Slc27a1 (solute carrier family 27 member 1) - Rat Genome Database

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Gene: Slc27a1 (solute carrier family 27 member 1) Rattus norvegicus
Analyze
Symbol: Slc27a1
Name: solute carrier family 27 member 1
RGD ID: 620927
Description: Predicted to enable several functions, including fatty acid-CoA ligase activity; icosanoid transmembrane transporter activity; and monocarboxylic acid transmembrane transporter activity. Predicted to be involved in several processes, including glucose import in response to insulin stimulus; lipid transport across blood-brain barrier; and monocarboxylic acid transport. Predicted to act upstream of or within several processes, including adiponectin-activated signaling pathway; positive regulation of heat generation; and response to insulin. Located in caveola and mitochondrial inner membrane. Biomarker of familial hyperlipidemia; glucose intolerance; hyperinsulinism; myocardial infarction; and obesity. Orthologous to human SLC27A1 (solute carrier family 27 member 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2-Ethylhexanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arachidonate--CoA ligase; FATP; FATP-1; fatty acid transport protein; fatty acid transport protein 1; long-chain fatty acid transport protein 1; long-chain-fatty-acid--CoA ligase; solute carrier family 27 (fatty acid transporter), member 1; solute carrier family 27, member 1; very long-chain acyl-CoA synthetase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,311,859 - 18,337,024 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,313,015 - 18,330,045 (+)EnsemblGRCr8
mRatBN7.21618,278,984 - 18,300,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,278,984 - 18,296,063 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,329,890 - 18,346,962 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,461,772 - 19,478,909 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,382,827 - 18,399,900 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,997,823 - 20,016,193 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,999,112 - 20,016,190 (+)Ensemblrn6Rnor6.0
Rnor_5.01619,859,540 - 19,880,871 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,769,909 - 18,786,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,482,929 - 18,499,970 (+)NCBICelera
RGSC_v3.11618,769,906 - 18,786,985 (+)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-Ethylhexanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-iodothyronamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
9-cis-retinoic acid  (EXP,ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
cisplatin  (ISO)
CL316243  (EXP)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diquat  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Mesaconitine  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
rebaudioside A  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium dodecyl sulfate  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
sulfluramid  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. Chabowski A, etal., FEBS Lett. 2005 Apr 25;579(11):2428-32.
2. Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats. Deng JY, etal., Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H978-87. Epub 2007 Mar 30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Heather LC, etal., Cardiovasc Res. 2006 Dec 1;72(3):430-7. Epub 2006 Sep 1.
5. Fiber type- and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content. Marotta M, etal., Metabolism. 2004 Aug;53(8):1032-6.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions. Ortegren U, etal., FEBS J. 2006 Jul;273(14):3381-92. Epub 2006 Jun 26.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Molecular cloning of fatty acid-transport protein cDNA from rat. Schaap FG, etal., Biochim Biophys Acta 1997 Oct 9;1354(1):29-34.
14. Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. Sebastian D, etal., J Lipid Res. 2009 May 9.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Wu Q, etal., Mol Cell Biol. 2006 May;26(9):3455-67.
Additional References at PubMed
PMID:7954810   PMID:9671728   PMID:10593920   PMID:12235169   PMID:12533547   PMID:12566451   PMID:14991074   PMID:15496455   PMID:17130465   PMID:18258213   PMID:19523918   PMID:19560442  
PMID:19946888   PMID:20667975   PMID:21395585   PMID:21442160   PMID:28035674   PMID:28178239   PMID:30053369   PMID:31091338  


Genomics

Comparative Map Data
Slc27a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,311,859 - 18,337,024 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,313,015 - 18,330,045 (+)EnsemblGRCr8
mRatBN7.21618,278,984 - 18,300,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,278,984 - 18,296,063 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,329,890 - 18,346,962 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,461,772 - 19,478,909 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,382,827 - 18,399,900 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,997,823 - 20,016,193 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,999,112 - 20,016,190 (+)Ensemblrn6Rnor6.0
Rnor_5.01619,859,540 - 19,880,871 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,769,909 - 18,786,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,482,929 - 18,499,970 (+)NCBICelera
RGSC_v3.11618,769,906 - 18,786,985 (+)NCBI
Cytogenetic Map16p14NCBI
SLC27A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,468,767 - 17,506,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,467,666 - 17,506,190 (+)Ensemblhg38GRCh38
GRCh371917,581,333 - 17,616,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,442,300 - 17,477,977 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1917,482,907 - 17,518,593 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,146,725 - 17,182,058 (+)NCBIHuRef
CHM1_11917,580,668 - 17,616,359 (+)NCBICHM1_1
T2T-CHM13v2.01917,602,871 - 17,640,805 (+)NCBIT2T-CHM13v2.0
Slc27a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,021,372 - 72,039,951 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,021,526 - 72,039,946 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38871,568,728 - 71,587,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,568,882 - 71,587,302 (+)Ensemblmm10GRCm38
MGSCv37874,092,826 - 74,110,607 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36874,497,916 - 74,515,697 (+)NCBIMGSCv36mm8
Celera874,083,284 - 74,101,015 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Slc27a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524805,014 - 821,838 (-)Ensembl
ChiLan1.0NW_004955524803,793 - 821,920 (-)NCBIChiLan1.0ChiLan1.0
SLC27A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,340,328 - 22,376,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,345,812 - 21,383,151 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01916,956,000 - 16,993,429 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11917,929,785 - 17,966,171 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,929,785 - 17,966,171 (+)EnsemblpanPan2panpan1.1
SLC27A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,309,094 - 45,341,101 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,310,088 - 45,340,230 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2045,223,163 - 45,255,236 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02045,796,156 - 45,828,264 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,796,156 - 45,829,217 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,032,656 - 45,064,717 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,442,740 - 45,474,725 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,718,788 - 45,750,750 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc27a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,877,674 - 203,901,327 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,427,874 - 3,449,489 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,426,807 - 3,451,259 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC27A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,203,388 - 60,235,588 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1260,203,374 - 60,235,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,752,658 - 59,771,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC27A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,967,126 - 15,995,039 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660743,430,291 - 3,458,931 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc27a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624908531,308 - 549,990 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624908531,313 - 549,570 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc27a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11313,377,936 - 13,395,571 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc27a1
345 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:119
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000024659
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
RH127318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,288,679 - 18,288,883 (+)MAPPERmRatBN7.2
Rnor_6.01620,008,807 - 20,009,010NCBIRnor6.0
Rnor_5.01619,869,235 - 19,869,438UniSTSRnor5.0
RGSC_v3.41618,779,604 - 18,779,807UniSTSRGSC3.4
Celera1618,492,586 - 18,492,789UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001428638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024659   ⟹   ENSRNOP00000024659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,314,291 - 18,330,045 (+)Ensembl
mRatBN7.2 Ensembl1618,278,984 - 18,296,063 (+)Ensembl
Rnor_6.0 Ensembl1619,999,112 - 20,016,190 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095535   ⟹   ENSRNOP00000077487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,313,015 - 18,330,044 (+)Ensembl
mRatBN7.2 Ensembl1618,280,289 - 18,296,063 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101879   ⟹   ENSRNOP00000083160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,314,512 - 18,330,045 (+)Ensembl
mRatBN7.2 Ensembl1618,279,789 - 18,296,042 (+)Ensembl
RefSeq Acc Id: NM_053580   ⟹   NP_446032
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,312,967 - 18,330,046 (+)NCBI
mRatBN7.21618,278,984 - 18,296,064 (+)NCBI
Rnor_6.01619,999,112 - 20,016,191 (+)NCBI
Rnor_5.01619,859,540 - 19,880,871 (+)NCBI
RGSC_v3.41618,769,909 - 18,786,988 (+)RGD
Celera1618,482,929 - 18,499,970 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252953   ⟹   XP_006253015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,182 - 18,330,046 (+)NCBI
mRatBN7.21618,280,507 - 18,296,064 (+)NCBI
Rnor_6.01620,000,567 - 20,016,193 (+)NCBI
Rnor_5.01619,859,540 - 19,880,871 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252954   ⟹   XP_006253016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,313,897 - 18,330,046 (+)NCBI
mRatBN7.21618,279,786 - 18,296,064 (+)NCBI
Rnor_6.01619,999,914 - 20,016,191 (+)NCBI
Rnor_5.01619,859,540 - 19,880,871 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771156   ⟹   XP_008769378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,337,024 (+)NCBI
mRatBN7.21618,280,393 - 18,300,173 (+)NCBI
Rnor_6.01620,000,414 - 20,016,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094877   ⟹   XP_038950805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,330,681 (+)NCBI
mRatBN7.21618,280,393 - 18,296,705 (+)NCBI
RefSeq Acc Id: XM_063275793   ⟹   XP_063131863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,246 - 18,330,046 (+)NCBI
RefSeq Acc Id: XM_063275794   ⟹   XP_063131864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,330,681 (+)NCBI
RefSeq Acc Id: XM_063275795   ⟹   XP_063131865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,313,630 - 18,330,046 (+)NCBI
RefSeq Acc Id: XM_063275796   ⟹   XP_063131866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,311,859 - 18,330,046 (+)NCBI
RefSeq Acc Id: XR_010058325
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,314,265 - 18,337,024 (+)NCBI
RefSeq Acc Id: NP_446032   ⟸   NM_053580
- UniProtKB: P97849 (UniProtKB/Swiss-Prot),   Q6GMM8 (UniProtKB/TrEMBL),   F7EPC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253016   ⟸   XM_006252954
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006253015   ⟸   XM_006252953
- Peptide Label: isoform X2
- UniProtKB: P97849 (UniProtKB/Swiss-Prot),   A0A8I5YCE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769378   ⟸   XM_008771156
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000024659   ⟸   ENSRNOT00000024659
RefSeq Acc Id: XP_038950805   ⟸   XM_039094877
- Peptide Label: isoform X1
- UniProtKB: P97849 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000083160   ⟸   ENSRNOT00000101879
Ensembl Acc Id: ENSRNOP00000077487   ⟸   ENSRNOT00000095535
RefSeq Acc Id: XP_063131866   ⟸   XM_063275796
- Peptide Label: isoform X3
- UniProtKB: P97849 (UniProtKB/Swiss-Prot),   F7EPC1 (UniProtKB/TrEMBL),   Q6GMM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131865   ⟸   XM_063275795
- Peptide Label: isoform X3
- UniProtKB: P97849 (UniProtKB/Swiss-Prot),   F7EPC1 (UniProtKB/TrEMBL),   Q6GMM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131863   ⟸   XM_063275793
- Peptide Label: isoform X1
- UniProtKB: P97849 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131864   ⟸   XM_063275794
- Peptide Label: isoform X1
- UniProtKB: P97849 (UniProtKB/Swiss-Prot)
Protein Domains
AMP-binding enzyme C-terminal   AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97849-F1-model_v2 AlphaFold P97849 1-646 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700008
Promoter ID:EPDNEW_R10530
Type:single initiation site
Name:Slc27a1_1
Description:solute carrier family 27 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,999,142 - 19,999,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620927 AgrOrtholog
BioCyc Gene G2FUF-11838 BioCyc
Ensembl Genes ENSRNOG00000018170 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024659 ENTREZGENE
  ENSRNOT00000095535 ENTREZGENE
  ENSRNOT00000101879 ENTREZGENE
Gene3D-CATH 3.30.300.30 UniProtKB/Swiss-Prot
  3.40.50.12780 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104661 IMAGE-MGC_LOAD
InterPro AMP-bd_C UniProtKB/Swiss-Prot
  AMP-bd_C_sf UniProtKB/Swiss-Prot
  AMP-binding_CS UniProtKB/Swiss-Prot
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:91570 IMAGE-MGC_LOAD
NCBI Gene 94172 ENTREZGENE
PANTHER LONG-CHAIN FATTY ACID TRANSPORT PROTEIN UniProtKB/Swiss-Prot
  PTHR43107:SF7 UniProtKB/Swiss-Prot
Pfam AMP-binding UniProtKB/Swiss-Prot
  AMP-binding_C UniProtKB/Swiss-Prot
PhenoGen Slc27a1 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018170 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot
UniProt A0A8I5YCE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8J5_RAT UniProtKB/TrEMBL
  A6K9W3_RAT UniProtKB/TrEMBL
  A6K9W4_RAT UniProtKB/TrEMBL
  F7EPC1 ENTREZGENE, UniProtKB/TrEMBL
  P97849 ENTREZGENE
  Q6GMM8 ENTREZGENE, UniProtKB/TrEMBL
  S27A1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc27a1  solute carrier family 27 member 1  Slc27a1  solute carrier family 27 (fatty acid transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc27a1  solute carrier family 27 (fatty acid transporter), member 1    fatty acid transport protein  Name updated 1299863 APPROVED
2002-08-07 Slc27a1  fatty acid transport protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process involved in myocardial fatty acid utilization 730038