Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Akap8 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of AKAP8 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of AKAP8 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of AKAP8 mRNA | CTD | PMID:17557909 | 17alpha-ethynylestradiol | affects expression | ISO | Akap8 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of AKAP8 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | Akap8 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of AKAP8 mRNA | CTD | PMID:17942748 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Akap8 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of AKAP8 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AKAP8 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Akap8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of AKAP8 mRNA | CTD | PMID:21570461 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19954255 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of AKAP8 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of AKAP8 mRNA | CTD | PMID:21346803 | 2-palmitoylglycerol | increases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of AKAP8 mRNA | CTD | PMID:37199045 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | Akap8 (Mus musculus) | 6480464 | 3 more ... | CTD | PMID:19467301 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of AKAP8 mRNA | CTD | PMID:19162173 | aflatoxin B1 | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of AKAP8 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | AKAP8 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of AKAP8 exon | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of AKAP8 mRNA | CTD | PMID:16483693 | Aroclor 1254 | decreases expression | ISO | Akap8 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of AKAP8 mRNA | CTD | PMID:23650126 | arsane | affects methylation | ISO | AKAP8 (Homo sapiens) | 6480464 | Arsenic affects the methylation of AKAP8 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | AKAP8 (Homo sapiens) | 6480464 | Arsenic affects the methylation of AKAP8 gene | CTD | PMID:25304211 | azoxystrobin | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of AKAP8 mRNA | CTD | PMID:33854195 | azoxystrobin | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | azoxystrobin results in decreased expression of AKAP8 mRNA | CTD | PMID:33512557 | benzo[a]pyrene | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of AKAP8 mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of AKAP8 mRNA | CTD | PMID:25181051 | bisphenol A | decreases methylation | ISO | AKAP8 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of AKAP8 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Akap8 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of AKAP8 mRNA | CTD | PMID:32156529 and PMID:33221593 | camptothecin | increases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Camptothecin results in increased expression of AKAP8 mRNA | CTD | PMID:33770205 | carbon nanotube | decreases expression | ISO | Akap8 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of AKAP8 mRNA | CTD | PMID:33854195 | cisplatin | increases phosphorylation | ISO | Akap8 (Mus musculus) | 6480464 | Cisplatin results in increased phosphorylation of AKAP8 protein | CTD | PMID:22006019 | clofibrate | affects expression | ISO | Akap8 (Mus musculus) | 6480464 | Clofibrate affects the expression of AKAP8 mRNA | CTD | PMID:17585979 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of AKAP8 mRNA | CTD | PMID:12851107 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of AKAP8 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of AKAP8 mRNA | CTD | PMID:30556269 | copper(II) sulfate | increases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of AKAP8 mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | AKAP8 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of AKAP8 protein | CTD | PMID:35688186 | crocidolite asbestos | decreases expression | ISO | Akap8 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of AKAP8 mRNA | CTD | PMID:29279043 | cyclophosphamide | increases expression | EXP | | 6480464 | Cyclophosphamide results in increased expression of AKAP8 mRNA | CTD | PMID:27281708 | cyclosporin A | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of AKAP8 mRNA | CTD | PMID:19770486 | doxorubicin | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of AKAP8 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | AKAP8 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKAP8 protein | CTD | PMID:23301498 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of AKAP8 mRNA | CTD | PMID:24136188 | FR900359 | increases phosphorylation | ISO | AKAP8 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of AKAP8 protein | CTD | PMID:37730182 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of AKAP8 mRNA | CTD | PMID:22061828 | glyphosate | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of AKAP8 mRNA | CTD | PMID:33854195 | imidacloprid | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of AKAP8 mRNA | CTD | PMID:33854195 | lead diacetate | increases methylation | EXP | | 6480464 | lead acetate results in increased methylation of AKAP8 gene | CTD | PMID:29571894 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of AKAP8 mRNA | CTD | PMID:20360939 | paracetamol | affects expression | ISO | Akap8 (Mus musculus) | 6480464 | Acetaminophen affects the expression of AKAP8 mRNA | CTD | PMID:17562736 | phenobarbital | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of AKAP8 mRNA | CTD | PMID:31836555 | picoxystrobin | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of AKAP8 mRNA | CTD | PMID:33512557 | pirinixic acid | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of AKAP8 mRNA | CTD | PMID:12727805 | progesterone | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Progesterone results in decreased expression of AKAP8 mRNA | CTD | PMID:18037150 | resveratrol | decreases expression | ISO | Akap8 (Mus musculus) | 6480464 | resveratrol results in decreased expression of AKAP8 protein | CTD | PMID:25505154 | resveratrol | multiple interactions | ISO | AKAP8 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of AKAP8 mRNA | CTD | PMID:23557933 | rotenone | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of AKAP8 mRNA | CTD | PMID:33512557 | silicon dioxide | increases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of AKAP8 mRNA | CTD | PMID:25351596 | tamoxifen | affects expression | ISO | Akap8 (Mus musculus) | 6480464 | Tamoxifen affects the expression of AKAP8 mRNA | CTD | PMID:17555576 | temozolomide | increases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of AKAP8 mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of AKAP8 mRNA | CTD | PMID:31150632 | tetraphene | increases expression | ISO | Akap8 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of AKAP8 mRNA | CTD | PMID:26377693 | thiabendazole | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of AKAP8 mRNA | CTD | PMID:33854195 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of AKAP8 mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of AKAP8 mRNA | CTD | PMID:24935251 and PMID:28542535 | tunicamycin | increases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of AKAP8 mRNA | CTD | PMID:33770205 | valproic acid | affects expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of AKAP8 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of AKAP8 mRNA | CTD | PMID:22083351 | vorinostat | decreases expression | ISO | AKAP8 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of AKAP8 mRNA | CTD | PMID:22083351 | |