Ambra1 (autophagy and beclin 1 regulator 1) - Rat Genome Database

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Pathways
Gene: Ambra1 (autophagy and beclin 1 regulator 1) Rattus norvegicus
Analyze
Symbol: Ambra1
Name: autophagy and beclin 1 regulator 1
RGD ID: 621330
Description: Predicted to enable enzyme binding activity; protein phosphatase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in cellular response to starvation; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of autophagy. Predicted to be located in axoneme; cytosol; and phagocytic vesicle. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoskeleton; mitochondrion; and nucleus. Orthologous to human AMBRA1 (autophagy and beclin 1 regulator 1); PARTICIPATES IN inositol metabolic pathway; mitochondrial autophagy pathway; phosphoinositide metabolic pathway; INTERACTS WITH ammonium chloride; atrazine; Bardoxolone methyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activating molecule in BECN1-regulated autophagy protein 1; autophagy/beclin 1 regulator 1; ischemia related factor NYW-1; Nyw1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,156,626 - 98,345,876 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,156,652 - 98,345,872 (+)EnsemblGRCr8
mRatBN7.2377,700,936 - 77,890,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,176,110 - 81,365,398 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,775,135 - 89,964,426 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,626,389 - 87,815,655 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,634,470 - 80,830,068 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,634,470 - 80,830,068 (+)Ensemblrn6Rnor6.0
Rnor_5.0387,332,352 - 87,528,736 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,109,632 - 76,298,784 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,904,996 - 77,092,869 (+)NCBICelera
RGSC_v3.1376,049,420 - 76,098,445 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys. Cui J, etal., PLoS One. 2013;8(7):e69720. doi: 10.1371/journal.pone.0069720. Epub 2013 Jul 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
4. AMBRA1, a novel α-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy. Miki Y, etal., Brain Pathol. 2018 Jan;28(1):28-42. doi: 10.1111/bpa.12461. Epub 2017 Mar 15.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging. Sepe S, etal., Neurobiol Aging. 2014 Jan;35(1):96-108. doi: 10.1016/j.neurobiolaging.2013.07.001. Epub 2013 Aug 2.
10. Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes. Shi C, etal., Biochem Biophys Res Commun. 2014 Sep 26;452(3):308-14. doi: 10.1016/j.bbrc.2014.08.017. Epub 2014 Aug 10.
Additional References at PubMed
PMID:12477932   PMID:17589504   PMID:21753002   PMID:22493499   PMID:24089209   PMID:24879156   PMID:25215947   PMID:25891078   PMID:33083461  


Genomics

Comparative Map Data
Ambra1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,156,626 - 98,345,876 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,156,652 - 98,345,872 (+)EnsemblGRCr8
mRatBN7.2377,700,936 - 77,890,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,176,110 - 81,365,398 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,775,135 - 89,964,426 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,626,389 - 87,815,655 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,634,470 - 80,830,068 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,634,470 - 80,830,068 (+)Ensemblrn6Rnor6.0
Rnor_5.0387,332,352 - 87,528,736 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,109,632 - 76,298,784 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,904,996 - 77,092,869 (+)NCBICelera
RGSC_v3.1376,049,420 - 76,098,445 (+)NCBI
Cytogenetic Map3q24NCBI
AMBRA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,396,412 - 46,594,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,396,414 - 46,594,125 (-)Ensemblhg38GRCh38
GRCh371146,417,962 - 46,615,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,374,541 - 46,569,490 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1146,566,035 - 46,760,894 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,124,697 - 46,322,307 (-)NCBIHuRef
CHM1_11146,416,414 - 46,614,031 (-)NCBICHM1_1
T2T-CHM13v2.01146,552,487 - 46,750,082 (-)NCBIT2T-CHM13v2.0
Ambra1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,560,464 - 91,749,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,560,479 - 91,749,194 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,730,138 - 91,918,849 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,730,134 - 91,918,849 (+)Ensemblmm10GRCm38
MGSCv37291,570,295 - 91,759,006 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36291,531,062 - 91,719,688 (+)NCBIMGSCv36mm8
Celera293,119,370 - 93,309,250 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
Ambra1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,455,380 - 1,644,452 (+)Ensembl
ChiLan1.0NW_0049554221,455,392 - 1,644,368 (+)NCBIChiLan1.0ChiLan1.0
AMBRA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2948,609,561 - 48,810,770 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,616,387 - 48,817,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,355,026 - 46,556,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,905,454 - 47,103,205 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,905,454 - 47,103,205 (-)EnsemblpanPan2panpan1.1
AMBRA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,903,815 - 43,073,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,932,513 - 43,072,827 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1841,632,454 - 41,802,531 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01843,559,883 - 43,730,082 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,559,910 - 43,764,738 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,045,129 - 43,215,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,596,905 - 42,766,984 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,330,120 - 43,500,181 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ambra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,382,209 - 20,565,226 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,493,774 - 2,676,912 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,493,823 - 2,676,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMBRA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,935,375 - 16,119,079 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1215,935,354 - 16,119,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,313,942 - 17,465,127 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMBRA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,777,807 - 18,932,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,734,926 - 18,932,785 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038116,020,095 - 116,218,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ambra1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,966,898 - 2,160,465 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247671,967,002 - 2,160,102 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ambra1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1565,873,993 - 66,062,789 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ambra1
1256 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:102
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000045644
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
A001T07  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,890,028 - 77,890,137 (+)MAPPERmRatBN7.2
Rnor_6.0380,829,876 - 80,829,984NCBIRnor6.0
Rnor_5.0387,528,544 - 87,528,652UniSTSRnor5.0
RGSC_v3.4376,298,592 - 76,298,700UniSTSRGSC3.4
Celera377,092,677 - 77,092,785UniSTS
Cytogenetic Map3q24UniSTS
WI-14603  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,890,091 - 77,890,217 (+)MAPPERmRatBN7.2
Rnor_6.0380,829,939 - 80,830,064NCBIRnor6.0
Rnor_5.0387,528,607 - 87,528,732UniSTSRnor5.0
RGSC_v3.4376,298,655 - 76,298,780UniSTSRGSC3.4
Celera377,092,740 - 77,092,865UniSTS
Cytogenetic Map3q24UniSTS
BF397482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,717,281 - 77,717,407 (+)MAPPERmRatBN7.2
Rnor_6.0380,650,815 - 80,650,940NCBIRnor6.0
Rnor_5.0387,348,697 - 87,348,822UniSTSRnor5.0
RGSC_v3.4376,125,976 - 76,126,101UniSTSRGSC3.4
Celera376,921,359 - 76,921,484UniSTS
RH 3.4 Map3704.9UniSTS
Cytogenetic Map3q24UniSTS
AI176253  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,844,887 - 77,845,006 (+)MAPPERmRatBN7.2
Rnor_6.0380,784,470 - 80,784,588NCBIRnor6.0
Rnor_5.0387,483,343 - 87,483,461UniSTSRnor5.0
RGSC_v3.4376,253,465 - 76,253,583UniSTSRGSC3.4
Celera377,047,569 - 77,047,687UniSTS
Cytogenetic Map3q24UniSTS
AI176683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,700,842 - 77,701,050 (+)MAPPERmRatBN7.2
Rnor_6.0380,634,377 - 80,634,584NCBIRnor6.0
Rnor_5.0387,332,259 - 87,332,466UniSTSRnor5.0
RGSC_v3.4376,109,539 - 76,109,746UniSTSRGSC3.4
Celera376,904,903 - 76,905,110UniSTS
Cytogenetic Map3q24UniSTS
UniSTS:225336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,718,970 - 77,719,101 (+)MAPPERmRatBN7.2
Rnor_6.0380,652,504 - 80,652,634NCBIRnor6.0
Rnor_5.0387,350,386 - 87,350,516UniSTSRnor5.0
RGSC_v3.4376,127,665 - 76,127,795UniSTSRGSC3.4
Celera376,923,048 - 76,923,178UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001134341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB027149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000045644   ⟹   ENSRNOP00000039742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,156,652 - 98,345,872 (+)Ensembl
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)Ensembl
Rnor_6.0 Ensembl380,634,470 - 80,830,068 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084809   ⟹   ENSRNOP00000075219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl380,676,820 - 80,732,084 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085614   ⟹   ENSRNOP00000073365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,156,652 - 98,345,872 (+)Ensembl
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)Ensembl
Rnor_6.0 Ensembl380,670,140 - 80,830,058 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093866   ⟹   ENSRNOP00000087603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,156,652 - 98,345,872 (+)Ensembl
mRatBN7.2 Ensembl377,700,936 - 77,890,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105609   ⟹   ENSRNOP00000091295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,156,668 - 98,345,872 (+)Ensembl
mRatBN7.2 Ensembl377,700,989 - 77,890,218 (+)Ensembl
RefSeq Acc Id: NM_001134341   ⟹   NP_001127813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,626 - 98,345,876 (+)NCBI
mRatBN7.2377,700,936 - 77,890,221 (+)NCBI
Rnor_6.0380,634,470 - 80,830,068 (+)NCBI
Rnor_5.0387,332,352 - 87,528,736 (+)NCBI
RGSC_v3.4376,109,632 - 76,298,784 (+)RGD
Celera376,904,996 - 77,092,869 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762030   ⟹   XP_008760252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,630 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762031   ⟹   XP_008760253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762032   ⟹   XP_008760254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762033   ⟹   XP_008760255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762034   ⟹   XP_008760256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
Rnor_6.0380,634,632 - 80,830,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105763   ⟹   XP_038961691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
RefSeq Acc Id: XM_039105764   ⟹   XP_038961692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
mRatBN7.2377,701,048 - 77,890,218 (+)NCBI
RefSeq Acc Id: XM_039105765   ⟹   XP_038961693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,222,264 - 98,345,873 (+)NCBI
mRatBN7.2377,771,393 - 77,890,218 (+)NCBI
RefSeq Acc Id: XM_063284450   ⟹   XP_063140520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,157,193 - 98,345,873 (+)NCBI
RefSeq Acc Id: XM_063284451   ⟹   XP_063140521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
RefSeq Acc Id: XM_063284452   ⟹   XP_063140522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,157,193 - 98,345,873 (+)NCBI
RefSeq Acc Id: XM_063284453   ⟹   XP_063140523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,156,732 - 98,345,873 (+)NCBI
RefSeq Acc Id: XM_063284454   ⟹   XP_063140524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,157,183 - 98,345,873 (+)NCBI
RefSeq Acc Id: NP_001127813   ⟸   NM_001134341
- UniProtKB: F1LNQ2 (UniProtKB/TrEMBL),   A6HNE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760252   ⟸   XM_008762030
- Peptide Label: isoform X1
- UniProtKB: F1LNQ2 (UniProtKB/TrEMBL),   A6HNE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760254   ⟸   XM_008762032
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760253   ⟸   XM_008762031
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008760255   ⟸   XM_008762033
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K5B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760256   ⟸   XM_008762034
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AF66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075219   ⟸   ENSRNOT00000084809
Ensembl Acc Id: ENSRNOP00000039742   ⟸   ENSRNOT00000045644
Ensembl Acc Id: ENSRNOP00000073365   ⟸   ENSRNOT00000085614
RefSeq Acc Id: XP_038961691   ⟸   XM_039105763
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038961692   ⟸   XM_039105764
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038961693   ⟸   XM_039105765
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000091295   ⟸   ENSRNOT00000105609
Ensembl Acc Id: ENSRNOP00000087603   ⟸   ENSRNOT00000093866
RefSeq Acc Id: XP_063140521   ⟸   XM_063284451
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K5B6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140523   ⟸   XM_063284453
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063140524   ⟸   XM_063284454
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063140520   ⟸   XM_063284450
- Peptide Label: isoform X1
- UniProtKB: A6HNE5 (UniProtKB/TrEMBL),   F1LNQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140522   ⟸   XM_063284452
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K5B6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNQ2-F1-model_v2 AlphaFold F1LNQ2 1-1300 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692219
Promoter ID:EPDNEW_R2743
Type:initiation region
Name:Ambra1_1
Description:autophagy and beclin 1 regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0380,634,523 - 80,634,583EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621330 AgrOrtholog
BioCyc Gene G2FUF-48719 BioCyc
Ensembl Genes ENSRNOG00000017422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045644 ENTREZGENE
  ENSRNOT00000045644.7 UniProtKB/TrEMBL
  ENSRNOT00000085614 ENTREZGENE
  ENSRNOT00000085614.3 UniProtKB/TrEMBL
  ENSRNOT00000093866 ENTREZGENE
  ENSRNOT00000093866.2 UniProtKB/TrEMBL
  ENSRNOT00000105609 ENTREZGENE
  ENSRNOT00000105609.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7373916 IMAGE-MGC_LOAD
InterPro AMBRA1_autophagy UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:59319 UniProtKB/TrEMBL
MGC_CLONE MGC:112805 IMAGE-MGC_LOAD
NCBI Gene 59319 ENTREZGENE
PANTHER ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1 UniProtKB/TrEMBL
  ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PhenoGen Ambra1 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017422 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K5B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF66 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGV8 ENTREZGENE, UniProtKB/TrEMBL
  A6HNE5 ENTREZGENE, UniProtKB/TrEMBL
  F1LNQ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Ambra1  autophagy and beclin 1 regulator 1  Ambra1  autophagy/beclin 1 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nyw1  ischemia related factor NYW-1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nyw1  ischemia related factor NYW-1      Symbol and Name status set to provisional 70820 PROVISIONAL