBI
Rnor_5.01013,352,991 - 13,359,367 (-)NCBI
RGSC_v3.41013,415,671 - 13,420,715 (-)RGD
Celera1012,882,252 - 12,887,296 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245898   ⟹   XP_006245960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,700,764 - 13,707,147 (-)NCBI
mRatBN7.21013,196,204 - 13,202,580 (-)NCBI
Rnor_6.01013,537,031 - 13,543,407 (-)NCBI
Rnor_5.01013,352,991 - 13,359,367 (-)NCBI
Sequence:
RefSeq Acc Id: NP_570836   ⟸   NM_130823
- UniProtKB: P63081 (UniProtKB/Swiss-Prot),   A6HCQ5 (UniProtKB/TrEMBL),   A0A8L2Q4M1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245960   ⟸   XM_006245898
- Peptide Label: isoform X1
- UniProtKB: P63081 (UniProtKB/Swiss-Prot),   A6HCQ5 (UniProtKB/TrEMBL),   A0A8L2Q4M1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008736   ⟸   ENSRNOT00000008736
Ensembl Acc Id: ENSRNOP00000087132   ⟸   ENSRNOT00000104238
Ensembl Acc Id: ENSRNOP00000088542   ⟸   ENSRNOT00000113937
Protein Domains
V-ATPase proteolipid subunit C-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63081-F1-model_v2 AlphaFold P63081 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697004
Promoter ID:EPDNEW_R7529
Type:initiation region
Name:Atp6v0c_1
Description:ATPase H+ transporting V0 subunit C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,542,033 - 13,542,093EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621394 AgrOrtholog
BioCyc Gene G2FUF-25873 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
BioCyc Pathway Image PWY-7980 BioCyc
Ensembl Genes ENSRNOG00000006542 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008736 ENTREZGENE
  ENSRNOT00000113937.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.610 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918203 IMAGE-MGC_LOAD
InterPro ATPase_proteolipid_c-like_dom UniProtKB/Swiss-Prot
  ATPase_proteolipid_csu UniProtKB/Swiss-Prot
  ATPase_proteolipid_su_C_euk UniProtKB/Swiss-Prot
  F/V-ATP_Csub_sf UniProtKB/Swiss-Prot
KEGG Report rno:170667 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72710 IMAGE-MGC_LOAD
NCBI Gene 170667 ENTREZGENE
PANTHER V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT UniProtKB/Swiss-Prot
Pfam ATP-synt_C UniProtKB/Swiss-Prot
PhenoGen Atp6v0c PhenoGen
PRINTS VACATPASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006542 RatGTEx
Superfamily-SCOP SSF81333 UniProtKB/Swiss-Prot
UniProt A0A8L2Q4M1 ENTREZGENE, UniProtKB/TrEMBL
  A6HCQ4_RAT UniProtKB/TrEMBL
  A6HCQ5 ENTREZGENE, UniProtKB/TrEMBL
  A6HCQ6_RAT UniProtKB/TrEMBL
  P63081 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P23967 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Atp6v0c  ATPase H+ transporting V0 subunit C  Atp6v0c  ATPase, H+ transporting, lysosomal V0 subunit C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atp6v0c  ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c  Atp6v0c  ATPase, H+ transporting, lysosomal V0 subunit C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Atp6v0c  ATPase, H+ transporting, lysosomal V0 subunit C  Atp6v0c  ATPase, H transporting, lysosomal V0 subunit c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atp6v0c  ATPase, H transporting, lysosomal V0 subunit c    ATPase, H+ transporting, V0 subunit C  Name updated 1299863 APPROVED
2005-01-20 Atp6v0c  ATPase, H+ transporting, V0 subunit C  Atp6l  ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa  Symbol and Name updated 1299863 APPROVED
2002-08-07 Atp6l  ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to lysosomes and to the Golgi apparatus 631903
gene_protein 16 kDa subunit 631903
gene_protein isoelectric point is 9.5 631903