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Gene: Olah (oleoyl-ACP hydrolase) Rattus norvegicus

Analyze

Symbol:

Olah

Name:

oleoyl-ACP hydrolase

RGD ID:

621115

Description:

Enables fatty acyl-[ACP] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Located in cytosol. Orthologous to human OLAH (oleoyl-ACP hydrolase); PARTICIPATES IN fatty acid biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 3,7-dihydropurine-6-thione; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Mch; medium-chain S-acyl fatty acid synthetase thio ester hydrolase (MCH); medium-chain S-acyl fatty acid synthetase thioester hydrolase; S-acyl fatty acid synthase thioesterase, medium chain; Thedc1; thioesterase domain containing 1; thioesterase domain-containing protein 1; thioesterase II

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OLAH (oleoyl-ACP hydrolase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Olah (oleoyl-ACP hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Olah (oleoyl-ACP hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OLAH (oleoyl-ACP hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Olah (oleoyl-ACP hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OLAH (oleoyl-ACP hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OLAH (oleoyl-ACP hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Olah (oleoyl-ACP hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Olah (oleoyl-ACP hydrolase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	OLAH (oleoyl-ACP hydrolase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	olah (oleoyl-ACP hydrolase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	olah	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	79,786,441 - 79,811,692 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	79,786,832 - 79,811,688 (+)	Ensembl				GRCr8
mRatBN7.2	17	74,877,651 - 74,902,517 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	74,877,655 - 74,902,518 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	78,344,154 - 78,369,062 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	82,179,537 - 82,204,441 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	76,227,488 - 76,252,386 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	78,878,673 - 78,903,919 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	78,879,058 - 78,903,967 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	80,520,857 - 80,545,540 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	85,996,338 - 86,021,192 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	74,257,064 - 74,281,908 (+)	NCBI		Celera
RGSC_v3.1	17	86,007,173 - 86,032,019 (+)	NCBI
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,7-dihydropurine-6-thione (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

dexamethasone (EXP)

ethyl methanesulfonate (ISO)

genistein (ISO)

hydroquinone (ISO)

isotretinoin (ISO)

mercaptopurine (EXP)

methyl methanesulfonate (ISO)

mifepristone (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

nitrofen (EXP)

okadaic acid (ISO)

paracetamol (EXP)

progesterone (ISO)

purine-6-thiol (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

testosterone (ISO)

trichloroethene (EXP)

valproic acid (ISO)

vincristine (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid biosynthetic process (IEA)

fatty acid metabolic process (IEA)

lipid biosynthetic process (IBA)

lipid metabolic process (IEA)

medium-chain fatty acid biosynthetic process (IDA,IEA,ISO)

Cellular Component

cytosol (IDA,IEA,TAS)

Molecular Function

fatty acyl-[ACP] hydrolase activity (EXP,IDA,IEA,ISO,ISS)

hydrolase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

fatty acid biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Purification and properties of a thioesterase from lactating rat mammary gland which modifies the product specificity of fatty acid synthetase.	Libertini LJ and Smith S, J Biol Chem. 1978 Mar 10;253(5):1393-401.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Cloning and sequencing of the medium-chain S-acyl fatty acid synthetase thioester hydrolase cDNA from rat mammary gland.	Naggert J, etal., Biochem J 1987 Apr 15;243(2):597-601.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Molecular cloning and sequence analysis of complementary DNA encoding rat mammary gland medium-chain S-acyl fatty acid synthetase thio ester hydrolase.	Safford R, etal., Biochemistry 1987 Mar 10;26(5):1358-64.
10.	Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase.	Tai MH, etal., Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1852-6.

Additional References at PubMed

PMID:3104035	PMID:3567174	PMID:15905320	PMID:26663084

Genomics

Comparative Map Data

Olah
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	79,786,441 - 79,811,692 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	79,786,832 - 79,811,688 (+)	Ensembl				GRCr8
mRatBN7.2	17	74,877,651 - 74,902,517 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	74,877,655 - 74,902,518 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	78,344,154 - 78,369,062 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	82,179,537 - 82,204,441 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	76,227,488 - 76,252,386 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	78,878,673 - 78,903,919 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	78,879,058 - 78,903,967 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	80,520,857 - 80,545,540 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	85,996,338 - 86,021,192 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	74,257,064 - 74,281,908 (+)	NCBI		Celera
RGSC_v3.1	17	86,007,173 - 86,032,019 (+)	NCBI
Cytogenetic Map	17	q12.3	NCBI

OLAH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	15,032,195 - 15,073,853 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	15,032,227 - 15,073,853 (+)	Ensembl			hg38	GRCh38
GRCh37	10	15,085,942 - 15,115,852 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	15,125,951 - 15,155,857 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	15,125,967 - 15,155,857	NCBI
Celera	10	15,014,547 - 15,044,484 (+)	NCBI		Celera
Cytogenetic Map	10	p13	NCBI
HuRef	10	14,996,532 - 15,026,428 (+)	NCBI		HuRef
CHM1_1	10	15,086,018 - 15,115,972 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	15,046,189 - 15,087,828 (+)	NCBI		T2T-CHM13v2.0

Olah
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	3,343,019 - 3,367,964 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	3,343,019 - 3,398,247 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	3,341,987 - 3,366,569 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	3,341,982 - 3,397,210 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	3,259,259 - 3,283,841 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	3,259,259 - 3,283,841 (-)	NCBI		MGSCv36	mm8
Celera	2	3,293,581 - 3,318,824 (-)	NCBI		Celera
Cytogenetic Map	2	A1	NCBI
cM Map	2	1.88	NCBI

Olah
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	19,376,190 - 19,394,119 (-)	Ensembl
ChiLan1.0	NW_004955429	19,375,366 - 19,394,068 (-)	NCBI	ChiLan1.0	ChiLan1.0

OLAH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	27,871,899 - 27,913,162 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	27,863,914 - 27,918,488 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	15,356,380 - 15,386,599 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	15,642,307 - 15,667,461 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	15,642,307 - 15,667,461 (+)	Ensembl			panPan2	panpan1.1

Olah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	6,954,560 - 7,020,324 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936613	1,541,001 - 1,571,117 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936613	1,541,001 - 1,570,882 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OLAH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	46,752,243 - 46,771,986 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	46,752,241 - 46,770,881 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	51,485,496 - 51,511,675 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OLAH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	15,028,667 - 15,048,611 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	15,032,574 - 15,048,568 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666051	20,576,767 - 20,590,550 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Olah
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624805	476,612 - 495,158 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624805	476,106 - 494,612 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Olah
361 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	154
Count of miRNA genes:	119
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000022043
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	70613502	86062352	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63697147	82818564	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	64569820	86954580	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	9	65	134	70	69	39	86	39	6	310	181	11	105	68	92	30	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M16200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y00311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022043 ⟹ ENSRNOP00000022043

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,786,832 - 79,811,656 (+)	Ensembl
mRatBN7.2 Ensembl	17	74,877,655 - 74,902,370 (+)	Ensembl
Rnor_6.0 Ensembl	17	78,879,058 - 78,903,967 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097965 ⟹ ENSRNOP00000083086

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	79,790,905 - 79,811,688 (+)	Ensembl
mRatBN7.2 Ensembl	17	74,881,728 - 74,902,518 (+)	Ensembl

RefSeq Acc Id:

NM_022705 ⟹ NP_073196

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	79,786,832 - 79,811,680 (+)	NCBI
mRatBN7.2	17	74,877,655 - 74,902,510 (+)	NCBI
Rnor_6.0	17	78,879,060 - 78,903,912 (+)	NCBI
Rnor_5.0	17	80,520,857 - 80,545,540 (+)	NCBI
RGSC_v3.4	17	85,996,338 - 86,021,192 (+)	RGD
Celera	17	74,257,064 - 74,281,908 (+)	RGD

Sequence:

show sequence

GGGGGGGTTGCTGTGCCTCTCACTGTGGTTCGATCTCTCCTCTGGAAGGAGCATAGCTGAAAGC
TGATCTTCTGGTCTCCAGAACGCTTCTGAGATTTTGCCATCGAGTCCATTTCCTTCTCTTCTTC
CCTATCTCTTTTTCTTCACTGCCCTTTAAAAGCAGGATTCTGAGTGACAGCCATAGTCAACAGG
TTAAAAAGAAAGCTGGTCCCTTGGTATACTGAAGGCTTACTGGAGATTTTTGTGCCCAGAGGGA
ATTGAATTCAGCGTGGACACAGAAGGTTGAAGGAGCAACAACCCCTAATCAACTCACAGAATGG
AGACAGCAGTCAATGCTAAGAGTCCCAGGAATGAAAAGGTTTTGAACTGTTTGTATCAAAATCC
TGATGCAGTTTTCAAGCTGATCTGCTTCCCTTGGGCAGGAGGCGGCTCCATCCATTTTGCCAAG
TGGGGCCAAAAGATTAACGACTCTCTGGAAGTGCATGCTGTAAGACTGGCTGGAAGAGAAACCC
GACTTGGAGAACCTTTCGCAAATGACATCTACCAGATAGCTGATGAAATCGTGACCGCCCTGTT
GCCCATCATTCAGGATAAAGCTTTTGCGTTTTTTGGCCACAGTTTTGGATCCTACATTGCTCTT
ATTACTGCTCTGCTCCTAAAGGAGAAATACAAAATGGAGCCGCTGCATATTTTTGTATCCGGTG
CATCCGCCCCTCACTCAACATCCCGGCCTCAAGTTCCTGATCTTAACGAATTGACAGAAGAACA
AGTCAGACATCACCTTCTGGATTTCGGAGGCACGCCCAAGCATCTCATAGAAGACCAGGATGTT
CTGAGGATGTTCATTCCTTTGCTGAAGGCAGATGCTGGCGTTGTGAAAAAATTCATCTTTGACA
AGCCCTCCAAAGCTCTTCTCTCTCTGGACATAACGGGCTTCCTTGGATCTGAAGATACAATAAA
GGACATAGAAGGCTGGCAAGACCTAACCAGTGGGAAGTTTGATGTCCACATGCTGCCAGGCGAC
CACTTTTATCTGATGAAGCCCGACAACGAGAACTTTATCAAGAACTACATAGCCAAGTGCTTGG
AACTCTCGTCACTCACTTGACTACTTTTAGATGAGCTTTCTTTGGGGCTGTGGATATGCAGACG
GTTCAAAAGCTGCTCCTCTGGGTCCAGCTTTTAGTTCTTAGAGGTTGGAAAGGTGCATATTAAT
GAATTTCTTCGTGGAGCATTTATCTCTCTGGGGAAAGGACACGGCTGAAGAGGCGCACAGGCAC
TATTGGGAGCTAACAGAGGGGAGAGGGGGGTGGTTTTCTTTGGGGGGATGTTGCCCTCAGTAGG
TACCCATGCTCCAGTAAATGACACTACACCCTGTGGCACATGCAGGCAGCTCTAATGCAGACTC
AGTGGGAAGTTGGGAGGCATACATGTTGGGGGACATCTGTCACGGGGCTTGGAAAGACAAGTGA
GGGTCTGATCAAAACCTGCTGTTTACATTTTCAAAGAATAAATAAAAAATTATGCT

hide sequence

RefSeq Acc Id:

XM_017600660 ⟹ XP_017456149

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	79,786,441 - 79,811,692 (+)	NCBI
mRatBN7.2	17	74,877,651 - 74,902,517 (+)	NCBI
Rnor_6.0	17	78,878,673 - 78,903,919 (+)	NCBI

Sequence:

show sequence

ATAATGAACAACCTTCTGTTGTTAAAATATTTATCTGTATTCCGCCTCCGCTTGCCCATCTTCC
TTGGAAGAAGTAGACATATTTTTCTGCTGTTTACGTTGTTACTTTGAGTTTTAGCTTTTATTTT
GAGCTAGTCTTTCTTTCTAGCTCTGGCTAACTTCAAACTTCCAATCCTCCTGCTTCAGCGTCCA
ATGTGCTGGGATCGCAGGCAGGTACCCCCACTCTCAGTGGCATTTTGTATCGTTATCTAAGAAG
CAAAAACTTGCTCACAGAGTCAGCGGCCACCTAGAAAATTATCAAGGCTTGCTGTGCCTCTCAC
TGTGGTTCGATCTCTCCTCTGGAAGGAGCATAGCTGAAAGCTGATCTTCTGGTCTCCAGAACGC
TTCTGAGATTTTGCCATCGAGGTTTGTGAGTTAAACCTTGGTCTTAACATGACGGCCAGGGATT
CAGGGGATTTCTAGGTGTCCATTTCCTTCTCTTCTTCCCTATCTCTTTTTCTTCACTGCCCTTT
AAAAGCAGGATTCTGAGTGACAGCCATAGTCAACAGGTTAAAAAGAAAGCTGGTCCCTTGGTAT
ACTGAAGGCTTACTGGAGATTTTTGTGCCCAGAGGGGAATTGAATTCAGCGTGGACACAGAAGG
TTGAAGGAGCAACAACCCCTAATCAACTCACAGAATGGAGACAGCAGTCAATGCTAAGAGTCCC
AGGAATGAAAAGGTTTTGAACTGTTTGTATCAAAATCCTGATGCAGTTTTCAAGCTGATCTGCT
TCCCTTGGGCAGGAGGCGGCTCCATCCATTTTGCCAAGTGGGGCCAAAAGATTAACGACTCTCT
GGAAGTGCATGCTGTAAGACTGGCTGGAAGAGAAACCCGACTTGGAGAACCTTTCGCAAATGAC
ATCTACCAGATAGCTGATGAAATCGTGACCGCCCTGTTGCCCATCATTCAGGATAAAGCTTTTG
CGTTTTTTGGCCACAGTTTTGGATCCTACATTGCTCTTATTACTGCTCTGCTCCTAAAGGAGAA
ATACAAAATGGAGCCACTGCATATTTTTGTATCCGGTGCATCCGCCCCTCACTCAACATCCCGG
CCTCAAGTTCCTGATCTTAACGAATTGACAGAAGAACAAGTCAGACATCACCTTCTGGATTTCG
GAGGCACGCCCAAGCATCTCATAGAAGACCAGGATGTTCTGAGGATGTTCATTCCTTTGCTGAA
GGCAGATGCTGGCGTTGTGAAAAAATTCATCTTTGACAAGCCCTCCAAAGCTCTTCTCTCTCTG
GACATAACGGGCTTCCTTGGATCTGAAGATACAATAAAGGACATAGAAGGCTGGCAAGACCTAA
CCAGTGGGAAGTTTGATGTCCACATGCTGCCAGGTGACCACTTTTATCTGATGAAGCCCGACAA
CGAGAACTTTATCAAGAACTACATAGCCAAGTGCTTGGAACTCTCGTCACTCACTTGACTACTT
TTAGATGAGCTTTCTTTGGGGCTGTGGATATGCAGACGGTTCAAAAGCTGCTCCTCTGGGTCCA
GCTTTTAGTTCTTAGAGGTTGGAAAGGTGCATATTAATGAATTTCTTCGTGGAGCATTTATCTC
TCTGGGGAAAGGACACGGCTGAAGAGGCGCACAGGCACTATTGGGAGCTAACAGAGGGGAGAGG
GGGGTGGTTTTCTTTGGGGGGATGTTGCCCTCAGTAGGTACCCATGCTCCAGTAAATGACACTA
CACCCTTGTGCCACATGCAGGCAGCTCTAATCAGACTCAGTGGGAAGTTGGGAGGCATACATGT
TGGGGGACATCTGTCACGGGGCTTGGAAAGACAAGTGAGGGTCTGATCAAAACCTGCTGTTTAC
ATTTTCAAAGAATAAATAAAAAATATTGCTAAAGGAA

hide sequence

RefSeq Acc Id:

XM_063276728 ⟹ XP_063132798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	79,786,441 - 79,811,692 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_073196	(Get FASTA)	NCBI Sequence Viewer
	XP_017456149	(Get FASTA)	NCBI Sequence Viewer
	XP_063132798	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41578	(Get FASTA)	NCBI Sequence Viewer
	CAA68411	(Get FASTA)	NCBI Sequence Viewer
	EDL78698	(Get FASTA)	NCBI Sequence Viewer
	EDL78699	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022043
	ENSRNOP00000022043.2
GenBank Protein	P08635	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_073196 ⟸ NM_022705

- UniProtKB:

P08635 (UniProtKB/Swiss-Prot), A6JM21 (UniProtKB/TrEMBL), A0A8I6GAB2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRE
TRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVS
GASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIF
DKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKC
LELSSLT

hide sequence

RefSeq Acc Id:	XP_017456149 ⟸ XM_017600660
- Peptide Label:	isoform X1
- UniProtKB:	P08635 (UniProtKB/Swiss-Prot), A6JM21 (UniProtKB/TrEMBL), A0A8I6GAB2 (UniProtKB/TrEMBL)
- Sequence:	show sequence METAVNAKSPRNEKVLNCLYQNPDAVFKLICFPWAGGGSIHFAKWGQKINDSLEVHAVRLAGRE TRLGEPFANDIYQIADEIVTALLPIIQDKAFAFFGHSFGSYIALITALLLKEKYKMEPLHIFVS GASAPHSTSRPQVPDLNELTEEQVRHHLLDFGGTPKHLIEDQDVLRMFIPLLKADAGVVKKFIF DKPSKALLSLDITGFLGSEDTIKDIEGWQDLTSGKFDVHMLPGDHFYLMKPDNENFIKNYIAKC LELSSLT hide sequence

Ensembl Acc Id:

ENSRNOP00000022043 ⟸ ENSRNOT00000022043

Ensembl Acc Id:

ENSRNOP00000083086 ⟸ ENSRNOT00000097965

RefSeq Acc Id:	XP_063132798 ⟸ XM_063276728
- Peptide Label:	isoform X1
- UniProtKB:	P08635 (UniProtKB/Swiss-Prot), A0A8I6GAB2 (UniProtKB/TrEMBL), A6JM21 (UniProtKB/TrEMBL)

Protein Domains

Thioesterase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P08635-F1-model_v2	AlphaFold	P08635	1-263	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700586

Promoter ID:

EPDNEW_R11110

Type:

single initiation site

Name:

Olah_1

Description:

oleoyl-ACP hydrolase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	78,879,055 - 78,879,115	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621115	AgrOrtholog
BioCyc Gene	G2FUF-8642	BioCyc
Ensembl Genes	ENSRNOG00000016403	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000022043	ENTREZGENE
	ENSRNOT00000022043.5	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot
	TEII	UniProtKB/Swiss-Prot
	Thioesterase	UniProtKB/Swiss-Prot
KEGG Report	rno:64669	UniProtKB/Swiss-Prot
NCBI Gene	64669	ENTREZGENE
PANTHER	PTHR11487	UniProtKB/Swiss-Prot
	S-ACYL FATTY ACID SYNTHASE THIOESTERASE, MEDIUM CHAIN	UniProtKB/Swiss-Prot
Pfam	Thioesterase	UniProtKB/Swiss-Prot
PhenoGen	Olah	PhenoGen
RatGTEx	ENSRNOG00000016403	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot
UniProt	A0A8I6GAB2	ENTREZGENE, UniProtKB/TrEMBL
	A6JM21	ENTREZGENE, UniProtKB/TrEMBL
	P08635	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-22	Olah	oleoyl-ACP hydrolase	Thedc1	thioesterase domain containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Thedc1	thioesterase domain containing 1	Mch	medium-chain S-acyl fatty acid synthetase thio ester hydrolase (MCH)	Symbol and Name updated	1299863	APPROVED
2002-08-07	Mch	medium-chain S-acyl fatty acid synthetase thio ester hydrolase (MCH)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)