Slc22a4 (solute carrier family 22 member 4) - Rat Genome Database

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Gene: Slc22a4 (solute carrier family 22 member 4) Rattus norvegicus
Analyze
Symbol: Slc22a4
Name: solute carrier family 22 member 4
RGD ID: 621149
Description: Enables quaternary ammonium group transmembrane transporter activity. Involved in several processes, including acetylcholine uptake; lactation; and liver regeneration. Located in apical plasma membrane; mitochondrion; and neuronal cell body. Biomarker of chronic obstructive pulmonary disease and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human SLC22A4 (solute carrier family 22 member 4); PARTICIPATES IN cisplatin response pathway; INTERACTS WITH (R)-carnitine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Octn1; organic cation transporter OCTN1; organic cation/carnitine transporter 1; solute carrier family 22 (organic cation transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,634,098 - 38,687,409 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,634,098 - 38,679,920 (-)EnsemblGRCr8
mRatBN7.21038,133,333 - 38,179,932 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,133,322 - 38,179,720 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,818,653 - 42,864,486 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,308,749 - 42,354,587 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,812,450 - 37,858,285 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,334,972 - 39,373,508 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01039,121,490 - 39,154,295 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1037,476,326 - 37,522,094 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-carnitine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
ammonium chloride  (EXP)
angelicin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
atrazine  (EXP)
atropine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
diltiazem  (ISO)
dithioerythritol  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ergothioneine  (ISO)
ethanol  (ISO)
flecainide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
graphite  (EXP)
hydroxyurea  (ISO)
imperatorin  (ISO)
ipratropium  (ISO)
L-cysteine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lidocaine  (ISO)
mangiferin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methyl methacrylate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nifedipine  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
pirinixic acid  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
probenecid  (ISO)
propafenone  (ISO)
propranolol  (ISO)
psoralen  (ISO)
quercetin  (ISO)
rotenone  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
spironolactone  (ISO)
succimer  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraethylammonium  (ISO)
tetrahydropalmatine  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-piceid  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IDA,IEA,ISO,ISS)
basal plasma membrane  (IEA,ISO,ISS)
membrane  (IEA)
mitochondrial membrane  (IEA,ISO,ISS)
mitochondrion  (IDA,IEA,ISO)
neuronal cell body  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60. Ben Said M, etal., Hum Genet. 2016 May;135(5):513-24. doi: 10.1007/s00439-016-1657-7. Epub 2016 Mar 29.
2. Membrane transporters as mediators of Cisplatin effects and side effects. Ciarimboli G Scientifica (Cairo). 2012;2012:473829. doi: 10.6064/2012/473829. Epub 2012 Nov 25.
3. Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver. Dransfeld O, etal., Liver Int. 2005 Dec;25(6):1243-58.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats. Gutgesell A, etal., Metabolism. 2009 Feb;58(2):226-32. doi: 10.1016/j.metabol.2008.09.018.
6. Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons. Jong NN, etal., J Pharmacol Exp Ther. 2011 Aug;338(2):537-47. doi: 10.1124/jpet.111.181297. Epub 2011 May 23.
7. Dysregulation of renal transporters in a rodent model of viral Infection. Karimian Pour N and Piquette-Miller M, Int Immunopharmacol. 2020 Mar;80:106135. doi: 10.1016/j.intimp.2019.106135. Epub 2020 Jan 14.
8. Endotoxin Modulates the Expression of Renal Drug Transporters in HIV-1 Transgenic Rats. Karimian Pour N and Piquette-Miller M, J Pharm Pharm Sci. 2018;21(1s):117s-129s. doi: 10.18433/jpps30017.
9. Transport of organic cations across the blood-testis barrier. Maeda T, etal., Mol Pharm. 2007 Jul-Aug;4(4):600-7. Epub 2007 Jul 7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). Nakamura T, etal., Biol Pharm Bull. 2008 Aug;31(8):1580-4. doi: 10.1248/bpb.31.1580.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily. Oppedisano F, etal., Nutrients. 2020 May 15;12(5):1435. doi: 10.3390/nu12051435.
15. Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter. Pochini L, etal., Biochim Biophys Acta. 2016 Apr;1858(4):653-60. doi: 10.1016/j.bbamem.2015.12.026. Epub 2015 Dec 23.
16. Cigarette smoke extract combined with lipopolysaccharide reduces OCTN1/2 expression in human alveolar epithelial cells in vitro and rat lung in vivo under inflammatory conditions. Qi C, etal., Int Immunopharmacol. 2020 Oct;87:106812. doi: 10.1016/j.intimp.2020.106812. Epub 2020 Jul 21.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Effects of 1α,25-dihydroxyvitamin D3 on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats. Vo DK, etal., J Pharm Investig. 2022;52(3):341-351. doi: 10.1007/s40005-022-00563-1. Epub 2022 Mar 10.
21. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Wu X, etal., Biochim Biophys Acta 2000 Jun 1;1466(1-2):315-27.
22. L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. Yi Y, etal., Toxicology. 2021 Jul;459:152853. doi: 10.1016/j.tox.2021.152853. Epub 2021 Jul 9.
Additional References at PubMed
PMID:9426230   PMID:10655497   PMID:11010964   PMID:14651853   PMID:15523054   PMID:16729965   PMID:17011512   PMID:18614015   PMID:18641280   PMID:35559956  


Genomics

Comparative Map Data
Slc22a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,634,098 - 38,687,409 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,634,098 - 38,679,920 (-)EnsemblGRCr8
mRatBN7.21038,133,333 - 38,179,932 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,133,322 - 38,179,720 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,818,653 - 42,864,486 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,308,749 - 42,354,587 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,812,450 - 37,858,285 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,334,972 - 39,373,508 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01039,121,490 - 39,154,295 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1037,476,326 - 37,522,094 (-)NCBICelera
Cytogenetic Map10q22NCBI
SLC22A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,294,394 - 132,344,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,293,769 - 132,344,206 (+)Ensemblhg38GRCh38
GRCh375131,630,087 - 131,679,883 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,658,044 - 131,707,798 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345131,658,043 - 131,707,796NCBI
Celera5127,760,255 - 127,809,972 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,822,406 - 126,872,150 (+)NCBIHuRef
CHM1_15131,062,911 - 131,112,639 (+)NCBICHM1_1
T2T-CHM13v2.05132,814,292 - 132,864,084 (+)NCBIT2T-CHM13v2.0
Slc22a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,873,941 - 53,920,866 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,873,949 - 53,918,916 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,983,115 - 54,030,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,983,123 - 54,028,090 (-)Ensemblmm10GRCm38
MGSCv371153,796,628 - 53,841,592 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,826,549 - 53,871,513 (-)NCBIMGSCv36mm8
Celera1158,570,827 - 58,615,496 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.07NCBI
Slc22a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,671,772 - 3,737,612 (+)Ensembl
ChiLan1.0NW_0049554083,671,772 - 3,737,946 (+)NCBIChiLan1.0ChiLan1.0
SLC22A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,609,074 - 127,662,069 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,750,856 - 125,801,453 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,717,077 - 127,766,793 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,879,374 - 133,929,439 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,879,387 - 133,929,439 (+)EnsemblpanPan2panpan1.1
SLC22A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,599,281 - 20,643,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,401,045 - 19,445,624 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01121,384,967 - 21,429,553 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11120,103,729 - 20,148,455 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,951,861 - 19,996,466 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,593,741 - 20,638,332 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101975630
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,822,961 - 115,872,218 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,825,814 - 2,874,774 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,825,814 - 2,874,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,595,584 - 134,639,777 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12134,594,843 - 134,641,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,999,122 - 140,061,471 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,123,442 - 35,173,254 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,124,433 - 35,173,264 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603442,770,859 - 42,820,375 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,698,456 - 39,808,718 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473339,740,026 - 39,809,265 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a4
272 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000058907
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox49  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1037,476,562 - 37,476,747UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 17 45 66 136 93 11 44 36 32 12 12

Sequence


RefSeq Acc Id: NM_022270   ⟹   NP_071606
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,634,098 - 38,679,920 (-)NCBI
mRatBN7.21038,133,335 - 38,179,161 (-)NCBI
Rnor_6.01039,334,972 - 39,373,508 (-)NCBI
Rnor_5.01039,121,490 - 39,154,295 (-)NCBI
Celera1037,476,326 - 37,522,094 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086772   ⟹   XP_038942700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,634,099 - 38,687,409 (-)NCBI
mRatBN7.21038,133,333 - 38,179,932 (-)NCBI
RefSeq Acc Id: XM_039086773   ⟹   XP_038942701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,634,099 - 38,687,409 (-)NCBI
mRatBN7.21038,133,333 - 38,179,928 (-)NCBI
RefSeq Acc Id: XM_039086775   ⟹   XP_038942703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,634,099 - 38,679,582 (-)NCBI
mRatBN7.21038,133,333 - 38,178,790 (-)NCBI
RefSeq Acc Id: XM_039086776   ⟹   XP_038942704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,634,099 - 38,666,079 (-)NCBI
mRatBN7.21038,133,333 - 38,165,328 (-)NCBI
RefSeq Acc Id: XM_039086777   ⟹   XP_038942705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,634,099 - 38,679,594 (-)NCBI
mRatBN7.21038,133,333 - 38,178,830 (-)NCBI
RefSeq Acc Id: XM_063269796   ⟹   XP_063125866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,634,099 - 38,666,199 (-)NCBI
RefSeq Acc Id: NP_071606   ⟸   NM_022270
- UniProtKB: Q9R141 (UniProtKB/Swiss-Prot),   A6HEF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038942700   ⟸   XM_039086772
- Peptide Label: isoform X1
- UniProtKB: D3ZCM6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942701   ⟸   XM_039086773
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942705   ⟸   XM_039086777
- Peptide Label: isoform X4
- UniProtKB: A6HEG0 (UniProtKB/TrEMBL),   A6HEF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942703   ⟸   XM_039086775
- Peptide Label: isoform X4
- UniProtKB: A6HEG0 (UniProtKB/TrEMBL),   A6HEF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942704   ⟸   XM_039086776
- Peptide Label: isoform X4
- UniProtKB: A6HEG0 (UniProtKB/TrEMBL),   A6HEF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125866   ⟸   XM_063269796
- Peptide Label: isoform X3
- UniProtKB: A6HEF9 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCM6-F1-model_v2 AlphaFold D3ZCM6 1-528 view protein structure
AF-Q9R141-F1-model_v2 AlphaFold Q9R141 1-553 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621149 AgrOrtholog
BioCyc Gene G2FUF-25122 BioCyc
Ensembl Genes ENSRNOG00000046195 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058907 ENTREZGENE
  ENSRNOT00000058907.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
  S22A4/5 UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:64037 UniProtKB/Swiss-Prot
NCBI Gene 64037 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc22a4 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046195 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A6HEF8 ENTREZGENE, UniProtKB/TrEMBL
  A6HEF9 ENTREZGENE, UniProtKB/TrEMBL
  A6HEG0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCM6 ENTREZGENE, UniProtKB/TrEMBL
  Q9R141 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc22a4  solute carrier family 22 member 4  Slc22a4  solute carrier family 22 (organic cation/zwitterion transporter), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc22a4  solute carrier family 22 (organic cation/zwitterion transporter), member 4  Slc22a4  solute carrier family 22 (organic cation transporter), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Slc22a4  solute carrier family 22 (organic cation transporter), member 4  Octn1  organic cation transporter OCTN1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Octn1  organic cation transporter OCTN1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, intestine, kidney, brain, heart and placenta 633351