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Gene: Adgrl4 (adhesion G protein-coupled receptor L4) Rattus norvegicus

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Symbol:

Adgrl4

Name:

adhesion G protein-coupled receptor L4

RGD ID:

621136

Description:

Predicted to enable G protein-coupled receptor activity. Involved in protein-containing complex assembly. Located in cytoplasmic vesicle and plasma membrane. Biomarker of glioblastoma. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

EGF, latrophilin and seven transmembrane domain containing 1; EGF, latrophilin and seven transmembrane domain-containing protein 1; EGF, latrophilin seven transmembrane domain containing 1; EGF,latrophilin and seven transmembrane domain-containing protein 1; EGF-TM7-latrophilin-related protein; Eltd1; Etl

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADGRL4 (adhesion G protein-coupled receptor L4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Adgrl4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adgrl4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADGRL4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADGRL4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adgrl4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADGRL4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADGRL4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adgrl4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Adgrl4 (adhesion G protein-coupled receptor L4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	POLR3A (RNA polymerase III subunit A)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Adgrl4 (adhesion G protein-coupled receptor L4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ADGRL4 (adhesion G protein-coupled receptor L4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adgrl4 (adhesion G protein-coupled receptor L4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lat-1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Cirl	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Cirl	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	mth-2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	adgrl4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	243,014,927 - 243,117,226 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	243,014,796 - 243,117,222 (+)	Ensembl				GRCr8
mRatBN7.2	2	240,354,909 - 240,457,231 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	240,354,941 - 240,457,225 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	248,150,182 - 248,254,960 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	246,037,208 - 246,141,984 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	240,908,297 - 241,010,524 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	256,609,787 - 256,724,642 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	256,609,787 - 256,724,641 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	275,293,988 - 275,408,900 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	249,764,600 - 249,866,831 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	232,295,578 - 232,396,733 (+)	NCBI		Celera
RGSC_v3.1	2	249,779,206 - 249,881,437 (+)	NCBI
Cytogenetic Map	2	q45	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

glioblastoma (IEP,ISO)

hypertrophic cardiomyopathy (ISO)

Left Ventricular Hypertrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

7,12-dimethyltetraphene (EXP)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

brequinar (ISO)

Butylbenzyl phthalate (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

carbonyl sulfide (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

cobalt dichloride (ISO)

crocidolite asbestos (ISO)

dibenz[a,h]anthracene (ISO)

diquat (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethylparaben (ISO)

folic acid (ISO)

folpet (ISO)

fulvestrant (ISO)

isoprenaline (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

PCB138 (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

Senkirkine (EXP)

sunitinib (ISO)

tetraphene (ISO)

thiram (ISO)

titanium dioxide (ISO)

toluene (EXP)

topotecan (EXP)

tremolite asbestos (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IBA,IEA)

protein-containing complex assembly (IDA)

signal transduction (IEA)

Cellular Component

cytoplasmic vesicle (IDA)

membrane (IEA)

plasma membrane (IBA,IDA,IEA)

Molecular Function

calcium ion binding (IEA)

G protein-coupled receptor activity (IBA,IEA)

transmembrane signaling receptor activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily.	Nechiporuk T, etal., J Biol Chem 2001 Feb 9;276(6):4150-7.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	ELTD1, a potential new biomarker for gliomas.	Towner RA, etal., Neurosurgery. 2013 Jan;72(1):77-90; discussion 91. doi: 10.1227/NEU.0b013e318276b29d.
9.	Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.	Xiao J, etal., PLoS One. 2012;7(5):e35779. doi: 10.1371/journal.pone.0035779. Epub 2012 May 11.
10.	ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.	Ziegler J, etal., Neuro Oncol. 2017 Feb 1;19(2):175-185. doi: 10.1093/neuonc/now147.

Genomics

Comparative Map Data

Adgrl4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	243,014,927 - 243,117,226 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	243,014,796 - 243,117,222 (+)	Ensembl				GRCr8
mRatBN7.2	2	240,354,909 - 240,457,231 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	240,354,941 - 240,457,225 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	248,150,182 - 248,254,960 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	246,037,208 - 246,141,984 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	240,908,297 - 241,010,524 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	256,609,787 - 256,724,642 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	256,609,787 - 256,724,641 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	275,293,988 - 275,408,900 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	249,764,600 - 249,866,831 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	232,295,578 - 232,396,733 (+)	NCBI		Celera
RGSC_v3.1	2	249,779,206 - 249,881,437 (+)	NCBI
Cytogenetic Map	2	q45	NCBI

ADGRL4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	78,889,764 - 79,006,730 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	78,889,764 - 79,282,124 (-)	Ensembl			hg38	GRCh38
GRCh37	1	79,355,449 - 79,472,415 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	79,128,037 - 79,245,083 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	77,595,032 - 77,712,073 (-)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	77,487,868 - 77,604,946 (-)	NCBI		HuRef
CHM1_1	1	79,471,875 - 79,588,556 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	78,728,626 - 78,845,196 (-)	NCBI		T2T-CHM13v2.0

Adgrl4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	151,143,519 - 151,250,718 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	151,143,524 - 151,250,723 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	151,437,882 - 151,545,081 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	151,437,887 - 151,545,086 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	151,100,846 - 151,208,045 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	151,375,268 - 151,482,467 (+)	NCBI		MGSCv36	mm8
Celera	3	157,902,449 - 158,009,462 (+)	NCBI		Celera
Cytogenetic Map	3	H3	NCBI
cM Map	3	76.76	NCBI

Adgrl4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	14,395,558 - 14,487,856 (+)	Ensembl
ChiLan1.0	NW_004955423	14,395,712 - 14,487,803 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADGRL4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	147,892,334 - 148,008,807 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	147,048,791 - 147,165,268 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	78,099,504 - 78,216,060 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	80,236,721 - 80,353,157 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	80,236,040 - 80,353,157 (-)	Ensembl			panPan2	panpan1.1

ADGRL4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	68,078,481 - 68,189,422 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	68,078,246 - 68,220,743 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	70,736,971 - 70,847,924 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	68,665,910 - 68,775,602 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	68,665,865 - 68,803,027 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	68,170,982 - 68,281,896 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	68,116,156 - 68,227,448 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	68,602,665 - 68,712,408 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adgrl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	90,076,709 - 90,181,473 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936571	5,587,059 - 5,691,670 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936571	5,587,077 - 5,691,623 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADGRL4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	134,362,901 - 134,462,694 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	134,362,714 - 134,462,697 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	124,520,112 - 124,620,447 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADGRL4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	54,208,073 - 54,325,120 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	54,208,321 - 54,327,545 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	63,213,110 - 63,333,108 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adgrl4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	18,306,871 - 18,396,342 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624742	18,306,809 - 18,397,683 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Adgrl4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	9,445,032 - 9,549,862 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Adgrl4
528 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	21
Count of miRNA genes:	20
Interacting mature miRNAs:	21
Transcripts:	ENSRNOT00000047564
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	221088977	243501206	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
8693622	Alc26	Alcohol consumption QTL 26	2.4	0.667	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	223810546	243965570	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	220274283	249795005	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat

Markers in Region

BF404923

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	240,357,127 - 240,357,237 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	256,611,974 - 256,612,083	NCBI	Rnor6.0
Rnor_5.0	2	275,296,175 - 275,296,284	UniSTS	Rnor5.0
RGSC_v3.4	2	249,766,787 - 249,766,896	UniSTS	RGSC3.4
Celera	2	232,297,760 - 232,297,869	UniSTS
RH 3.4 Map	2	1653.81	UniSTS
Cytogenetic Map	2	q45	UniSTS

AI237194

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	240,456,851 - 240,457,036 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	256,724,268 - 256,724,452	NCBI	Rnor6.0
Rnor_5.0	2	275,408,521 - 275,408,705	UniSTS	Rnor5.0
RGSC_v3.4	2	249,866,457 - 249,866,641	UniSTS	RGSC3.4
Celera	2	232,396,359 - 232,396,543	UniSTS
RH 3.4 Map	2	1654.81	UniSTS
Cytogenetic Map	2	q45	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	33	59	6	297	133	11	141	81	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF192401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF192402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000047564 ⟹ ENSRNOP00000045890

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	243,014,796 - 243,117,222 (+)	Ensembl
mRatBN7.2 Ensembl	2	240,354,941 - 240,457,225 (+)	Ensembl
Rnor_6.0 Ensembl	2	256,609,787 - 256,724,641 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088437 ⟹ ENSRNOP00000071560

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	243,015,043 - 243,117,222 (+)	Ensembl
mRatBN7.2 Ensembl	2	240,354,968 - 240,457,225 (+)	Ensembl
Rnor_6.0 Ensembl	2	256,609,787 - 256,724,641 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000126308 ⟹ ENSRNOP00000102405

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	243,014,939 - 243,113,033 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000130640 ⟹ ENSRNOP00000098828

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	243,014,796 - 243,117,222 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000155090 ⟹ ENSRNOP00000107605

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	243,014,796 - 243,117,222 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000166088 ⟹ ENSRNOP00000099575

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	243,015,060 - 243,117,222 (+)	Ensembl

RefSeq Acc Id:

NM_022294 ⟹ NP_071630

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	243,014,939 - 243,117,221 (+)	NCBI
mRatBN7.2	2	240,354,941 - 240,457,226 (+)	NCBI
Rnor_6.0	2	256,609,787 - 256,724,642 (+)	NCBI
Rnor_5.0	2	275,293,988 - 275,408,900 (+)	NCBI
RGSC_v3.4	2	249,764,600 - 249,866,831 (+)	RGD
Celera	2	232,295,578 - 232,396,733 (+)	RGD

Sequence:

show sequence

CCACAGGCTGAGACTAGAGTCCAGGCTGTTTGGGTGAAGGGGCCTGGCGGCCGGACGTGGCCTG
CAGAGTCTGGGCTGTGCACACATTCACACAAAAGAGGCCGGGAAGTGACAGGAGGAAGCTGTGC
GTCACAAGGGACTGAGCGGGACCCTGCCGCGCCTGCCCAGCTCCAGGACAGACCCCAACTCTTG
CCTTCAGCGCTCTGCGGAGCCAGCCAGCTCCACCCGGCTTCCAATGAGACTCCTCCTGCTTCTA
GTGGGTCTCTCCACTTTGCTGAATCACTCCTACACACAAAACTGCAAGACACCGTGTCTCCCAA
ATGCCAAGTGTGAGGTGTTGGACGAAGTGGCAGCCTGCTTCTGCAGTACAGGCTACACTGGGAA
TGGCATCACGATTTGTGAAGATGTAGACGAGTGCAACGAGACCTCCGTCTGCGGTGATCACGCT
GTGTGTGAAAACACGAATGGAGGATTTAGCTGCTTCTGCGTGGAAGGTTATCAGACCTCCACCG
GGAAGACGCAGTTCACGCCTAATGATGGCTCTTACTGCCAAGATGTAGACGAGTGCAACGAGAC
CTCCGTCTGCGGTGATCACGCTGTGTGTGAAAACACGAACGGAGGATTTAGCTGCTTCTGCGTG
GAAGGTTATCAGACCTCCACCGGGAAGACGCAGTTCACGCCTAATGATGGCTCTTACTGCCAAG
AAATTGTGAATTCAAATTGCCACTTAGAGCATGACTGCATTGCTGCAAACATTAATAAAACTCT
AAAAAGAATTGGACCCATAACAGAACAGCTGACTTTACTCCATGAAATCTACAAGAATTCTGAG
GCTGAGCTTTCTCTGGTGGATATAGTCACATACATAGAGATACTAACAGAATCATCCTCACTAC
AAGGCTACATAAAGAACACCACTTCGCCCAAGGATGCCTACTTCGGTTCAGCTCTTACTGAATT
TGGAAAAACCGTCAATAATTTTGTTGAAAAGAACACACATGAAATGTGGGACCAGTTACCTACA
AATCGTAGAAGACTCCATCTCACAAAACTGATGCACGCTGCTGAGCACGTCACCTTACAGATCT
CTCAGAACATCCAGAAGAATACTCAGTTTGACATGAATTCTACCGACTTGGCTCTCAAGGTTTT
CGTTTTTGATTCAGTTCACATGAAGCATACTCATCCCCATATGAATGTGGACGGAGGCTATGTA
AAAATATCCCCGAGGAGAAAATCTGCATATGACCCAAATGGCAACGTCATTGTTGCATTCCTGT
GCTATAGGAGCATTGGCCCCTTGCTTTCCTCATCTGACGACTTCTTACTGGGCGCTCAGAGTGA
CAATTCCAAAGGAAAGGAGAAGGTCATTTCTTCAGTGATTTCTGCCTCAATTAGCTCAAACCCA
CCCACACTGTATGAACTTGAAAAAATTACATTTACACTGAGTCATGTAAAGCTCTCAGATAAGC
ACCAGACACAGTGCGCCTTTTGGAACTACTCAGTCGATGACATGAACAATGGCAGCTGGTCATC
TGAGGGCTGTGAGCTGACATACTCCAACGACACCCATACTTCCTGCCGATGTAGTCATCTGACA
CACTTTGCGATTTTGATGTCCCCCAGTACCTCCATTGAAGTTAAAGATTACAATATCCTGACGA
GGATCACTCAGCTGGGAATAATCATCTCCCTGATCTGCCTCGCCATATGCATTTTCACCTTCTG
GTTCTTCAGTGAGATTCAAAGCACCAGGACCACAATCCACAAGAATCTCTGCTGCAGCCTCTTT
CTTGCACAACTAGTTTTTCTTGTCGGCATCAACATAAACACAAACAAGCTGGTCTGCTCTATCA
TCGCTGGCCTGCTCCATTACTTCTTCTTAGCTGCCTTTGCCTGGATGTGCATTGAAGGCATCTA
CCTATACCTCATCGTTGTTGGGCTCATCTATAACAAGGGGTTTTTACACAAGAACTTCTATATC
TTTGGCTATCTTAGCCCGGCTGTAGTTGTTGGATTCTCGGCCTCTTTGGGATACAGATATTATG
GTACCACCAAAGTATGTTGGTTGAGCACTGAAAACAACTTTATCTGGAGCTTCATAGGGCCAGC
GTGTCTAATCATTCTTGTTAATCTCTTGGCTTTTGGAGTTATCATATACAAAGTGTTCCGCCAC
ACTGCTGGACTGAAGCCAGAAGTTAGTTGCTACGAGAACATAAGGTCTTGCGCCAGAGGAGCCC
TGGCCCTCCTCTTCCTTCTGGGTACCACCTGGACCTTTGGGGTTCTCCACGTAGTGCATGCATC
TGTTGTGACAGCCTACCTCTTCACAGTCAGCAACGCTTTCCAAGGGATGTTTATTTTCTTATTC
CTATGTGTTTTATCTAGAAAGATTCAAGAAGAATATTACAGATTGTTCAAAAATGTCCCCTGCT
GTTTTGAATGTTTAAGATAAACAACGAGAAGACACAATAATTATAGCTGAAATGAAATGGAAAT
TCCAAGATTTCGGATAGCCTGTGTGACAAAAATGAGCCTGCCTTCATTGTTAGTAATTAATTTC
AAATTCGCTTTTCTGTTCGCAGTATAAAAGATGTAGTTAATGTGAGATAAAATTATGGGCCAGA
GAGCTCCTGTGTGTTTTCCTACATGACATAGTTAGATATGTCAAAAATAGTACTGCAGATATTT
GGAAAGTAATTGGTTTCTCTGGAGTGATATCACTGTGCCCAAGGAAAGATTTCTTTCTAACACA
AGAAATAGATGAATGTCCTCAAGGAAGCGACTGGCTTGATATCTTTGTGACTCATGTTGCCTTT
CAAACGAGTCCCCTACCACCATAGTAATGAGTTCCTTTGCAGAAAGGAGAGTATAAGAAACTTG
GAGGGGCAGAATATGAAGCAATGGAGAAGCCTTCTCTGACAAGGAATTGTCATTCCAATAAAAT
TGGCTTTCTCCAAAATTGAAGAGGAAAAAATTTTCAGGCTAAAATAACGAAAAAGGAAATGCAT
CCTAGCACTTTGGGAATTGGTCTGAACTTAAAAGGCCCAGACCTAAATTTACTACATCCATGTT
CTTCCTTACTGTTCTAAACCAAAGAAAAACCTTAAAATTTACAGATACATGGATGAGTGTTCTC
ACATAACATCATATTTGAATGTAAATTTTTTTCATTCCTCACAGATTAAGACTTCAGCAACATA
TTTGGTAAAACATAAATTTGTCAAACTATAAGACTGTTCATATCTTTAGTGAAAAAATAGAATG
TGAAGTATTTTGTCTATAATATTTTACTGTTATGAAAATAATCTTTTCATATTAGAGCAGTATA
CTTGAATACTTTACTGTTTTTAATCTTACAAATAGTGTGATTCATGTTGCAACCAGCCCTTTTA
ATTGACTGTATTTAAAAGGGCATTATAAATTTAAACTATTGATGAAGTAAATTATAATGGTTTT
CTGATCAGAAAATACATACTTAAAGCATTATTTATAACAAATAAAAAGTCACTGAGCACTGCAG
GGGTTTCACAGTGGATCTGATATTTTTAGACCGTTTCCTATCACCTATCAGTCTATTTACTTAA
ATGTACAGCTCTACCAATTCTCTTACTCAAAGGAAGAGGCAGTATTTTTCTCAGAAGTGAGTCA
TTGTTCTGTACCTTCCTGGAGACATGATTCGATCCATTGAACATTGTGGTTTTAATTCTTGTGC
TGTTGAATGAAGCCTGACAAGACACCTCCTAAAAAATGAAATGTCAGCTGGATGAAGCAGCCCT
GCTACTGCCTGACTGAGTTGTTCTCTCAGGAAAGACCACTCACCTGCCAAGAAGCACGTTGCAT
CTCTACAGATCTCAGGGTTTCTCCCATGCCAAGTCTGTAGCCCACGAGCATCATTGTCATTCTA
AGATGGGACTGTAGAAATAGGATATCAAAACATAATCCGTTCAATCAATGGATAAGAAACTATC
ACATGTAGTAGACAGAATAACCCTTCTCAAATATTCATACACTCCTCTTCACAAGCTGTGGCCG
TGGTGGATAGTGAGGAGCAGGAGGTCCTGTCAGGAGGAAGAGTAGCTGAGGTCCACTCAGTTGG
AGAAGGCTCTCACTGTGCTGGGGGAAGTCAGCATGCTGACGATGTTACTTTAGTTTGGGTCTCT
TGTTTTGGACATCTCATTTCTAGAGCTGTAAAGACAATAAAATTCTATTATCAAAGCCAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039103036 ⟹ XP_038958964

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	243,014,927 - 243,117,226 (+)	NCBI
mRatBN7.2	2	240,354,912 - 240,457,231 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071630	(Get FASTA)	NCBI Sequence Viewer
	XP_038958964	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG33019	(Get FASTA)	NCBI Sequence Viewer
	AAG33020	(Get FASTA)	NCBI Sequence Viewer
	EDL82472	(Get FASTA)	NCBI Sequence Viewer
	EDL82473	(Get FASTA)	NCBI Sequence Viewer
	EDL82474	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000045890
	ENSRNOP00000045890.3
	ENSRNOP00000107605
GenBank Protein	Q9ESC1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071630 ⟸ NM_022294
- Peptide Label:	precursor
- UniProtKB:	Q9ESC0 (UniProtKB/Swiss-Prot), Q9ESC1 (UniProtKB/Swiss-Prot), A6HWI6 (UniProtKB/TrEMBL), A0A8L2R476 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLLLLLVGLSTLLNHSYTQNCKTPCLPNAKCEVLDEVAACFCSTGYTGNGITICEDVDECNET SVCGDHAVCENTNGGFSCFCVEGYQTSTGKTQFTPNDGSYCQDVDECNETSVCGDHAVCENTNG GFSCFCVEGYQTSTGKTQFTPNDGSYCQEIVNSNCHLEHDCIAANINKTLKRIGPITEQLTLLH EIYKNSEAELSLVDIVTYIEILTESSSLQGYIKNTTSPKDAYFGSALTEFGKTVNNFVEKNTHE MWDQLPTNRRRLHLTKLMHAAEHVTLQISQNIQKNTQFDMNSTDLALKVFVFDSVHMKHTHPHM NVDGGYVKISPRRKSAYDPNGNVIVAFLCYRSIGPLLSSSDDFLLGAQSDNSKGKEKVISSVIS ASISSNPPTLYELEKITFTLSHVKLSDKHQTQCAFWNYSVDDMNNGSWSSEGCELTYSNDTHTS CRCSHLTHFAILMSPSTSIEVKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHK NLCCSLFLAQLVFLVGININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIYLYLIVVGLIYNKGF LHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVI IYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWTFGVLHVVHASVVTAYLFTVSNAFQ GMFIFLFLCVLSRKIQEEYYRLFKNVPCCFECLR hide sequence

Ensembl Acc Id:

ENSRNOP00000045890 ⟸ ENSRNOT00000047564

Ensembl Acc Id:

ENSRNOP00000071560 ⟸ ENSRNOT00000088437

RefSeq Acc Id:	XP_038958964 ⟸ XM_039103036
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2R476 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000107605 ⟸ ENSRNOT00000155090

Ensembl Acc Id:

ENSRNOP00000102405 ⟸ ENSRNOT00000126308

Ensembl Acc Id:

ENSRNOP00000098828 ⟸ ENSRNOT00000130640

Ensembl Acc Id:

ENSRNOP00000099575 ⟸ ENSRNOT00000166088

Protein Domains

EGF-like G-protein coupled receptors family 2 profile GAIN-B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ESC1-F1-model_v2	AlphaFold	Q9ESC1	1-738	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691820

Promoter ID:

EPDNEW_R2344

Type:

initiation region

Name:

Adgrl4_1

Description:

adhesion G protein-coupled receptor L4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	256,609,964 - 256,610,024	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621136	AgrOrtholog
BioCyc Gene	G2FUF-50830	BioCyc
Ensembl Genes	ENSRNOG00000033940	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000047564	ENTREZGENE
	ENSRNOT00000047564.5	UniProtKB/Swiss-Prot
	ENSRNOT00000155090	ENTREZGENE
Gene3D-CATH	2.60.220.50	UniProtKB/Swiss-Prot
	Laminin	UniProtKB/Swiss-Prot
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
InterPro	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/Swiss-Prot
	EGF_Ca-bd_CS	UniProtKB/Swiss-Prot
	GAIN_B	UniProtKB/Swiss-Prot
	GAIN_dom_N	UniProtKB/Swiss-Prot
	GAIN_dom_sf	UniProtKB/Swiss-Prot
	GPCR_2-like	UniProtKB/Swiss-Prot
	GPCR_2_secretin-like	UniProtKB/Swiss-Prot
	GPCR_2_secretin-like_CS	UniProtKB/Swiss-Prot
	GPS	UniProtKB/Swiss-Prot
	NOTCH1_EGF-like	UniProtKB/Swiss-Prot
KEGG Report	rno:64124	UniProtKB/Swiss-Prot
NCBI Gene	64124	ENTREZGENE
PANTHER	ADHESION G PROTEIN-COUPLED RECEPTOR L4	UniProtKB/Swiss-Prot
	ADHESION G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot
Pfam	7tm_2	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	GAIN	UniProtKB/Swiss-Prot
	GPS	UniProtKB/Swiss-Prot
PhenoGen	Adgrl4	PhenoGen
PRINTS	GPCRSECRETIN	UniProtKB/Swiss-Prot
PROSITE	ASX_HYDROXYL	UniProtKB/Swiss-Prot
	EGF_2	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F2_2	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot
	GPS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000033940	RatGTEx
SMART	EGF	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	GPS	UniProtKB/Swiss-Prot
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot
UniProt	A0A8L2R476	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L588_RAT	UniProtKB/TrEMBL
	A0ABK0LCS2_RAT	UniProtKB/TrEMBL
	A6HWI6	ENTREZGENE, UniProtKB/TrEMBL
	AGRL4_RAT	UniProtKB/Swiss-Prot
	Q9ESC0	ENTREZGENE
	Q9ESC1	ENTREZGENE
UniProt Secondary	Q9ESC0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-03-16	Adgrl4	adhesion G protein-coupled receptor L4	Eltd1	EGF, latrophilin and seven transmembrane domain containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Eltd1	EGF, latrophilin and seven transmembrane domain containing 1		EGF, latrophilin seven transmembrane domain containing 1	Name updated	1299863	APPROVED
2004-12-14	Eltd1	EGF, latrophilin seven transmembrane domain containing 1	Etl	ETL protein	Symbol and Name updated	1299863	APPROVED
2002-08-07	Etl	ETL protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	associated with cell membranes; localized in cytoplasmic vesicles	632805
gene_domains	contains a large extracellular domain with epidermal growth factor (EGF)-like repeats and a seven-transmembrane domain	632805
gene_expression	expressed in cardiomyocytes, enriched in vascular and bronchiolar smooth muscle cells	632805
gene_product	member of the secretin family of G-protein-coupled peptide hormone receptors and the EGF-TM7 subfamily of receptors	632805
gene_protein	738 amino acids	632805

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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