Npr2 (natriuretic peptide receptor 2) - Rat Genome Database

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Gene: Npr2 (natriuretic peptide receptor 2) Rattus norvegicus
Analyze
Symbol: Npr2
Name: natriuretic peptide receptor 2
RGD ID: 620851
Description: Enables peptide hormone binding activity. Involved in cGMP-mediated signaling; positive regulation of signal transduction; and wound healing. Predicted to be located in membrane and synapse. Predicted to be active in several cellular components, including cilium; neuron projection; and nucleus. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2); PARTICIPATES IN C-type natriuretic peptide signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ANP-B; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B; NPR-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,678,197 - 62,697,360 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl562,678,367 - 62,697,343 (+)EnsemblGRCr8
mRatBN7.2557,883,171 - 57,901,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx559,863,179 - 59,881,665 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,681,991 - 61,700,479 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,653,242 - 61,671,683 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,128,186 - 59,147,321 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,128,315 - 59,147,255 (+)Ensemblrn6Rnor6.0
Rnor_5.0563,652,957 - 63,672,114 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,107,563 - 60,127,960 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,463,705 - 56,482,048 (+)NCBICelera
RGSC_v3.1560,107,741 - 60,128,139 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonia  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
furan  (EXP)
indometacin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrethrins  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of meiosis involved in egg activation  (IEA,ISO)
axonogenesis  (IEA,ISO)
axonogenesis involved in innervation  (IEA,ISO)
blood circulation  (IEA,ISO)
blood vessel development  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
bone development  (ISO)
bone growth  (IEA,ISO)
c-di-GMP signaling  (IEA,ISO)
cartilage development  (IEA,ISO)
cellular response to cGMP  (IEA,ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IEA,ISO)
cellular response to peptide  (IEA,ISO)
cGMP biosynthetic process  (IBA,IDA,IEA,ISO)
cGMP metabolic process  (IEA,ISO)
chemical synaptic transmission  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
chromosome organization  (IEA,ISO)
collateral sprouting  (IEA,ISO)
cumulus cell differentiation  (IEA,ISO)
cyclic nucleotide biosynthetic process  (IEA)
digestive tract development  (IEA,ISO)
digestive tract morphogenesis  (IEA,ISO)
endochondral ossification  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
execution phase of apoptosis  (IEA,ISO)
female genitalia development  (IEA,ISO)
gastric emptying  (IEA,ISO)
genitalia morphogenesis  (IEA,ISO)
germ cell development  (IEA,ISO)
growth plate cartilage development  (IEA,ISO)
intracellular signal transduction  (IEA)
limb development  (IEA,ISO)
limb morphogenesis  (IEA,ISO)
lymph vessel development  (IEA,ISO)
MAPK cascade  (IEA,ISO)
meiotic cell cycle process involved in oocyte maturation  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of meiotic cell cycle  (ISO)
negative regulation of oocyte maturation  (ISO)
nerve development  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuronal action potential  (IEA,ISO)
oocyte development  (IEA,ISO)
ossification  (IEA)
ovarian follicle development  (IEA,ISO)
positive regulation of platelet-derived growth factor receptor signaling pathway  (IMP)
post-anal tail morphogenesis  (IEA,ISO)
receptor guanylyl cyclase signaling pathway  (IBA,IEA,ISO,ISS)
response to fibroblast growth factor  (IEA,ISO)
response to hormone  (IEA,ISO)
response to luteinizing hormone  (IEA,ISO)
response to salt  (IEA,ISO)
response to wounding  (IEA,ISO)
sensory perception of sound  (IEA,ISO)
single fertilization  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO)
spermatogenesis  (IEA,ISO)
startle response  (IEA,ISO)
vacuole organization  (IEA,ISO)
vascular wound healing  (IEA,ISO)
vasculogenesis  (IEA,ISO)
vestibulocochlear nerve development  (IEA,ISO)
vestibulocochlear nerve maturation  (IEA,ISO)
white fat cell differentiation  (IEA,ISO)
wound healing  (IEA,IMP)

Cellular Component
cilium  (IEA,ISO)
cytoplasm  (IEA,ISO)
membrane  (IEA)
neuron projection  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population. Doyle DD, etal., Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2117-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Forced homodimerization by site-directed mutagenesis alters guanylyl cyclase activity of natriuretic peptide receptor B. Langenickel T, etal., Hypertension. 2004 Feb;43(2):460-5. Epub 2003 Dec 22.
6. Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B. Langenickel TH, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4735-40. Epub 2006 Mar 14.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury. Pellet-Many C, etal., Cardiovasc Res. 2015 Nov 1;108(2):288-98. doi: 10.1093/cvr/cvv229. Epub 2015 Sep 25.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Rahmutula D and Gardner DG, Endocrinology. 2005 Nov;146(11):4968-74. Epub 2005 Aug 18.
13. Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension. Rehemudula D, etal., Circ Res. 1999 Mar 19;84(5):605-10.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Schulz S, etal., Cell 1989 Sep 22;58(6):1155-62.
18. Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides. Sorci G, etal., Brain Res. 1995 Jun 12;683(1):51-8.
19. A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse. Tsuji T and Kunieda T, J Biol Chem. 2005 Apr 8;280(14):14288-92. Epub 2005 Feb 18.
Additional References at PubMed
PMID:624676   PMID:1660465   PMID:1672777   PMID:9624142   PMID:14514678   PMID:14687666   PMID:15371450   PMID:16272201   PMID:17629948   PMID:19837875   PMID:19969282   PMID:20079378  
PMID:20304036   PMID:20880010   PMID:20947764   PMID:20977274   PMID:24001744   PMID:24333928   PMID:24352806   PMID:24471569   PMID:25183874   PMID:26980729   PMID:27496871   PMID:27557795  
PMID:28743500   PMID:28964968   PMID:37774352  


Genomics

Comparative Map Data
Npr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,678,197 - 62,697,360 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl562,678,367 - 62,697,343 (+)EnsemblGRCr8
mRatBN7.2557,883,171 - 57,901,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx559,863,179 - 59,881,665 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,681,991 - 61,700,479 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,653,242 - 61,671,683 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,128,186 - 59,147,321 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,128,315 - 59,147,255 (+)Ensemblrn6Rnor6.0
Rnor_5.0563,652,957 - 63,672,114 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,107,563 - 60,127,960 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera556,463,705 - 56,482,048 (+)NCBICelera
RGSC_v3.1560,107,741 - 60,128,139 (+)NCBI
Cytogenetic Map5q22NCBI
NPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,791,591 - 35,809,731 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,791,003 - 35,809,732 (+)Ensemblhg38GRCh38
GRCh37935,791,588 - 35,809,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,782,406 - 35,799,728 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34935,782,405 - 35,799,709NCBI
Celera935,725,947 - 35,743,260 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,748,436 - 35,765,752 (+)NCBIHuRef
CHM1_1935,792,795 - 35,810,116 (+)NCBICHM1_1
T2T-CHM13v2.0935,777,317 - 35,830,398 (+)NCBIT2T-CHM13v2.0
Npr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,629,015 - 43,651,437 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,631,935 - 43,651,244 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38443,629,015 - 43,651,437 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,631,935 - 43,651,244 (+)Ensemblmm10GRCm38
MGSCv37443,644,807 - 43,664,116 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36443,653,035 - 43,672,344 (+)NCBIMGSCv36mm8
Celera443,666,379 - 43,685,849 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Npr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472506,351 - 523,316 (-)Ensembl
ChiLan1.0NW_004955472506,351 - 523,647 (-)NCBIChiLan1.0ChiLan1.0
NPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,779,098 - 88,796,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,785,250 - 88,802,729 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,642,534 - 35,660,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,445,576 - 36,462,637 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,445,576 - 36,462,637 (+)EnsemblpanPan2panpan1.1
NPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,283,680 - 52,339,247 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,321,590 - 52,339,249 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1150,888,024 - 50,906,818 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01153,385,429 - 53,404,264 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,386,145 - 53,450,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,929,955 - 51,948,772 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,913,486 - 51,932,996 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,615,631 - 52,634,454 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,231,815 - 167,250,482 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,779,392 - 3,798,501 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,779,398 - 3,798,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,508,998 - 236,529,128 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11236,508,994 - 236,529,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,233,393 - 264,254,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,795,822 - 44,844,464 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,793,253 - 44,813,671 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603841,900,466 - 41,949,193 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,974,810 - 4,993,817 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248684,974,690 - 4,993,886 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Npr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v112,850,623 - 2,870,957 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npr2
89 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000021802
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
BE097058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,896,526 - 57,896,687 (+)MAPPERmRatBN7.2
Rnor_6.0559,142,258 - 59,142,418NCBIRnor6.0
Rnor_5.0563,667,050 - 63,667,210UniSTSRnor5.0
RGSC_v3.4560,122,907 - 60,123,067UniSTSRGSC3.4
Celera556,476,995 - 56,477,155UniSTS
RH 3.4 Map5394.5UniSTS
Cytogenetic Map5q22UniSTS
RH141203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,901,764 - 57,901,982 (+)MAPPERmRatBN7.2
Rnor_6.0559,147,496 - 59,147,713NCBIRnor6.0
Rnor_5.0563,672,288 - 63,672,505UniSTSRnor5.0
RGSC_v3.4560,128,145 - 60,128,362UniSTSRGSC3.4
Celera556,482,233 - 56,482,450UniSTS
RH 3.4 Map5395.0UniSTS
Cytogenetic Map5q22UniSTS
RH141379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,901,334 - 57,901,535 (+)MAPPERmRatBN7.2
Rnor_6.0559,147,066 - 59,147,266NCBIRnor6.0
Rnor_5.0563,671,858 - 63,672,058UniSTSRnor5.0
RGSC_v3.4560,127,715 - 60,127,915UniSTSRGSC3.4
Celera556,481,803 - 56,482,003UniSTS
RH 3.4 Map5395.6UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 81 59 6 345 181 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021802   ⟹   ENSRNOP00000021802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl562,678,367 - 62,697,343 (+)Ensembl
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)Ensembl
Rnor_6.0 Ensembl559,128,315 - 59,147,255 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112447   ⟹   ENSRNOP00000086809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl562,678,367 - 62,697,343 (+)Ensembl
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)Ensembl
RefSeq Acc Id: NM_053838   ⟹   NP_446290
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,678,942 - 62,697,350 (+)NCBI
mRatBN7.2557,883,171 - 57,901,580 (+)NCBI
Rnor_6.0559,128,903 - 59,147,311 (+)NCBI
Rnor_5.0563,652,957 - 63,672,114 (+)NCBI
RGSC_v3.4560,107,563 - 60,127,960 (+)RGD
Celera556,463,705 - 56,482,048 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238010   ⟹   XP_006238072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,678,197 - 62,697,360 (+)NCBI
mRatBN7.2557,883,207 - 57,901,590 (+)NCBI
Rnor_6.0559,128,186 - 59,147,321 (+)NCBI
Rnor_5.0563,652,957 - 63,672,114 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287066   ⟹   XP_063143136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,687,999 - 62,697,360 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446290 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238072 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143136 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41205 (Get FASTA)   NCBI Sequence Viewer  
  EDL98761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021802
  ENSRNOP00000086809
GenBank Protein P16067 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446290   ⟸   NM_053838
- Peptide Label: precursor
- UniProtKB: P16067 (UniProtKB/Swiss-Prot),   A6IJ41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238072   ⟸   XM_006238010
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UJL6 (UniProtKB/TrEMBL),   A6IJ41 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021802   ⟸   ENSRNOT00000021802
Ensembl Acc Id: ENSRNOP00000086809   ⟸   ENSRNOT00000112447
RefSeq Acc Id: XP_063143136   ⟸   XM_063287066
- Peptide Label: isoform X2
Protein Domains
Guanylate cyclase   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16067-F1-model_v2 AlphaFold P16067 1-1047 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620851 AgrOrtholog
BioCyc Gene G2FUF-41499 BioCyc
Ensembl Genes ENSRNOG00000015991 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021802 ENTREZGENE
  ENSRNOT00000112447 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  ANPR/GUC UniProtKB/Swiss-Prot
  Cyclic_nucleotide_synthase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:116564 UniProtKB/Swiss-Prot
NCBI Gene 116564 ENTREZGENE
PANTHER ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 UniProtKB/Swiss-Prot
  GUANYLYL CYCLASE UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Guanylate_cyc UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PharmGKB NPR2 RGD
PhenoGen Npr2 PhenoGen
PRINTS NATPEPTIDER UniProtKB/Swiss-Prot
PROSITE ANF_RECEPTORS UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015991 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6GEF8_RAT UniProtKB/TrEMBL
  A0A8L2UJL6 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ41 ENTREZGENE, UniProtKB/TrEMBL
  ANPRB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-07 Npr2  natriuretic peptide receptor 2  Npr2  natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Npr2  natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)  Npr2  natriuretic peptide receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Npr2  natriuretic peptide receptor 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Npr2  natriuretic peptide receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology has 78% identity to npr1 receptor 728952