Tpp1 (tripeptidyl peptidase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tpp1 (tripeptidyl peptidase 1) Rattus norvegicus
Analyze
Symbol: Tpp1
Name: tripeptidyl peptidase 1
RGD ID: 621296
Description: Enables endopeptidase activity; peptide binding activity; and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in several cellular components, including lysosome; membrane raft; and recycling endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 7 and neuronal ceroid lipofuscinosis 2. Orthologous to human TPP1 (tripeptidyl peptidase 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ceroid-lipofuscinosis, neuronal 2; Cln2; TPP-1; TPP-I; tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl-peptidase 1; tripeptidyl-peptidase I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,509,816 - 169,515,939 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1169,509,815 - 169,516,024 (-)EnsemblGRCr8
mRatBN7.21160,097,984 - 160,104,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1160,096,833 - 160,104,129 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1168,120,535 - 168,126,656 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,306,532 - 175,312,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,208,290 - 168,214,411 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,588,036 - 170,594,159 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,588,035 - 170,594,168 (-)Ensemblrn6Rnor6.0
Rnor_5.01177,592,725 - 177,600,011 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41163,490,394 - 163,496,517 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1158,029,903 - 158,035,938 (-)NCBICelera
RGSC_v3.11163,585,870 - 163,591,994 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
Abemaciclib  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Golgi apparatus  (IEA,ISO,ISS)
lysosome  (IEA,ISO,ISS)
melanosome  (IEA)
membrane raft  (IEA,ISO,ISS)
recycling endosome  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis. Ezaki J, etal., Biochem Biophys Res Commun. 2000 Feb 24;268(3):904-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, etal., Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13566-71.
4. Genetical studies of low plasma alkaline phosphatase (ALP) activity in the IS strain of rats. Maekawa R, etal., Jikken Dobutsu 1982 Jan;31(1):13-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis. Sleat DE, etal., Science 1997 Sep 19;277(5333):1802-5.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases. Wlodawer A, etal., BMC Struct Biol. 2003 Nov 11;3:8.
Additional References at PubMed
PMID:8215436   PMID:9659384   PMID:9989590   PMID:10617131   PMID:10965052   PMID:11054422   PMID:12134079   PMID:14651853   PMID:15158442   PMID:15317752   PMID:15483130   PMID:17237713  
PMID:18317235   PMID:19056867   PMID:19941651   PMID:20404094   PMID:21492153   PMID:23376485   PMID:23533145   PMID:24841565   PMID:25636608   PMID:27263093   PMID:31533043   PMID:35805162  


Genomics

Comparative Map Data
Tpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,509,816 - 169,515,939 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1169,509,815 - 169,516,024 (-)EnsemblGRCr8
mRatBN7.21160,097,984 - 160,104,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1160,096,833 - 160,104,129 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1168,120,535 - 168,126,656 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,306,532 - 175,312,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,208,290 - 168,214,411 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,588,036 - 170,594,159 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,588,035 - 170,594,168 (-)Ensemblrn6Rnor6.0
Rnor_5.01177,592,725 - 177,600,011 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41163,490,394 - 163,496,517 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1158,029,903 - 158,035,938 (-)NCBICelera
RGSC_v3.11163,585,870 - 163,591,994 (-)NCBI
Cytogenetic Map1q32NCBI
TPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,612,768 - 6,619,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,612,768 - 6,619,448 (-)Ensemblhg38GRCh38
GRCh37116,633,999 - 6,640,653 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,590,573 - 6,597,268 (-)NCBIBuild 36Build 36hg18NCBI36
Celera116,753,063 - 6,759,757 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef116,292,929 - 6,299,623 (-)NCBIHuRef
CHM1_1116,632,898 - 6,639,593 (-)NCBICHM1_1
T2T-CHM13v2.0116,671,236 - 6,677,889 (-)NCBIT2T-CHM13v2.0
Tpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,394,018 - 105,401,489 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,394,018 - 105,401,442 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387105,744,811 - 105,752,282 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,744,811 - 105,752,235 (-)Ensemblmm10GRCm38
MGSCv377112,893,361 - 112,900,721 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367105,618,668 - 105,626,028 (-)NCBIMGSCv36mm8
Celera7106,016,147 - 106,023,505 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.97NCBI
Tpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,324,856 - 22,330,912 (-)Ensembl
ChiLan1.0NW_00495541422,324,847 - 22,330,912 (-)NCBIChiLan1.0ChiLan1.0
TPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v299,049,953 - 9,056,684 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1119,013,770 - 9,020,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,744,815 - 6,751,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,427,516 - 6,434,222 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,427,522 - 6,434,222 (-)EnsemblpanPan2panpan1.1
TPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,921,764 - 29,926,974 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,921,764 - 29,926,986 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2129,623,623 - 29,628,832 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02130,747,948 - 30,753,157 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,746,092 - 30,753,273 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12130,068,707 - 30,073,915 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02130,234,365 - 30,239,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,429,691 - 30,434,901 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494755,998,722 - 56,005,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842669,863 - 676,720 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936842669,869 - 676,706 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,135,642 - 3,143,404 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.193,135,580 - 3,143,408 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,792,812 - 3,800,637 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,205,999 - 58,211,743 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,206,072 - 58,210,945 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038156,031,787 - 156,038,501 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248178,104,939 - 8,111,035 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248178,104,934 - 8,111,049 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tpp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12104,587,631 - 104,593,584 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tpp1
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:497
Count of miRNA genes:237
Interacting mature miRNAs:281
Transcripts:ENSRNOT00000026280
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Bda72  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81169,513,425 - 169,513,977 (+)Marker Load Pipeline
mRatBN7.21160,101,593 - 160,102,145 (+)MAPPERmRatBN7.2
Rnor_6.01170,591,646 - 170,592,197NCBIRnor6.0
Rnor_5.01177,597,498 - 177,598,049UniSTSRnor5.0
RGSC_v3.41163,494,004 - 163,494,555UniSTSRGSC3.4
Celera1158,033,425 - 158,033,976UniSTS
Cytogenetic Map1q33UniSTS
AW107731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21160,098,383 - 160,098,574 (+)MAPPERmRatBN7.2
Rnor_6.01170,588,436 - 170,588,626NCBIRnor6.0
Rnor_5.01177,594,288 - 177,594,478UniSTSRnor5.0
RGSC_v3.41163,490,794 - 163,490,984UniSTSRGSC3.4
Celera1158,030,215 - 158,030,405UniSTS
Cytogenetic Map1q33UniSTS
UniSTS:496054  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81169,513,687 - 169,513,968 (+)Marker Load Pipeline
mRatBN7.21160,101,855 - 160,102,136 (+)MAPPERmRatBN7.2
Rnor_6.01170,591,908 - 170,592,188NCBIRnor6.0
Rnor_5.01177,597,760 - 177,598,040UniSTSRnor5.0
RGSC_v3.41163,494,266 - 163,494,546UniSTSRGSC3.4
Celera1158,033,687 - 158,033,967UniSTS
Cytogenetic Map1q33UniSTS
PCDH16_1801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21160,104,936 - 160,105,822 (+)MAPPERmRatBN7.2
Rnor_6.01170,594,988 - 170,595,873NCBIRnor6.0
Rnor_5.01177,600,840 - 177,601,725UniSTSRnor5.0
RGSC_v3.41163,497,346 - 163,498,231UniSTSRGSC3.4
Celera1158,036,769 - 158,037,654UniSTS
Cytogenetic Map1q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026280   ⟹   ENSRNOP00000026280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1169,509,815 - 169,516,024 (-)Ensembl
mRatBN7.2 Ensembl1160,096,833 - 160,104,081 (-)Ensembl
Rnor_6.0 Ensembl1170,588,035 - 170,594,168 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105058   ⟹   ENSRNOP00000092024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1169,509,815 - 169,515,948 (-)Ensembl
mRatBN7.2 Ensembl1160,096,833 - 160,104,129 (-)Ensembl
RefSeq Acc Id: NM_031357   ⟹   NP_112647
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,509,816 - 169,515,939 (-)NCBI
mRatBN7.21160,097,984 - 160,104,108 (-)NCBI
Rnor_6.01170,588,036 - 170,594,159 (-)NCBI
Rnor_5.01177,592,725 - 177,600,011 (-)NCBI
RGSC_v3.41163,490,394 - 163,496,517 (-)RGD
Celera1158,029,903 - 158,035,938 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112647   ⟸   NM_031357
- Peptide Label: precursor
- UniProtKB: Q9EQV6 (UniProtKB/Swiss-Prot),   Q642E6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026280   ⟸   ENSRNOT00000026280
Ensembl Acc Id: ENSRNOP00000092024   ⟸   ENSRNOT00000105058
Protein Domains
Peptidase S53   Peptidase S53 activation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQV6-F1-model_v2 AlphaFold Q9EQV6 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690293
Promoter ID:EPDNEW_R818
Type:multiple initiation site
Name:Tpp1_1
Description:tripeptidyl peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01170,594,183 - 170,594,243EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621296 AgrOrtholog
BioCyc Gene G2FUF-58007 BioCyc
Ensembl Genes ENSRNOG00000019212 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026280 ENTREZGENE
Gene3D-CATH 3.40.50.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107183 IMAGE-MGC_LOAD
InterPro Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  S53_propep UniProtKB/Swiss-Prot
  Sedolisin_dom UniProtKB/Swiss-Prot
  Tripeptidyl-peptidase_I UniProtKB/Swiss-Prot
KEGG Report rno:83534 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93364 IMAGE-MGC_LOAD
NCBI Gene 83534 ENTREZGENE
PANTHER PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2 UniProtKB/Swiss-Prot
  TRIPEPTIDYL-PEPTIDASE 1 UniProtKB/Swiss-Prot
Pfam Peptidase_S8 UniProtKB/Swiss-Prot
  Pro-kuma_activ UniProtKB/Swiss-Prot
PhenoGen Tpp1 PhenoGen
PROSITE SEDOLISIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019212 RatGTEx
SMART Pro-kuma_activ UniProtKB/Swiss-Prot
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot
  SSF52743 UniProtKB/Swiss-Prot
UniProt A0A8I6GJE9_RAT UniProtKB/TrEMBL
  A6I7N0_RAT UniProtKB/TrEMBL
  A6I7N2_RAT UniProtKB/TrEMBL
  A6I7N3_RAT UniProtKB/TrEMBL
  A6I7N4_RAT UniProtKB/TrEMBL
  A6I7N5_RAT UniProtKB/TrEMBL
  F7F942_RAT UniProtKB/TrEMBL
  Q642E6 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQV6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Tpp1  tripeptidyl peptidase 1  Tpp1  tripeptidyl peptidase I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tpp1  tripeptidyl peptidase I  Cln2  ceroid-lipofuscinosis, neuronal 2  Symbol and Name updated 1299863 APPROVED
2005-01-20 Cln2  ceroid-lipofuscinosis, neuronal 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cln2        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes the lysosomal storage disease classic late infantile neuronal ceroid lipofuscinosis (CLN2) 1302340