Nlgn1 (neuroligin 1) - Rat Genome Database

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Gene: Nlgn1 (neuroligin 1) Rattus norvegicus
Analyze
Symbol: Nlgn1
Name: neuroligin 1
RGD ID: 621117
Description: Enables several functions, including cell adhesion mediator activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of cellular component organization; and synapse organization. Acts upstream of or within synapse organization. Located in several cellular components, including cell surface; dendrite; and filopodium tip. Part of protein complex involved in cell-cell adhesion. Is active in glutamatergic synapse and postsynaptic specialization membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN1 (neuroligin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; androgen antagonist; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuroligin I; neuroligin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82110,184,987 - 111,110,316 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2110,186,573 - 110,909,984 (-)EnsemblGRCr8
mRatBN7.22108,256,236 - 109,181,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2108,257,824 - 109,002,464 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2114,911,902 - 115,636,061 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02113,024,456 - 113,748,622 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02107,789,905 - 108,510,927 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02111,057,291 - 111,973,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2111,057,291 - 111,793,326 (-)Ensemblrn6Rnor6.0
Rnor_5.02130,770,580 - 131,688,440 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42111,189,470 - 111,948,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2103,515,760 - 104,229,754 (-)NCBICelera
RGSC_v3.12111,133,661 - 111,893,471 (-)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AMPA glutamate receptor clustering  (IMP,ISO,ISS)
AMPA selective glutamate receptor signaling pathway  (IDA)
calcium-dependent cell-cell adhesion  (IDA,ISO,NAS)
cell adhesion  (IEA)
cell-cell adhesion involved in synapse maturation  (NAS)
cellular response to calcium ion  (IDA)
cytoskeletal matrix organization at active zone  (IMP,ISO)
establishment of protein localization  (ISO,ISS)
excitatory synapse assembly  (ISO)
heterophilic cell-cell adhesion  (ISO,ISS)
inhibitory postsynaptic potential  (IDA,ISO)
long-term synaptic potentiation  (IMP)
maintenance of synapse structure  (NAS)
membrane assembly  (IEA)
modulation of chemical synaptic transmission  (IMP,ISO)
negative regulation of dendritic spine morphogenesis  (ISO,ISS)
nervous system development  (ISO,ISS)
neurexin clustering involved in presynaptic membrane assembly  (ISO,ISS)
neuron cell-cell adhesion  (IDA,IEA,ISO,NAS)
neuron projection arborization  (IGI)
neuron projection development  (IGI,ISO)
neuron projection morphogenesis  (NAS)
neuronal ion channel clustering  (TAS)
NMDA glutamate receptor clustering  (IDA,ISO)
NMDA selective glutamate receptor signaling pathway  (IDA,IMP,ISO)
positive regulation of circadian sleep/wake cycle, wakefulness  (ISO,ISS)
positive regulation of dendritic spine development  (IDA,IEA,IMP,ISO)
positive regulation of excitatory postsynaptic potential  (IDA,IMP,ISO)
positive regulation of filopodium assembly  (IDA)
positive regulation of intracellular signal transduction  (IDA)
positive regulation of multicellular organismal process  (IEA)
positive regulation of neuromuscular synaptic transmission  (NAS)
positive regulation of neuron projection development  (NAS)
positive regulation of presynaptic active zone assembly  (IDA)
positive regulation of protein localization to synapse  (IEA,IMP)
positive regulation of ruffle assembly  (IDA)
positive regulation of synapse assembly  (IDA,IEA,ISO)
positive regulation of synaptic transmission, GABAergic  (IDA,NAS)
positive regulation of synaptic transmission, glutamatergic  (IDA,IMP,NAS)
positive regulation of synaptic vesicle clustering  (ISO)
positive regulation of synaptic vesicle endocytosis  (IMP,ISO)
positive regulation of synaptic vesicle exocytosis  (IMP,ISO)
postsynaptic density protein 95 clustering  (IDA,IMP,ISO,ISS)
postsynaptic membrane assembly  (ISO,ISS)
postsynaptic specialization assembly  (ISO)
presynaptic membrane assembly  (IDA,IEA,ISO)
protein localization to synapse  (ISO,ISS)
protein targeting  (IDA)
receptor localization to synapse  (ISO,ISS)
regulation of membrane potential  (IEA)
regulation of nervous system process  (IEA)
regulation of neuron differentiation  (ISO,ISS)
regulation of NMDA receptor activity  (IMP)
regulation of postsynaptic density assembly  (ISO)
regulation of presynapse organization  (EXP,IDA,IMP)
regulation of respiratory gaseous exchange by nervous system process  (ISO)
regulation of signal transduction  (IEA)
rhythmic process  (IEA)
synapse assembly  (IDA,IEA,IMP,ISO,ISS,NAS)
synapse maturation  (NAS)
synapse organization  (IDA,ISO)
synaptic membrane adhesion  (ISO)
synaptic vesicle clustering  (IDA,IMP,ISO,ISS)
synaptic vesicle targeting  (ISO,ISS)
synaptic vesicle transport  (IMP)
terminal button organization  (IMP,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Arac D, etal., Neuron. 2007 Dec 20;56(6):992-1003.
2. Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Barrow SL, etal., Neural Dev. 2009 May 18;4:17. doi: 10.1186/1749-8104-4-17.
3. Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms. Benner O, etal., J Biol Chem. 2023 Dec;299(12):105361. doi: 10.1016/j.jbc.2023.105361. Epub 2023 Oct 20.
4. A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Boucard AA, etal., Neuron. 2005 Oct 20;48(2):229-36. doi: 10.1016/j.neuron.2005.08.026.
5. Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. Chen X, etal., Nat Struct Mol Biol. 2008 Jan;15(1):50-6. Epub 2007 Dec 16.
6. Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex. Chih B, etal., Neuron. 2006 Jul 20;51(2):171-8. doi: 10.1016/j.neuron.2006.06.005.
7. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
8. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. Chubykin AA, etal., J Biol Chem. 2005 Jun 10;280(23):22365-74. Epub 2005 Mar 29.
9. Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Chubykin AA, etal., Neuron. 2007 Jun 21;54(6):919-31.
10. Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb. Clarris HJ, etal., Int J Dev Biol 2002;46(4):649-52.
11. Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. Comoletti D, etal., J Biol Chem. 2003 Dec 12;278(50):50497-505. Epub 2003 Sep 30.
12. Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity. Constance WD, etal., Elife. 2018 Mar 5;7. pii: 31659. doi: 10.7554/eLife.31659.
13. Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding. Dresbach T, etal., Mol Cell Neurosci. 2004 Nov;27(3):227-35.
14. Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability. Fang M, etal., Mol Neurobiol. 2016 Jan;53(1):270-84. doi: 10.1007/s12035-014-8999-8. Epub 2014 Nov 27.
15. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
16. Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Futai K, etal., Nat Neurosci. 2007 Feb;10(2):186-95. Epub 2007 Jan 21.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1ß and activation of fibroblast growth factor receptor-1. Gjørlund MD, etal., FASEB J. 2012 Oct;26(10):4174-86. doi: 10.1096/fj.11-202242. Epub 2012 Jun 29.
19. Neuroligin 1: a splice site-specific ligand for beta-neurexins. Ichtchenko K, etal., Cell 1995 May 5;81(3):435-43.
20. Structures, alternative splicing, and neurexin binding of multiple neuroligins. Ichtchenko K, etal., J Biol Chem 1996 Feb 2;271(5):2676-82.
21. Binding of neuroligins to PSD-95. Irie M, etal., Science. 1997 Sep 5;277(5331):1511-5.
22. Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult. Jackson J, etal., PLoS One. 2012;7(4):e35557. doi: 10.1371/journal.pone.0035557. Epub 2012 Apr 23.
23. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
24. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. Leone P, etal., EMBO J. 2010 Jul 21;29(14):2461-71. doi: 10.1038/emboj.2010.123. Epub 2010 Jun 11.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds. Mondin M, etal., J Neurosci. 2011 Sep 21;31(38):13500-15. doi: 10.1523/JNEUROSCI.6439-10.2011.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. Nguyen T and Sudhof TC, J Biol Chem. 1997 Oct 10;272(41):26032-9.
29. Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. Paskus JD, etal., Cell Rep. 2019 Dec 3;29(10):2944-2952.e5. doi: 10.1016/j.celrep.2019.10.115.
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Scheiffele P, etal., Cell. 2000 Jun 9;101(6):657-69.
33. A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP. Shipman SL and Nicoll RA, Neuron. 2012 Oct 18;76(2):309-16. doi: 10.1016/j.neuron.2012.07.024. Epub 2012 Oct 17.
34. Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Song JY, etal., Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1100-5.
35. Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation. Stan A, etal., Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11116-21. doi: 10.1073/pnas.0914233107. Epub 2010 Jun 1.
36. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function. Suckow AT, etal., J Biol Chem. 2012 Jun 8;287(24):19816-26. doi: 10.1074/jbc.M111.280537. Epub 2012 Apr 23.
37. Abundance and Significance of Neuroligin-1 and Neurexin II in the Enteric Nervous System of Embryonic Rats. Wang D, etal., Biomed Res Int. 2017;2017:1209360. doi: 10.1155/2017/1209360. Epub 2017 Jan 18.
38. Postsynaptic Neuroligin1 regulates presynaptic maturation. Wittenmayer N, etal., Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13564-9. doi: 10.1073/pnas.0905819106. Epub 2009 Jul 23.
Additional References at PubMed
PMID:9694864   PMID:11329178   PMID:12202822   PMID:12796785   PMID:14769026   PMID:15458844   PMID:15620359   PMID:16298368   PMID:16982420   PMID:17474715   PMID:18334216   PMID:18579781  
PMID:18755801   PMID:19098102   PMID:19105974   PMID:20176955   PMID:20573900   PMID:20739565   PMID:20869594   PMID:21056983   PMID:21356198   PMID:21532576   PMID:21788371   PMID:21911064  
PMID:22671294   PMID:22840401   PMID:22960622   PMID:23143522   PMID:23269831   PMID:23426688   PMID:23716671   PMID:23791195   PMID:24613359   PMID:24860089   PMID:25157101   PMID:26325471  
PMID:26440732   PMID:26771491   PMID:27423632   PMID:28875935   PMID:29592780   PMID:30049666   PMID:30790215   PMID:32915137   PMID:34353896  


Genomics

Comparative Map Data
Nlgn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82110,184,987 - 111,110,316 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2110,186,573 - 110,909,984 (-)EnsemblGRCr8
mRatBN7.22108,256,236 - 109,181,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2108,257,824 - 109,002,464 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2114,911,902 - 115,636,061 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02113,024,456 - 113,748,622 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02107,789,905 - 108,510,927 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02111,057,291 - 111,973,681 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2111,057,291 - 111,793,326 (-)Ensemblrn6Rnor6.0
Rnor_5.02130,770,580 - 131,688,440 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42111,189,470 - 111,948,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2103,515,760 - 104,229,754 (-)NCBICelera
RGSC_v3.12111,133,661 - 111,893,471 (-)NCBI
Cytogenetic Map2q24NCBI
NLGN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383173,395,952 - 174,294,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3173,396,284 - 174,294,372 (+)Ensemblhg38GRCh38
GRCh373173,113,742 - 174,012,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363174,598,938 - 175,483,810 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343174,598,945 - 175,483,818NCBI
Celera3171,515,223 - 172,400,529 (+)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3170,489,300 - 171,374,847 (+)NCBIHuRef
CHM1_13173,079,120 - 173,964,074 (+)NCBICHM1_1
T2T-CHM13v2.03176,181,719 - 177,081,314 (+)NCBIT2T-CHM13v2.0
Nlgn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39325,475,972 - 26,387,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl325,480,379 - 26,386,609 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38325,421,808 - 26,332,866 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl325,426,215 - 26,332,460 (-)Ensemblmm10GRCm38
MGSCv37325,330,763 - 26,230,831 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36325,622,914 - 26,522,982 (-)NCBIMGSCv36mm8
Celera325,414,194 - 26,317,921 (-)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.38NCBI
Nlgn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554203,549,021 - 4,167,493 (+)Ensembl
ChiLan1.0NW_0049554203,360,745 - 4,171,587 (+)NCBIChiLan1.0ChiLan1.0
NLGN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22171,247,516 - 172,162,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13171,252,234 - 172,164,121 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03170,416,885 - 171,333,094 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13178,595,014 - 179,505,810 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3178,810,253 - 179,503,756 (+)EnsemblpanPan2panpan1.1
NLGN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13437,397,772 - 38,203,634 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3437,572,629 - 38,203,177 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3446,409,660 - 47,225,945 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03437,484,369 - 38,313,800 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3437,659,077 - 38,308,775 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13437,576,956 - 38,230,342 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03437,390,518 - 38,201,245 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03437,647,698 - 38,463,980 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nlgn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602104,390,734 - 105,051,988 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936703758,647 - 1,414,185 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936703951,935 - 1,415,991 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLGN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13112,035,854 - 112,725,618 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113111,851,007 - 112,727,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213120,802,484 - 121,025,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLGN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11515,129,976 - 16,017,107 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606323,867,631 - 24,767,924 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlgn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473051,650,815 - 52,295,023 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473051,451,546 - 52,300,413 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nlgn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13128,120,382 - 128,979,051 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nlgn1
7120 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:16
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000041111, ENSRNOT00000043276
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat

Markers in Region
D2Rat335  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82110,931,411 - 110,931,650 (+)Marker Load Pipeline
mRatBN7.22109,002,666 - 109,002,905 (+)MAPPERmRatBN7.2
Rnor_6.02111,793,698 - 111,793,936NCBIRnor6.0
Rnor_5.02131,507,359 - 131,507,597UniSTSRnor5.0
RGSC_v3.42111,948,881 - 111,949,119UniSTSRGSC3.4
RGSC_v3.42111,948,880 - 111,949,118RGDRGSC3.4
Celera2104,230,490 - 104,230,717UniSTS
RGSC_v3.12111,893,842 - 111,894,080RGD
SHRSP x BN Map238.8198RGD
SHRSP x BN Map238.8198UniSTS
Cytogenetic Map2q24UniSTS
BF394648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22108,497,744 - 108,497,968 (+)MAPPERmRatBN7.2
Rnor_6.02111,293,266 - 111,293,489NCBIRnor6.0
Rnor_5.02131,006,639 - 131,006,862UniSTSRnor5.0
RGSC_v3.42111,433,889 - 111,434,112UniSTSRGSC3.4
Celera2103,744,650 - 103,744,873UniSTS
RH 3.4 Map2725.8UniSTS
Cytogenetic Map2q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 4 28 149 54 51 22 21 22 6 164 76 8 129 51 88 29 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041111   ⟹   ENSRNOP00000040172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2108,257,824 - 108,981,046 (-)Ensembl
Rnor_6.0 Ensembl2111,059,105 - 111,065,413 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092660   ⟹   ENSRNOP00000075793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2110,186,573 - 110,909,984 (-)Ensembl
mRatBN7.2 Ensembl2108,257,824 - 109,002,464 (-)Ensembl
Rnor_6.0 Ensembl2111,057,291 - 111,793,326 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107850   ⟹   ENSRNOP00000094652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2110,186,573 - 110,909,984 (-)Ensembl
mRatBN7.2 Ensembl2108,257,824 - 109,002,464 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142652   ⟹   ENSRNOP00000099159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2110,186,573 - 110,909,984 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150531   ⟹   ENSRNOP00000103300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2110,186,573 - 110,909,984 (-)Ensembl
RefSeq Acc Id: NM_053868   ⟹   NP_446320
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,186,573 - 110,930,676 (-)NCBI
mRatBN7.22108,257,824 - 109,001,931 (-)NCBI
Rnor_6.02111,058,792 - 111,792,962 (-)NCBI
Rnor_5.02130,770,580 - 131,688,440 (-)NCBI
RGSC_v3.42111,189,470 - 111,948,145 (-)RGD
Celera2103,515,760 - 104,229,754 (-)RGD
Sequence:
RefSeq Acc Id: XM_017590583   ⟹   XP_017446072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,931,262 (-)NCBI
mRatBN7.22108,256,236 - 109,002,510 (-)NCBI
Rnor_6.02111,057,291 - 111,793,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590590   ⟹   XP_017446079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,931,262 (-)NCBI
mRatBN7.22108,256,236 - 109,002,512 (-)NCBI
Rnor_6.02111,057,291 - 111,793,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101567   ⟹   XP_038957495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,931,262 (-)NCBI
mRatBN7.22108,256,236 - 109,002,513 (-)NCBI
RefSeq Acc Id: XM_039101568   ⟹   XP_038957496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,108,134 (-)NCBI
mRatBN7.22108,256,236 - 109,180,818 (-)NCBI
RefSeq Acc Id: XM_039101569   ⟹   XP_038957497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,110,316 (-)NCBI
mRatBN7.22108,256,236 - 109,181,530 (-)NCBI
RefSeq Acc Id: XM_039101570   ⟹   XP_038957498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,108,134 (-)NCBI
mRatBN7.22108,256,236 - 109,180,818 (-)NCBI
RefSeq Acc Id: XM_039101571   ⟹   XP_038957499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,108,134 (-)NCBI
mRatBN7.22108,256,236 - 109,180,818 (-)NCBI
RefSeq Acc Id: XM_039101572   ⟹   XP_038957500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,110,316 (-)NCBI
mRatBN7.22108,256,236 - 109,181,530 (-)NCBI
RefSeq Acc Id: XM_039101573   ⟹   XP_038957501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,110,316 (-)NCBI
mRatBN7.22108,256,236 - 109,181,530 (-)NCBI
RefSeq Acc Id: XM_039101574   ⟹   XP_038957502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,931,262 (-)NCBI
mRatBN7.22108,256,236 - 109,002,513 (-)NCBI
RefSeq Acc Id: XM_039101575   ⟹   XP_038957503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,911,326 (-)NCBI
mRatBN7.22108,256,236 - 108,982,692 (-)NCBI
RefSeq Acc Id: XM_039101576   ⟹   XP_038957504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,931,262 (-)NCBI
mRatBN7.22108,256,236 - 109,002,517 (-)NCBI
RefSeq Acc Id: XM_039101577   ⟹   XP_038957505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,931,262 (-)NCBI
mRatBN7.22108,256,236 - 109,002,512 (-)NCBI
RefSeq Acc Id: XM_063281157   ⟹   XP_063137227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,108,134 (-)NCBI
RefSeq Acc Id: XM_063281158   ⟹   XP_063137228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,110,316 (-)NCBI
RefSeq Acc Id: XM_063281159   ⟹   XP_063137229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,110,316 (-)NCBI
RefSeq Acc Id: XM_063281160   ⟹   XP_063137230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,108,134 (-)NCBI
RefSeq Acc Id: XM_063281161   ⟹   XP_063137231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,108,134 (-)NCBI
RefSeq Acc Id: XM_063281162   ⟹   XP_063137232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,110,316 (-)NCBI
RefSeq Acc Id: XM_063281163   ⟹   XP_063137233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,108,134 (-)NCBI
RefSeq Acc Id: XM_063281164   ⟹   XP_063137234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 111,110,316 (-)NCBI
RefSeq Acc Id: XM_063281165   ⟹   XP_063137235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82110,184,987 - 110,931,262 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446320 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446072 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446079 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957495 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957496 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957497 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957498 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957499 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957500 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957501 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957502 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957503 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957504 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957505 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137227 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137228 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137229 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137230 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137231 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137232 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137233 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137234 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137235 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA85720 (Get FASTA)   NCBI Sequence Viewer  
  EDM01096 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040172.3
  ENSRNOP00000075793
  ENSRNOP00000075793.2
  ENSRNOP00000094652
  ENSRNOP00000099159
  ENSRNOP00000103300
GenBank Protein Q62765 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446320   ⟸   NM_053868
- Peptide Label: precursor
- UniProtKB: Q62765 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446079   ⟸   XM_017590590
- Peptide Label: isoform X7
- UniProtKB: Q62765 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017446072   ⟸   XM_017590583
- Peptide Label: isoform X6
- UniProtKB: Q62765 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040172   ⟸   ENSRNOT00000041111
Ensembl Acc Id: ENSRNOP00000075793   ⟸   ENSRNOT00000092660
RefSeq Acc Id: XP_038957500   ⟸   XM_039101572
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957501   ⟸   XM_039101573
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957497   ⟸   XM_039101569
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957498   ⟸   XM_039101570
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957499   ⟸   XM_039101571
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957496   ⟸   XM_039101568
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957504   ⟸   XM_039101576
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957502   ⟸   XM_039101574
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957495   ⟸   XM_039101567
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957505   ⟸   XM_039101577
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957503   ⟸   XM_039101575
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000094652   ⟸   ENSRNOT00000107850
RefSeq Acc Id: XP_063137234   ⟸   XM_063281164
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137232   ⟸   XM_063281162
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137228   ⟸   XM_063281158
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137229   ⟸   XM_063281159
- Peptide Label: isoform X4
- UniProtKB: Q62765 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137233   ⟸   XM_063281163
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137231   ⟸   XM_063281161
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137230   ⟸   XM_063281160
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063137227   ⟸   XM_063281157
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GKV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137235   ⟸   XM_063281165
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000103300   ⟸   ENSRNOT00000150531
Ensembl Acc Id: ENSRNOP00000099159   ⟸   ENSRNOT00000142652
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62765-F1-model_v2 AlphaFold Q62765 1-843 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621117 AgrOrtholog
BioCyc Gene G2FUF-53532 BioCyc
Ensembl Genes ENSRNOG00000032576 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041111.3 UniProtKB/Swiss-Prot
  ENSRNOT00000092660 ENTREZGENE
  ENSRNOT00000092660.2 UniProtKB/Swiss-Prot
  ENSRNOT00000107850 ENTREZGENE
  ENSRNOT00000142652 ENTREZGENE
  ENSRNOT00000150531 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Neuroligin/BSAL UniProtKB/Swiss-Prot
  Nlgn UniProtKB/Swiss-Prot
KEGG Report rno:116647 UniProtKB/Swiss-Prot
NCBI Gene 116647 ENTREZGENE
PANTHER NEUROLIGIN UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Nlgn1 PhenoGen
PRINTS NEUROLIGIN UniProtKB/Swiss-Prot
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032576 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A8I6GKV2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LD52_RAT UniProtKB/TrEMBL
  A6IHE8_RAT UniProtKB/TrEMBL
  NLGN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Nlgn1  neuroligin 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Nlgn1  neuroligin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed by second order mitral cells during early postnatal development in the olfactory bulb 727397