Blvra (biliverdin reductase A) - Rat Genome Database

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Gene: Blvra (biliverdin reductase A) Rattus norvegicus
Analyze
Symbol: Blvra
Name: biliverdin reductase A
RGD ID: 620721
Description: Enables biliberdin reductase (NADH) activity. Predicted to be involved in heme catabolic process. Predicted to act upstream of or within several processes, including apoptotic DNA fragmentation; cell surface receptor signaling pathway; and intracellular signaling cassette. Predicted to be active in cell surface; cytosol; and nucleus. Orthologous to human BLVRA (biliverdin reductase A); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: biliverdin-IX alpha-reductase; BVR A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Blvra-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,793,397 - 134,819,367 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3134,794,203 - 134,819,785 (+)EnsemblGRCr8
mRatBN7.23114,340,778 - 114,366,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,340,838 - 114,366,033 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,241,628 - 118,258,247 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,837,178 - 126,853,796 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,497,554 - 124,514,173 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,552,550 - 119,577,796 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,561,290 - 119,577,806 (+)Ensemblrn6Rnor6.0
Rnor_5.03126,078,399 - 126,103,278 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43114,627,972 - 114,645,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,190,091 - 113,206,438 (+)NCBICelera
RGSC_v3.13114,533,549 - 114,550,577 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
eugenol  (EXP)
fenthion  (ISO)
ferroheme b  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
heme b  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methidathion  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO,ISS)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Expression and characterization of a cDNA for rat kidney biliverdin reductase. Evidence suggesting the liver and kidney enzymes are the same transcript product. Fakhrai H and Maines MD, J Biol Chem 1992 Feb 25;267(6):4023-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Site-directed mutagenesis of cysteine residues in biliverdin reductase. Roles in substrate and cofactor binding. McCoubrey WK and Maines MD, Eur J Biochem. 1994 Jun 1;222(2):597-603. doi: 10.1111/j.1432-1033.1994.tb18902.x.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. Whitby FG, etal., J Mol Biol 2002 Jun 21;319(5):1199-210.
Additional References at PubMed
PMID:10858451   PMID:10957639   PMID:15081633   PMID:17402939   PMID:19056867   PMID:20458337   PMID:20876213   PMID:23376485   PMID:23722043  


Genomics

Comparative Map Data
Blvra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,793,397 - 134,819,367 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3134,794,203 - 134,819,785 (+)EnsemblGRCr8
mRatBN7.23114,340,778 - 114,366,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,340,838 - 114,366,033 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,241,628 - 118,258,247 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,837,178 - 126,853,796 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,497,554 - 124,514,173 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,552,550 - 119,577,796 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,561,290 - 119,577,806 (+)Ensemblrn6Rnor6.0
Rnor_5.03126,078,399 - 126,103,278 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43114,627,972 - 114,645,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,190,091 - 113,206,438 (+)NCBICelera
RGSC_v3.13114,533,549 - 114,550,577 (+)NCBI
Cytogenetic Map3q36NCBI
BLVRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38743,758,122 - 43,807,342 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl743,758,009 - 43,808,097 (+)Ensemblhg38GRCh38
GRCh37743,798,279 - 43,846,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36743,764,797 - 43,813,466 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34743,571,511 - 43,620,179NCBI
Celera743,788,116 - 43,836,787 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef743,683,311 - 43,732,096 (+)NCBIHuRef
CHM1_1743,802,192 - 43,850,836 (+)NCBICHM1_1
T2T-CHM13v2.0743,915,726 - 43,965,608 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2743,837,746 - 43,886,418 (+)NCBI
Blvra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,912,549 - 126,939,004 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,912,585 - 126,939,004 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382127,070,629 - 127,097,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,070,665 - 127,097,084 (+)Ensemblmm10GRCm38
MGSCv372126,896,393 - 126,922,820 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362126,762,108 - 126,788,525 (+)NCBIMGSCv36mm8
Celera2128,297,794 - 128,324,229 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Blvra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955460125,854 - 167,506 (-)Ensembl
ChiLan1.0NW_004955460129,077 - 167,345 (-)NCBIChiLan1.0ChiLan1.0
BLVRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2644,643,057 - 44,691,982 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1792,967,799 - 93,016,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0740,444,095 - 40,492,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1740,489,360 - 40,537,048 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl740,489,360 - 40,526,132 (-)EnsemblpanPan2panpan1.1
BLVRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1186,424,833 - 6,506,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl186,426,255 - 6,495,647 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha186,272,541 - 6,352,306 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0186,469,626 - 6,549,500 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,469,704 - 6,517,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,459,325 - 6,537,172 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0186,427,441 - 6,505,905 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,540,330 - 6,618,770 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Blvra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,599,685 - 99,639,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647818,833,172 - 18,852,839 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647818,811,452 - 18,850,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BLVRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1851,131,584 - 51,185,435 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11851,131,576 - 51,185,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21856,025,303 - 56,079,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BLVRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,777,171 - 14,820,690 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,773,621 - 14,820,782 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660627,690,355 - 7,735,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Blvra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474017,462,537 - 17,478,269 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474017,462,201 - 17,505,725 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Blvra
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15105,908,551 - 105,928,074 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Blvra
218 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:48
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000015843
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH130837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2245,539,078 - 45,539,284 (+)MAPPERmRatBN7.2
mRatBN7.23114,365,735 - 114,365,941 (+)MAPPERmRatBN7.2
Rnor_6.0245,770,526 - 45,770,731NCBIRnor6.0
Rnor_6.03119,577,496 - 119,577,701NCBIRnor6.0
Rnor_5.03126,102,975 - 126,103,180UniSTSRnor5.0
Rnor_5.0264,801,675 - 64,801,880UniSTSRnor5.0
RGSC_v3.4245,420,413 - 45,420,618UniSTSRGSC3.4
RGSC_v3.43114,644,709 - 114,644,914UniSTSRGSC3.4
Celera3113,206,143 - 113,206,348UniSTS
Celera241,301,734 - 41,301,939UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015843   ⟹   ENSRNOP00000015843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3134,794,203 - 134,819,785 (+)Ensembl
mRatBN7.2 Ensembl3114,340,838 - 114,366,033 (+)Ensembl
Rnor_6.0 Ensembl3119,561,290 - 119,577,806 (+)Ensembl
RefSeq Acc Id: NM_053850   ⟹   NP_446302
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,802,910 - 134,819,365 (+)NCBI
mRatBN7.23114,349,576 - 114,366,031 (+)NCBI
Rnor_6.03119,561,301 - 119,577,791 (+)NCBI
Rnor_5.03126,078,399 - 126,103,278 (+)NCBI
RGSC_v3.43114,627,972 - 114,645,004 (+)RGD
Celera3113,190,091 - 113,206,438 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234894   ⟹   XP_006234956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,793,397 - 134,819,367 (+)NCBI
mRatBN7.23114,340,782 - 114,366,048 (+)NCBI
Rnor_6.03119,552,550 - 119,577,796 (+)NCBI
Rnor_5.03126,078,399 - 126,103,278 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234895   ⟹   XP_006234957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,793,397 - 134,819,367 (+)NCBI
mRatBN7.23114,340,778 - 114,366,036 (+)NCBI
Rnor_6.03119,552,556 - 119,577,796 (+)NCBI
Rnor_5.03126,078,399 - 126,103,278 (+)NCBI
Sequence:
RefSeq Acc Id: NP_446302   ⟸   NM_053850
- UniProtKB: P46844 (UniProtKB/Swiss-Prot),   Q6AZ33 (UniProtKB/TrEMBL),   F7EW70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234956   ⟸   XM_006234894
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006234957   ⟸   XM_006234895
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000015843   ⟸   ENSRNOT00000015843
Protein Domains
Biliverdin reductase catalytic   Gfo/Idh/MocA-like oxidoreductase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46844-F1-model_v2 AlphaFold P46844 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692395
Promoter ID:EPDNEW_R2920
Type:multiple initiation site
Name:Blvra_1
Description:biliverdin reductase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03119,561,327 - 119,561,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620721 AgrOrtholog
BioCyc Gene G2FUF-48011 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
Ensembl Genes ENSRNOG00000011778 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015843 ENTREZGENE
Gene3D-CATH Dihydrodipicolinate Reductase, domain 2 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126157 IMAGE-MGC_LOAD
InterPro Biliverdin_Rdtase_A UniProtKB/Swiss-Prot
  Biliverdin_Rdtase_cat UniProtKB/Swiss-Prot
  Gfo/Idh/MocA_Oxidoreductases UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Oxidoreductase_N UniProtKB/Swiss-Prot
KEGG Report rno:116599 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93279 IMAGE-MGC_LOAD
NCBI Gene 116599 ENTREZGENE
PANTHER BILIVERDIN REDUCTASE A UniProtKB/Swiss-Prot
  BILIVERDIN REDUCTASE A UniProtKB/Swiss-Prot
Pfam Biliv-reduc_cat UniProtKB/Swiss-Prot
  GFO_IDH_MocA UniProtKB/Swiss-Prot
PhenoGen Blvra PhenoGen
PIRSF Biliverdin_reductase_A UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011778 RatGTEx
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
UniProt BIEA_RAT UniProtKB/Swiss-Prot
  F7EW70 ENTREZGENE, UniProtKB/TrEMBL
  P46844 ENTREZGENE
  Q6AZ33 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Blvra  biliverdin reductase A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Blvra  biliverdin reductase A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction forms an enzyme cofactor complex with NADH or NADPH 727572