Ugt2b35 (UDP glucuronosyltransferase 2 family, polypeptide B35) - Rat Genome Database

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Gene: Ugt2b35 (UDP glucuronosyltransferase 2 family, polypeptide B35) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
RGD ID: 620895
Description: Predicted to enable glucuronosyltransferase activity. Involved in response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93327; UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glucuronosyltransferase 2 family, polypeptide B36; UDP glycosyltransferase 2 family, polypeptide B4; UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 2B12; UDP-glucuronosyltransferase 2B15; UDP-glucuronosyltransferase 2B36; UDP-glucuronosyltransferase 2B4; UDPGT 2B12; UDPGT 2B15; UDPGT 2B36; UDPGT 2B4; Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,208,389 - 21,245,893 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,208,430 - 21,246,694 (+)EnsemblGRCr8
mRatBN7.21420,853,441 - 20,891,039 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,853,587 - 20,891,037 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1421,191,279 - 21,229,131 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,510,208 - 22,548,062 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,041,310 - 21,079,160 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,553,633 - 22,591,461 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,553,650 - 22,591,461 (+)Ensemblrn6Rnor6.0
Rnor_5.01422,455,301 - 22,493,180 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,454,256 - 22,493,510 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,358,391 - 20,395,704 (+)NCBICelera
RGSC_v3.11422,454,274 - 22,493,504 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. Green MD, etal., Arch Biochem Biophys 1995 Oct 1;322(2):460-8.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog, and monkey liver microsomes and by expressed rat and human UDP-glucuronosyltransferases. Xu L, etal., Drug Metab Dispos. 2006 Aug;34(8):1406-10. Epub 2006 May 23.
Additional References at PubMed
PMID:1906977   PMID:12477932   PMID:28442641  


Genomics

Variants

.
Variants in Ugt2b35
203 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
13 8 14 55 91 87 59 23 59 6 208 57 35 71 54 28

Sequence


Ensembl Acc Id: ENSRNOT00000002712   ⟹   ENSRNOP00000002712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,208,430 - 21,246,694 (+)Ensembl
mRatBN7.2 Ensembl1420,853,587 - 20,891,037 (+)Ensembl
Rnor_6.0 Ensembl1422,553,662 - 22,591,461 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092201   ⟹   ENSRNOP00000074037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1422,553,650 - 22,590,423 (+)Ensembl
RefSeq Acc Id: NM_001004271   ⟹   NP_001004271
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,208,441 - 21,245,893 (+)NCBI
mRatBN7.21420,853,587 - 20,891,039 (+)NCBI
Rnor_6.01422,553,662 - 22,591,461 (+)NCBI
Rnor_5.01422,455,301 - 22,493,180 (+)NCBI
RGSC_v3.41422,454,256 - 22,493,510 (+)RGD
Celera1420,358,391 - 20,395,704 (+)RGD
Sequence:
RefSeq Acc Id: XM_008770060   ⟹   XP_008768282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,208,389 - 21,226,726 (+)NCBI
mRatBN7.21420,853,441 - 20,861,373 (+)NCBI
Rnor_6.01422,553,633 - 22,561,154 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001004271 (Get FASTA)   NCBI Sequence Viewer  
  XP_008768282 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA83404 (Get FASTA)   NCBI Sequence Viewer  
  AAA83405 (Get FASTA)   NCBI Sequence Viewer  
  AAH78782 (Get FASTA)   NCBI Sequence Viewer  
  EDL89823 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002712
GenBank Protein P36511 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004271   ⟸   NM_001004271
- Peptide Label: precursor
- UniProtKB: P36511 (UniProtKB/Swiss-Prot),   Q68G19 (UniProtKB/TrEMBL),   F7FMW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768282   ⟸   XM_008770060
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000074037   ⟸   ENSRNOT00000092201
Ensembl Acc Id: ENSRNOP00000002712   ⟸   ENSRNOT00000002712

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36511-F1-model_v2 AlphaFold P36511 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699265
Promoter ID:EPDNEW_R9780
Type:multiple initiation site
Name:Ugt2b35_1
Description:UDP glucuronosyltransferase 2 family, polypeptide B35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,553,651 - 22,553,711EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620895 AgrOrtholog
BioCyc Gene G2FUF-16100 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6398 [melatonin degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
  PWY-6261 BioCyc
  PWY-6313 BioCyc
  PWY-6398 BioCyc
Ensembl Genes ENSRNOG00000001980 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002712 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107952 IMAGE-MGC_LOAD
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:93327 IMAGE-MGC_LOAD
NCBI Gene 83808 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP-GLUCURONOSYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PharmGKB UGT2B15 RGD
PhenoGen Ugt2b35 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001980 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt F7FMW8 ENTREZGENE, UniProtKB/TrEMBL
  P36511 ENTREZGENE
  Q68G19 ENTREZGENE, UniProtKB/TrEMBL
  UDB15_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Ugt2b35  UDP glucuronosyltransferase 2 family, polypeptide B35  Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Ugt2b15  UDP glucuronosyltransferase 2 family, polypeptide B15  Ugt2b36  UDP glucuronosyltransferase 2 family, polypeptide B36  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Ugt2b36  UDP glucuronosyltransferase 2 family, polypeptide B36  Ugt2b4  UDP glycosyltransferase 2 family, polypeptide B4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ugt2b4  UDP glycosyltransferase 2 family, polypeptide B4  Ugt2b12  UDP-glucuronosyltransferase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ugt2b12  UDP-glucuronosyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein subunit molecular mass of 53 kDa 729992