Dut (deoxyuridine triphosphatase) - Rat Genome Database

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Pathways
Gene: Dut (deoxyuridine triphosphatase) Rattus norvegicus
Analyze
Symbol: Dut
Name: deoxyuridine triphosphatase
RGD ID: 620849
Description: Enables several functions, including dUTP diphosphatase activity; peroxisome proliferator activated receptor binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in liver development; pyrimidine deoxyribonucleotide metabolic process; and regulation of protein-containing complex assembly. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUT (deoxyuridine triphosphatase); PARTICIPATES IN pyrimidine metabolic pathway; beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridinetriphosphatase (dUTPase); Dutp; dUTP pyrophosphatase; dUTPase; PIP4; PPAR-interacting protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dut-ps   LOC100526819  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83132,952,258 - 132,963,433 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3132,952,394 - 132,964,956 (+)EnsemblGRCr8
mRatBN7.23112,498,864 - 112,509,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,498,982 - 112,510,771 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3116,358,986 - 116,369,833 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03124,954,504 - 124,965,351 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03122,614,871 - 122,625,718 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,514,399 - 117,525,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,514,444 - 117,525,446 (+)Ensemblrn6Rnor6.0
Rnor_5.03124,038,120 - 124,049,168 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43112,551,434 - 112,562,434 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3111,355,479 - 111,366,436 (+)NCBICelera
RGSC_v3.13112,457,006 - 112,468,009 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bufalin  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
erythromycin estolate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
levofloxacin  (EXP)
limonene  (EXP)
maneb  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
mitochondrion  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha. Chu R, etal., J Biol Chem 1996 Nov 1;271(44):27670-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat. Gruppuso PA, etal., Biochim Biophys Acta. 2000 Dec 1;1494(3):242-7.
4. Purification and characterization of deoxyuridine triphosphate nucleotidohydrolase from anemic rat spleen: a trimer composition of the enzyme protein. Hokari S and Sakagishi Y, Arch Biochem Biophys. 1987 Mar;253(2):350-6.
5. Deoxyuridine triphosphate nucleotidohydrolase activity and its correlation with multiplication of erythroid cells in rat spleen. Hokari S, etal., Biochem Int. 1987 May;14(5):851-7.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Immunohistochemical detection of dUTPase in intracranial tumors. Romeike BF, etal., Pathol Res Pract. 2005;201(11):727-32. Epub 2005 Oct 19.
14. Reversible effect of calcium-binding protein regucalcin on the Ca(2+)-induced inhibition of deoxyuridine 5'-triphosphatase activity in rat liver cytosol. Yamaguchi M and Sakurai T, Mol Cell Biochem. 1992 Mar 4;110(1):25-9.
Additional References at PubMed
PMID:8631816   PMID:8889548   PMID:14651853   PMID:18614015   PMID:20458337   PMID:22658674   PMID:28073829   PMID:34800366  


Genomics

Comparative Map Data
Dut
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83132,952,258 - 132,963,433 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3132,952,394 - 132,964,956 (+)EnsemblGRCr8
mRatBN7.23112,498,864 - 112,509,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,498,982 - 112,510,771 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3116,358,986 - 116,369,833 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03124,954,504 - 124,965,351 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03122,614,871 - 122,625,718 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,514,399 - 117,525,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,514,444 - 117,525,446 (+)Ensemblrn6Rnor6.0
Rnor_5.03124,038,120 - 124,049,168 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43112,551,434 - 112,562,434 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3111,355,479 - 111,366,436 (+)NCBICelera
RGSC_v3.13112,457,006 - 112,468,009 (+)NCBI
Cytogenetic Map3q36NCBI
DUT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381548,331,095 - 48,343,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1548,331,011 - 48,343,373 (+)Ensemblhg38GRCh38
GRCh371548,623,292 - 48,635,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361546,410,913 - 46,422,862 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341546,411,721 - 46,422,855NCBI
Celera1525,516,088 - 25,528,037 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1525,456,621 - 25,468,570 (+)NCBIHuRef
CHM1_11548,741,653 - 48,753,602 (+)NCBICHM1_1
T2T-CHM13v2.01546,139,356 - 46,151,634 (+)NCBIT2T-CHM13v2.0
Dut
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,089,168 - 125,100,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2125,089,110 - 125,100,528 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382125,247,248 - 125,259,049 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,247,190 - 125,258,608 (+)Ensemblmm10GRCm38
MGSCv372125,072,984 - 125,084,785 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362124,938,923 - 124,950,049 (+)NCBIMGSCv36mm8
Celera2126,491,099 - 126,502,875 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.33NCBI
Dut
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554095,574,694 - 5,584,134 (-)Ensembl
ChiLan1.0NW_0049554095,574,810 - 5,584,135 (-)NCBIChiLan1.0ChiLan1.0
DUT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21637,571,636 - 37,582,801 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11541,753,022 - 41,764,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01527,280,025 - 27,292,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11545,604,061 - 45,616,022 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1545,603,807 - 45,616,022 (+)EnsemblpanPan2panpan1.1
DUT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13014,572,766 - 14,585,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3014,572,602 - 14,585,530 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3014,494,200 - 14,507,265 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03014,706,670 - 14,719,522 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3014,706,505 - 14,719,499 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13014,629,328 - 14,642,402 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03014,744,651 - 14,757,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03014,856,699 - 14,869,776 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dut
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864092,822,523 - 92,833,400 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647110,671,722 - 10,681,351 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647110,670,604 - 10,681,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1123,450,858 - 123,462,245 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11123,451,207 - 123,462,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21137,480,904 - 137,492,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12634,941,775 - 34,954,184 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2634,940,702 - 34,953,166 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048106,175,656 - 106,187,091 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dut
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473111,378,944 - 11,388,057 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473111,378,882 - 11,388,677 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dut
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15103,575,331 - 103,586,962 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dut
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000009549
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH128566  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,368,930 - 48,369,114 (+)MAPPERmRatBN7.2
Rnor_6.0148,565,047 - 48,565,230NCBIRnor6.0
Rnor_5.0151,190,802 - 51,190,985UniSTSRnor5.0
RGSC_v3.4142,826,437 - 42,826,620UniSTSRGSC3.4
Celera144,160,979 - 44,161,162UniSTS
RH 3.4 Map1585.3UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map3q36UniSTS
D1Bda1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,509,632 - 112,509,834 (+)MAPPERmRatBN7.2
mRatBN7.2148,368,897 - 48,369,099 (-)MAPPERmRatBN7.2
mRatBN7.2148,368,897 - 48,369,099 (+)MAPPERmRatBN7.2
mRatBN7.23112,509,632 - 112,509,834 (-)MAPPERmRatBN7.2
Rnor_6.03117,525,088 - 117,525,289NCBIRnor6.0
Rnor_6.0148,565,014 - 48,565,215NCBIRnor6.0
Rnor_5.0151,190,817 - 51,191,018UniSTSRnor5.0
Rnor_5.03124,048,806 - 124,049,007UniSTSRnor5.0
RGSC_v3.43112,562,078 - 112,562,279UniSTSRGSC3.4
RGSC_v3.4142,826,404 - 42,826,605UniSTSRGSC3.4
Celera144,160,946 - 44,161,147UniSTS
Celera3111,366,080 - 111,366,281UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map3q36UniSTS
BF390230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,509,559 - 112,509,730 (+)MAPPERmRatBN7.2
Rnor_6.03117,525,015 - 117,525,185NCBIRnor6.0
Rnor_5.03124,048,733 - 124,048,903UniSTSRnor5.0
RGSC_v3.43112,562,005 - 112,562,175UniSTSRGSC3.4
Celera3111,366,007 - 111,366,177UniSTS
RH 3.4 Map3982.9UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001040271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI705003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW530495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB325379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U64030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009549   ⟹   ENSRNOP00000009549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3132,952,405 - 132,964,956 (+)Ensembl
mRatBN7.2 Ensembl3112,498,982 - 112,510,771 (+)Ensembl
Rnor_6.0 Ensembl3117,514,444 - 117,525,446 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137124   ⟹   ENSRNOP00000112289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3132,952,394 - 132,961,572 (+)Ensembl
RefSeq Acc Id: NM_001040271   ⟹   NP_001035361
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,899 - 132,963,430 (+)NCBI
mRatBN7.23112,499,458 - 112,509,989 (+)NCBI
Rnor_6.03117,514,913 - 117,525,444 (+)NCBI
Rnor_5.03124,038,120 - 124,049,168 (+)NCBI
RGSC_v3.43112,551,434 - 112,562,434 (+)RGD
Celera3111,355,948 - 111,366,436 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053592   ⟹   NP_446044
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,430 - 132,963,430 (+)NCBI
mRatBN7.23112,498,989 - 112,509,989 (+)NCBI
Rnor_6.03117,514,444 - 117,525,444 (+)NCBI
Rnor_5.03124,038,120 - 124,049,168 (+)NCBI
RGSC_v3.43112,551,434 - 112,562,434 (+)RGD
Celera3111,355,479 - 111,366,436 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762188   ⟹   XP_008760410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,258 - 132,963,433 (+)NCBI
mRatBN7.23112,498,955 - 112,509,994 (+)NCBI
Rnor_6.03117,514,406 - 117,525,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105649   ⟹   XP_038961577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,610 - 132,963,433 (+)NCBI
mRatBN7.23112,499,192 - 112,509,994 (+)NCBI
RefSeq Acc Id: XM_039105651   ⟹   XP_038961579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,961,587 - 132,963,433 (+)NCBI
mRatBN7.23112,501,312 - 112,509,994 (+)NCBI
RefSeq Acc Id: XM_063284325   ⟹   XP_063140395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,393 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284326   ⟹   XP_063140396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,962,620 (+)NCBI
RefSeq Acc Id: XM_063284327   ⟹   XP_063140397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284328   ⟹   XP_063140398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,393 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284329   ⟹   XP_063140399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,962,620 (+)NCBI
RefSeq Acc Id: XM_063284330   ⟹   XP_063140400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,389 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284331   ⟹   XP_063140401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284332   ⟹   XP_063140402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,269 - 132,961,425 (+)NCBI
RefSeq Acc Id: XM_063284333   ⟹   XP_063140403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,389 - 132,956,815 (+)NCBI
RefSeq Acc Id: XM_063284334   ⟹   XP_063140404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,390 - 132,956,814 (+)NCBI
RefSeq Acc Id: XM_063284335   ⟹   XP_063140405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,461 - 132,963,433 (+)NCBI
RefSeq Acc Id: XR_010064679
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,963,145 (+)NCBI
RefSeq Acc Id: XR_010064680
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,962,620 (+)NCBI
RefSeq Acc Id: XR_010064681
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,389 - 132,962,620 (+)NCBI
RefSeq Acc Id: NP_446044   ⟸   NM_053592
- Peptide Label: isoform 1
- UniProtKB: P70583 (UniProtKB/Swiss-Prot),   A6HPW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001035361   ⟸   NM_001040271
- Peptide Label: isoform 2
- UniProtKB: A6HPW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760410   ⟸   XM_008762188
- Peptide Label: isoform X7
- Sequence:
Ensembl Acc Id: ENSRNOP00000009549   ⟸   ENSRNOT00000009549
RefSeq Acc Id: XP_038961577   ⟸   XM_039105649
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038961579   ⟸   XM_039105651
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063140402   ⟸   XM_063284332
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063140397   ⟸   XM_063284327
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140401   ⟸   XM_063284331
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063140396   ⟸   XM_063284326
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140399   ⟸   XM_063284329
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063140400   ⟸   XM_063284330
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063140403   ⟸   XM_063284333
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063140404   ⟸   XM_063284334
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063140395   ⟸   XM_063284325
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140398   ⟸   XM_063284328
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140405   ⟸   XM_063284335
- Peptide Label: isoform X12
Ensembl Acc Id: ENSRNOP00000112289   ⟸   ENSRNOT00000137124
Protein Domains
dUTPase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70583-F1-model_v2 AlphaFold P70583 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692380
Promoter ID:EPDNEW_R2903
Type:initiation region
Name:Dut_1
Description:deoxyuridine triphosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03117,514,430 - 117,514,490EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620849 AgrOrtholog
BioCyc Gene G2FUF-48047 BioCyc
BioCyc Pathway PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7206 [pyrimidine deoxyribonucleotides dephosphorylation] BioCyc
BioCyc Pathway Image PWY-7184 BioCyc
  PWY-7206 BioCyc
Ensembl Genes ENSRNOG00000007221 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009549 ENTREZGENE
  ENSRNOT00000009549.3 UniProtKB/Swiss-Prot
  ENSRNOT00000137124 ENTREZGENE
Gene3D-CATH 2.70.40.10 UniProtKB/Swiss-Prot
InterPro dUTPase-like UniProtKB/Swiss-Prot
  dUTPase-like_sf UniProtKB/Swiss-Prot
  dUTPase_1 UniProtKB/Swiss-Prot
  dUTPase_trimeric UniProtKB/Swiss-Prot
KEGG Report rno:497778 UniProtKB/Swiss-Prot
NCBI Gene 497778 ENTREZGENE
PANTHER DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE UniProtKB/Swiss-Prot
  PTHR11241 UniProtKB/Swiss-Prot
Pfam dUTPase UniProtKB/Swiss-Prot
PhenoGen Dut PhenoGen
RatGTEx ENSRNOG00000007221 RatGTEx
Superfamily-SCOP SSF51283 UniProtKB/Swiss-Prot
UniProt A0ABK0M2K9_RAT UniProtKB/TrEMBL
  A6HPW5 ENTREZGENE, UniProtKB/TrEMBL
  A6HPW6 ENTREZGENE, UniProtKB/TrEMBL
  DUT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dut  deoxyuridine triphosphatase  Dutp    Symbol updated 1299863 APPROVED
2004-12-14 Dutp  deoxyuridine triphosphatase  Dut  Deoxyuridinetriphosphatase (dUTPase)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Dut        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA present in all tissues studied 728628
gene_homology protein shares 92% identity with human dUTPase 728628
gene_physical_interaction interacts with three isoforms of PPAR, but not retinoid X receptor or thyroid hormone receptor 728628
gene_process prevents PPAR/retinoid X receptor heterodimerization, inhibition of PPAR is ligand-independent 728628
gene_protein predicted protein contains 203 aa residues 728628