Acot2 (acyl-CoA thioesterase 2) - Rat Genome Database

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Gene: Acot2 (acyl-CoA thioesterase 2) Rattus norvegicus
Analyze
Symbol: Acot2
Name: acyl-CoA thioesterase 2
RGD ID: 621055
Description: Enables long-chain fatty acyl-CoA hydrolase activity. Involved in several processes, including long-chain fatty-acyl-CoA catabolic process; response to epidermal growth factor; and response to hypoxia. Predicted to be located in mitochondrion. Used to study type 2 diabetes mellitus. Orthologous to human ACOT2 (acyl-CoA thioesterase 2); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acyl coenzyme A thioester hydrolase; acyl-coenzyme A thioesterase 2, mitochondrial; ARTISt/p43; mitochondrial acyl-CoA thioesterase 1; MTE-I; Mte1; very-long-chain acyl-CoA thioesterase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,341,426 - 109,352,818 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6109,342,646 - 109,350,502 (+)EnsemblGRCr8
mRatBN7.26103,611,738 - 103,619,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6103,611,544 - 103,619,245 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6103,773,494 - 103,780,324 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,072,709 - 104,079,539 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,442,160 - 103,448,992 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06107,460,596 - 107,468,324 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6107,460,668 - 107,467,487 (+)Ensemblrn6Rnor6.0
Rnor_5.06118,076,465 - 118,084,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46108,017,574 - 108,024,387 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6101,441,758 - 101,448,571 (+)NCBICelera
RGSC_v3.16108,021,029 - 108,027,840 (+)NCBI
Cytogenetic Map6q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,3-dinitrobenzene  (EXP)
1-aminobenzotriazole  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
ciprofibrate  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
fenofibrate  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
GW 6471  (EXP)
GW 7647  (ISO)
hydralazine  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
metformin  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-1,2-dichloropropane  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
selenium atom  (ISO)
senecionine  (ISO)
sinapic acid  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sulfluramid  (ISO)
sulforaphane  (EXP)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. New enzymes involved in the mechanism of action of epidermal growth factor in a clonal strain of Leydig tumor cells. Castilla R, etal., Endocrinology. 2008 Jul;149(7):3743-52. Epub 2008 Apr 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. King KL, etal., J Lipid Res. 2007 Jul;48(7):1511-7. Epub 2007 Apr 16.
4. The messenger RNA profiles in liver, hypothalamus, white adipose tissue, and skeletal muscle of female Zucker diabetic fatty rats after topiramate treatment. Liang Y, etal., Metabolism. 2006 Oct;55(10):1411-9.
5. Proteomic analysis of mitochondrial proteins in cardiomyocytes from chronic stressed rat. Liu XH, etal., Proteomics. 2004 Oct;4(10):3167-76.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme Q. Moreno M, etal., FASEB J. 2003 Jun;17(9):1112-4. Epub 2003 Apr 8.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Stavinoha MA, etal., Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E888-95. Epub 2004 Aug 3.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver. Svensson LT, etal., Biochem J 1998 Feb 1;329 ( Pt 3):601-8.
16. Very long chain and long chain acyl-CoA thioesterases in rat liver mitochondria. Identification, purification, characterization, and induction by peroxisome proliferators. Svensson LT, etal., J Biol Chem. 1995 May 19;270(20):12177-83.
17. cDNA cloning and genomic organization of peroxisome proliferator-inducible long-chain acyl-CoA hydrolase from rat liver cytosol. Yamada J, etal., Biochem Biophys Res Commun 1998 Jul 30;248(3):608-12.
Additional References at PubMed
PMID:10944470   PMID:14651853   PMID:16103133   PMID:16940157   PMID:18614015   PMID:20178365   PMID:21094633   PMID:23376485  


Genomics

Comparative Map Data
Acot2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,341,426 - 109,352,818 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6109,342,646 - 109,350,502 (+)EnsemblGRCr8
mRatBN7.26103,611,738 - 103,619,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6103,611,544 - 103,619,245 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6103,773,494 - 103,780,324 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,072,709 - 104,079,539 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06103,442,160 - 103,448,992 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06107,460,596 - 107,468,324 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6107,460,668 - 107,467,487 (+)Ensemblrn6Rnor6.0
Rnor_5.06118,076,465 - 118,084,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46108,017,574 - 108,024,387 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6101,441,758 - 101,448,571 (+)NCBICelera
RGSC_v3.16108,021,029 - 108,027,840 (+)NCBI
Cytogenetic Map6q31NCBI
ACOT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381473,567,620 - 73,575,658 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1473,567,620 - 73,575,658 (+)Ensemblhg38GRCh38
GRCh371474,034,324 - 74,042,362 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361473,105,525 - 73,112,112 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1454,071,870 - 54,078,454 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1454,202,099 - 54,210,141 (+)NCBIHuRef
CHM1_11473,973,914 - 73,981,955 (+)NCBICHM1_1
T2T-CHM13v2.01467,775,130 - 67,783,167 (+)NCBIT2T-CHM13v2.0
Acot2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,034,635 - 84,040,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,034,635 - 84,040,647 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381283,987,861 - 83,993,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1283,987,861 - 83,993,873 (+)Ensemblmm10GRCm38
MGSCv371285,328,811 - 85,334,827 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361284,877,638 - 84,883,625 (+)NCBIMGSCv36mm8
Celera1285,434,445 - 85,440,461 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1238.99NCBI
ACOT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21574,655,251 - 74,665,746 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11473,874,828 - 73,889,496 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01454,128,445 - 54,135,067 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11472,985,087 - 72,993,182 (+)NCBIPanPan1.1PanPan1.1panPan2
ACOT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1846,851,109 - 46,873,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl846,852,880 - 46,911,640 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha846,535,270 - 46,544,386 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0847,079,920 - 47,089,052 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,081,692 - 47,140,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1846,747,622 - 46,756,745 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0846,731,860 - 46,774,959 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,121,855 - 47,164,838 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Acot2
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:64
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000013515
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat

Markers in Region
RH128388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26103,618,160 - 103,618,356 (+)MAPPERmRatBN7.2
Rnor_6.06107,467,081 - 107,467,276NCBIRnor6.0
Rnor_5.06118,076,869 - 118,077,064UniSTSRnor5.0
RGSC_v3.46108,023,987 - 108,024,182UniSTSRGSC3.4
Celera6101,448,171 - 101,448,366UniSTS
RH 3.4 Map6733.1UniSTS
Cytogenetic Map6q31UniSTS
BE101215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26103,610,620 - 103,610,794 (+)MAPPERmRatBN7.2
Rnor_6.06107,459,541 - 107,459,714NCBIRnor6.0
Rnor_5.06118,084,431 - 118,084,604UniSTSRnor5.0
RGSC_v3.46108,016,447 - 108,016,620UniSTSRGSC3.4
Celera6101,440,631 - 101,440,804UniSTS
RH 3.4 Map6734.7UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013515   ⟹   ENSRNOP00000013515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6109,342,840 - 109,349,673 (+)Ensembl
mRatBN7.2 Ensembl6103,611,748 - 103,618,567 (+)Ensembl
Rnor_6.0 Ensembl6107,460,668 - 107,467,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104100   ⟹   ENSRNOP00000084930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6109,342,646 - 109,349,673 (+)Ensembl
mRatBN7.2 Ensembl6103,611,544 - 103,618,571 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115016   ⟹   ENSRNOP00000086137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6109,342,804 - 109,350,502 (+)Ensembl
mRatBN7.2 Ensembl6103,611,738 - 103,619,245 (+)Ensembl
RefSeq Acc Id: NM_138907   ⟹   NP_620262
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,342,840 - 109,349,673 (+)NCBI
mRatBN7.26103,611,738 - 103,618,571 (+)NCBI
Rnor_6.06107,460,668 - 107,467,481 (+)NCBI
Rnor_5.06118,076,465 - 118,084,645 (-)NCBI
RGSC_v3.46108,017,574 - 108,024,387 (+)RGD
Celera6101,441,758 - 101,448,571 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240320   ⟹   XP_006240382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,341,426 - 109,352,818 (+)NCBI
mRatBN7.26103,611,744 - 103,619,404 (+)NCBI
Rnor_6.06107,460,596 - 107,468,324 (+)NCBI
Rnor_5.06118,076,465 - 118,084,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063261537   ⟹   XP_063117607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,341,426 - 109,347,236 (+)NCBI
RefSeq Acc Id: NP_620262   ⟸   NM_138907
- UniProtKB: O88268 (UniProtKB/Swiss-Prot),   O55171 (UniProtKB/Swiss-Prot),   Q6IMX8 (UniProtKB/TrEMBL),   A6JDS4 (UniProtKB/TrEMBL),   F7F6S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240382   ⟸   XM_006240320
- Peptide Label: isoform X1
- UniProtKB: O88268 (UniProtKB/Swiss-Prot),   O55171 (UniProtKB/Swiss-Prot),   A0A8I6A1M5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013515   ⟸   ENSRNOT00000013515
Ensembl Acc Id: ENSRNOP00000084930   ⟸   ENSRNOT00000104100
Ensembl Acc Id: ENSRNOP00000086137   ⟸   ENSRNOT00000115016
RefSeq Acc Id: XP_063117607   ⟸   XM_063261537
- Peptide Label: isoform X2
Protein Domains
Acyl-CoA thioester hydrolase/bile acid-CoA amino   BAAT/Acyl-CoA thioester hydrolase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55171-F1-model_v2 AlphaFold O55171 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694715
Promoter ID:EPDNEW_R5239
Type:initiation region
Name:Acot2_1
Description:acyl-CoA thioesterase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06107,460,655 - 107,460,715EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621055 AgrOrtholog
BioCyc Gene G2FUF-36847 BioCyc
BioCyc Pathway PWY-5148 [acyl-CoA hydrolysis] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-5996 [oleate biosynthesis II (animals and fungi)] BioCyc
  PWY-8042 [acylceramide biosynthesis] BioCyc
  PWY3O-1801 [palmitoleate biosynthesis IV (fungi and animals)] BioCyc
BioCyc Pathway Image PWY-5148 BioCyc
  PWY-5972 BioCyc
  PWY-5996 BioCyc
  PWY-8042 BioCyc
  PWY3O-1801 BioCyc
Ensembl Genes ENSRNOG00000010134 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013515 ENTREZGENE
  ENSRNOT00000115016 ENTREZGENE
Gene3D-CATH 2.60.40.2240 UniProtKB/Swiss-Prot
  3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104319 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Acyl-CoA_thioEstase_long-chain UniProtKB/Swiss-Prot
  BAAT_C UniProtKB/Swiss-Prot
  Thio_Ohase/aa_AcTrfase UniProtKB/Swiss-Prot
  Thio_Ohase/BAAT_N UniProtKB/Swiss-Prot
MGC_CLONE MGC:91482 IMAGE-MGC_LOAD
NCBI Gene 192272 ENTREZGENE
PANTHER ACYL-COENZYME A THIOESTERASE 1-RELATED UniProtKB/Swiss-Prot
  ACYL-COENZYME A THIOESTERASE-RELATED UniProtKB/Swiss-Prot
Pfam BAAT_C UniProtKB/Swiss-Prot
  Bile_Hydr_Trans UniProtKB/Swiss-Prot
PhenoGen Acot2 PhenoGen
PIRSF Acyl-CoA_hydro UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010134 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A8I6A1M5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GCA2_RAT UniProtKB/TrEMBL
  A6JDS4 ENTREZGENE, UniProtKB/TrEMBL
  ACOT2_RAT UniProtKB/Swiss-Prot
  F7F6S1 ENTREZGENE, UniProtKB/TrEMBL
  O55171 ENTREZGENE
  O88268 ENTREZGENE
  Q6IMX8 ENTREZGENE
UniProt Secondary O88268 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Acot2  acyl-CoA thioesterase 2  Mte1  mitochondrial acyl-CoA thioesterase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mte1  mitochondrial acyl-CoA thioesterase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mte1  mitochondrial acyl-CoA thioesterase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 727625
gene_domains contains a active-site serine motif (Gly-Xaa-Ser-Xaa-Gly) 727625