Ppargc1a (PPARG coactivator 1 alpha) - Rat Genome Database

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Gene: Ppargc1a (PPARG coactivator 1 alpha) Rattus norvegicus
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Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
RGD ID: 620925
Description: Enables several functions, including alpha-tubulin binding activity; nuclear estrogen receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; regulation of primary metabolic process; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); sciatic neuropathy; and steatotic liver disease (multiple). Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); liver disease (multiple); placental insufficiency; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LRPGC1; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1-alpha; PGC-1alpha; PGC-1v; PGCvf; PGCvf-1; PGCvf1; PPAR gamma coactivator 1alpha variant form-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1; Ppargc1a-vf1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1463,273,189 - 63,729,213 (+)EnsemblGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)Ensemblrn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1458,516,257 - 58,607,916 (+)NCBICelera
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Cytogenetic Map14q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (IEP)
acute kidney failure  (ISO)
age related macular degeneration  (ISS)
Albuminuria  (ISO)
Alzheimer's disease  (IDA,ISO)
amblyopia  (IEP)
amnestic disorder  (IEP)
amyotrophic lateral sclerosis  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (IEP,ISO)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISS)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IDA,ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IDA)
congenital hypothyroidism  (IEP)
congestive heart failure  (ISO,ISS)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IDA,IEP)
dilated cardiomyopathy  (IDA)
Diseases of the Aged  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,IMP,ISO)
Fetal Growth Retardation  (IEP)
glucose intolerance  (ISO)
heart disease  (IDA)
Huntington's disease  (IDA,IEP,ISO)
hyperglycemia  (IDA,IEP,ISO)
hyperthyroidism  (IEP)
Hypertriglyceridemia  (IEP)
Hypoxia  (IEP)
Insulin Resistance  (IEP,ISO)
Kearns-Sayre syndrome  (ISO)
kidney cancer  (ISO)
kidney failure  (IDA)
Kidney Reperfusion Injury  (IDA)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
macular degeneration  (ISO)
malignant fibrous histiocytoma  (ISO)
melanoma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatotic liver disease  (IDA,IEP,ISO)
Metabolic Syndrome  (IEP)
morbid obesity  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (ISO)
nephrotic syndrome  (IEP)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (IDA,IEP,ISO)
Parkinson's disease  (ISO,ISS)
Parkinsonism  (ISO)
placental insufficiency  (IEP)
Plaque, Atherosclerotic  (ISO)
prediabetes syndrome  (IEP)
primary biliary cholangitis  (IEP)
pulmonary emphysema  (ISO)
renal fibrosis  (IEP)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (IEP)
schizophrenia  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (IEP)
Sleep Initiation and Maintenance Disorders  (ISO)
Spinal Cord Injuries  (IDA)
steatotic liver disease  (IDA,IEP,ISO)
Takotsubo Cardiomyopathy  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IDA,IEP,ISO)
Ventricular Dysfunction, Right  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-adrenaline  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1D-myo-inositol 1-phosphate  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,6-dioxoheptanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (EXP,ISO)
acarbose  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
adenosine  (ISO)
adenosine 5'-monophosphate  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP,ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alloxan  (EXP)
allyl isothiocyanate  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (EXP)
alpha-Zearalanol  (EXP)
aminoguanidine  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
angiotensin II  (EXP)
Ankaflavin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
benfotiamine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP,ISO)
Betanin  (EXP)
bezafibrate  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bosentan  (ISO)
brequinar  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
bupivacaine  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butan-2-one  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (ISO)
caffeine  (EXP)
calcitriol  (EXP,ISO)
calycosin  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
carvedilol  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
chicoric acid  (EXP)
CHIR 99021  (ISO)
chitosan  (ISO)
chlormidazole  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholate  (EXP)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clenbuterol  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cortisone  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
D-glucurono-6,3-lactone  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (ISO)
decanoic acid  (ISO)
dehydroepiandrosterone  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydrofolic acid  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (EXP,ISO)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
farnesol  (EXP)
fenofibrate  (ISO)
fenoterol  (ISO)
fenpyroximate  (ISO)
ferulic acid  (EXP,ISO)
flavonoids  (ISO)
fluoxastrobin  (ISO)
folic acid  (ISO)
folpet  (ISO)
formononetin  (EXP)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
galactose  (EXP)
gamma-hexachlorocyclohexane  (ISO)
Genipin  (ISO)
Geniposide  (ISO)
Gingerenone A  (ISO)
ginsenoside Rg2  (ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
GW 1929  (ISO)
GW 501516  (ISO)
haloperidol  (ISO)
harmine  (ISO)
hemin  (EXP)
herbicide  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
ICI 118551  (ISO)
Ile(5)-angiotensin II  (EXP)
imidacloprid  (ISO)
imisopasem manganese  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
inositol  (EXP)
inulin  (ISO)
ionomycin  (EXP)
iprodione  (EXP)
isobutanol  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isoxazoles  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
ketotifen  (ISO)
kresoxim-methyl  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
Licarin A  (ISO)
limonene  (ISO)
linagliptin  (EXP,ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
losartan  (EXP)
lovastatin  (ISO)
luzindole  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
mabuterol  (ISO)
Magnolol  (EXP)
malic acid  (ISO)
malonic acid  (ISO)
malvidin  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
meldonium  (EXP,ISO)
mesalamine  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP,ISO)
metoprolol  (EXP)
Mitoquinone  (EXP)
MitoTEMPO  (ISO)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP,ISO)
morphine hydrochloride  (EXP)
Morroniside  (ISO)
myo-inositol hexakisphosphate  (ISO)
N(6)-butyryl-cAMP  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-phosphocreatine  (EXP)
naringin  (EXP)
nebivolol  (ISO)
neohesperidin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitrites  (EXP)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
NMN zwitterion  (ISO)
nordihydroguaiaretic acid  (EXP)
NSC 23766  (ISO)
O-acetyl-L-carnitine  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
oleic acid  (ISO)
orientin  (ISO)
oxaloacetic acid  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
peroxynitrous acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
Phytolaccoside E  (ISO)
picloram  (ISO)
picoxystrobin  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(guanylic acid)  (EXP)
poly(vinylpyrrolidone)  (ISO)
potassium chloride  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP,ISO)
pramipexole  (EXP)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propionic acid  (ISO)
propranolol  (ISO)
prostaglandin D2  (ISO)
prostaglandin I2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
pyridaben  (ISO)
pyridoxine  (EXP,ISO)
pyrroloquinoline quinone  (EXP,ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-homocysteine  (ISO)
Salmeterol xinafoate  (ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
SB 431542  (ISO)
SB-239063  (EXP)
selenium atom  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver(1+) nitrate  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium hydrogensulfite  (EXP)
splitomicin  (EXP)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetradecanoic acid  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trichlopyr  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trilobatin  (EXP)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (EXP)
vorinostat  (ISO)
ziram  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (IEP)
adipose tissue development  (ISO)
autophagy of mitochondrion  (IEP)
cellular response to caffeine  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to fatty acid  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IDA)
cellular response to fructose stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to ionomycin  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to nitrite  (IEP)
cellular response to oxidative stress  (ISO,ISS)
cellular response to potassium ion  (IEP)
cellular response to resveratrol  (IEP)
cellular response to thyroid hormone stimulus  (IDA,IEP)
cellular response to transforming growth factor beta stimulus  (IDA)
cellular response to tumor necrosis factor  (IEP)
cerebellum development  (IEP)
circadian regulation of gene expression  (ISO,ISS)
developmental process  (IEA)
DNA-templated transcription  (IEA)
energy homeostasis  (IBA,ISO,ISS)
fatty acid oxidation  (IEP)
forebrain development  (IEP)
galactose metabolic process  (IEP)
gluconeogenesis  (IEA,IEP,ISO,ISS)
homeostatic process  (IEA)
mitochondrion organization  (IEA,IEP,IMP,ISO)
negative regulation of glycolytic process  (IMP)
negative regulation of mitochondrial fission  (IMP)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of protein phosphorylation  (IMP)
negative regulation of signaling receptor activity  (IMP)
negative regulation of smooth muscle cell migration  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP,ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of DNA-templated transcription  (IMP,ISO)
positive regulation of fatty acid oxidation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of podocyte apoptotic process  (IMP)
positive regulation of progesterone biosynthetic process  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of circadian rhythm  (ISO,ISS)
regulation of DNA-templated transcription  (ISO,ISS)
regulation of NMDA receptor activity  (IMP)
respiratory electron transport chain  (ISO,ISS)
response to activity  (IDA,IEP)
response to dehydroepiandrosterone  (IEP)
response to dietary excess  (ISO)
response to electrical stimulus  (IEP)
response to electrical stimulus involved in regulation of muscle adaptation  (IEP)
response to epinephrine  (IEP)
response to fructose  (IEP)
response to hypobaric hypoxia  (IEP)
response to hypoxia  (IEP)
response to ischemia  (IEP)
response to L-leucine  (IEP)
response to methionine  (IEP)
response to morphine  (IEP)
response to muscle activity  (IEA,IEP,ISO,ISS)
response to norepinephrine  (IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to reactive oxygen species  (IEP)
response to starvation  (IEP)
response to thyroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
rhythmic process  (IEA)
skeletal muscle atrophy  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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27. High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARalpha-FoxO3a-PGC-1alpha pathway. Chung HW, etal., Nephrol Dial Transplant. 2012 Jun;27(6):2213-25. doi: 10.1093/ndt/gfr613. Epub 2011 Nov 9.
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31. Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain. Cowell RM, etal., J Comp Neurol. 2007 May 1;502(1):1-18.
32. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cui L, etal., Cell. 2006 Oct 6;127(1):59-69.
33. The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells. Dimopoulos N, etal., FEBS Lett. 2007 Oct 2;581(24):4743-8. Epub 2007 Sep 6.
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62. Truncated peroxisome proliferator-activated receptor-gamma coactivator 1alpha splice variant is severely altered in Huntington's disease. Johri A, etal., Neurodegener Dis. 2011;8(6):496-503. doi: 10.1159/000327910. Epub 2011 Jul 15.
63. Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression. Kakuma T, etal., Endocrinology 2000 Dec;141(12):4576-82.
64. Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha. Karsenty J, etal., Eur J Nutr. 2013 Dec;52(8):1865-74. doi: 10.1007/s00394-012-0488-0. Epub 2012 Dec 27.
65. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion. Khader A, etal., Transplantation. 2014 Jul 27;98(2):148-56. doi: 10.1097/TP.0000000000000194.
66. Sequential signaling cascade of IL-6 and PGC-1alpha is involved in high glucose-induced podocyte loss and growth arrest. Kim DI and Park SH, Biochem Biophys Res Commun. 2013 Jun 14;435(4):702-7. doi: 10.1016/j.bbrc.2013.05.046. Epub 2013 May 18.
67. Suppression of PGC-1{alpha} (PPAR-gamma-coactivator-1{alpha}) normalizes the glucolipotoxicity induced decreased BETA2 gene transcription and improved glucose tolerance in diabetic rats. Kim JW, etal., Endocrinology. 2009 Jun 11.
68. beta-Adrenergic Stimulation Does Not Activate p38 MAPKinase or Induce PGC-1alpha in Skeletal Muscle. Kim SH, etal., Am J Physiol Endocrinol Metab. 2013 Mar 5.
69. Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression. Kusuhara K, etal., Biol Chem. 2007 May;388(5):481-8.
70. AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures. Labuzek K, etal., Neurotoxicology. 2010 Jan;31(1):134-46. doi: 10.1016/j.neuro.2009.10.006. Epub 2009 Oct 22.
71. PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study. Lai CQ, etal., Diabetes. 2008 Apr;57(4):809-16. Epub 2007 Dec 27.
72. Effect of chronic contractile activity on mRNA stability in skeletal muscle. Lai RY, etal., Am J Physiol Cell Physiol. 2010 Jul;299(1):C155-63. doi: 10.1152/ajpcell.00523.2009. Epub 2010 Apr 7.
73. Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. Lane RH, etal., Endocrinology 2002 Jul;143(7):2486-90.
74. Peroxisome proliferator-activated receptor delta agonist attenuates hepatic steatosis by anti-inflammatory mechanism. Lee MY, etal., Exp Mol Med. 2012 Oct 31;44(10):578-85. doi: 10.3858/emm.2012.44.10.066.
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78. A common variant in the peroxisome proliferator-activated receptor-gamma coactivator-1alpha gene is associated with nonalcoholic fatty liver disease in obese children. Lin YC, etal., Am J Clin Nutr. 2013 Feb;97(2):326-31. doi: 10.3945/ajcn.112.046417. Epub 2012 Dec 26.
79. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Ling C, etal., Diabetologia. 2008 Apr;51(4):615-22. Epub 2008 Feb 13.
80. [Increased expression of gluconeogenic enzymes in the liver of IUGR rats and subsequent insulin resistance]. Liu XM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):216-20.
81. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). Louet JF, etal., J Biol Chem 2002 Oct 11;277(41):37991-8000.
82. The neuroprotective effect of NeuroAid on morphine-induced amnesia with respect to the expression of TFAM, PGC-1α, ΔfosB and CART genes in the hippocampus of male Wistar rats. Malboosi N, etal., Gene. 2020 Jun 5;742:144601. doi: 10.1016/j.gene.2020.144601. Epub 2020 Mar 19.
83. Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats. Marosi K, etal., Neuroscience. 2012 Dec 13;226:21-8. doi: 10.1016/j.neuroscience.2012.09.001. Epub 2012 Sep 12.
84. Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter. Martin E, etal., Hum Mol Genet. 2011 Jun 15;20(12):2422-34. doi: 10.1093/hmg/ddr148. Epub 2011 Apr 14.
85. Differential regulation of PGC-1alpha expression in rat liver and skeletal muscle in response to voluntary running. Matiello R, etal., Nutr Metab (Lond). 2010 Apr 30;7:36.
86. Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. Menconi MJ, etal., Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E533-43. Epub 2010 Jul 20.
87. Quantitative immuno-electron microscopic analysis of depolarization-induced expression of PGC-1alpha in cultured rat visual cortical neurons. Meng H, etal., Brain Res. 2007 Oct 17;1175:10-6. Epub 2007 Aug 9.
88. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
89. Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase. Mo L, etal., Free Radic Biol Med. 2012 Oct 1;53(7):1440-50. doi: 10.1016/j.freeradbiomed.2012.07.080. Epub 2012 Aug 4.
90. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Muller YL, etal., Diabetes. 2003 Mar;52(3):895-8.
91. Disorder of fatty acid metabolism in the kidney of PAN-induced nephrotic rats. Muroya Y, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1070-9. doi: 10.1152/ajprenal.00365.2011. Epub 2012 Aug 8.
92. Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. Naples SP, etal., Appl Physiol Nutr Metab. 2010 Apr;35(2):151-62. doi: 10.1139/H09-139.
93. Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain. Naudi A, etal., Rejuvenation Res. 2007 Dec;10(4):473-84.
94. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
95. Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain. Ndubuizu OI, etal., Brain Res. 2010 Dec 17;1366:101-9. Epub 2010 Sep 25.
96. Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity. Oberkofler H, etal., J Biol Chem 2002 May 10;277(19):16750-7.
97. Transcutaneous application of carbon dioxide (CO2) induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo. Onishi Y, etal., PLoS One. 2012;7(11):e49189. doi: 10.1371/journal.pone.0049189. Epub 2012 Nov 15.
98. Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese. Pardina E, etal., BBA Clin. 2016 Jan 8;5:54-65. doi: 10.1016/j.bbacli.2015.12.002. eCollection 2016 Jun.
99. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. Patel SA, etal., Endocrinology. 2012 Nov;153(11):5231-46. doi: 10.1210/en.2012-1368. Epub 2012 Sep 18.
100. Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats. Paternain L, etal., Dis Model Mech. 2012 Sep;5(5):691-7. doi: 10.1242/dmm.009043. Epub 2012 Jul 5.
101. Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease. Patki G and Lau YS, Neurosci Lett. 2011 Nov 21;505(3):268-72. Epub 2011 Oct 21.
102. NO modulates the molecular basis of rat interscapular brown adipose tissue thermogenesis. Petrovic V, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2010 Aug;152(2):147-59. doi: 10.1016/j.cbpc.2010.03.008. Epub 2010 Apr 2.
103. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
104. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
105. Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells. Planavila A, etal., Biochim Biophys Acta. 2005 Sep 15;1736(2):120-7.
106. Methyl donor deficiency impairs fatty acid oxidation through PGC-1alpha hypomethylation and decreased ER-alpha, ERR-alpha, and HNF-4alpha in the rat liver. Pooya S, etal., J Hepatol. 2012 Aug;57(2):344-51. doi: 10.1016/j.jhep.2012.03.028. Epub 2012 Apr 17.
107. Association of the PGC-1alpha rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus. Prior SL, etal., Dis Markers. 2012;32(6):363-9. doi: 10.3233/DMA-2012-0894.
108. PGC-1alpha Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity. Puddifoot C, etal., J Neurosci. 2012 May 16;32(20):6995-7000.
109. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Qin W, etal., Arch Neurol. 2009 Mar;66(3):352-61. doi: 10.1001/archneurol.2008.588.
110. PGC-1{alpha} Attenuates Neointimal Formation via Inhibition of Vascular Smooth Muscle Cell Migration in the Injured Rat Carotid Artery. Qu A, etal., Am J Physiol Cell Physiol. 2009 Jun 24.
111. Population stratification may bias analysis of PGC-1alpha as a modifier of age at Huntington disease motor onset. Ramos EM, etal., Hum Genet. 2012 Dec;131(12):1833-40. doi: 10.1007/s00439-012-1205-z. Epub 2012 Jul 25.
112. The key role of PGC-1alpha in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure. Rao J, etal., Mol Cell Biochem. 2012 Aug;367(1-2):9-18. doi: 10.1007/s11010-012-1313-z. Epub 2012 Apr 15.
113. Pre-diabetes alters testicular PGC1-alpha/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress. Rato L, etal., Biochim Biophys Acta. 2014 Mar;1837(3):335-44. doi: 10.1016/j.bbabio.2013.12.008. Epub 2013 Dec 20.
114. GOA pipeline RGD automated data pipeline
115. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
116. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
117. Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. Ribel-Madsen R, etal., PLoS One. 2012;7(12):e51302. doi: 10.1371/journal.pone.0051302. Epub 2012 Dec 10.
118. Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers. Ringseis R, etal., J Nutr. 2013 Feb;143(2):125-31. doi: 10.3945/jn.112.164038. Epub 2012 Dec 19.
119. Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Rodriguez-Enriquez S, etal., Autophagy. 2009 Nov;5(8):1099-106. Epub 2009 Nov 13.
120. Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats. Ropelle ER, etal., J Physiol. 2009 May 1;587(Pt 9):2069-76. doi: 10.1113/jphysiol.2008.164202. Epub 2009 Mar 9.
121. Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes. Roy Chowdhury SK, etal., Brain. 2012 Jun;135(Pt 6):1751-66. doi: 10.1093/brain/aws097. Epub 2012 May 4.
122. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Russell LK, etal., Circ Res. 2004 Mar 5;94(4):525-33. Epub 2004 Jan 15.
123. PGC1alpha-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Ryan JJ, etal., Am J Respir Crit Care Med. 2013 Apr 15;187(8):865-78. doi: 10.1164/rccm.201209-1687OC.
124. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the omega-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. SanGiovanni JP, etal., PLoS One. 2013;8(1):e53155. doi: 10.1371/journal.pone.0053155. Epub 2013 Jan 15.
125. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Santos JM and Kowluru RA, Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8791-8. Print 2011.
126. Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations. Schlagowski AI, etal., J Appl Physiol (1985). 2014 Feb 15;116(4):364-75. doi: 10.1152/japplphysiol.01177.2013. Epub 2013 Dec 12.
127. PGC1alpha plays a critical role in TWEAK-induced cardiac dysfunction. Shi J, etal., PLoS One. 2013;8(1):e54054. doi: 10.1371/journal.pone.0054054. Epub 2013 Jan 16.
128. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Shin JH, etal., Cell. 2011 Mar 4;144(5):689-702.
129. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Siddiqui A, etal., Free Radic Biol Med. 2012 Aug 15;53(4):993-1003. doi: 10.1016/j.freeradbiomed.2012.05.024. Epub 2012 Jun 15.
130. The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is dependent on reactive oxygen species. Silveira LR, etal., Biochim Biophys Acta. 2006 Sep;1763(9):969-76. Epub 2006 Jul 7.
131. Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development. Sinha RA, etal., Biochem Biophys Res Commun. 2010 Jul 2;397(3):548-52. doi: 10.1016/j.bbrc.2010.05.154. Epub 2010 May 31.
132. AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle. Smith BK, etal., J Physiol. 2013 Mar 15;591(Pt 6):1551-61. doi: 10.1113/jphysiol.2012.245944. Epub 2013 Jan 7.
133. A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. Soyal SM, etal., Hum Mol Genet. 2012 May 28.
134. Skeletal muscle oxidative metabolism in an animal model of pulmonary emphysema: formoterol and skeletal muscle dysfunction. Sullo N, etal., Am J Respir Cell Mol Biol. 2013 Feb;48(2):198-203. doi: 10.1165/rcmb.2012-0167OC. Epub 2012 Nov 9.
135. Bone marrow-derived mononuclear cell therapy alleviates left ventricular remodeling and improves heart function in rat-dilated cardiomyopathy. Sun CK, etal., Crit Care Med. 2009 Apr;37(4):1197-205.
136. Nandrolone attenuates aortic adaptation to exercise in rats. Sun M, etal., Cardiovasc Res. 2013 Mar 15;97(4):686-95. doi: 10.1093/cvr/cvs423. Epub 2013 Jan 20.
137. Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model. Sung PH, etal., Int Heart J. 2009 Mar;50(2):191-206.
138. Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue. Sutherland LN, etal., J Physiol. 2009 Apr 1;587(Pt 7):1607-17. doi: 10.1113/jphysiol.2008.165464. Epub 2009 Feb 16.
139. Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo. Suwa M, etal., J Appl Physiol (1985). 2006 Dec;101(6):1685-92. Epub 2006 Aug 10.
140. Neuropathology of Partial PGC-1alpha Deficiency Recapitulates Features of Mitochondrial Encephalopathies but Not of Neurodegenerative Diseases. Szalardy L, etal., Neurodegener Dis. 2013 Feb 13.
141. PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease. Taherzadeh-Fard E, etal., Mol Neurodegener. 2011 May 19;6(1):32.
142. QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats. Tang DX, etal., Evid Based Complement Alternat Med. 2013;2013:480597. doi: 10.1155/2013/480597. Epub 2013 Feb 26.
143. Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Terada S, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):350-4.
144. Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. Thakran S, etal., J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
145. Decreased mRNA expression of PGC-1alpha and PGC-1alpha-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS. Thau N, etal., J Neuropathol Exp Neurol. 2012 Dec;71(12):1064-74. doi: 10.1097/NEN.0b013e318275df4b.
146. PGC-1alpha promotes recovery after acute kidney injury during systemic inflammation in mice. Tran M, etal., J Clin Invest. 2011 Oct;121(10):4003-14. doi: 10.1172/JCI58662. Epub 2011 Sep 1.
147. Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat. Varatharajalu R, etal., Am J Pathol. 2014 Jul;184(7):2035-44. doi: 10.1016/j.ajpath.2014.03.005. Epub 2014 May 6.
148. PGC1alpha Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress. Vazquez F, etal., Cancer Cell. 2013 Feb 12. pii: S1535-6108(13)00034-2. doi: 10.1016/j.ccr.2012.11.020.
149. Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats. Vlamings R, etal., Neurobiol Dis. 2012 Dec;48(3):488-94. doi: 10.1016/j.nbd.2012.07.006. Epub 2012 Jul 17.
150. Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat. Wadley GD, etal., Am J Physiol Endocrinol Metab. 2008 May;294(5):E861-9. doi: 10.1152/ajpendo.00037.2008. Epub 2008 Mar 4.
151. Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training. Wadley GD, etal., Am J Physiol Endocrinol Metab. 2013 Mar 5.
152. The role of PGC-1 and Apoepsilon4 in insomnia. Wang CC and Lung FW, Psychiatr Genet. 2012 Apr;22(2):82-7.
153. A single nucleotide polymorphism in the coding region of PGC-1alpha is a male-specific modifier of Huntington disease age-at-onset in a large European cohort. Weydt P, etal., BMC Neurol. 2014 Jan 2;14:1. doi: 10.1186/1471-2377-14-1.
154. The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease. Weydt P, etal., Mol Neurodegener. 2009 Jan 8;4:3. doi: 10.1186/1750-1326-4-3.
155. Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression. Wright DC, etal., J Biol Chem. 2007 Jan 5;282(1):194-9. Epub 2006 Nov 12.
156. Nandrolone normalizes determinants of muscle mass and fiber type after spinal cord injury. Wu Y, etal., J Neurotrauma. 2012 May 20;29(8):1663-75. Epub 2012 Apr 16.
157. PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy. Xiong S, etal., J Biol Chem. 2010 Jan 22;285(4):2474-87. doi: 10.1074/jbc.M109.065235. Epub 2009 Nov 23.
158. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1alpha expression. Xu W, etal., Exp Cell Res. 2011 May 1;317(8):1083-92. doi: 10.1016/j.yexcr.2010.10.006. Epub 2010 Oct 15.
159. The protective role of peroxisome proliferator-activated receptor gamma coactivator-1alpha in hyperthyroid cardiac hypertrophy. Xu W, etal., J Cell Physiol. 2012 Sep;227(9):3243-53. doi: 10.1002/jcp.24015.
160. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
161. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
162. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. Yang SJ, etal., PLoS One. 2011 Feb 23;6(2):e17057.
163. PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1. Yazawa T, etal., Mol Endocrinol. 2010 Mar;24(3):485-96. doi: 10.1210/me.2009-0352. Epub 2010 Feb 4.
164. Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Yoshizawa T, etal., Hypertension. 2013 Feb;61(2):341-51. doi: 10.1161/HYPERTENSIONAHA.111.00647. Epub 2013 Jan 7.
165. AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory factor 1 expression in rat visual cortical neurons. Yu L and Yang SJ, Neuroscience. 2010 Aug 11;169(1):23-38. doi: 10.1016/j.neuroscience.2010.04.063. Epub 2010 May 18.
166. Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1alpha-Sirt3 axis. Yu X, etal., Molecules. 2012 Sep 20;17(9):11216-28.
167. Activation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Yuan Y, etal., Kidney Int. 2012 Oct;82(7):771-89. doi: 10.1038/ki.2012.188. Epub 2012 May 30.
168. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
169. Novel Small-Molecule PGC-1alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice. Zhang LN, etal., Diabetes. 2012 Dec 18.
170. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Zhang M, etal., Mol Cell Endocrinol. 2012 Nov 5;363(1-2):122-30. doi: 10.1016/j.mce.2012.08.006. Epub 2012 Aug 16.
171. Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha). Zhang Y, etal., J Biol Chem. 2004 Dec 24;279(52):53963-71. Epub 2004 Oct 6.
172. The effect of overexpression of PGC-1alpha on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model. Zhao XY, etal., Hear Res. 2013 Feb;296:13-24. doi: 10.1016/j.heares.2012.11.007. Epub 2012 Nov 16.
173. Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. Zheng Z, etal., Diabetes. 2010 Sep;59(9):2315-25. Epub 2010 Jun 21.
174. Age-related decline of the cytochrome c oxidase subunit expression in the auditory cortex of the mimetic aging rat model associated with the common deletion. Zhong Y, etal., Hear Res. 2012 Dec;294(1-2):40-8. doi: 10.1016/j.heares.2012.09.006. Epub 2012 Sep 27.
175. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Zhou L, etal., Hepatology. 2012 Nov 23. doi: 10.1002/hep.26167.
176. PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. Zhu L, etal., PLoS One. 2009;4(1):e4182. doi: 10.1371/journal.pone.0004182. Epub 2009 Jan 14.
177. Diammonium glycyrrhizinate upregulates PGC-1alpha and protects against Abeta1-42-induced neurotoxicity. Zhu X, etal., PLoS One. 2012;7(4):e35823. Epub 2012 Apr 23.
Additional References at PubMed
PMID:10913342   PMID:12531492   PMID:12734114   PMID:12821652   PMID:14570700   PMID:14576981   PMID:14744933   PMID:15044597   PMID:15165993   PMID:15199055   PMID:15681609   PMID:15716268  
PMID:15733855   PMID:15967803   PMID:16014350   PMID:16271724   PMID:16352671   PMID:16488887   PMID:16720625   PMID:17239528   PMID:17273866   PMID:17284668   PMID:17476214   PMID:17488713  
PMID:17640976   PMID:17952069   PMID:18555842   PMID:18789599   PMID:18798693   PMID:18972406   PMID:18993053   PMID:19082571   PMID:19179292   PMID:19345188   PMID:19389810   PMID:19542216  
PMID:19651776   PMID:19686839   PMID:19698760   PMID:19766270   PMID:19773550   PMID:19774670   PMID:19774674   PMID:20086200   PMID:20143420   PMID:20359506   PMID:20385772   PMID:20457122  
PMID:20566846   PMID:20661474   PMID:20799369   PMID:20849372   PMID:21106753   PMID:21162799   PMID:21307617   PMID:21536107   PMID:21590341   PMID:21789886   PMID:21972093   PMID:21994947  
PMID:22064484   PMID:22234788   PMID:22237023   PMID:22342160   PMID:22354784   PMID:22461724   PMID:22533417   PMID:22738191   PMID:22899824   PMID:23117952   PMID:23139024   PMID:23212379  
PMID:23292098   PMID:23505321   PMID:23515531   PMID:23525105   PMID:23525500   PMID:23602251   PMID:23635713   PMID:23836911   PMID:23880578   PMID:23948478   PMID:23994518   PMID:24005768  
PMID:24084166   PMID:24096033   PMID:24562467   PMID:24726645   PMID:24898700   PMID:25118933   PMID:25333348   PMID:25402826   PMID:25572651   PMID:25675425   PMID:25824459   PMID:25853493  
PMID:25972379   PMID:26020641   PMID:26054747   PMID:26102301   PMID:26118953   PMID:26287659   PMID:26310573   PMID:26844631   PMID:27076782   PMID:27132229   PMID:27174562   PMID:27178364  
PMID:27302464   PMID:27453548   PMID:27526155   PMID:27793739   PMID:28467933   PMID:28482939   PMID:29383690   PMID:29543139   PMID:29604268   PMID:29901150   PMID:29913155   PMID:30221360  
PMID:30223807   PMID:30396162   PMID:30541949   PMID:30664159   PMID:30676864   PMID:31085594   PMID:31238070   PMID:31242648   PMID:31340436   PMID:31471878   PMID:31778153   PMID:32114097  
PMID:32121211   PMID:32305957   PMID:32323734   PMID:32529514   PMID:32851675   PMID:33008083   PMID:33268575   PMID:33576345   PMID:33625690   PMID:33661552   PMID:33847873   PMID:34482051  
PMID:34530866   PMID:34576046   PMID:34636198   PMID:35180801   PMID:35395161   PMID:35569770   PMID:35883637   PMID:36414561   PMID:36481985   PMID:36922709   PMID:37085803   PMID:37526811  
PMID:37962014   PMID:38139395   PMID:38677116  


Genomics

Comparative Map Data
Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1463,273,189 - 63,729,213 (+)EnsemblGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)Ensemblrn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1458,516,257 - 58,607,916 (+)NCBICelera
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Cytogenetic Map14q11NCBI
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl423,755,041 - 23,904,089 (-)Ensemblhg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
T2T-CHM13v2.0423,773,791 - 24,454,625 (-)NCBIT2T-CHM13v2.0
Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)Ensemblmm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)Ensembl
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)EnsemblpanPan2panpan1.1
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,992,463 - 87,261,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364775,199,881 - 5,488,226 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,946,992 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247558,375,596 - 8,465,297 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppargc1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,020,476 - 54,669,089 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppargc1a
3972 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:28
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000006071
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
MARC_49176-49177:1118326844:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21459,495,697 - 59,496,182 (+)MAPPERmRatBN7.2
Rnor_6.01463,169,863 - 63,170,347NCBIRnor6.0
Rnor_5.01463,269,140 - 63,269,624UniSTSRnor5.0
RGSC_v3.41464,352,392 - 64,352,876UniSTSRGSC3.4
Celera1458,590,965 - 58,591,449UniSTS
Cytogenetic Map14q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 43 59 6 307 143 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB025784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY237127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY382577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC227803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006071   ⟹   ENSRNOP00000006071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,634,259 - 63,725,848 (+)Ensembl
mRatBN7.2 Ensembl1459,421,542 - 59,512,656 (+)Ensembl
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105198   ⟹   ENSRNOP00000076568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,639,158 - 63,729,213 (+)Ensembl
mRatBN7.2 Ensembl1459,426,456 - 59,512,656 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108897   ⟹   ENSRNOP00000086053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,634,259 - 63,726,255 (+)Ensembl
mRatBN7.2 Ensembl1459,421,606 - 59,512,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116869   ⟹   ENSRNOP00000093101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,273,189 - 63,729,213 (+)Ensembl
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133457   ⟹   ENSRNOP00000098873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,621,638 - 63,729,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138915   ⟹   ENSRNOP00000100468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,273,189 - 63,729,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143067   ⟹   ENSRNOP00000112414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,637,911 - 63,729,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145100   ⟹   ENSRNOP00000102592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,634,259 - 63,729,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147736   ⟹   ENSRNOP00000102276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,551,980 - 63,729,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170033   ⟹   ENSRNOP00000101841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1463,635,053 - 63,729,213 (+)Ensembl
RefSeq Acc Id: NM_031347   ⟹   NP_112637
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,308 - 63,725,344 (+)NCBI
mRatBN7.21459,421,606 - 59,512,656 (+)NCBI
Rnor_6.01463,095,827 - 63,186,819 (+)NCBI
Rnor_5.01463,182,479 - 63,286,252 (+)NCBI
RGSC_v3.41464,278,115 - 64,370,912 (+)RGD
Celera1458,516,257 - 58,607,916 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092489   ⟹   XP_038948417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,129 - 63,729,215 (+)NCBI
mRatBN7.21459,421,414 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092490   ⟹   XP_038948418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,620,036 - 63,729,215 (+)NCBI
mRatBN7.21459,407,506 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092491   ⟹   XP_038948419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,073,505 - 63,729,215 (+)NCBI
mRatBN7.21458,860,752 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092492   ⟹   XP_038948420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,131 - 63,729,215 (+)NCBI
mRatBN7.21459,421,852 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_063273669   ⟹   XP_063129739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,620,036 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273670   ⟹   XP_063129740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,073,505 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273671   ⟹   XP_063129741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,125 - 63,725,858 (+)NCBI
RefSeq Acc Id: XM_063273672   ⟹   XP_063129742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,127 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273673   ⟹   XP_063129743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,131 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273674   ⟹   XP_063129744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,635,467 - 63,729,215 (+)NCBI
RefSeq Acc Id: NP_112637   ⟸   NM_031347
- UniProtKB: Q9QYK2 (UniProtKB/Swiss-Prot),   A6IJI5 (UniProtKB/TrEMBL),   A0A8I5Y905 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006071   ⟸   ENSRNOT00000006071
RefSeq Acc Id: XP_038948419   ⟸   XM_039092491
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948418   ⟸   XM_039092490
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948417   ⟸   XM_039092489
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948420   ⟸   XM_039092492
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086053   ⟸   ENSRNOT00000108897
Ensembl Acc Id: ENSRNOP00000093101   ⟸   ENSRNOT00000116869
Ensembl Acc Id: ENSRNOP00000076568   ⟸   ENSRNOT00000105198
RefSeq Acc Id: XP_063129740   ⟸   XM_063273670
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL),   A0A8I6AWK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129739   ⟸   XM_063273669
- Peptide Label: isoform X5
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129741   ⟸   XM_063273671
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A531 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129742   ⟸   XM_063273672
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A531 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129743   ⟸   XM_063273673
- Peptide Label: isoform X9
- UniProtKB: A0A8L2Q1Y2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129744   ⟸   XM_063273674
- Peptide Label: isoform X9
- UniProtKB: A0A8L2Q1Y2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098873   ⟸   ENSRNOT00000133457
Ensembl Acc Id: ENSRNOP00000102592   ⟸   ENSRNOT00000145100
Ensembl Acc Id: ENSRNOP00000100468   ⟸   ENSRNOT00000138915
Ensembl Acc Id: ENSRNOP00000102276   ⟸   ENSRNOT00000147736
Ensembl Acc Id: ENSRNOP00000112414   ⟸   ENSRNOT00000143067
Ensembl Acc Id: ENSRNOP00000101841   ⟸   ENSRNOT00000170033
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYK2-F1-model_v2 AlphaFold Q9QYK2 1-796 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699342
Promoter ID:EPDNEW_R9866
Type:multiple initiation site
Name:Ppargc1a_1
Description:PPARG coactivator 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01463,095,778 - 63,095,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620925 AgrOrtholog
BioCyc Gene G2FUF-15584 BioCyc
Ensembl Genes ENSRNOG00000004473 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000108897 ENTREZGENE
  ENSRNOT00000116869 ENTREZGENE
  ENSRNOT00000133457 ENTREZGENE
  ENSRNOT00000145100 ENTREZGENE
  ENSRNOT00000170033 ENTREZGENE
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PGC-1 UniProtKB/Swiss-Prot
  PPARGC1A_RRM UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:83516 UniProtKB/Swiss-Prot
NCBI Gene 83516 ENTREZGENE
PANTHER PTHR15528 UniProtKB/Swiss-Prot
  PTHR15528:SF10 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Ppargc1a PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004473 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8I5Y905 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A531 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q1Y2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KWK4_RAT UniProtKB/TrEMBL
  A0ABK0KZ43_RAT UniProtKB/TrEMBL
  A0ABK0L1Q3_RAT UniProtKB/TrEMBL
  A0ABK0LAS6_RAT UniProtKB/TrEMBL
  A0ABK0MAT0_RAT UniProtKB/TrEMBL
  A6IJI5 ENTREZGENE, UniProtKB/TrEMBL
  A6IJI6_RAT UniProtKB/TrEMBL
  A6IJI7_RAT UniProtKB/TrEMBL
  PRGC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ppargc1a  PPARG coactivator 1 alpha  Ppargc1a  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ppargc1a  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Ppargc1a  peroxisome proliferative activated receptor, gamma, coactivator 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Ppargc1a  peroxisome proliferative activated receptor, gamma, coactivator 1 alpha  Ppargc1  peroxisome proliferative activated receptor, gamma, coactivator 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ppargc1  peroxisome proliferative activated receptor, gamma, coactivator 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process regulates gluconeogenic genes by cAMP and glucocorticoids; induces liver carnitine palmitoyltransferase I gene expression by cAMP 633650