Epcam (epithelial cell adhesion molecule) - Rat Genome Database

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Gene: Epcam (epithelial cell adhesion molecule) Rattus norvegicus
Analyze
Symbol: Epcam
Name: epithelial cell adhesion molecule
RGD ID: 621365
Description: Enables cadherin binding activity involved in cell-cell adhesion. Involved in cell-cell adhesion via plasma-membrane adhesion molecules; negative regulation of apoptotic process; and positive regulation of cell motility. Located in bicellular tight junction; cell surface; and lateral plasma membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Egp314; ep-CAM; epithelial glycoprotein 314; Tacstd1; tumor-associated calcium signal transducer 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,633,715 - 12,649,678 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl612,631,611 - 12,649,702 (-)EnsemblGRCr8
mRatBN7.266,880,142 - 6,896,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,878,237 - 6,896,127 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,162,229 - 7,178,185 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,471,633 - 7,487,591 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,998,763 - 7,014,715 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,282,194 - 11,308,870 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,281,964 - 11,298,216 (-)Ensemblrn6Rnor6.0
Rnor_5.0621,264,116 - 21,280,078 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4611,176,664 - 11,192,628 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera66,637,498 - 6,653,429 (-)NCBICelera
RGSC_v3.1611,176,663 - 11,192,627 (+)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-schisandrin B  (EXP)
(20S)-ginsenoside Rg3  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylfuran  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carboplatin  (ISO)
casticin  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crizotinib  (ISO)
cumene  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
eugenol  (EXP,ISO)
flavonol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
GW 3965  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metronidazole  (EXP)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
omeprazole  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
raloxifene  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vinorelbine  (ISO)
vorinostat  (ISO)
XMU-MP-1  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cancer stem cell markers correlate with early recurrence and survival in hepatocellular carcinoma. Guo Z, etal., World J Gastroenterol. 2014 Feb 28;20(8):2098-106. doi: 10.3748/wjg.v20.i8.2098.
3. The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. Ladwein M, etal., Exp Cell Res. 2005 Oct 1;309(2):345-57.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Claudin-7 regulates EpCAM-mediated functions in tumor progression. Nubel T, etal., Mol Cancer Res. 2009 Mar;7(3):285-99. doi: 10.1158/1541-7786.MCR-08-0200. Epub 2009 Mar 10.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. EGP-314 is expressed differentially in three brain zones at an early time in an experimentally induced ischemia rat model. Ortiz-Plata A, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):55-62. Epub 2005 Apr 7.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. EpCAM-associated claudin-7 supports lymphatic spread and drug resistance in rat pancreatic cancer. Thuma F and Zoller M, Int J Cancer. 2013 Aug 15;133(4):855-66. doi: 10.1002/ijc.28085. Epub 2013 Mar 9.
13. Metastasis-association of the rat ortholog of the human epithelial glycoprotein antigen EGP314. Wurfel J, etal., Oncogene 1999 Apr 8;18(14):2323-34.
Additional References at PubMed
PMID:9382878   PMID:11487543   PMID:15195135   PMID:15922867   PMID:16545622   PMID:17599412   PMID:18025791   PMID:19056867   PMID:19136966   PMID:19785009   PMID:23098445   PMID:23376485  
PMID:25367431  


Genomics

Comparative Map Data
Epcam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,633,715 - 12,649,678 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl612,631,611 - 12,649,702 (-)EnsemblGRCr8
mRatBN7.266,880,142 - 6,896,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,878,237 - 6,896,127 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,162,229 - 7,178,185 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,471,633 - 7,487,591 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,998,763 - 7,014,715 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,282,194 - 11,308,870 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,281,964 - 11,298,216 (-)Ensemblrn6Rnor6.0
Rnor_5.0621,264,116 - 21,280,078 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4611,176,664 - 11,192,628 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera66,637,498 - 6,653,429 (-)NCBICelera
RGSC_v3.1611,176,663 - 11,192,627 (+)NCBI
Cytogenetic Map6q12NCBI
EPCAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,369,311 - 47,387,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,345,158 - 47,387,601 (+)Ensemblhg38GRCh38
GRCh37247,596,450 - 47,614,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,449,971 - 47,467,661 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34247,508,117 - 47,525,808NCBI
Celera247,435,038 - 47,452,920 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef247,332,819 - 47,350,813 (+)NCBIHuRef
CHM1_1247,526,380 - 47,544,227 (+)NCBICHM1_1
T2T-CHM13v2.0247,374,345 - 47,392,054 (+)NCBIT2T-CHM13v2.0
Epcam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,943,407 - 87,958,555 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,943,407 - 87,958,557 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381787,635,979 - 87,651,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,635,979 - 87,651,129 (+)Ensemblmm10GRCm38
MGSCv371788,035,319 - 88,050,467 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361787,545,034 - 87,559,453 (+)NCBIMGSCv36mm8
Celera1792,042,942 - 92,058,080 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
Epcam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544114,155,082 - 14,169,161 (+)Ensembl
ChiLan1.0NW_00495544114,155,084 - 14,167,584 (+)NCBIChiLan1.0ChiLan1.0
EPCAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,997,263 - 79,015,018 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A79,001,229 - 79,018,984 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,490,748 - 47,508,418 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,414,791 - 48,432,038 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,413,520 - 48,432,038 (+)EnsemblpanPan2panpan1.1
EPCAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,446,165 - 49,498,690 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,485,746 - 49,498,475 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1049,340,952 - 49,353,876 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01050,358,759 - 50,372,148 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,357,906 - 50,373,405 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,066,503 - 50,079,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,354,644 - 50,367,879 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,540,181 - 50,553,474 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Epcam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,590,900 - 33,604,003 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,019,918 - 5,032,414 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,019,513 - 5,032,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPCAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,168,852 - 93,185,653 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1393,169,800 - 93,185,221 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,312,713 - 99,328,225 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPCAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11459,815,128 - 59,832,360 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1459,815,064 - 59,832,229 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604552,016,345 - 52,034,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epcam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,754,602 - 28,770,758 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473828,755,039 - 28,770,160 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Epcam
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v175,324,704 - 5,341,046 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Epcam
94 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:283
Count of miRNA genes:201
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000021135
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat

Markers in Region
D6Wox32  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.266,880,190 - 6,880,356 (+)MAPPERmRatBN7.2
Rnor_6.0611,282,243 - 11,282,408NCBIRnor6.0
Rnor_5.0621,264,165 - 21,264,330UniSTSRnor5.0
RGSC_v3.4611,192,414 - 11,192,579UniSTSRGSC3.4
Celera66,637,547 - 6,637,712UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 59 145 91 90 59 70 59 6 326 162 11 124 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000021135   ⟹   ENSRNOP00000021135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,633,716 - 12,649,682 (-)Ensembl
mRatBN7.2 Ensembl66,880,143 - 6,896,107 (-)Ensembl
Rnor_6.0 Ensembl611,281,964 - 11,298,216 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095257   ⟹   ENSRNOP00000078936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,638,832 - 12,647,067 (-)Ensembl
mRatBN7.2 Ensembl66,885,259 - 6,893,492 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109202   ⟹   ENSRNOP00000077664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,631,611 - 12,649,702 (-)Ensembl
mRatBN7.2 Ensembl66,878,237 - 6,896,127 (-)Ensembl
RefSeq Acc Id: NM_138541   ⟹   NP_612550
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,633,715 - 12,649,678 (-)NCBI
mRatBN7.266,880,142 - 6,896,103 (-)NCBI
Rnor_6.0611,282,194 - 11,298,156 (-)NCBI
Rnor_5.0621,264,116 - 21,280,078 (-)NCBI
RGSC_v3.4611,176,664 - 11,192,628 (+)RGD
Celera66,637,498 - 6,653,429 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_612550 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH72691 (Get FASTA)   NCBI Sequence Viewer  
  CAA04498 (Get FASTA)   NCBI Sequence Viewer  
  EDM02636 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021135
  ENSRNOP00000021135.5
GenBank Protein O55159 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_612550   ⟸   NM_138541
- Peptide Label: precursor
- UniProtKB: O55159 (UniProtKB/Swiss-Prot),   A0A8I5YCG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021135   ⟸   ENSRNOT00000021135
Ensembl Acc Id: ENSRNOP00000077664   ⟸   ENSRNOT00000109202
Ensembl Acc Id: ENSRNOP00000078936   ⟸   ENSRNOT00000095257
Protein Domains
Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55159-F1-model_v2 AlphaFold O55159 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694396
Promoter ID:EPDNEW_R4921
Type:multiple initiation site
Name:Epcam_1
Description:epithelial cell adhesion molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0611,298,174 - 11,298,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621365 AgrOrtholog
BioCyc Gene G2FUF-38744 BioCyc
Ensembl Genes ENSRNOG00000015667 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021135 ENTREZGENE
  ENSRNOT00000021135.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.800.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623760 IMAGE-MGC_LOAD
  IMAGE:7098920 IMAGE-MGC_LOAD
InterPro EPCAM-Trop-2_C UniProtKB/Swiss-Prot
  EPCAM/Trop-2 UniProtKB/Swiss-Prot
  EpCAM_N UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report rno:171577 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72276 IMAGE-MGC_LOAD
  MGC:91434 IMAGE-MGC_LOAD
NCBI Gene 171577 ENTREZGENE
PANTHER EPITHELIAL CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
  PTHR14168 UniProtKB/Swiss-Prot
Pfam EPCAM-Trop-2_C UniProtKB/Swiss-Prot
  EpCAM_N UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Epcam PhenoGen
PROSITE THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015667 RatGTEx
SMART SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57610 UniProtKB/Swiss-Prot
UniProt A0A8I5YCG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMC1_RAT UniProtKB/TrEMBL
  EPCAM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-13 Epcam  epithelial cell adhesion molecule  Tacstd1  tumor-associated calcium signal transducer 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Tacstd1  tumor-associated calcium signal transducer 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tacstd1  tumor-associated calcium signal transducer 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the epithelial cells of metastasizing rat tumors 634200