Sardh (sarcosine dehydrogenase) - Rat Genome Database

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Gene: Sardh (sarcosine dehydrogenase) Rattus norvegicus
Analyze
Symbol: Sardh
Name: sarcosine dehydrogenase
RGD ID: 621125
Description: Enables flavin adenine dinucleotide binding activity; folic acid binding activity; and sarcosine dehydrogenase activity. Involved in choline catabolic process; glycine biosynthetic process; and tetrahydrofolate interconversion. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase); PARTICIPATES IN choline metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC366279; sarcosine dehydrogenase, mitochondrial; similar to sarcosine dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,908,621 - 30,973,409 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,908,621 - 30,972,137 (-)EnsemblGRCr8
mRatBN7.2310,510,553 - 10,575,342 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,510,553 - 10,573,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx313,577,541 - 13,639,718 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,162,940 - 22,225,121 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,418,235 - 20,480,397 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,737,203 - 5,802,153 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)Ensemblrn6Rnor6.0
Rnor_5.0311,100,670 - 11,164,367 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.436,076,166 - 6,142,565 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera35,308,395 - 5,369,033 (-)NCBICelera
RGSC_v3.136,076,465 - 6,142,865 (-)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dextran sulfate  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
glyphosate  (EXP)
GSK-J4  (ISO)
imidacloprid  (EXP)
indometacin  (EXP)
iodide salt  (EXP)
methapyrilene  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IBA,IDA,IEA)
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and tissue distribution of rat sarcosine dehydrogenase. Bergeron F, etal., Eur J Biochem 1998 Nov 1;257(3):556-61.
2. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver. Porter DH, etal., Arch Biochem Biophys. 1985 Dec;243(2):396-407. doi: 10.1016/0003-9861(85)90516-8.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
14. Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins. Wittwer AJ and Wagner C, J Biol Chem. 1981 Apr 25;256(8):4109-15.
Additional References at PubMed
PMID:4055729   PMID:14651853   PMID:18614015  


Genomics

Comparative Map Data
Sardh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,908,621 - 30,973,409 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,908,621 - 30,972,137 (-)EnsemblGRCr8
mRatBN7.2310,510,553 - 10,575,342 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,510,553 - 10,573,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx313,577,541 - 13,639,718 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,162,940 - 22,225,121 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,418,235 - 20,480,397 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,737,203 - 5,802,153 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)Ensemblrn6Rnor6.0
Rnor_5.0311,100,670 - 11,164,367 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.436,076,166 - 6,142,565 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera35,308,395 - 5,369,033 (-)NCBICelera
RGSC_v3.136,076,465 - 6,142,865 (-)NCBI
Cytogenetic Map3p12NCBI
SARDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,659,418 - 133,739,955 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,663,528 - 133,739,976 (-)Ensemblhg38GRCh38
GRCh379136,528,682 - 136,605,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,518,503 - 135,594,863 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349133,558,235 - 133,634,596NCBI
Celera9107,075,562 - 107,151,924 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9106,029,059 - 106,104,804 (-)NCBIHuRef
CHM1_19136,678,641 - 136,754,578 (-)NCBICHM1_1
T2T-CHM13v2.09145,875,436 - 145,955,389 (-)NCBIT2T-CHM13v2.0
Sardh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,078,405 - 27,138,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,078,405 - 27,138,349 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38227,188,393 - 27,248,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,188,393 - 27,248,337 (-)Ensemblmm10GRCm38
MGSCv37227,044,902 - 27,102,332 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36227,011,391 - 27,068,821 (-)NCBIMGSCv36mm8
Celera226,892,296 - 26,949,897 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.31NCBI
Sardh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,933,918 - 2,976,931 (-)Ensembl
ChiLan1.0NW_0049555132,933,918 - 2,975,645 (-)NCBIChiLan1.0ChiLan1.0
SARDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,613,842 - 5,696,750 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,616,176 - 5,696,436 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,786,774 - 104,864,480 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,398,806 - 133,473,642 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,398,806 - 133,473,642 (-)EnsemblpanPan2panpan1.1
SARDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,030,397 - 50,093,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,030,707 - 50,091,553 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha949,310,923 - 49,374,527 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0950,904,459 - 50,967,629 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,904,464 - 50,967,596 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,665,765 - 49,728,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0950,007,753 - 50,071,562 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,086,168 - 50,149,420 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sardh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,077,144 - 200,131,802 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,243,762 - 3,297,905 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,244,302 - 3,297,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SARDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,230,375 - 273,294,621 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11273,230,357 - 273,295,170 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,204,192 - 307,268,081 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SARDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,397,312 - 4,469,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,397,539 - 4,469,562 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666058519,221 - 596,979 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sardh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,032,326 - 2,066,584 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247602,030,835 - 2,070,517 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sardh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v159,411,910 - 9,474,359 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sardh
634 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:71
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000009555
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
D3Mgh17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,549,351 - 10,549,499 (+)MAPPERmRatBN7.2
Rnor_6.035,775,856 - 5,776,005NCBIRnor6.0
Rnor_5.0311,139,240 - 11,139,389UniSTSRnor5.0
Celera35,345,934 - 5,346,083UniSTS
RH 3.4 Map321.9RGD
RH 3.4 Map321.9UniSTS
Cytogenetic Map3p12UniSTS
RH129217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,510,597 - 10,510,789 (+)MAPPERmRatBN7.2
Rnor_6.035,737,248 - 5,737,439NCBIRnor6.0
Rnor_5.0311,100,716 - 11,100,907UniSTSRnor5.0
RGSC_v3.436,075,178 - 6,075,369UniSTSRGSC3.4
Celera35,307,407 - 5,307,598UniSTS
Cytogenetic Map3p12UniSTS
RH129462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,510,611 - 10,510,820 (+)MAPPERmRatBN7.2
Rnor_6.035,737,262 - 5,737,470NCBIRnor6.0
Rnor_5.0311,100,730 - 11,100,938UniSTSRnor5.0
RGSC_v3.436,075,192 - 6,075,400UniSTSRGSC3.4
Celera35,307,421 - 5,307,629UniSTS
Cytogenetic Map3p12UniSTS
BE097994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,541,407 - 10,541,561 (+)MAPPERmRatBN7.2
Rnor_6.035,768,098 - 5,768,252NCBIRnor6.0
Rnor_5.0311,131,482 - 11,131,636UniSTSRnor5.0
RGSC_v3.436,105,948 - 6,106,102UniSTSRGSC3.4
Celera35,337,989 - 5,338,143UniSTS
RH 3.4 Map314.0UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 76 59 6 340 176 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009555   ⟹   ENSRNOP00000009555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,908,621 - 30,972,137 (-)Ensembl
mRatBN7.2 Ensembl310,510,553 - 10,573,874 (-)Ensembl
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)Ensembl
RefSeq Acc Id: NM_001423000   ⟹   NP_001409929
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,972,137 (-)NCBI
RefSeq Acc Id: NM_053664   ⟹   NP_446116
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,971,657 (-)NCBI
mRatBN7.2310,511,586 - 10,573,573 (-)NCBI
Rnor_6.035,738,236 - 5,800,388 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
RGSC_v3.436,076,166 - 6,142,565 (-)RGD
Celera35,308,395 - 5,369,033 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233731   ⟹   XP_006233793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,972,216 (-)NCBI
mRatBN7.2310,510,553 - 10,574,149 (-)NCBI
Rnor_6.035,737,203 - 5,800,956 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233733   ⟹   XP_006233795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,973,409 (-)NCBI
mRatBN7.2310,510,553 - 10,575,342 (-)NCBI
Rnor_6.035,737,203 - 5,802,153 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104090   ⟹   XP_038960018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,943,117 - 30,972,171 (-)NCBI
mRatBN7.2310,545,045 - 10,574,095 (-)NCBI
RefSeq Acc Id: XM_063282992   ⟹   XP_063139062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,943,117 - 30,972,217 (-)NCBI
RefSeq Acc Id: XM_063282993   ⟹   XP_063139063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,947,283 - 30,972,161 (-)NCBI
RefSeq Acc Id: NP_446116   ⟸   NM_053664
- UniProtKB: Q64380 (UniProtKB/Swiss-Prot),   O88499 (UniProtKB/Swiss-Prot),   A6JTK8 (UniProtKB/TrEMBL),   F1LRY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233795   ⟸   XM_006233733
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006233793   ⟸   XM_006233731
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000009555   ⟸   ENSRNOT00000009555
RefSeq Acc Id: XP_038960018   ⟸   XM_039104090
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001409929   ⟸   NM_001423000
- UniProtKB: Q64380 (UniProtKB/Swiss-Prot),   O88499 (UniProtKB/Swiss-Prot),   A6JTK8 (UniProtKB/TrEMBL),   F1LRY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139062   ⟸   XM_063282992
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139063   ⟸   XM_063282993
- Peptide Label: isoform X3
Protein Domains
Aminomethyltransferase C-terminal   Aminomethyltransferase folate-binding   FAD dependent oxidoreductase   FAD dependent oxidoreductase central

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64380-F1-model_v2 AlphaFold Q64380 1-919 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691924
Promoter ID:EPDNEW_R2448
Type:single initiation site
Name:Sardh_1
Description:sarcosine dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,802,123 - 5,802,183EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621125 AgrOrtholog
BioCyc Gene G2FUF-50304 BioCyc
BioCyc Pathway PWY-3661-1 [glycine betaine degradation II (mammalian)] BioCyc
BioCyc Pathway Image PWY-3661-1 BioCyc
Ensembl Genes ENSRNOG00000006916 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000009555 ENTREZGENE
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
  Aminomethyltransferase beta-barrel domains UniProtKB/Swiss-Prot
  Aminomethyltransferase beta-barrel domains UniProtKB/Swiss-Prot
  D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/Swiss-Prot
  Probable tRNA modification gtpase trme, domain 1 UniProtKB/Swiss-Prot
InterPro FAD-dep_OxRdtase UniProtKB/Swiss-Prot
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  FAO_M UniProtKB/Swiss-Prot
  GCST/YgfZ/DmdA UniProtKB/Swiss-Prot
  GCV_T_C UniProtKB/Swiss-Prot
  GCV_T_N UniProtKB/Swiss-Prot
  GcvT/YgfZ_C UniProtKB/Swiss-Prot
  TrmE/GcvT_dom1 UniProtKB/Swiss-Prot
KEGG Report rno:114123 UniProtKB/Swiss-Prot
NCBI Gene 114123 ENTREZGENE
PANTHER AMINOMETHYLTRANSFERASE UniProtKB/Swiss-Prot
  SARCOSINE DEHYDROGENASE UniProtKB/Swiss-Prot
Pfam DAO UniProtKB/Swiss-Prot
  FAO_M UniProtKB/Swiss-Prot
  GCV_T UniProtKB/Swiss-Prot
  GCV_T_C UniProtKB/Swiss-Prot
PhenoGen Sardh PhenoGen
RatGTEx ENSRNOG00000006916 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot
  Folate-binding domain UniProtKB/Swiss-Prot
  SSF101790 UniProtKB/Swiss-Prot
  SSF51905 UniProtKB/Swiss-Prot
UniProt A6JTK8 ENTREZGENE, UniProtKB/TrEMBL
  F1LRY5 ENTREZGENE, UniProtKB/TrEMBL
  O88499 ENTREZGENE
  Q64380 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88499 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Sardh  sarcosine dehydrogenase  LOC366279  similar to sarcosine dehydrogenase  Data merged from RGD:1587293 737654 PROVISIONAL
2006-11-19 LOC366279  similar to sarcosine dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Sardh  sarcosine dehydrogenase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Sardh  sarcosine dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the mitochondrial matrix 634034
gene_expression expressed in liver,lung, pancreas, kidney, thymus, and oviduct 634034