Psmc4 (proteasome 26S subunit, ATPase 4) - Rat Genome Database

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Gene: Psmc4 (proteasome 26S subunit, ATPase 4) Rattus norvegicus
Analyze
Symbol: Psmc4
Name: proteasome 26S subunit, ATPase 4
RGD ID: 621102
Description: Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within blastocyst development. Located in inclusion body. Part of cytosolic proteasome complex. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4; S6 ATPase; TAT-binding protein 7; TBP-7; Tbp7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,476,690 - 92,485,268 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,476,690 - 92,485,060 (-)EnsemblGRCr8
mRatBN7.2183,349,127 - 83,357,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,348,592 - 83,357,494 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,759,384 - 88,767,734 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,217,473 - 97,225,843 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,515,238 - 90,523,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,978,220 - 84,986,536 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,978,206 - 84,986,581 (-)Ensemblrn6Rnor6.0
Rnor_5.0186,194,919 - 86,203,235 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,151,149 - 83,159,464 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,748,725 - 77,757,041 (-)NCBICelera
RGSC_v3.1183,229,258 - 83,237,575 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
elesclomol  (ISO)
epoxomicin  (ISO)
ethanol  (EXP)
fenthion  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
imidacloprid  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nobiletin  (ISO)
okadaic acid  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Activity-dependent dynamics and sequestration of proteasomes in dendritic spines. Bingol B and Schuman EM, Nature. 2006 Jun 29;441(7097):1144-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing. Makino Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):1049-54.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. Rousseau E, etal., J Biol Chem. 2009 Jan 16;284(3):1917-29. doi: 10.1074/jbc.M806256200. Epub 2008 Nov 5.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses. Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.
Additional References at PubMed
PMID:9688553   PMID:10945464   PMID:15489334   PMID:16857966   PMID:17323924   PMID:19946888   PMID:21630459   PMID:22871113   PMID:31904090   PMID:35352799  


Genomics

Comparative Map Data
Psmc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,476,690 - 92,485,268 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,476,690 - 92,485,060 (-)EnsemblGRCr8
mRatBN7.2183,349,127 - 83,357,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,348,592 - 83,357,494 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,759,384 - 88,767,734 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,217,473 - 97,225,843 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,515,238 - 90,523,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,978,220 - 84,986,536 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,978,206 - 84,986,581 (-)Ensemblrn6Rnor6.0
Rnor_5.0186,194,919 - 86,203,235 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,151,149 - 83,159,464 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,748,725 - 77,757,041 (-)NCBICelera
RGSC_v3.1183,229,258 - 83,237,575 (-)NCBI
Cytogenetic Map1q21NCBI
PSMC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,971,165 - 39,981,764 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,971,162 - 39,981,764 (+)Ensemblhg38GRCh38
GRCh371940,477,072 - 40,487,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,168,913 - 45,179,193 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341945,168,912 - 45,179,191NCBI
Celera1937,275,447 - 37,285,724 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,913,453 - 36,924,135 (+)NCBIHuRef
CHM1_11940,476,958 - 40,487,716 (+)NCBICHM1_1
T2T-CHM13v2.01942,791,375 - 42,801,971 (+)NCBIT2T-CHM13v2.0
Psmc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,741,127 - 27,749,517 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,741,132 - 27,749,526 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,041,702 - 28,050,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,041,707 - 28,050,101 (-)Ensemblmm10GRCm38
MGSCv37728,826,721 - 28,835,111 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,750,477 - 27,758,803 (-)NCBIMGSCv36mm8
Celera722,608,215 - 22,616,605 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.11NCBI
Psmc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555781,113,445 - 1,120,370 (-)Ensembl
ChiLan1.0NW_0049555781,113,445 - 1,120,050 (-)NCBIChiLan1.0ChiLan1.0
PSMC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,232,549 - 46,243,056 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,103,185 - 48,113,698 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,018,112 - 37,028,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,533,141 - 45,543,245 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,533,141 - 45,543,245 (+)EnsemblpanPan2panpan1.1
PSMC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,548,351 - 113,557,725 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,548,373 - 113,557,630 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1112,952,245 - 112,961,621 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,148,644 - 114,157,982 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,148,650 - 114,157,892 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,707,548 - 113,716,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,340,335 - 113,349,711 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,334,441 - 114,343,783 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psmc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,094,546 - 14,100,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,522,615 - 2,528,284 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,522,665 - 2,528,279 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,406,376 - 48,416,215 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1648,406,237 - 48,414,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PSMC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,486,303 - 34,495,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,486,338 - 34,495,251 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607312,578,624 - 12,587,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925119,777 - 130,723 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624925119,837 - 127,678 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Psmc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,923,149 - 167,931,625 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psmc4
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000025819
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
STS-T26522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,349,154 - 83,349,325 (+)MAPPERmRatBN7.2
Rnor_6.0184,978,239 - 84,978,409NCBIRnor6.0
Rnor_5.0186,194,938 - 86,195,108UniSTSRnor5.0
RGSC_v3.4183,151,167 - 83,151,337UniSTSRGSC3.4
Celera177,748,744 - 77,748,914UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025819   ⟹   ENSRNOP00000025819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,476,690 - 92,485,060 (-)Ensembl
mRatBN7.2 Ensembl183,348,592 - 83,357,494 (-)Ensembl
Rnor_6.0 Ensembl184,978,206 - 84,986,581 (-)Ensembl
RefSeq Acc Id: NM_057122   ⟹   NP_476463
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,476,690 - 92,485,060 (-)NCBI
mRatBN7.2183,349,127 - 83,357,497 (-)NCBI
Rnor_6.0184,978,220 - 84,986,536 (-)NCBI
Rnor_5.0186,194,919 - 86,203,235 (-)NCBI
RGSC_v3.4183,151,149 - 83,159,464 (-)RGD
Celera177,748,725 - 77,757,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063267909   ⟹   XP_063123979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,476,695 - 92,485,268 (-)NCBI
RefSeq Acc Id: NP_476463   ⟸   NM_057122
- UniProtKB: Q63570 (UniProtKB/Swiss-Prot),   A6J9G3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025819   ⟸   ENSRNOT00000025819
RefSeq Acc Id: XP_063123979   ⟸   XM_063267909
- Peptide Label: isoform X1
Protein Domains
AAA ATPase AAA+ lid   AAA+ ATPase   ATPase AAA-type core   Proteasomal ATPase second OB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63570-F1-model_v2 AlphaFold Q63570 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689860
Promoter ID:EPDNEW_R385
Type:multiple initiation site
Name:Psmc4_1
Description:proteasome 26S subunit, ATPase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,986,562 - 84,986,622EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621102 AgrOrtholog
BioCyc Gene G2FUF-60267 BioCyc
Ensembl Genes ENSRNOG00000018994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025819 ENTREZGENE
  ENSRNOT00000025819.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889167 IMAGE-MGC_LOAD
InterPro 26S_Proteasome_ATPase UniProtKB/Swiss-Prot
  AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
KEGG Report rno:117262 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72664 IMAGE-MGC_LOAD
NCBI Gene 117262 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
PhenoGen Psmc4 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018994 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6J9G2_RAT UniProtKB/TrEMBL
  A6J9G3 ENTREZGENE, UniProtKB/TrEMBL
  A6J9G4_RAT UniProtKB/TrEMBL
  PRS6B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Psmc4  proteasome 26S subunit, ATPase 4  Psmc4  proteasome (prosome, macropain) 26S subunit, ATPase, 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Psmc4  proteasome (prosome, macropain) 26S subunit, ATPase, 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Psmc4  proteasome (prosome, macropain) 26S subunit, ATPase, 4      Symbol and Name status set to provisional 70820 PROVISIONAL