Lin7a (lin-7 homolog A, crumbs cell polarity complex component) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lin7a (lin-7 homolog A, crumbs cell polarity complex component) Rattus norvegicus
Analyze
Symbol: Lin7a
Name: lin-7 homolog A, crumbs cell polarity complex component
RGD ID: 621256
Description: Enables PDZ domain binding activity. Predicted to be involved in neurotransmitter secretion; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle transport. Predicted to act upstream of or within inner ear development. Located in basolateral plasma membrane. Is active in synapse. Orthologous to human LIN7A (lin-7 homolog A, crumbs cell polarity complex component); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lin-7 homolog a (C. elegans); lin-7-Ba; lin-7A; LOC100911013; LOC100911160; MALS-1; mammalian lin-seven protein 1; protein lin-7 homolog A; protein lin-7 homolog A-like; veli-1 protein; Veli1; vertebrate lin-7 homolog 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8744,473,568 - 44,629,074 (+)NCBIGRCr8
mRatBN7.2742,586,704 - 42,742,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl742,586,719 - 42,730,550 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0749,429,613 - 49,627,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl749,385,705 - 49,656,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0749,860,444 - 49,889,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4745,970,622 - 46,116,986 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1745,990,892 - 46,137,257 (+)NCBI
Celera739,460,246 - 39,603,293 (+)NCBICelera
Cytogenetic Map7q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
calcitriol  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzacamene  (EXP)
ethanol  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
glafenine  (EXP)
isoprenaline  (ISO)
leflunomide  (ISO)
maneb  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
orphenadrine  (EXP)
oxycodone  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Ptaquiloside  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Butz S, etal., Cell 1998 Sep 18;94(6):773-82.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. MALS is a binding partner of IRSp53 at cell-cell contacts. Hori K, etal., FEBS Lett. 2003 Nov 6;554(1-2):30-4.
5. Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions. Irie M, etal., Oncogene 1999 May 6;18(18):2811-7.
6. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. Jo K, etal., J Neurosci. 1999 Jun 1;19(11):4189-99.
7. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11.
8. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus. Straight SW, etal., Am J Physiol Renal Physiol. 2000 Mar;278(3):F464-75.
Additional References at PubMed
PMID:12351654   PMID:12393911   PMID:14622577   PMID:14681019   PMID:15689499   PMID:16186258   PMID:16192269   PMID:17237226   PMID:17604280   PMID:18054859   PMID:20458337   PMID:21795542  
PMID:22871113  


Genomics

Comparative Map Data
Lin7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8744,473,568 - 44,629,074 (+)NCBIGRCr8
mRatBN7.2742,586,704 - 42,742,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl742,586,719 - 42,730,550 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0749,429,613 - 49,627,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl749,385,705 - 49,656,856 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0749,860,444 - 49,889,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4745,970,622 - 46,116,986 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1745,990,892 - 46,137,257 (+)NCBI
Celera739,460,246 - 39,603,293 (+)NCBICelera
Cytogenetic Map7q21NCBI
LIN7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381280,792,520 - 80,937,934 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1280,792,520 - 80,937,934 (-)EnsemblGRCh38hg38GRCh38
GRCh371281,186,299 - 81,331,713 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361279,715,302 - 79,855,825 (-)NCBINCBI36Build 36hg18NCBI36
Build 341279,693,638 - 79,834,162NCBI
Celera1280,857,386 - 80,997,854 (-)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1278,248,054 - 78,388,586 (-)NCBIHuRef
CHM1_11281,157,566 - 81,298,106 (-)NCBICHM1_1
T2T-CHM13v2.01280,771,214 - 80,916,777 (-)NCBIT2T-CHM13v2.0
Lin7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910107,107,410 - 107,261,007 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10107,107,547 - 107,257,335 (+)EnsemblGRCm39 Ensembl
GRCm3810107,271,549 - 107,425,146 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10107,271,686 - 107,421,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710106,708,887 - 106,862,199 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610106,675,941 - 106,829,253 (+)NCBIMGSCv36mm8
Celera10109,214,597 - 109,367,553 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1055.83NCBI
Lin7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540519,413,817 - 19,548,716 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540519,403,002 - 19,548,716 (-)NCBIChiLan1.0ChiLan1.0
LIN7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21088,840,533 - 88,988,187 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11288,836,928 - 88,984,590 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01278,312,501 - 78,456,871 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11281,423,133 - 81,567,522 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1281,442,152 - 81,567,522 (-)Ensemblpanpan1.1panPan2
LIN7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11523,101,524 - 23,186,343 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1523,111,944 - 23,187,354 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1523,528,909 - 23,652,711 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01523,466,000 - 23,590,006 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1523,474,291 - 23,588,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11523,043,326 - 23,167,286 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01523,102,924 - 23,227,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01523,343,341 - 23,467,440 (-)NCBIUU_Cfam_GSD_1.0
Lin7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494537,101,803 - 37,239,332 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366981,686,929 - 1,810,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366981,675,329 - 1,810,845 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIN7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5100,538,065 - 100,674,551 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15100,533,630 - 100,686,709 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25105,473,697 - 105,629,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIN7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11176,269,360 - 76,412,638 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1176,282,218 - 76,413,171 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037169,017,193 - 169,173,186 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lin7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624837104,948 - 258,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lin7a
1055 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000006083, ENSRNOT00000072526
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat

Markers in Region
D7Got236  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2742,656,348 - 42,656,521 (+)MAPPERmRatBN7.2
Rnor_6.0749,540,510 - 49,540,682NCBIRnor6.0
Rnor_5.0749,553,142 - 49,553,314UniSTSRnor5.0
RGSC_v3.4746,042,788 - 46,042,960UniSTSRGSC3.4
Celera739,529,222 - 39,529,410UniSTS
Cytogenetic Map7q21UniSTS
BF387563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2742,672,951 - 42,673,124 (+)MAPPERmRatBN7.2
Rnor_6.0749,557,113 - 49,557,285NCBIRnor6.0
Rnor_5.0749,569,745 - 49,569,917UniSTSRnor5.0
RGSC_v3.4746,059,391 - 46,059,563UniSTSRGSC3.4
Celera739,545,805 - 39,545,977UniSTS
RH 3.4 Map7349.51UniSTS
Cytogenetic Map7q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 31 113 91 90 59 24 59 6 197 78 93 45 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000006083   ⟹   ENSRNOP00000006083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl749,385,705 - 49,627,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072526   ⟹   ENSRNOP00000065432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl742,586,719 - 42,730,550 (+)Ensembl
Rnor_6.0 Ensembl749,429,613 - 49,656,856 (+)Ensembl
RefSeq Acc Id: NM_001408921   ⟹   NP_001395850
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8744,473,568 - 44,629,074 (+)NCBI
mRatBN7.2742,587,099 - 42,742,609 (+)NCBI
RefSeq Acc Id: XM_063264348   ⟹   XP_063120418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8744,534,103 - 44,624,274 (+)NCBI
Ensembl Acc Id: ENSRNOP00000065432   ⟸   ENSRNOT00000072526
Ensembl Acc Id: ENSRNOP00000006083   ⟸   ENSRNOT00000006083
RefSeq Acc Id: NP_001395850   ⟸   NM_001408921
- UniProtKB: M0R7K1 (UniProtKB/TrEMBL),   A6IGC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120418   ⟸   XM_063264348
- Peptide Label: isoform X1
- UniProtKB: A6IGC8 (UniProtKB/TrEMBL)
Protein Domains
L27   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z250-F1-model_v2 AlphaFold Q9Z250 1-232 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695180
Promoter ID:EPDNEW_R5705
Type:multiple initiation site
Name:Lin7a_1
Description:lin-7 homolog A, crumbs cell polarity complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0749,429,589 - 49,429,649EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621256 AgrOrtholog
BioCyc Gene G2FUF-34180 BioCyc
Ensembl Genes ENSRNOG00000004527 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072526.4 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L27_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIN7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_complex_regulator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 85327 ENTREZGENE
PANTHER PROTEIN LIN-7 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN LIN-7 HOMOLOG A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lin7a PhenoGen
PIRSF Lin-7_homologue UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004527 RatGTEx
SMART L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IGC4_RAT UniProtKB/TrEMBL
  A6IGC5 ENTREZGENE, UniProtKB/TrEMBL
  A6IGC6_RAT UniProtKB/TrEMBL
  A6IGC8 ENTREZGENE, UniProtKB/TrEMBL
  LIN7A_RAT UniProtKB/Swiss-Prot
  M0R7K1 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z250 ENTREZGENE
UniProt Secondary Q9Z251 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Lin7a  lin-7 homolog A, crumbs cell polarity complex component  LOC100911160  protein lin-7 homolog A-like  Data merged from RGD:6494726 737654 PROVISIONAL
2016-03-01 Lin7a  lin-7 homolog A, crumbs cell polarity complex component  Lin7a  lin-7 homolog a (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Lin7a  lin-7 homolog a (C. elegans)  LOC100911013  protein lin-7 homolog A-like  Data merged from RGD:6495191 737654 PROVISIONAL
2012-07-05 LOC100911160  protein lin-7 homolog A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100911013  protein lin-7 homolog A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-12-14 Lin7a  lin-7 homolog a (C. elegans)  Veli1  lin-7-Ba  Symbol and Name updated 1299863 APPROVED
2002-08-07 Veli1  lin-7-Ba      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression ubiquitously expressed 633233