Tnfaip6 (TNF alpha induced protein 6) - Rat Genome Database

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Gene: Tnfaip6 (TNF alpha induced protein 6) Rattus norvegicus
Analyze
Symbol: Tnfaip6
Name: TNF alpha induced protein 6
RGD ID: 621359
Description: Predicted to enable several functions, including carboxylesterase activity; fibronectin binding activity; and hyaluronic acid binding activity. Involved in positive regulation of cell migration. Located in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Tnfip6; tumor necrosis factor alpha induced protein 6; tumor necrosis factor induced protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8356,911,398 - 56,930,797 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl356,911,252 - 56,930,796 (+)EnsemblGRCr8
mRatBN7.2336,502,250 - 36,521,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl336,502,188 - 36,521,649 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx339,888,035 - 39,907,355 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0348,472,812 - 48,492,136 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0346,257,353 - 46,276,679 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0337,545,238 - 37,564,704 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)Ensemblrn6Rnor6.0
Rnor_5.0342,649,266 - 42,663,190 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera334,646,103 - 34,665,498 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzohydrazide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
Aeol 10150  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpidem  (ISO)
amodiaquine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzyl bromide  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chondroitin sulfate  (ISO)
Chorionic gonadotropin  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cobalt(2+) sulfate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entacapone  (ISO)
epoxiconazole  (ISO)
esmolol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fludrocortisone  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glycitein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium atom  (ISO)
magnesium dichloride  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
nebivolol  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
pepstatin A  (ISO)
peptidoglycan  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirprofen  (ISO)
procyclidine  (ISO)
progesterone  (ISO)
propanal  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
tartrazine  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trazodone  (ISO)
Trihexyphenidyl  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
zafirlukast  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice. Fulop C, etal., Development 2003 May;130(10):2253-61.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. TSG-6 controls transcription and activation of matrix metalloproteinase 1 in conjunctivochalasis. Guo P, etal., Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1372-80. doi: 10.1167/iovs.11-8738. Print 2012 Mar.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Oh JY, etal., Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16875-80. doi: 10.1073/pnas.1012451107. Epub 2010 Sep 13.
6. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Park YD, etal., Clin Exp Allergy. 2006 May;36(5):649-57.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6. Roddy GW, etal., Stem Cells. 2011 Oct;29(10):1572-9. doi: 10.1002/stem.708.
11. Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6. Wang N, etal., PLoS One. 2012;7(8):e43768. doi: 10.1371/journal.pone.0043768. Epub 2012 Aug 17.
12. Expression of tumor necrosis factor-stimulated gene-6 in the rat ovary in response to an ovulatory dose of gonadotropin. Yoshioka S, etal., Endocrinology. 2000 Nov;141(11):4114-9.
Additional References at PubMed
PMID:12477932   PMID:16873769   PMID:20463016   PMID:21569482   PMID:24488915   PMID:26953231   PMID:27435674   PMID:28975447   PMID:30584538   PMID:30984789   PMID:33670243   PMID:34145502  
PMID:35690131  


Genomics

Comparative Map Data
Tnfaip6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8356,911,398 - 56,930,797 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl356,911,252 - 56,930,796 (+)EnsemblGRCr8
mRatBN7.2336,502,250 - 36,521,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl336,502,188 - 36,521,649 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx339,888,035 - 39,907,355 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0348,472,812 - 48,492,136 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0346,257,353 - 46,276,679 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0337,545,238 - 37,564,704 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)Ensemblrn6Rnor6.0
Rnor_5.0342,649,266 - 42,663,190 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera334,646,103 - 34,665,498 (+)NCBICelera
Cytogenetic Map3q12NCBI
TNFAIP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382151,357,592 - 151,381,340 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2151,357,592 - 151,380,046 (+)Ensemblhg38GRCh38
GRCh372152,214,106 - 152,236,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,922,351 - 151,944,806 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342152,039,612 - 152,062,067NCBI
Celera2145,828,376 - 145,850,827 (+)NCBICelera
Cytogenetic Map2q23.3NCBI
HuRef2144,110,453 - 144,133,100 (+)NCBIHuRef
CHM1_12152,219,924 - 152,242,420 (+)NCBICHM1_1
T2T-CHM13v2.02151,809,346 - 151,833,086 (+)NCBIT2T-CHM13v2.0
Tnfaip6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39251,928,125 - 51,946,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl251,928,021 - 51,946,698 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38252,038,113 - 52,056,681 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl252,038,009 - 52,056,686 (+)Ensemblmm10GRCm38
MGSCv37251,893,633 - 51,912,201 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36251,860,122 - 51,878,690 (+)NCBIMGSCv36mm8
Celera253,762,777 - 53,783,057 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map229.98NCBI
Tnfaip6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544016,916,055 - 16,944,190 (+)Ensembl
ChiLan1.0NW_00495544016,915,952 - 16,944,375 (+)NCBIChiLan1.0ChiLan1.0
TNFAIP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21354,047,676 - 54,070,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B54,062,655 - 54,085,417 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B38,669,652 - 38,692,037 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B155,933,842 - 155,956,382 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B155,933,842 - 155,956,382 (+)EnsemblpanPan2panpan1.1
TNFAIP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11952,607,598 - 52,623,799 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1952,607,713 - 52,623,811 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1952,770,629 - 52,786,812 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01954,118,538 - 54,134,777 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1954,118,552 - 54,135,260 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11952,832,140 - 52,848,316 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01952,902,916 - 52,919,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01954,369,113 - 54,385,510 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnfaip6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303115,472,309 - 115,488,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646926,129,331 - 26,145,422 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646926,129,339 - 26,145,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15862,015 - 881,461 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115862,013 - 881,352 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215157,132,380 - 157,151,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11036,792,505 - 36,814,271 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1036,792,514 - 36,814,494 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040162,729,309 - 162,750,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfaip6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248665,706,850 - 5,728,771 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248665,706,483 - 5,758,666 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tnfaip6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1529,818,207 - 29,837,686 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tnfaip6
168 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:203
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000070792
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)34542360958601291Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 151 86 85 54 26 54 6 280 126 11 130 76 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000070792   ⟹   ENSRNOP00000064253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl356,911,252 - 56,930,796 (+)Ensembl
mRatBN7.2 Ensembl336,502,188 - 36,521,649 (+)Ensembl
Rnor_6.0 Ensembl337,545,238 - 37,564,699 (+)Ensembl
RefSeq Acc Id: NM_053382   ⟹   NP_445834
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8356,911,398 - 56,930,797 (+)NCBI
mRatBN7.2336,502,250 - 36,521,652 (+)NCBI
Rnor_6.0337,545,238 - 37,564,704 (+)NCBI
Rnor_5.0342,649,266 - 42,663,190 (+)NCBI
Celera334,646,103 - 34,665,498 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445834 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD56634 (Get FASTA)   NCBI Sequence Viewer  
  AAI58667 (Get FASTA)   NCBI Sequence Viewer  
  EDM00443 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064253
  ENSRNOP00000064253.3
RefSeq Acc Id: NP_445834   ⟸   NM_053382
- Peptide Label: precursor
- UniProtKB: B0BN34 (UniProtKB/TrEMBL),   M0R4G8 (UniProtKB/TrEMBL),   A0A9K3Y887 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064253   ⟸   ENSRNOT00000070792
Protein Domains
CUB   Link

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4G8-F1-model_v2 AlphaFold M0R4G8 1-273 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692076
Promoter ID:EPDNEW_R2600
Type:single initiation site
Name:Tnfaip6_1
Description:TNF alpha induced protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0337,545,169 - 37,545,229EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621359 AgrOrtholog
BioCyc Gene G2FUF-49736 BioCyc
Ensembl Genes ENSRNOG00000050792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070792 ENTREZGENE
  ENSRNOT00000070792.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8370218 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  CUB_dom UniProtKB/TrEMBL
  Link UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  Spermadhesin-Link_domain UniProtKB/TrEMBL
KEGG Report rno:84397 UniProtKB/TrEMBL
MGC_CLONE MGC:187662 IMAGE-MGC_LOAD
NCBI Gene 84397 ENTREZGENE
PANTHER CUBILIN-LIKE PROTEIN UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Xlink UniProtKB/TrEMBL
PhenoGen Tnfaip6 PhenoGen
PRINTS LINKMODULE UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LINK_1 UniProtKB/TrEMBL
  LINK_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050792 RatGTEx
SMART CUB UniProtKB/TrEMBL
  LINK UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
UniProt A0A9K3Y887 ENTREZGENE, UniProtKB/TrEMBL
  B0BN34 ENTREZGENE, UniProtKB/TrEMBL
  M0R4G8 ENTREZGENE
UniProt Secondary M0R4G8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Tnfaip6  TNF alpha induced protein 6  Tnfaip6  tumor necrosis factor alpha induced protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tnfaip6  tumor necrosis factor alpha induced protein 6  Tnfip6  tumor necrosis factor induced protein 6  Symbol and Name updated 1299863 APPROVED
2002-08-07 Tnfip6  tumor necrosis factor induced protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL