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Gene: Slc28a3 (solute carrier family 28 member 3) Rattus norvegicus

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Symbol:

Slc28a3

Name:

solute carrier family 28 member 3

RGD ID:

621224

Description:

Predicted to enable purine-specific nucleoside:sodium symporter activity; pyrimidine- and adenosine-specific:sodium symporter activity; and uridine transmembrane transporter activity. Involved in retina homeostasis. Predicted to be located in brush border membrane. Predicted to be active in plasma membrane. Orthologous to human SLC28A3 (solute carrier family 28 member 3); PARTICIPATES IN azathioprine pharmacodynamics pathway; gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; INTERACTS WITH 17beta-estradiol; alpha-Zearalanol; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CNT 3; Cnt3; concentrative Na(+)-nucleoside cotransporter 3; rCNT3; solute carrier family 28 (concentrative nucleoside transporter), member 3; solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC28A3 (solute carrier family 28 member 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc28a3 (solute carrier family 28 (sodium-coupled nucleoside transporter), member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc28a3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC28A3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC28A3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc28a3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC28A3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC28A3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc28a3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc28a3 (solute carrier family 28 member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC28A3 (solute carrier family 28 member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc28a3 (solute carrier family 28 (sodium-coupled nucleoside transporter), member 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	slc-28.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CNT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CNT2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	slc-28.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc28a3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	6,068,034 - 6,120,421 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	6,068,060 - 6,120,417 (+)	Ensembl				GRCr8
mRatBN7.2	17	6,062,563 - 6,112,965 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	6,062,549 - 6,114,038 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	6,086,344 - 6,136,146 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	7,619,406 - 7,669,479 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	6,082,764 - 6,132,562 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	6,459,024 - 6,509,761 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	6,459,056 - 6,509,799 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	8,665,223 - 8,715,359 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	11,992,175 - 12,042,696 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	6,174,351 - 6,224,191 (+)	NCBI		Celera
RGSC_v3.1	17	11,992,174 - 12,042,694 (+)	NCBI
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Diabetes Mellitus (IDA)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3-iodothyronamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

cholesterol (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dimethylarsinic acid (ISO)

Domiphen bromide (ISO)

furan (EXP)

methylarsonic acid (ISO)

ozone (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

prothioconazole (ISO)

rac-lactic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nucleoside transmembrane transport (IEA,ISO)

purine nucleobase transmembrane transport (IEA)

purine nucleoside transmembrane transport (IBA,ISO)

pyrimidine nucleobase transport (IEA)

pyrimidine nucleoside transport (IBA,ISO)

pyrimidine-containing compound transmembrane transport (IEA,ISO)

retina homeostasis (IDA)

sodium ion transmembrane transport (IEA)

uridine transmembrane transport (IEA,ISO)

Cellular Component

brush border membrane (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

nucleoside transmembrane transporter activity (IEA)

protein binding (ISO)

purine-specific nucleoside:sodium symporter activity (IBA,IEA,ISO)

pyrimidine- and adenosine-specific:sodium symporter activity (IBA,IEA,ISO)

symporter activity (IEA)

uridine transmembrane transporter activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

azathioprine pharmacodynamics pathway (ISO)

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

mercaptopurine pharmacokinetics pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The concentrative nucleoside transporter family, SLC28.	Gray JH, etal., Pflugers Arch 2004 Feb;447(5):728-34. Epub 2003 Jul 11.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier.	Nagase K, etal., Biochim Biophys Acta. 2006 Jan;1758(1):13-9. Epub 2006 Feb 2.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes.	Rodriguez-Mulero S, etal., Kidney Int. 2005 Aug;68(2):665-72.

Additional References at PubMed

PMID:11032837	PMID:25034758

Genomics

Comparative Map Data

Slc28a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	6,068,034 - 6,120,421 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	6,068,060 - 6,120,417 (+)	Ensembl				GRCr8
mRatBN7.2	17	6,062,563 - 6,112,965 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	6,062,549 - 6,114,038 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	6,086,344 - 6,136,146 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	7,619,406 - 7,669,479 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	6,082,764 - 6,132,562 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	6,459,024 - 6,509,761 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	6,459,056 - 6,509,799 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	8,665,223 - 8,715,359 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	11,992,175 - 12,042,696 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	6,174,351 - 6,224,191 (+)	NCBI		Celera
RGSC_v3.1	17	11,992,174 - 12,042,694 (+)	NCBI
Cytogenetic Map	17	p14	NCBI

SLC28A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	84,275,457 - 84,368,727 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	84,275,457 - 84,340,758 (-)	Ensembl			hg38	GRCh38
GRCh37	9	86,890,372 - 86,983,642 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	86,082,912 - 86,173,233 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	84,122,645 - 84,212,967	NCBI
Celera	9	57,464,095 - 57,554,419 (-)	NCBI		Celera
Cytogenetic Map	9	q21.32-q21.33	NCBI
HuRef	9	56,716,695 - 56,809,112 (-)	NCBI		HuRef
CHM1_1	9	87,037,314 - 87,129,976 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	96,425,798 - 96,519,059 (-)	NCBI		T2T-CHM13v2.0

Slc28a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	58,701,121 - 58,758,691 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	58,693,213 - 58,758,691 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	58,553,307 - 58,610,877 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	58,545,399 - 58,610,877 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	58,654,668 - 58,712,238 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	58,562,930 - 58,620,491 (-)	NCBI		MGSCv36	mm8
Celera	13	59,616,100 - 59,674,204 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	31.07	NCBI

Slc28a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	2,894,935 - 2,947,330 (+)	Ensembl
ChiLan1.0	NW_004955432	2,892,594 - 2,948,196 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC28A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	83,435,004 - 83,499,435 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	83,442,587 - 83,505,373 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	40,525,543 - 40,604,426 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	83,629,202 - 83,721,337 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	83,629,202 - 83,693,822 (-)	Ensembl			panPan2	panpan1.1

SLC28A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	75,035,690 - 75,109,216 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	75,035,952 - 75,205,084 (+)	Ensembl			canFam3	CanFam3.1
ROS_Cfam_1.0	1	75,342,372 - 75,419,786 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	75,342,585 - 75,512,258 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	75,151,290 - 75,228,693 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	74,919,180 - 74,988,194 (+)	NCBI		UNSW_CanFamBas_1.0
UNSW_CanFamBas_1.0	1	74,991,077 - 74,996,566 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	75,622,824 - 75,700,238 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc28a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	121,757,555 - 121,804,293 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004937156	124,342 - 165,937 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC28A3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	30,669,904 - 30,729,301 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	30,663,060 - 30,730,766 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	34,734,234 - 34,768,178 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC28A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	95,088,902 - 95,179,201 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	95,091,301 - 95,127,745 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	83,510,606 - 83,576,481 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc28a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624809	7,857,518 - 7,896,055 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624809	7,855,397 - 7,943,832 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc28a3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	79,527,108 - 79,576,643 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc28a3
532 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	92
Count of miRNA genes:	84
Interacting mature miRNAs:	86
Transcripts:	ENSRNOT00000025745
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	1	21499218	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	9	50	123	55	59	29	30	29	6	217	98	2	107	66	85	30	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_080908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY059414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025745 ⟹ ENSRNOP00000025745

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	6,068,060 - 6,120,417 (+)	Ensembl
mRatBN7.2 Ensembl	17	6,062,549 - 6,114,038 (+)	Ensembl
Rnor_6.0 Ensembl	17	6,459,056 - 6,509,799 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000159704 ⟹ ENSRNOP00000102142

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	6,068,060 - 6,120,417 (+)	Ensembl

RefSeq Acc Id:

NM_080908 ⟹ NP_543184

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	6,068,069 - 6,118,108 (+)	NCBI
mRatBN7.2	17	6,062,597 - 6,112,639 (+)	NCBI
Rnor_6.0	17	6,459,109 - 6,509,481 (+)	NCBI
Rnor_5.0	17	8,665,223 - 8,715,359 (+)	NCBI
RGSC_v3.4	17	11,992,175 - 12,042,696 (+)	RGD
Celera	17	6,174,351 - 6,224,191 (+)	NCBI

Sequence:

show sequence

ATGTCCAGGTCAGACCCAGACCCGGGAAAGAATTCGGAGCCCAGTAAGAGCAAGATGAGCCTGG
AGCTGAGGCCAACAGCCCCCAGCGACCAGGGCCGCCTCAACGAAGCCTTCCAGGATGAAGACCT
GGAAGAGCAGAACGCTCCAGGAAACAGCACAGTCAGGAGCAGAGTTGTACAGAGTGGGGAGCAA
GGACGGGCCAAACAGGACGACAGGCAGATCACGATTGAGCAGGAGCCTCTAGGACCCAAAGAAG
GCACAGAGGAAGAGAGCGAAGATGAACGTCAGAAAGGGTTCTTGGAAAGGAAGTATGATACGGT
TTGTGAGTTTTGTAGAAAGCACAGAGTCATTCTCCAGCACACCATCTGGGCAGTTTTACTGACA
GGTTTCCTGGCCCTGGTGATTGCAGCCTGTGCACTAAACTTCCACCGAGCCCTTCCCCTTTTTG
TGATCACCTTGGTGACCATCTTCTTCGTCGTCTGGGATCGCTTGATGGCCAAATACGAACAGCG
AATCGATGATGTCCTGTCTCCCGGCAAAAGGCTGCTTGAGAGGCATTGGTTCTGGCTGAAGTGG
GTGGTCTGGTGCTCACTGATCTTGGCGGTCATTCTCTGGCTGGCTCTGGACACGGCCAGGCTGG
GCCAACAGCAGCTGATATCCTTTGGTGGGCTCGTCATGTATATTGTTCTGCTATTCCTGTTTTC
CAAGCATCCGACCAGAGTTTACTGGAGGCCTGTCTTTTGGGGAATTGGACTGCAGTTTCTTCTT
GGGCTCTTAATTCTAAGGACTAGGCCTGGATTTGTTGCTTTTGATTGGATGGGGAAACAAGTTC
AGACTTTTCTGGGGTACACTGACGCTGGAGCCCAGTTTGTCTTTGGAGAAAAGTATACAGACCA
CTTCTTTGCATTTAAGATCCTTCCCATTGTGGTTTTCTTCAGCACCGTGATGTCTATGCTCTAT
TATCTGGGACTGATGCAGTGGATTATCAGAAAGGTTGGGTGGCTAATGCTTGTCACTATGGGGT
CATCTCCCATTGAGTCCGTAGTTGCTGCTGGCAACATATTTGTTGGGCAAACAGAGTCTCCACT
ACTGGTTCAACCATATCTACCACACGTCACCAAGTCAGAACTGCACACCATCATGACAGCTGGT
TTTGCCACGATTGCTGGGAGCGTGTTGGGCGCGTACATCTCTTTTGGGGTGTCATCTACACACT
TGCTCACCGCTTCTGTCATGTCGGCGCCTGCAGCCCTGGCTGTGGCCAAACTCTTTTGGCCTGA
AACAGAGAAACCCAAAATAACCCTCAAGAATGCCATGAAAATGGAAAATGGTGATTCCCGGAAT
CTCCTGGAGGCGGCCACGCAGGGTGCATCTTCGTCCATCCCCCTGGTGGCAAACATCGCTGCAA
ATCTGATCGCCTTCCTGGCCTTGCTTTCCTTTGTGAACTCCGCTCTGTCTTGGTTTGGAAGCAT
GTTCGACTACCCACAGCTGAGTTTCGAGCTCATTTGTTCTTACATCTTCATGCCTTTCTCCTTC
ATGATGGGAGTCGACTGGCAAGACAGATTTATGGTCGCCAAACTCATAGGCTACAAGACGTTCT
TCAATGAATTTGTGGCTTATGAACACCTCTCAAAATTCATCAATTTGAGGAAAGCGGCTGGACC
CAAATTTGTGAATGGTGTGCAGCAATATATGTCAATTCGCTCGGAGACCATCGCAACTTACGCC
CTCTGTGGTTTTGCCAATTTTGGTTCCCTAGGAATAGTGATCGGTGGACTTACGTCTATAGCTC
CGTCCAGAAAGCGAGACATTGCCTCGGGAGCCATGAGAGCCCTGATTGCTGGGACCATTGCCTG
CTTCATGACAGCCTGCATCGCTGGCATGCTCTCTGACACCCCGGTGGCTATCAACTGCCACCAC
GTTCTAGAGAGCAGCAAAGTACTCAGCAACACAACTGAAGTGGCGTCTTGCTGTCAAGGCCTGT
TCAACAGCACTGTTGCCAGGGGACCAAATGACGTCCTCCCAGGAGGAAACTTCAGCCTCTACAC
TTTGAAGAGCTGCTGCAACCTGCTGAAACCACCAACGCTGAACTGTGGTTGGATCCCTAACATA
CCGTAA

hide sequence

RefSeq Acc Id:

XM_039095316 ⟹ XP_038951244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	6,068,034 - 6,120,421 (+)	NCBI
mRatBN7.2	17	6,062,563 - 6,112,965 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_543184	(Get FASTA)	NCBI Sequence Viewer
	XP_038951244	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL27091	(Get FASTA)	NCBI Sequence Viewer
	EDL93905	(Get FASTA)	NCBI Sequence Viewer
	EDL93906	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025745
	ENSRNOP00000102142
GenBank Protein	Q8VIH3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_543184 ⟸ NM_080908

- UniProtKB:

Q8VIH3 (UniProtKB/Swiss-Prot), G3V8H0 (UniProtKB/TrEMBL), A6KAJ7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSRSDPDPGKNSEPSKSKMSLELRPTAPSDQGRLNEAFQDEDLEEQNAPGNSTVRSRVVQSGEQ
GRAKQDDRQITIEQEPLGPKEGTEEESEDERQKGFLERKYDTVCEFCRKHRVILQHTIWAVLLT
GFLALVIAACALNFHRALPLFVITLVTIFFVVWDRLMAKYEQRIDDVLSPGKRLLERHWFWLKW
VVWCSLILAVILWLALDTARLGQQQLISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLL
GLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGEKYTDHFFAFKILPIVVFFSTVMSMLY
YLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKSELHTIMTAG
FATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENGDSRN
LLEAATQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIFMPFSF
MMGVDWQDRFMVAKLIGYKTFFNEFVAYEHLSKFINLRKAAGPKFVNGVQQYMSIRSETIATYA
LCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGMLSDTPVAINCHH
VLESSKVLSNTTEVASCCQGLFNSTVARGPNDVLPGGNFSLYTLKSCCNLLKPPTLNCGWIPNI
P

hide sequence

Ensembl Acc Id:

ENSRNOP00000025745 ⟸ ENSRNOT00000025745

RefSeq Acc Id:	XP_038951244 ⟸ XM_039095316
- Peptide Label:	isoform X1
- UniProtKB:	Q8VIH3 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000102142 ⟸ ENSRNOT00000159704

Protein Domains

Concentrative nucleoside transporter C-terminal Concentrative nucleoside transporter N-terminal Nucleoside transporter/FeoB GTPase Gate

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8VIH3-F1-model_v2	AlphaFold	Q8VIH3	1-705	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621224	AgrOrtholog
BioCyc Gene	G2FUF-10378	BioCyc
Ensembl Genes	ENSRNOG00000018853	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000025745	ENTREZGENE
	ENSRNOT00000159704	ENTREZGENE
InterPro	C_nuclsd_transpt	UniProtKB/Swiss-Prot
	C_nuclsd_transpt_met_bac	UniProtKB/Swiss-Prot
	CNT_C_dom	UniProtKB/Swiss-Prot
	CNT_N_dom	UniProtKB/Swiss-Prot
	Gate_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:140944	UniProtKB/Swiss-Prot
NCBI Gene	140944	ENTREZGENE
PANTHER	PTHR10590	UniProtKB/Swiss-Prot
	SOLUTE CARRIER FAMILY 28 MEMBER 3	UniProtKB/Swiss-Prot
Pfam	Gate	UniProtKB/Swiss-Prot
	Nucleos_tra2_C	UniProtKB/Swiss-Prot
	Nucleos_tra2_N	UniProtKB/Swiss-Prot
PharmGKB	SLC28A3	RGD
PhenoGen	Slc28a3	PhenoGen
RatGTEx	ENSRNOG00000018853	RatGTEx
UniProt	A0ABK0LC51_RAT	UniProtKB/TrEMBL
	A6KAJ7	ENTREZGENE, UniProtKB/TrEMBL
	A6KAJ8_RAT	UniProtKB/TrEMBL
	G3V8H0	ENTREZGENE, UniProtKB/TrEMBL
	Q8VIH3	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc28a3	solute carrier family 28 member 3	Slc28a3	solute carrier family 28 (concentrative nucleoside transporter), member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc28a3	solute carrier family 28 (concentrative nucleoside transporter), member 3	Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - SMPDB