Xpnpep1 (X-prolyl aminopeptidase 1) - Rat Genome Database

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Gene: Xpnpep1 (X-prolyl aminopeptidase 1) Rattus norvegicus
Analyze
Symbol: Xpnpep1
Name: X-prolyl aminopeptidase 1
RGD ID: 621274
Description: Enables aminopeptidase activity. Involved in proteolysis. Located in cytoplasm. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1); PARTICIPATES IN kallikrein-kinin cascade pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aminoacylproline aminopeptidase; cytoplasmic aminopeptidase P; cytosolic aminopeptidase P; sAmp; soluble aminopeptidase P; X-Pro aminopeptidase 1, soluble; X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; X-prolyl aminopeptidase 1, soluble; xaa-Pro aminopeptidase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,006,761 - 262,057,479 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1262,006,761 - 262,092,425 (-)EnsemblGRCr8
mRatBN7.21252,001,366 - 252,052,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,001,367 - 252,051,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1260,189,774 - 260,239,893 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01266,895,833 - 266,945,952 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01259,547,854 - 259,598,654 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1261,306,278 - 261,357,079 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1266,253,990 - 266,304,111 (-)NCBILyon_Normotensive
Lyon_Hypertensive1263,022,526 - 263,072,645 (-)NCBILyon_Hypertensive
F344_StmMcwi1259,569,076 - 259,619,195 (-)NCBIF344_StmMcwi
Rnor_6.01273,708,217 - 273,758,247 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1273,708,212 - 273,758,442 (-)Ensemblrn6Rnor6.0
Rnor_5.01281,121,567 - 281,171,473 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41259,089,652 - 259,139,681 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,726,460 - 247,776,301 (-)NCBICelera
RGSC_v3.11259,355,566 - 259,405,597 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
Evodiamine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
haloperidol  (ISO)
indometacin  (ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA,IEA)
cytosol  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and functional expression of the cytoplasmic form of rat aminopeptidase P. Czirjak G, etal., Biochim Biophys Acta 1999 Mar 19;1444(3):326-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11106490   PMID:12874451   PMID:15489334   PMID:17515839   PMID:18515364   PMID:20431301   PMID:22082260   PMID:22871113   PMID:23376485   PMID:23533145   PMID:26683993  


Genomics

Comparative Map Data
Xpnpep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,006,761 - 262,057,479 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1262,006,761 - 262,092,425 (-)EnsemblGRCr8
mRatBN7.21252,001,366 - 252,052,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,001,367 - 252,051,479 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1260,189,774 - 260,239,893 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01266,895,833 - 266,945,952 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01259,547,854 - 259,598,654 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1261,306,278 - 261,357,079 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1266,253,990 - 266,304,111 (-)NCBILyon_Normotensive
Lyon_Hypertensive1263,022,526 - 263,072,645 (-)NCBILyon_Hypertensive
F344_StmMcwi1259,569,076 - 259,619,195 (-)NCBIF344_StmMcwi
Rnor_6.01273,708,217 - 273,758,247 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1273,708,212 - 273,758,442 (-)Ensemblrn6Rnor6.0
Rnor_5.01281,121,567 - 281,171,473 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41259,089,652 - 259,139,681 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,726,460 - 247,776,301 (-)NCBICelera
RGSC_v3.11259,355,566 - 259,405,597 (-)NCBI
Cytogenetic Map1q55NCBI
XPNPEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810109,864,766 - 109,923,511 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10109,864,494 - 109,923,553 (-)Ensemblhg38GRCh38
GRCh3710111,624,524 - 111,683,269 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610111,614,514 - 111,673,192 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410111,614,513 - 111,673,192NCBI
Celera10105,356,208 - 105,414,975 (-)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef10105,255,598 - 105,314,375 (-)NCBIHuRef
CHM1_110111,906,232 - 111,965,041 (-)NCBICHM1_1
T2T-CHM13v2.010110,748,625 - 110,807,363 (-)NCBIT2T-CHM13v2.0
Xpnpep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391952,919,710 - 53,027,093 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1952,920,357 - 53,028,645 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381952,931,279 - 53,038,662 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1952,931,926 - 53,040,214 (-)Ensemblmm10GRCm38
MGSCv371953,065,673 - 53,113,032 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361953,044,495 - 53,091,854 (-)NCBIMGSCv36mm8
Celera1955,173,619 - 55,221,048 (-)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1946.91NCBI
Xpnpep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554851,436,834 - 1,501,463 (+)Ensembl
ChiLan1.0NW_0049554851,436,834 - 1,501,408 (+)NCBIChiLan1.0ChiLan1.0
XPNPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28121,743,866 - 121,802,631 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110121,749,204 - 121,807,967 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010106,457,390 - 106,516,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110109,908,285 - 109,967,100 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10109,908,285 - 109,967,094 (-)EnsemblpanPan2panpan1.1
XPNPEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12821,267,588 - 21,322,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2821,246,467 - 21,321,953 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2821,410,929 - 21,465,285 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02821,782,248 - 21,836,736 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2821,760,215 - 21,836,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12821,343,307 - 21,397,639 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02821,342,664 - 21,397,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02821,482,813 - 21,537,258 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Xpnpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721324,708,158 - 24,759,708 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936486801,328 - 853,147 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936486801,563 - 853,107 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XPNPEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14120,315,910 - 120,367,780 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114120,316,578 - 120,367,995 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214131,108,925 - 131,204,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XPNPEP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19102,792,424 - 102,840,479 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9102,782,895 - 102,784,895 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl9102,782,895 - 102,784,895 (-)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604863,982,600 - 64,043,409 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xpnpep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473736,343,159 - 36,402,940 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Xpnpep1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1252,427,441 - 52,477,062 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000033148
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
RH129041  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,001,395 - 252,001,585 (+)MAPPERmRatBN7.2
mRatBN7.21252,001,395 - 252,002,084 (+)MAPPERmRatBN7.2
Rnor_6.01273,708,246 - 273,708,934NCBIRnor6.0
Rnor_6.01273,708,246 - 273,708,435NCBIRnor6.0
Rnor_5.01281,121,596 - 281,122,284UniSTSRnor5.0
Rnor_5.01281,121,596 - 281,121,785UniSTSRnor5.0
RGSC_v3.41259,089,680 - 259,090,368UniSTSRGSC3.4
RGSC_v3.41259,089,680 - 259,089,869UniSTSRGSC3.4
Celera1247,726,489 - 247,726,678UniSTS
Celera1247,726,489 - 247,727,177UniSTS
RH 3.4 Map11664.5UniSTS
Cytogenetic Map1q55UniSTS
RH129233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,001,560 - 252,001,776 (+)MAPPERmRatBN7.2
Rnor_6.01273,708,411 - 273,708,626NCBIRnor6.0
Rnor_5.01281,121,761 - 281,121,976UniSTSRnor5.0
RGSC_v3.41259,089,845 - 259,090,060UniSTSRGSC3.4
Celera1247,726,654 - 247,726,869UniSTS
RH 3.4 Map11665.7UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033148   ⟹   ENSRNOP00000031325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,006,761 - 262,092,425 (-)Ensembl
mRatBN7.2 Ensembl1252,001,367 - 252,044,548 (-)Ensembl
Rnor_6.0 Ensembl1273,708,217 - 273,758,247 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088016   ⟹   ENSRNOP00000069329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,006,761 - 262,068,655 (-)Ensembl
mRatBN7.2 Ensembl1252,001,367 - 252,051,479 (-)Ensembl
Rnor_6.0 Ensembl1273,708,212 - 273,758,442 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111011   ⟹   ENSRNOP00000079124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,006,761 - 262,056,816 (-)Ensembl
mRatBN7.2 Ensembl1252,001,367 - 252,051,479 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158489   ⟹   ENSRNOP00000102637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1262,006,761 - 262,030,758 (-)Ensembl
RefSeq Acc Id: NM_001398660   ⟹   NP_001385589
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,006,761 - 262,056,816 (-)NCBI
mRatBN7.21252,001,366 - 252,051,421 (-)NCBI
Dahl_SR_JrHsd1261,306,278 - 261,357,079 (-)NCBI
Lyon_Normotensive1266,253,990 - 266,304,111 (-)NCBI
Lyon_Hypertensive1263,022,526 - 263,072,645 (-)NCBI
F344_StmMcwi1259,569,076 - 259,619,195 (-)NCBI
RefSeq Acc Id: NM_131913   ⟹   NP_571988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,006,761 - 262,056,816 (-)NCBI
mRatBN7.21252,001,366 - 252,051,421 (-)NCBI
Dahl_SR_JrHsd1261,306,278 - 261,357,079 (-)NCBI
Lyon_Normotensive1266,253,990 - 266,304,111 (-)NCBI
Lyon_Hypertensive1263,022,526 - 263,072,645 (-)NCBI
F344_StmMcwi1259,569,076 - 259,619,195 (-)NCBI
Rnor_6.01273,708,217 - 273,758,247 (-)NCBI
Rnor_5.01281,121,567 - 281,171,473 (-)NCBI
RGSC_v3.41259,089,652 - 259,139,681 (-)RGD
Celera1247,726,460 - 247,776,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084472   ⟹   XP_038940400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,006,762 - 262,057,479 (-)NCBI
mRatBN7.21252,001,367 - 252,052,077 (-)NCBI
RefSeq Acc Id: XM_063272403   ⟹   XP_063128473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81262,006,762 - 262,050,646 (-)NCBI
RefSeq Acc Id: NP_571988   ⟸   NM_131913
- Peptide Label: isoform 2
- UniProtKB: O54975 (UniProtKB/Swiss-Prot),   A6JHT7 (UniProtKB/TrEMBL),   A0A8L2QGG3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031325   ⟸   ENSRNOT00000033148
Ensembl Acc Id: ENSRNOP00000069329   ⟸   ENSRNOT00000088016
RefSeq Acc Id: XP_038940400   ⟸   XM_039084472
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G2V2 (UniProtKB/TrEMBL),   A0A8L2QGG3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079124   ⟸   ENSRNOT00000111011
RefSeq Acc Id: NP_001385589   ⟸   NM_001398660
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JV31 (UniProtKB/TrEMBL),   A6JHT6 (UniProtKB/TrEMBL),   A0A8L2QGG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128473   ⟸   XM_063272403
- Peptide Label: isoform X1
- UniProtKB: O54975 (UniProtKB/Swiss-Prot),   A6JHT7 (UniProtKB/TrEMBL),   A0A8L2QGG3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102637   ⟸   ENSRNOT00000158489
Protein Domains
Creatinase N-terminal   Peptidase M24   Peptidase M24 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54975-F1-model_v2 AlphaFold O54975 1-623 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690987
Promoter ID:EPDNEW_R1512
Type:multiple initiation site
Name:Xpnpep1_1
Description:X-prolyl aminopeptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01273,758,256 - 273,758,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621274 AgrOrtholog
BioCyc Gene G2FUF-55406 BioCyc
Ensembl Genes ENSRNOG00000012084 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000033148 ENTREZGENE
  ENSRNOT00000111011 ENTREZGENE
  ENSRNOT00000158489 ENTREZGENE
Gene3D-CATH 3.40.350.10 UniProtKB/Swiss-Prot
  3.90.230.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5600093 IMAGE-MGC_LOAD
InterPro Creatin/AminoP/Spt16_NTD UniProtKB/Swiss-Prot
  Creatinase/aminopeptidase-like UniProtKB/Swiss-Prot
  Creatinase_N UniProtKB/Swiss-Prot
  Pept_M24 UniProtKB/Swiss-Prot
  Pept_M24B UniProtKB/Swiss-Prot
  Peptidase_M24_C UniProtKB/Swiss-Prot
  Peptidase_M24B_aminopep-P_CS UniProtKB/Swiss-Prot
  X-Pro_aminopeptidase_P UniProtKB/Swiss-Prot
KEGG Report rno:170751 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72323 IMAGE-MGC_LOAD
NCBI Gene 170751 ENTREZGENE
PANTHER XAA-PRO AMINOPEPTIDASE 1 UniProtKB/Swiss-Prot
  XAA-PRO AMINOPEPTIDASE 1 UniProtKB/Swiss-Prot
Pfam Creatinase_N UniProtKB/Swiss-Prot
  Creatinase_N_2 UniProtKB/Swiss-Prot
  Peptidase_M24 UniProtKB/Swiss-Prot
  Peptidase_M24_C UniProtKB/Swiss-Prot
PhenoGen Xpnpep1 PhenoGen
PROSITE PROLINE_PEPTIDASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012084 RatGTEx
Superfamily-SCOP SSF53092 UniProtKB/Swiss-Prot
  SSF55920 UniProtKB/Swiss-Prot
UniProt A0A0G2JV31 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G2V2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QGG3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L214_RAT UniProtKB/TrEMBL
  A6JHT5_RAT UniProtKB/TrEMBL
  A6JHT6 ENTREZGENE, UniProtKB/TrEMBL
  A6JHT7 ENTREZGENE, UniProtKB/TrEMBL
  O54975 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Xpnpep1  X-prolyl aminopeptidase 1  Xpnpep1  X-prolyl aminopeptidase (aminopeptidase P) 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Xpnpep1  X-prolyl aminopeptidase (aminopeptidase P) 1, soluble    cytoplasmic aminopeptidase P  Name updated 1299863 APPROVED
2002-08-07 Xpnpep1  cytoplasmic aminopeptidase P      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed ubiquitously with highest expression in testis 634520