Uox (urate oxidase) - Rat Genome Database

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Gene: Uox (urate oxidase) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Uox
Name: urate oxidase
RGD ID: 621369
Description: Enables urate oxidase activity. Involved in urate catabolic process. Located in peroxisome. Used to study hyperuricemia; PARTICIPATES IN caffeine metabolic pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: UOX-2; urate oxidase 2; Uri; Uri2; Uri_mapped; uricase; uricase (mapped)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: Uoxem1Cya
Genetic Models: SD-Uoxem1Cya
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82238,147,130 - 238,183,320 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2238,083,686 - 238,183,370 (+)EnsemblGRCr8
mRatBN7.22235,486,867 - 235,523,053 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,440,619 - 235,523,029 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2243,283,023 - 243,318,323 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02241,174,028 - 241,208,972 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02236,040,679 - 236,075,987 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,452,282 - 252,488,497 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,452,269 - 252,488,396 (+)Ensemblrn6Rnor6.0
Rnor_5.02270,978,811 - 271,015,097 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42244,795,552 - 244,832,143 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2227,465,950 - 227,501,003 (+)NCBICelera
RGSC_v3.12244,782,291 - 244,818,883 (+)NCBI
Cytogenetic Map2q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
peroxisomal matrix  (TAS)
peroxisome  (IBA,IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The nucleotide sequence of a full length cDNA clone encoding rat liver urate oxidase. Alvares K, etal., Biochem Biophys Res Commun 1989 Feb 15;158(3):991-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesis. Ito M, etal., Biochem Biophys Res Commun. 1992 Aug 31;187(1):101-7.
4. Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase. Ito M, etal., Eur J Biochem 1988 Apr 15;173(2):459-63.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cloning and sequence analysis of cDNA for rat liver uricase. Motojima K, etal., J Biol Chem 1988 Nov 15;263(32):16677-81.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat. Reddy PG, etal., Proc Natl Acad Sci U S A. 1988 Dec;85(23):9081-5.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Rat urate oxidase: cloning and structural analysis of the gene and 5'-flanking region. Wang XD, etal., Gene 1991 Jan 15;97(2):223-9.
15. Uricase-deficient rat is generated with CRISPR/Cas9 technique. Yu Y, etal., PeerJ. 2020 Apr 27;8:e8971. doi: 10.7717/peerj.8971. eCollection 2020.
Additional References at PubMed
PMID:1783398   PMID:2338140   PMID:11306811   PMID:12477932   PMID:15489334   PMID:24550457   PMID:33648977   PMID:34437605  


Genomics

Variants

.
Variants in Uox
436 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:294
Count of miRNA genes:200
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000021970
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat

Markers in Region
D2Mgh13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82238,161,243 - 238,161,384 (+)Marker Load Pipeline
mRatBN7.22235,500,980 - 235,501,121 (+)MAPPERmRatBN7.2
Rnor_6.02252,466,425 - 252,466,565NCBIRnor6.0
Rnor_5.02270,992,735 - 270,992,875UniSTSRnor5.0
RGSC_v3.42244,809,624 - 244,809,764UniSTSRGSC3.4
RGSC_v3.42244,809,623 - 244,809,764RGDRGSC3.4
Celera2227,479,263 - 227,479,403UniSTS
RGSC_v3.12244,796,363 - 244,796,504RGD
SHRSP x BN Map2101.1198RGD
SHRSP x BN Map2101.1198UniSTS
Cytogenetic Map2q44UniSTS
UOX  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,501,372 - 235,501,478 (+)MAPPERmRatBN7.2
Rnor_6.02252,466,817 - 252,466,922NCBIRnor6.0
Rnor_5.02270,993,127 - 270,993,232UniSTSRnor5.0
RGSC_v3.42244,810,016 - 244,810,121UniSTSRGSC3.4
Celera2227,479,655 - 227,479,760UniSTS
Cytogenetic Map2q44UniSTS
RH136937  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,522,789 - 235,522,978 (+)MAPPERmRatBN7.2
Rnor_6.02252,488,234 - 252,488,422NCBIRnor6.0
Rnor_5.02271,014,834 - 271,015,022UniSTSRnor5.0
RGSC_v3.42244,832,230 - 244,832,418UniSTSRGSC3.4
Celera2227,501,090 - 227,501,278UniSTS
Cytogenetic Map2q44UniSTS
AI169989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,503,586 - 235,504,335 (+)MAPPERmRatBN7.2
Rnor_6.02252,469,031 - 252,469,779NCBIRnor6.0
Rnor_5.02270,995,341 - 270,996,089UniSTSRnor5.0
RGSC_v3.42244,812,230 - 244,812,978UniSTSRGSC3.4
Celera2227,481,869 - 227,482,617UniSTS
Cytogenetic Map2q44UniSTS


Genetic Models
This gene Uox is modified in the following models/strains:
SD-Uoxem1Cya    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 9 14 98 88 87 59 27 59 6 175 61 3 77 32 76 28 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001433782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT161601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000021970   ⟹   ENSRNOP00000021970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2238,147,116 - 238,182,965 (+)Ensembl
mRatBN7.2 Ensembl2235,440,619 - 235,523,029 (+)Ensembl
Rnor_6.0 Ensembl2252,452,269 - 252,488,396 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102853   ⟹   ENSRNOP00000088332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2238,156,360 - 238,179,984 (+)Ensembl
mRatBN7.2 Ensembl2235,486,848 - 235,520,810 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107313   ⟹   ENSRNOP00000087221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2238,147,170 - 238,179,970 (+)Ensembl
mRatBN7.2 Ensembl2235,486,907 - 235,519,709 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000127252   ⟹   ENSRNOP00000105950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2238,147,116 - 238,182,966 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136126   ⟹   ENSRNOP00000108727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2238,083,686 - 238,183,370 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150699   ⟹   ENSRNOP00000110384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2238,100,919 - 238,183,370 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164743   ⟹   ENSRNOP00000100526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2238,147,116 - 238,183,370 (+)Ensembl
RefSeq Acc Id: NM_053768   ⟹   NP_446220
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,147,130 - 238,182,966 (+)NCBI
mRatBN7.22235,486,867 - 235,522,703 (+)NCBI
Rnor_6.02252,452,311 - 252,488,147 (+)NCBI
Rnor_5.02270,978,811 - 271,015,097 (+)NCBI
RGSC_v3.42244,795,552 - 244,832,143 (+)RGD
Celera2227,465,950 - 227,501,003 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233450   ⟹   XP_006233512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,158,677 - 238,183,320 (+)NCBI
mRatBN7.22235,498,407 - 235,523,053 (+)NCBI
Rnor_6.02252,452,282 - 252,488,497 (+)NCBI
Rnor_5.02270,978,811 - 271,015,097 (+)NCBI
Sequence:
RefSeq Acc Id: NP_446220   ⟸   NM_053768
- UniProtKB: P09118 (UniProtKB/Swiss-Prot),   A0A8L2QB48 (UniProtKB/TrEMBL),   A6HWE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233512   ⟸   XM_006233450
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000021970   ⟸   ENSRNOT00000021970
Ensembl Acc Id: ENSRNOP00000087221   ⟸   ENSRNOT00000107313
Ensembl Acc Id: ENSRNOP00000088332   ⟸   ENSRNOT00000102853
Ensembl Acc Id: ENSRNOP00000110384   ⟸   ENSRNOT00000150699
Ensembl Acc Id: ENSRNOP00000105950   ⟸   ENSRNOT00000127252
Ensembl Acc Id: ENSRNOP00000100526   ⟸   ENSRNOT00000164743
Ensembl Acc Id: ENSRNOP00000108727   ⟸   ENSRNOT00000136126

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09118-F1-model_v2 AlphaFold P09118 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691816
Promoter ID:EPDNEW_R2341
Type:single initiation site
Name:Uox_1
Description:urate oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02252,452,297 - 252,452,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621369 AgrOrtholog
BioCyc Gene G2FUF-50897 BioCyc
BioCyc Pathway PWY-5691 [urate conversion to allantoin I] BioCyc
BioCyc Pathway Image PWY-5691 BioCyc
Ensembl Genes ENSRNOG00000016339 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000127252 ENTREZGENE
  ENSRNOT00000164743 ENTREZGENE
Gene3D-CATH Urate Oxidase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7325917 IMAGE-MGC_LOAD
InterPro Uricase UniProtKB/Swiss-Prot
  Uricase_CS UniProtKB/Swiss-Prot
KEGG Report rno:114768 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108593 IMAGE-MGC_LOAD
NCBI Gene 114768 ENTREZGENE
PANTHER PTHR42874 UniProtKB/Swiss-Prot
  URICASE UniProtKB/Swiss-Prot
Pfam Uricase UniProtKB/Swiss-Prot
PhenoGen Uox PhenoGen
PIRSF Urate_oxidase UniProtKB/Swiss-Prot
PRINTS URICASE UniProtKB/Swiss-Prot
PROSITE URICASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016339 RatGTEx
Superfamily-SCOP Tetrahydrobiopterin biosynthesis enzymes-like UniProtKB/Swiss-Prot
UniProt A0A8I6GEX3_RAT UniProtKB/TrEMBL
  A0A8I6GG42_RAT UniProtKB/TrEMBL
  A0A8L2QB48 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LD93_RAT UniProtKB/TrEMBL
  A0ABK0LK17_RAT UniProtKB/TrEMBL
  A0ABK0M098_RAT UniProtKB/TrEMBL
  A6HWE4 ENTREZGENE, UniProtKB/TrEMBL
  A6HWE5_RAT UniProtKB/TrEMBL
  P09118 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Uox  urate oxidase  Uri_mapped  uricase (mapped)  Data merged from RGD:3945 737654 APPROVED
2005-11-17 Uri_mapped  uricase (mapped)      Symbol and Name updated 1556543 APPROVED
2004-09-10 Uox  urate oxidase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Uox  urate oxidase      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Uri  Uricase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the electron-dense peroxisome core 730101