Blvra (biliverdin reductase A) - Rat Genome Database

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Gene: Blvra (biliverdin reductase A) Rattus norvegicus
Analyze
Symbol: Blvra
Name: biliverdin reductase A
RGD ID: 620721
Description: Enables biliberdin reductase (NAD+) activity. Predicted to be involved in heme catabolic process. Predicted to be active in cytosol. Orthologous to human BLVRA (biliverdin reductase A); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: biliverdin-IX alpha-reductase; BVR A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Blvra-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,793,397 - 134,819,367 (+)NCBIGRCr8
mRatBN7.23114,340,778 - 114,366,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,340,838 - 114,366,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,241,628 - 118,258,247 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,837,178 - 126,853,796 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,497,554 - 124,514,173 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,552,550 - 119,577,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,561,290 - 119,577,806 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,078,399 - 126,103,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,627,972 - 114,645,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,533,549 - 114,550,577 (+)NCBI
Celera3113,190,091 - 113,206,438 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
ferroheme b  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
heme b  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methidathion  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression and characterization of a cDNA for rat kidney biliverdin reductase. Evidence suggesting the liver and kidney enzymes are the same transcript product. Fakhrai H and Maines MD, J Biol Chem 1992 Feb 25;267(6):4023-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Site-directed mutagenesis of cysteine residues in biliverdin reductase. Roles in substrate and cofactor binding. McCoubrey WK and Maines MD, Eur J Biochem. 1994 Jun 1;222(2):597-603. doi: 10.1111/j.1432-1033.1994.tb18902.x.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. Whitby FG, etal., J Mol Biol 2002 Jun 21;319(5):1199-210.
Additional References at PubMed
PMID:10858451   PMID:10957639   PMID:15081633   PMID:17402939   PMID:19056867   PMID:20458337   PMID:20876213   PMID:23376485   PMID:23722043  


Genomics

Comparative Map Data
Blvra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,793,397 - 134,819,367 (+)NCBIGRCr8
mRatBN7.23114,340,778 - 114,366,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,340,838 - 114,366,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,241,628 - 118,258,247 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,837,178 - 126,853,796 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,497,554 - 124,514,173 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,552,550 - 119,577,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,561,290 - 119,577,806 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,078,399 - 126,103,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,627,972 - 114,645,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,533,549 - 114,550,577 (+)NCBI
Celera3113,190,091 - 113,206,438 (+)NCBICelera
Cytogenetic Map3q36NCBI
BLVRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38743,758,122 - 43,807,342 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl743,758,680 - 43,807,342 (+)EnsemblGRCh38hg38GRCh38
GRCh37743,798,279 - 43,846,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36743,764,797 - 43,813,466 (+)NCBINCBI36Build 36hg18NCBI36
Build 34743,571,511 - 43,620,179NCBI
Celera743,788,116 - 43,836,787 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef743,683,311 - 43,732,096 (+)NCBIHuRef
CHM1_1743,802,192 - 43,850,836 (+)NCBICHM1_1
T2T-CHM13v2.0743,915,726 - 43,965,608 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2743,837,746 - 43,886,418 (+)NCBI
Blvra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,912,549 - 126,939,004 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,912,585 - 126,939,004 (+)EnsemblGRCm39 Ensembl
GRCm382127,070,629 - 127,097,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,070,665 - 127,097,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv372126,896,393 - 126,922,820 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,762,108 - 126,788,525 (+)NCBIMGSCv36mm8
Celera2128,297,794 - 128,324,229 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Blvra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955460125,854 - 167,506 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955460129,077 - 167,345 (-)NCBIChiLan1.0ChiLan1.0
BLVRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2644,643,057 - 44,691,982 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1792,967,799 - 93,016,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0740,444,095 - 40,492,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1740,489,360 - 40,537,048 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl740,489,360 - 40,526,132 (-)Ensemblpanpan1.1panPan2
BLVRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1186,424,833 - 6,506,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl186,426,255 - 6,495,647 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha186,272,541 - 6,352,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0186,469,626 - 6,549,500 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,469,704 - 6,517,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,459,325 - 6,537,172 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0186,427,441 - 6,505,905 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,540,330 - 6,618,770 (-)NCBIUU_Cfam_GSD_1.0
Blvra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,599,685 - 99,639,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647818,833,172 - 18,852,839 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647818,811,452 - 18,850,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BLVRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1851,131,584 - 51,185,435 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11851,131,576 - 51,185,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21856,025,303 - 56,079,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BLVRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,777,171 - 14,820,690 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,773,621 - 14,820,782 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,690,355 - 7,735,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Blvra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474017,462,537 - 17,478,269 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474017,462,201 - 17,505,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Blvra
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:48
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000015843
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH130837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2245,539,078 - 45,539,284 (+)MAPPERmRatBN7.2
mRatBN7.23114,365,735 - 114,365,941 (+)MAPPERmRatBN7.2
Rnor_6.0245,770,526 - 45,770,731NCBIRnor6.0
Rnor_6.03119,577,496 - 119,577,701NCBIRnor6.0
Rnor_5.03126,102,975 - 126,103,180UniSTSRnor5.0
Rnor_5.0264,801,675 - 64,801,880UniSTSRnor5.0
RGSC_v3.4245,420,413 - 45,420,618UniSTSRGSC3.4
RGSC_v3.43114,644,709 - 114,644,914UniSTSRGSC3.4
Celera3113,206,143 - 113,206,348UniSTS
Celera241,301,734 - 41,301,939UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015843   ⟹   ENSRNOP00000015843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3114,340,838 - 114,366,033 (+)Ensembl
Rnor_6.0 Ensembl3119,561,290 - 119,577,806 (+)Ensembl
RefSeq Acc Id: NM_053850   ⟹   NP_446302
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,802,910 - 134,819,365 (+)NCBI
mRatBN7.23114,349,576 - 114,366,031 (+)NCBI
Rnor_6.03119,561,301 - 119,577,791 (+)NCBI
Rnor_5.03126,078,399 - 126,103,278 (+)NCBI
RGSC_v3.43114,627,972 - 114,645,004 (+)RGD
Celera3113,190,091 - 113,206,438 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234894   ⟹   XP_006234956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,793,397 - 134,819,367 (+)NCBI
mRatBN7.23114,340,782 - 114,366,048 (+)NCBI
Rnor_6.03119,552,550 - 119,577,796 (+)NCBI
Rnor_5.03126,078,399 - 126,103,278 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234895   ⟹   XP_006234957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83134,793,397 - 134,819,367 (+)NCBI
mRatBN7.23114,340,778 - 114,366,036 (+)NCBI
Rnor_6.03119,552,556 - 119,577,796 (+)NCBI
Rnor_5.03126,078,399 - 126,103,278 (+)NCBI
Sequence:
RefSeq Acc Id: NP_446302   ⟸   NM_053850
- UniProtKB: P46844 (UniProtKB/Swiss-Prot),   Q6AZ33 (UniProtKB/TrEMBL),   F7EW70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234956   ⟸   XM_006234894
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006234957   ⟸   XM_006234895
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000015843   ⟸   ENSRNOT00000015843
Protein Domains
Biliverdin reductase catalytic   Gfo/Idh/MocA-like oxidoreductase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46844-F1-model_v2 AlphaFold P46844 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692395
Promoter ID:EPDNEW_R2920
Type:multiple initiation site
Name:Blvra_1
Description:biliverdin reductase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03119,561,327 - 119,561,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620721 AgrOrtholog
BioCyc Gene G2FUF-48011 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
Ensembl Genes ENSRNOG00000011778 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055005283 UniProtKB/Swiss-Prot
  ENSRNOG00060014560 UniProtKB/Swiss-Prot
  ENSRNOG00065012868 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015843.7 UniProtKB/TrEMBL
  ENSRNOT00055008491 UniProtKB/Swiss-Prot
  ENSRNOT00060024902 UniProtKB/Swiss-Prot
  ENSRNOT00065021041 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126157 IMAGE-MGC_LOAD
InterPro Biliverdin_Rdtase_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biliverdin_Rdtase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gfo/Idh/MocA_Oxidoreductases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxidoreductase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116599 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93279 IMAGE-MGC_LOAD
NCBI Gene 116599 ENTREZGENE
PANTHER BILIVERDIN REDUCTASE A UniProtKB/Swiss-Prot
  BILIVERDIN REDUCTASE A UniProtKB/Swiss-Prot
  BILIVERDIN REDUCTASE A UniProtKB/TrEMBL
  BILIVERDIN REDUCTASE A UniProtKB/TrEMBL
Pfam Biliv-reduc_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GFO_IDH_MocA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Blvra PhenoGen
PIRSF Biliverdin_reductase_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011778 RatGTEx
  ENSRNOG00055005283 RatGTEx
  ENSRNOG00060014560 RatGTEx
  ENSRNOG00065012868 RatGTEx
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BIEA_RAT UniProtKB/Swiss-Prot
  F7EW70 ENTREZGENE, UniProtKB/TrEMBL
  P46844 ENTREZGENE
  Q6AZ33 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Blvra  biliverdin reductase A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Blvra  biliverdin reductase A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction forms an enzyme cofactor complex with NADH or NADPH 727572