P2ry2 (purinergic receptor P2Y2) - Rat Genome Database

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Gene: P2ry2 (purinergic receptor P2Y2) Rattus norvegicus
Analyze
Symbol: P2ry2
Name: purinergic receptor P2Y2
RGD ID: 62088
Description: Enables A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Involved in several processes, including G protein-coupled purinergic nucleotide receptor signaling pathway; positive regulation of penile erection; and regulation of secretion by cell. Located in apical plasma membrane; basolateral plasma membrane; and early endosome. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study impotence. Orthologous to human P2RY2 (purinergic receptor P2Y2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP receptor; P2U purinoceptor 1; P2U1; P2Y ATP receptor 2; P2Y purinoceptor 2; P2Y2; purinergic receptor P2Y, G-protein coupled 2; purinergic receptor P2Y, G-protein coupled, 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: P2ry2em6Mcwi ; P2ry2em7Mcwi
Genetic Models: SS-P2ry2em7Mcwi ; SS-P2ry2em6Mcwi
Is Marker For: Strains:   SD-Tg(Ubc-P2ry2)Besey
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,764,119 - 164,779,578 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1164,759,213 - 164,781,852 (-)EnsemblGRCr8
mRatBN7.21155,352,050 - 155,367,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,351,165 - 155,367,632 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1163,337,941 - 163,353,249 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,518,048 - 170,533,356 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,401,414 - 163,416,730 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,031,228 - 166,045,423 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,031,272 - 166,037,424 (-)Ensemblrn6Rnor6.0
Rnor_5.01172,227,726 - 172,241,921 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41158,440,018 - 158,454,213 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1153,434,723 - 153,448,921 (-)NCBICelera
RGSC_v3.11158,519,034 - 158,533,227 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
ATP  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenamidone  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glycidol  (EXP)
Goe 6976  (EXP)
hydrogen sulfide  (ISO)
ibuprofen  (ISO)
L-methionine  (ISO)
methamphetamine  (ISO)
methylarsonic acid  (ISO)
methylmercury(1+)  (EXP)
N-(3-oxododecanoyl)homoserine lactone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentanal  (ISO)
phenformin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
quercetin  (ISO)
rotenone  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
suramin  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (EXP)
urethane  (ISO)
UTP  (EXP,ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Development of a novel transgenic rat overexpressing the P2Y(2) nucleotide receptor using a lentiviral vector. Agca C, etal., J Vasc Res. 2009;46(5):447-58. Epub 2009 Jan 21.
2. P2Y2 receptor up-regulation induced by guanosine or UTP in rat brain cultured astrocytes. Ballerini P, etal., Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):293-308.
3. Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor. Chen ZP, etal., Endocrinology 1996 May;137(5):1833-40.
4. Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Cheung KK, etal., Dev Dyn. 2003 Oct;228(2):254-66.
5. P2Y receptors activate neuroprotective mechanisms in astrocytic cells. Chorna NE, etal., J Neurochem. 2004 Oct;91(1):119-32.
6. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
7. Long-term exposure to LPS enhances the rate of stimulated exocytosis and surfactant secretion in alveolar type II cells and upregulates P2Y2 receptor expression. Garcia-Verdugo I, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L708-17. Epub 2008 Aug 8.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Greig AV, etal., Exp Dermatol. 2003 Dec;12(6):860-71.
10. Management of erectile function by penile purinergic p2 receptors in the diabetic rat. Gur S, etal., J Urol. 2009 May;181(5):2375-82. Epub 2009 Mar 19.
11. ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. Hoebertz A, etal., J Cell Biochem 2002;86(3):413-9.
12. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. Honda S, etal., J Neurosci. 2001 Mar 15;21(6):1975-82.
13. Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. Horiuchi T, etal., Stroke. 2003 Jun;34(6):1473-8. Epub 2003 May 1.
14. P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Kishore BK, etal., Am J Physiol Renal Physiol. 2005 Jun;288(6):F1164-72. Epub 2005 Feb 1.
15. Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor. Kong Q, etal., J Neurochem. 2009 Jun;109(5):1300-10. Epub 2009 Mar 20.
16. Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Krzeminski P, etal., Brain Res Bull. 2007 Mar 30;71(6):587-92. Epub 2006 Dec 22.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Age-related changes in P2 receptor mRNA of rat cerebral arteries. Miao LY, etal., Exp Gerontol. 2001 Dec;37(1):67-79.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. Pillois X, etal., Circ Res 2002 Apr 5;90(6):678-81.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. Rodrigues RJ, etal., J Neurosci. 2005 Jul 6;25(27):6286-95.
25. Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta. Seye CI, etal., Arterioscler Thromb Vasc Biol 1997 Dec;17(12):3602-10.
26. Purinergic P2Y2 receptors induce increased MCP-1/CCL2 synthesis and release from rat alveolar and peritoneal macrophages. Stokes L and Surprenant A, J Immunol. 2007 Nov 1;179(9):6016-23.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Sun R, etal., Am J Physiol Renal Physiol. 2005 Sep;289(3):F585-92. Epub 2005 Apr 19.
29. Endocytosis mechanism of P2Y2 nucleotide receptor tagged with green fluorescent protein: clathrin and actin cytoskeleton dependence. Tulapurkar ME, etal., Cell Mol Life Sci. 2005 Jun;62(12):1388-99.
30. Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Yajima H, etal., Neurosci Res. 2005 Apr;51(4):405-16. Epub 2005 Jan 20.
31. Heteromeric association creates a P2Y-like adenosine receptor. Yoshioka K, etal., Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7617-22. Epub 2001 Jun 5.
Additional References at PubMed
PMID:7811468   PMID:12850289   PMID:14764443   PMID:15258260   PMID:15489334   PMID:16075244   PMID:16135088   PMID:16365320   PMID:16597733   PMID:17599409   PMID:17728398   PMID:18216148  
PMID:18337312   PMID:19140137   PMID:19191015   PMID:19244398   PMID:20007349   PMID:20619335   PMID:21296070   PMID:21300137   PMID:21487675   PMID:22733659   PMID:23249537   PMID:23592515  
PMID:23620825   PMID:23828651   PMID:24642246   PMID:24760984   PMID:24771361   PMID:26070527   PMID:26531757   PMID:28468962   PMID:28828576   PMID:30273839   PMID:30624816   PMID:31173231  
PMID:32751703   PMID:34780922   PMID:35154311   PMID:38043889  


Genomics

Comparative Map Data
P2ry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,764,119 - 164,779,578 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1164,759,213 - 164,781,852 (-)EnsemblGRCr8
mRatBN7.21155,352,050 - 155,367,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,351,165 - 155,367,632 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1163,337,941 - 163,353,249 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,518,048 - 170,533,356 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,401,414 - 163,416,730 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,031,228 - 166,045,423 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,031,272 - 166,037,424 (-)Ensemblrn6Rnor6.0
Rnor_5.01172,227,726 - 172,241,921 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41158,440,018 - 158,454,213 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1153,434,723 - 153,448,921 (-)NCBICelera
RGSC_v3.11158,519,034 - 158,533,227 (-)NCBI
Cytogenetic Map1q32NCBI
P2RY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,218,281 - 73,242,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,216,664 - 73,242,427 (+)Ensemblhg38GRCh38
GRCh371172,929,326 - 72,953,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,606,992 - 72,625,045 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341172,606,991 - 72,625,041NCBI
Celera1170,233,951 - 70,251,998 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,224,261 - 69,248,426 (+)NCBIHuRef
CHM1_11172,813,103 - 72,837,239 (+)NCBICHM1_1
T2T-CHM13v2.01173,146,472 - 73,170,656 (+)NCBIT2T-CHM13v2.0
P2ry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,645,775 - 100,661,260 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,645,775 - 100,662,073 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387100,996,568 - 101,012,053 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,996,568 - 101,012,866 (-)Ensemblmm10GRCm38
MGSCv377108,145,086 - 108,160,505 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367100,870,659 - 100,886,078 (-)NCBIMGSCv36mm8
Celera7101,348,339 - 101,363,985 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.47NCBI
P2ry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,248,082 - 18,260,450 (-)Ensembl
ChiLan1.0NW_00495541418,248,082 - 18,271,047 (-)NCBIChiLan1.0ChiLan1.0
P2RY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,162,581 - 74,187,602 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,206,019 - 75,231,038 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,294,366 - 68,319,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11171,517,063 - 71,541,109 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,532,958 - 71,534,091 (+)EnsemblpanPan2panpan1.1
P2RY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,987,568 - 25,009,754 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,992,848 - 24,996,059 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2124,753,351 - 24,793,458 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02125,195,604 - 25,235,719 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,195,629 - 25,216,051 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,989,138 - 25,029,222 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,190,157 - 25,231,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02125,105,502 - 25,145,605 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
P2ry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,831,899 - 60,845,324 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364982,432,448 - 2,444,354 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364982,432,436 - 2,444,495 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,672,403 - 7,695,163 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.197,672,294 - 7,695,085 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
P2RY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,461,929 - 64,481,429 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,479,642 - 64,480,775 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604361,405,464 - 61,424,948 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,706,017 - 3,719,649 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248173,706,017 - 3,721,045 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
P2ry2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1299,295,734 - 99,309,793 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in P2ry2
92 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:144
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000026115
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
PMC96855P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,353,908 - 155,354,686 (+)MAPPERmRatBN7.2
Rnor_6.01166,031,921 - 166,032,698NCBIRnor6.0
Rnor_5.01172,228,419 - 172,229,196UniSTSRnor5.0
RGSC_v3.41158,440,711 - 158,441,488UniSTSRGSC3.4
Celera1153,435,416 - 153,436,193UniSTS
Cytogenetic Map1q32UniSTS


Related Rat Strains
The following Strains have been annotated to P2ry2
SD-Tg(Ubc-P2ry2)Besey    


Genetic Models
This gene P2ry2 is modified in the following models/strains:
SS-P2ry2em7Mcwi     SS-P2ry2em6Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 153 91 90 59 86 59 6 357 186 11 133 88 93 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000026115   ⟹   ENSRNOP00000026115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,764,528 - 164,776,327 (-)Ensembl
mRatBN7.2 Ensembl1155,352,068 - 155,363,697 (-)Ensembl
Rnor_6.0 Ensembl1166,031,272 - 166,037,424 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114931   ⟹   ENSRNOP00000077949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,759,213 - 164,781,852 (-)Ensembl
mRatBN7.2 Ensembl1155,351,165 - 155,367,632 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139713   ⟹   ENSRNOP00000106977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,765,329 - 164,776,327 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147157   ⟹   ENSRNOP00000104809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,765,329 - 164,776,327 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154732   ⟹   ENSRNOP00000107515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1164,764,528 - 164,776,327 (-)Ensembl
RefSeq Acc Id: NM_017255   ⟹   NP_058951
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,764,119 - 164,779,488 (-)NCBI
mRatBN7.21155,352,050 - 155,367,423 (-)NCBI
Rnor_6.01166,031,228 - 166,045,423 (-)NCBI
Rnor_5.01172,227,726 - 172,241,921 (-)NCBI
RGSC_v3.41158,440,018 - 158,454,213 (-)RGD
Celera1153,434,723 - 153,448,921 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229757   ⟹   XP_006229819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,764,130 - 164,779,578 (-)NCBI
mRatBN7.21155,352,050 - 155,367,102 (-)NCBI
Rnor_6.01166,031,272 - 166,045,155 (-)NCBI
Rnor_5.01172,227,726 - 172,241,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109599   ⟹   XP_038965527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,764,130 - 164,775,781 (-)NCBI
mRatBN7.21155,352,050 - 155,364,030 (-)NCBI
RefSeq Acc Id: XM_063287642   ⟹   XP_063143712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,764,130 - 164,774,571 (-)NCBI
RefSeq Acc Id: NP_058951   ⟸   NM_017255
- UniProtKB: P41232 (UniProtKB/Swiss-Prot),   G3V8H8 (UniProtKB/TrEMBL),   A6I6S6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229819   ⟸   XM_006229757
- Peptide Label: isoform X1
- UniProtKB: P41232 (UniProtKB/Swiss-Prot),   G3V8H8 (UniProtKB/TrEMBL),   A6I6S6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026115   ⟸   ENSRNOT00000026115
RefSeq Acc Id: XP_038965527   ⟸   XM_039109599
- Peptide Label: isoform X1
- UniProtKB: P41232 (UniProtKB/Swiss-Prot),   G3V8H8 (UniProtKB/TrEMBL),   A6I6S6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077949   ⟸   ENSRNOT00000114931
RefSeq Acc Id: XP_063143712   ⟸   XM_063287642
- Peptide Label: isoform X1
- UniProtKB: P41232 (UniProtKB/Swiss-Prot),   A6I6S6 (UniProtKB/TrEMBL),   G3V8H8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106977   ⟸   ENSRNOT00000139713
Ensembl Acc Id: ENSRNOP00000104809   ⟸   ENSRNOT00000147157
Ensembl Acc Id: ENSRNOP00000107515   ⟸   ENSRNOT00000154732
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41232-F1-model_v2 AlphaFold P41232 1-374 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62088 AgrOrtholog
BioCyc Gene G2FUF-58309 BioCyc
Ensembl Genes ENSRNOG00000019283 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026115 ENTREZGENE
  ENSRNOT00000114931 ENTREZGENE
  ENSRNOT00000154732 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599916 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  P2Y2_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:29597 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72498 IMAGE-MGC_LOAD
NCBI Gene 29597 ENTREZGENE
PANTHER PTHR24231:SF17 UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB P2RY2 RGD
PhenoGen P2ry2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  P2Y2PRNOCPTR UniProtKB/Swiss-Prot
  P2YPURNOCPTR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019283 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6I6S6 ENTREZGENE, UniProtKB/TrEMBL
  G3V8H8 ENTREZGENE, UniProtKB/TrEMBL
  P2RY2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry2  purinergic receptor P2Y2  P2ry2  purinergic receptor P2Y, G-protein coupled, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-01-14 P2ry2  purinergic receptor P2Y, G-protein coupled, 2  P2ry2  purinergic receptor P2Y, G-protein coupled 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P2ry2  purinergic receptor P2Y, G-protein coupled 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression highly expressed in the neointima of injured arteries 729586
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_process mediates vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_protein 374 amino acids 729586
gene_regulation activated by ADP and UTP 729586
gene_regulation activated mainly by ADP and UTP 628452