Bcl2l2 (Bcl2-like 2) - Rat Genome Database

Name: Bcl2l2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Bcl2l2 (Bcl2-like 2) Rattus norvegicus

Analyze

Symbol:

Bcl2l2

Name:

Bcl2-like 2

RGD ID:

620717

Description:

Enables BH domain binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to several human genes including BCL2L2 (BCL2 like 2); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (-)-bornyl-caffeate; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

bcl-2-like protein 2; BCL-W; BCL-WEL; BCL-WS; Bclw; MGC91704

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BCL2L2 (BCL2 like 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Bcl2l2 (BCL2-like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BCL2L2 (BCL2 like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BCL2L2 (BCL2 like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough)	HGNC	Inparanoid, Panther
Homo sapiens (human):	SULT1E1 (sulfotransferase family 1E member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	BCL2L2 (BCL2 like 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Bcl2l2 (BCL2-like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ced-9	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	bcl2l2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	32,326,686 - 32,337,834 (+)	NCBI		GRCr8
mRatBN7.2	15	28,346,449 - 28,361,627 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	28,356,807 - 28,361,624 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	30,202,463 - 30,207,316 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	31,349,665 - 31,354,518 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	29,592,361 - 29,597,214 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	33,543,774 - 33,549,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	33,544,312 - 33,549,164 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	37,430,718 - 37,436,392 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	32,983,165 - 32,988,018 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	32,998,864 - 33,003,717 (+)	NCBI
Celera	15	27,934,581 - 27,939,434 (+)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (IEP,ISO)

atrophy of testis (ISO)

azoospermia (ISO)

B-cell lymphoma (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

Burkitt lymphoma (ISO)

colorectal adenocarcinoma (ISO)

diffuse large B-cell lymphoma (ISO)

epilepsy (IEP)

genetic disease (ISO)

lysinuric protein intolerance (ISO)

multiple sclerosis (ISO)

pterygium (IEP)

Specific Granule Deficiency (ISO)

transient cerebral ischemia (IEP,ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-bornyl-caffeate (EXP)

(1->4)-beta-D-glucan (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acrylamide (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (EXP,ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

crocidolite asbestos (ISO)

curcumin (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

DDE (EXP)

decabromodiphenyl ether (EXP)

deguelin (ISO)

dexamethasone (ISO)

diarsenic trioxide (EXP,ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (ISO)

erlotinib hydrochloride (ISO)

etoposide (ISO)

folic acid (ISO)

fulvestrant (ISO)

furosemide (EXP)

Fusarenone X (ISO)

gentamycin (EXP)

geraniol (ISO)

indometacin (ISO)

isoflurane (EXP)

kojic acid (ISO)

L-ascorbic acid (ISO)

L-methionine (ISO)

lidocaine (EXP)

methamphetamine (ISO)

methapyrilene (EXP)

methoxyacetic acid (EXP)

methylparaben (ISO)

Mitotane (EXP)

monocrotophos (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (ISO)

nickel dichloride (EXP)

niclosamide (ISO)

p-menthan-3-ol (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

picoxystrobin (ISO)

pinostrobin (ISO)

propylparaben (ISO)

pyrazinecarboxamide (EXP)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

silver atom (ISO)

silver(0) (ISO)

simazine (ISO)

sodium chromate (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrathiomolybdate(2-) (ISO)

trichloroethene (EXP)

triptonide (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid stimulus (IEP)

cellular response to amyloid-beta (IEP)

cellular response to estradiol stimulus (IEP)

cellular response to glycine (IEP)

extrinsic apoptotic signaling pathway in absence of ligand (IBA,ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (IBA)

negative regulation of apoptotic process (ISO)

negative regulation of intrinsic apoptotic signaling pathway (IBA)

negative regulation of mitochondrial membrane permeability (IDA)

negative regulation of release of cytochrome c from mitochondria (IDA)

regulation of apoptotic process (ISO)

release of cytochrome c from mitochondria (IBA)

response to ischemia (IEP)

Sertoli cell proliferation (ISO)

Cellular Component

Bcl-2 family protein complex (ISO)

cytosol (ISO)

mitochondrial membrane (IDA,ISO)

mitochondrial outer membrane (IBA)

Molecular Function

BH domain binding (IBA,IPI)

disordered domain specific binding (ISO)

identical protein binding (ISO)

protein binding (IPI,ISO)

protein heterodimerization activity (IBA)

protein homodimerization activity (IBA)

protein-containing complex binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

intrinsic apoptotic pathway (IMP,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	BCL-W has a fundamental role in B cell survival and lymphomagenesis.	Adams CM, etal., J Clin Invest. 2017 Feb 1;127(2):635-650. doi: 10.1172/JCI89486. Epub 2017 Jan 17.
2.	The Bcl-2 apoptotic switch in cancer development and therapy.	Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
3.	Regulation of Apoptosis by miR-122 in Pterygium via Targeting Bcl-w.	Cui YH, etal., Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3723-30. doi: 10.1167/iovs.16-19402.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats.	Geng Y, etal., Biol Pharm Bull. 2010;33(5):836-43.
6.	RNA expression bcl-w, a new related protein Bcl-2 family, and caspase-3 in isolated sertoli cells from pre-pubertal rat testes.	Giannattasio A, etal., J Endocrinol Invest 2002 Jul-Aug;25(7):RC23-5.
7.	Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system.	Hamner S, etal., Neuroscience 1999;91(2):673-84.
8.	Increased Bcl-w expression following focally evoked limbic seizures in the rat.	Henshall DC, etal., Neurosci Lett. 2001 Jun 15;305(3):153-6.
9.	Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.	Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
10.	Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats.	Hu XL, etal., Eur J Neurosci. 2004 Sep;20(5):1177-88.
11.	Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.	Huynh JL, etal., Nat Neurosci. 2014 Jan;17(1):121-30. doi: 10.1038/nn.3588. Epub 2013 Nov 24.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
14.	Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.	Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
15.	Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant.	Print CG, etal., Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12424-31.
16.	GOA pipeline	RGD automated data pipeline
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Testicular degeneration in Bclw-deficient mice.	Ross AJ, etal., Nat Genet 1998 Mar;18(3):251-6.
19.	p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells.	Song Y, etal., Toxicology. 2008 Nov 20;253(1-3):53-61. Epub 2008 Sep 4.
20.	Adeno-associated virus-mediated delivery of BCL-w gene improves outcome after transient focal cerebral ischemia.	Sun Y, etal., Gene Ther. 2003 Jan;10(2):115-22. doi: 10.1038/sj.gt.3301868.
21.	Bcl-w expression in colorectal adenocarcinoma.	Wilson JW, etal., Br J Cancer. 2000 Jan;82(1):178-85. doi: 10.1054/bjoc.1999.0897.
22.	Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway.	Yan C, etal., J Cereb Blood Flow Metab. 2000 Mar;20(3):620-30. doi: 10.1097/00004647-200003000-00020.
23.	Improvement of the viability of cultured rat neurons by the non-essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w.	Yang L, etal., Neurosci Lett. 2000 Dec 8;295(3):97-100.
24.	Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.	Yao M, etal., J Neurosci. 2007 Feb 7;27(6):1422-33. doi: 10.1523/JNEUROSCI.2382-06.2007.
25.	Neuroprotective properties of Bcl-w in Alzheimer disease.	Zhu X, etal., J Neurochem. 2004 Jun;89(5):1233-40. doi: 10.1111/j.1471-4159.2004.02416.x.

Additional References at PubMed

PMID:9731710	PMID:10579309	PMID:11161472	PMID:11784036	PMID:11980919	PMID:12115603	PMID:12477932	PMID:12787069	PMID:15689551	PMID:16645638	PMID:17289999	PMID:19766102
PMID:22000515	PMID:22094713	PMID:23376485	PMID:23516285	PMID:33128129	PMID:35894779

Genomics

Comparative Map Data

Bcl2l2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	32,326,686 - 32,337,834 (+)	NCBI		GRCr8
mRatBN7.2	15	28,346,449 - 28,361,627 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	28,356,807 - 28,361,624 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	30,202,463 - 30,207,316 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	31,349,665 - 31,354,518 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	29,592,361 - 29,597,214 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	33,543,774 - 33,549,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	33,544,312 - 33,549,164 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	37,430,718 - 37,436,392 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	32,983,165 - 32,988,018 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	32,998,864 - 33,003,717 (+)	NCBI
Celera	15	27,934,581 - 27,939,434 (+)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

BCL2L2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	23,306,833 - 23,311,751 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	23,298,790 - 23,311,751 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	23,776,042 - 23,780,960 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	22,845,852 - 22,850,808 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	22,845,875 - 22,850,798	NCBI
Celera	14	3,638,729 - 3,643,685 (+)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	3,892,647 - 3,897,644 (+)	NCBI		HuRef
CHM1_1	14	23,774,641 - 23,779,638 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	17,507,847 - 17,512,765 (+)	NCBI		T2T-CHM13v2.0

Bcl2l2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,120,900 - 55,125,691 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,120,834 - 55,125,691 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	54,883,366 - 54,890,858 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	54,892,500 - 54,898,169 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	14	54,883,377 - 54,888,234 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	55,502,262 - 55,507,071 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	53,837,630 - 53,842,439 (+)	NCBI		MGSCv36	mm8
Celera	14	52,689,850 - 52,694,635 (+)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	27.98	NCBI

BCL2L2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	3,569,335 - 3,573,922 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	3,569,399 - 3,586,070 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	3,517,730 - 3,520,191 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	3,677,216 - 3,679,677 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	3,677,216 - 3,693,900 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	3,368,789 - 3,371,249 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	3,430,095 - 3,432,556 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	3,692,030 - 3,694,491 (+)	NCBI		UU_Cfam_GSD_1.0

BCL2L2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,763,078 - 75,769,763 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,765,603 - 75,770,743 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,970,146 - 80,975,278 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Variants

Variants in Bcl2l2
40 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	574
Count of miRNA genes:	267
Interacting mature miRNAs:	362
Transcripts:	ENSRNOT00000020409
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	14481165	28469888	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	19856566	34924750	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat

Markers in Region

Bcl2l2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	28,358,046 - 28,358,825 (+)	MAPPER	mRatBN7.2
mRatBN7.2	X	18,645,579 - 18,645,758 (-)	MAPPER	mRatBN7.2
Rnor_6.0	5	131,563,338 - 131,563,516	NCBI	Rnor6.0
Rnor_6.0	15	33,545,587 - 33,546,365	NCBI	Rnor6.0
Rnor_5.0	15	37,432,533 - 37,433,311	UniSTS	Rnor5.0
Rnor_5.0	5	135,387,340 - 135,387,518	UniSTS	Rnor5.0
RGSC_v3.4	15	32,984,440 - 32,985,218	UniSTS	RGSC3.4
RGSC_v3.4	X	38,831,469 - 38,831,647	UniSTS	RGSC3.4
Celera	X	18,918,630 - 18,918,808	UniSTS
Celera	15	27,935,856 - 27,936,634	UniSTS
Cytogenetic Map	15	p13	UniSTS
Cytogenetic Map	X	q14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	42	33	23	13	23	7	10	74	35	36	11	7
Low		1	24	18	6	18	1	1			5		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_021850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF096291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY185098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY185099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY185100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC074021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000020409 ⟹ ENSRNOP00000020409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	28,356,807 - 28,361,624 (+)	Ensembl
Rnor_6.0 Ensembl	15	33,544,312 - 33,549,164 (+)	Ensembl

RefSeq Acc Id:

NM_021850 ⟹ NP_068622

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	32,326,761 - 32,331,614 (+)	NCBI
mRatBN7.2	15	28,356,772 - 28,361,625 (+)	NCBI
Rnor_6.0	15	33,544,312 - 33,549,165 (+)	NCBI
Rnor_5.0	15	37,430,718 - 37,436,392 (+)	NCBI
RGSC_v3.4	15	32,983,165 - 32,988,018 (+)	RGD
Celera	15	27,934,581 - 27,939,434 (+)	RGD

Sequence:

show sequence

CTTCCTTTCCTCCCTCTCTCCCTCCCTCCCTCCCTCCCTCCCAGCTCCTCCACCAGGAAACAAC
CGGATTCCCGATCCCGACCGAGGCCTTCTTCCTGACTCGGCTCCACTCTCGCCGGGAGGATGAA
AGGCCTCAGCTGGGGGCTCCCTGCCATCAGCACTGGGTCGTAAGAGCTGCCATCCAGGCTGGCC
GCCCGGATGGCGACCCCAGCCTCAACCCCAGACACACGGGCTCTAGTGGCTGACTTTGTAGGCT
ATAAGCTGAGGCAGAAGGGTTATGTCTGTGGAGCTGGCCCTGGGGAAGGCCCAGCAGCCGACCC
GCTGCACCAAGCCATGCGGGCAGCTGGAGACGAGTTTGAGACCCGCTTCCGGCGCACCTTCTCT
GACCTGGCCGCTCAGCTACACGTGACCCCAGGCTCAGCCCAGCAACGCTTCACCCAGGTTTCCG
ACGAACTTTTCCAAGGGGGCCCCAACTGGGGCCGTCTTGTGGCATTCTTTGTCTTTGGGGCTGC
CCTGTGTGCTGAGAGTGTCAACAAAGAAATGGAGCCATTGGTGGGACAAGTGCAGGATTGGATG
GTGACCTACCTGGAGACACGCTTGGCTGACTGGATCCACAGCAGTGGGGGCTGGGCGGAGTTCA
CAGCTCTATACGGGGACGGGGCCCTGGAGGAGGCACGGCGTCTGCGGGAGGGGAACTGGGCATC
AGTGAGGACAGTGCTGACGGGGGCTGTGGCACTGGGGGCCCTGGTAACTGTAGGGGCCTTTTTT
GCTAGCAAGTGAGAAAGTCTAGGGTCAGGTGGGGCTAGGTGTGGCTAGGGGCCAGGAGAGCTGG
AACAATAGAGAATGCCCTTGGAAGAAACTGGATGGTCACGGAACAGAGGAAGGCAGAGGAAGGT
AGTGTGTGTGGGAGCCAAGCACGCCAGGCAGGTGGCAGGAAGGAGGACTTGGAAACACTAAGGA
ATGTTTCAAGGCCAGGAACCCAGAGGGTGGAGTCATCCCACGGCTTGCAGGGAGGTGGGAGGAA
TCCTGCCTATATCGTGGGCACACAAACTACCTGGATCAGGGCTTGTGGTTCCAAGGAAGGTGAG
CTCACTTAAAAGATCGGTGTCTCTACTAGATGAATGGGATTTAGGGAACCTAGAACTCACCTCC
CTTTGGAATGGAAGCTTGGTGACTGGATGAAATGGCTGTGGCTGTGGGCTGCATGGGCACACCT
GTGCATGGGCACACCTGTGCATGGGCACACCTGTGCATGGGCACACCTGTGCATGGGCACATGC
AGGCATGCTCATGTGCATGCTGGGCTGTTTGTTGACTCTGATGATGGGGTACTTAGAGAAAACA
TTCCTTCTTGCTGTGGCAAGAACAAGGGCCAGTTCACTGCCCTTCTCCCCTCTGCCCCTTCCCT
AGACCTTAGGCCTCCAGGCTGGAGGAGGAACACTGTATCTAGACTAGGGCTCTGGCACTGCTGA
AAGTTGACAGGGCTTTGGAGAGAAGAGTTCTGCAGCTGGCCTTGTTCTTTACCATCCCCCTTCT
GTGTGCATCTGTGCACCCCGGCTGACAAAGGGCAAGGCTGTGGAGCCTGGGTGGATAGGAGCTT
TGGTACTTGGGCTTGCCTATCACCTTCCCCTCCAATGGAGGCACCTTGGTACCTAGAGTGTTGC
CTGTTTCTAGGACCTCTTTATCCAGCTGAGACTCTAAATTGGGGCACTAATTTTCCTTTAGAAG
ATACGGATATGAATGCTGATCTAGAATTCAGTTTAGTTCCTGAGCTGTCTCAGTGAGACTGCCG
ATGCCTAGAGAGGACCATTCCCACTCTGAGTCCCTTGGGAGTGATGGGGACAGGTACTCCTTGC
CTGGCCTATTCTGTGTGGTGGGTTTTGGTGCTGCTGTATCAGGGGCCAGGTGTATGGGTTCTAG
AGTACCTGCCACGACTTCAACACGTTTTCTTTTGAAGCCATCCATGCTCTTTGCATAGGTTGTG
TTGTCAGTACTTGAGTCTCTGAAGATGTCGGTCACGTTAGAACTCACAGTCCAGTCCTCTAGAA
CAAACCCAGACCATAGCTTTTTCTTTCGAGGGAGGAATCATTCACTCCAAACGCATGCCCTGAG
CCAGACCTCACTGCTGCACTTTCCAAGGTGCTAACATTGCTGCTCTTTGACGCCAACTTCGTTC
GCAGTGCTCTAGAACCCTACCTACCTATCCTGAGCACTGACCAGCTTGGCTAGGCCACAGCTGA
CTCGCCTCTTCACTTGGTCCTAGAATGTGGCATCGTATCGTGCTTGCTAGAATGTGGGACCAAA
TTGGCCTCAGGTGTTTAGTCCAGACTTTTGCTTCTGAGAGAAGGTTGCACTTTTTGATAGTGTC
TGTGGGGGATGTGGGAGGCTGCATGTGCCAGTTGGTGTATTTTGAGGGTGATGATCTAAGAAAC
TCAGAGCTGTCTCTGGCAAGCAGTTGGAGTGGGAGGCTCTGACTTGCTCAGGACAAACTAGGCC
AGTGGTTTTCAAACTGCTTGGCAGAGCCCCGAAGTGTCCTAGGGGTTGCCTCAGGAGTCCTTAG
GGAGATGAGGGAGTGGAGGGCTGGGCAGTTTGCCCTCAAACAGAACAGCTCCCCTTGTAGCTGT
CTTATGTATCGGGGTTCAGGGTAAGATTTTATTTGTGGTAAGGGCTTTGCTGCTGAAAAAAGTT
AGAAAACCACTGACTAGACCATCAGCTCCATTTGGAGTCTGTGCTCCTCCGAGTTCCGGGAAGA
CTCTCTGCTCTACCCTTCCCACGGGACCCCTACCCAAGTTAGCATTCCTGGGGGCCTTTAGCAA
ACAGGAGCAGTGGGAACCAGGGTCGGGTTACCAACACCCTCTGCTGCTGAGCCTCCAGACAGGT
GAAAGGAGAGGCCGTTATGGGAAGCTAAAGGGTTGGTCTTGGTCTGGATTCCCAGAAGCTTAGC
TTAGATGGGACCACAGTGGGGAGTTGTGACCTGTTCTGCCCTTCGTTTTGAGGGCCAGTGGAAA
CCCAGAGACTCTTCTGTCAGGGAAAACCAGGGACTGTCTTTCAGAGCCATATAGTTCCTTGGGA
TCAGCTCTTGGCCAAGAGGGCTGAGTATGGCTCCCAACTTTTAAATCCATTTCATTTTTTTAAA
TGAGGGAAATAGATCTAATTTTTCAGATATTAAGTAGGTGGAGAGGATGTTCTTGCTCTCCAAA
GCCCAAAGGGATAAATAGGGACTTTGCTTAGGCCAAGGCAAGAGCGGAAGTGGGGCAAGTCAGT
CCTGCAGTTGTCAATCCTACTCCCCACCTCACTAGGGCATACATATACTATTTTACTTTTTTAA
AATCATAAACGGCAGGAGAACAGATTTGGTTAGTTTAGAAGAAGAGAAAAAGCTCTATAAATAT
AAATATATATTCCTGTATTTTTATTTAATAATTTATAAATGCCAAGTTCATTTGACTTTTATTT
TTGTGTAATATGTAATGGTCGTATTAAAAATAAACAAATAAAGCCCAGAAATTTAATGAGAAGT
AAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017599793 ⟹ XP_017455282

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	32,327,629 - 32,331,611 (+)	NCBI
mRatBN7.2	15	28,357,257 - 28,361,622 (+)	NCBI
Rnor_6.0	15	33,544,793 - 33,549,165 (+)	NCBI

Sequence:

show sequence

GTCCTCTTCCTTTCTGCCCCATTACAGCCCTTGGCTTTTCCCATCTTCCTATTCAGCCCCTGTC
TCCTCCCTATCTTGTGCCTCTGCCAACATCTTCACATCATGCTCCTGGGGAGGTCTTTAGCCTC
TTCCTGTAGCCAGAAAGGTATGTGTGTGTGCGCGTGTGTGCGCGCGCAGAGGTGTCATACAGCT
GGTGGTGTCGTATGAAAGGAATCTGAAGTAGTCTAAAAATAAGATTTCCTGTTGCACACTTAAT
TTGACATGTTATACGTGGCCAGCTGCTTATGCTCTGAAACCTCCCCAAGACTTAAATCCTTTGC
TCTTGCTTGTCCCTGCCCAGTGGCCTCTGAGCATTTCACCTATCTCAGGAGCTTGATCAAATAG
AAAATGTCCCTTTTTGGTCTCTGTCAATATTTTTCATATATTTATGTCAGTCTGTCATCCTTGC
CCCTTTCAGCCGCCCGGATGGCGACCCCAGCCTCAACCCCAGACACACGGGCTCTAGTGGCTGA
CTTTGTAGGCTATAAGCTGAGGCAGAAGGGTTATGTCTGTGGAGCTGGCCCTGGGGAAGGCCCA
GCAGCCGACCCGCTGCACCAAGCCATGCGGGCAGCTGGAGACGAGTTTGAGACCCGCTTCCGGC
GCACCTTCTCTGACCTGGCCGCTCAGCTACACGTGACCCCAGGCTCAGCCCAGCAACGCTTCAC
CCAGGTTTCCGACGAACTTTTCCAAGGGGGCCCCAACTGGGGCCGTCTTGTGGCATTCTTTGTC
TTTGGGGCTGCCCTGTGTGCTGAGAGTGTCAACAAAGAAATGGAGCCATTGGTGGGACAAGTGC
AGGATTGGATGGTGACCTACCTGGAGACACGCTTGGCTGACTGGATCCACAGCAGTGGGGGCTG
GGCGGAGTTCACAGCTCTATACGGGGACGGGGCCCTGGAGGAGGCACGGCGTCTGCGGGAGGGG
AACTGGGCATCAGTGAGGACAGTGCTGACGGGGGCTGTGGCACTGGGGGCCCTGGTAACTGTAG
GGGCCTTTTTTGCTAGCAAGTGAGAAAGTCTAGGGTCAGGTGGGGCTAGGTGTGGCTAGGGGCC
AGGAGAGCTGGAACAATAGAGAATGCCCTTGGAAGAAACTGGATGGTCACGGAACAGAGGAAGG
CAGAGGAAGGTAGTGTGTGTGGGAGCCAAGCACGCCAGGCAGGTGGCAGGAAGGAGGACTTGGA
AACACTAAGGAATGTTTCAAGGCCAGGAACCCAGAGGGTGGAGTCATCCCACGGCTTGCAGGGA
GGTGGGAGGAATCCTGCCTATATCGTGGGCACACAAACTACCTGGATCAGGGCTTGTGGTTCCA
AGGAAGGTGAGCTCACTTAAAAGATCGGTGTCTCTACTAGATGAATGGGATTTAGGGAACCTAG
AACTCACCTCCCTTTGGAATGGAAGCTTGGTGACTGGATGAAATGGCTGTGGCTGTGGGCTGCA
TGGGCACACCTGTGCATGGGCACACCTGTGCATGGGCACACCTGTGCATGGGCACACCTGTGCA
TGGGCACATGCAGGCATGCTCATGTGCATGCTGGGCTGTTTGTTGACTCTGATGATGGGGTACT
TAGAGAAAACATTCCTTCTTGCTGTGGCAAGAACAAGGGCCAGTTCACTGCCCTTCTCCCCTCT
GCCCCTTCCCTAGACCTTAGGCCTCCAGGCTGGAGGAGGAACACTGTATCTAGACTAGGGCTCT
GGCACTGCTGAAAGTTGACAGGGCTTTGGAGAGAAGAGTTCTGCAGCTGGCCTTGTTCTTTACC
ATCCCCCTTCTGTGTGCATCTGTGCACCCCGGCTGACAAAGGGCAAGGCTGTGGAGCCTGGGTG
GATAGGAGCTTTGGTACTTGGGCTTGCCTATCACCTTCCCCTCCAATGGAGGCACCTTGGTACC
TAGAGTGTTGCCTGTTTCTAGGACCTCTTTATCCAGCTGAGACTCTAAATTGGGGCACTAATTT
TCCTTTAGAAGATACGGATATGAATGCTGATCTAGAATTCAGTTTAGTTCCTGAGCTGTCTCAG
TGAGACTGCCGATGCCTAGAGAGGACCATTCCCACTCTGAGTCCCTTGGGAGTGATGGGGACAG
GTACTCCTTGCCTGGCCTATTCTGTGTGGTGGGTTTTGGTGCTGCTGTATCAGGGGCCAGGTGT
ATGGGTTCTAGAGTACCTGCCACGACTTCAACACGTTTTCTTTTGAAGCCATCCATGCTCTTTG
CATAGGTTGTGTTGTCAGTACTTGAGTCTCTGAAGATGTCGGTCACGTTAGAACTCACAGTCCA
GTCCTCTAGAACAAACCCAGACCATAGCTTTTTCTTTCGAGGGAGGAATCATTCACTCCAAACG
CATGCCCTGAGCCAGACCTCACTGCTGCACTTTCCAAGGTGCTAACATTGCTGCTCTTTGACGC
CAACTTCGTTCGCAGTGCTCTAGAACCCTACCTACCTATCCTGAGCACTGACCAGCTTGGCTAG
GCCACAGCTGACTCGCCTCTTCACTTGGTCCTAGAATGTGGCATCGTATCGTGCTTGCTAGAAT
GTGGGACCAAATTGGCCTCAGGTGTTTAGTCCAGACTTTTGCTTCTGAGAGAAGGTTGCACTTT
TTGATAGTGTCTGTGGGGGATGTGGGAGGCTGCATGTGCCAGTTGGTGTATTTTGAGGGTGATG
ATCTAAGAAACTCAGAGCTGTCTCTGGCAAGCAGTTGGAGTGGGAGGCTCTGACTTGCTCAGGA
CAAACTAGGCCAGTGGTTTTCAAACTGCTTGGCAGAGCCCCGAAGTGTCCTAGGGGTTGCCTCA
GGAGTCCTTAGGGAGATGAGGGAGTGGAGGGCTGGGCAGTTTGCCCTCAAACAGAACAGCTCCC
CTTGTAGCTGTCTTATGTATCGGGGTTCAGGGTAAGATTTTATTTGTGGTAAGGGCTTTGCTGC
TGAAAAAAGTTAGAAAACCACTGACTAGACCATCAGCTCCATTTGGAGTCTGTGCTCCTCCGAG
TTCCGGGAAGACTCTCTGCTCTACCCTTCCCACGGGACCCCTACCCAAGTTAGCATTCCTGGGG
GCCTTTAGCAAACAGGAGCAGTGGGAACCAGGGTCGGGTTACCAACACCCTCTGCTGCTGAGCC
TCCAGACAGGTGAAAGGAGAGGCCGTTATGGGAAGCTAAAGGGTTGGTCTTGGTCTGGATTCCC
AGAAGCTTAGCTTAGATGGGACCACAGTGGGGAGTTGTGACCTGTTCTGCCCTTCGTTTTGAGG
GCCAGTGGAAACCCAGAGACTCTTCTGTCAGGGAAAACCAGGGACTGTCTTTCAGAGCCATATA
GTTCCTTGGGATCAGCTCTTGGCCAAGAGGGCTGAGTATGGCTCCCAACTTTTAAATCCATTTC
ATTTTTTTAAATGAGGGAAATAGATCTAATTTTTCAGATATTAAGTAGGTGGAGAGGATGTTCT
TGCTCTCCAAAGCCCAAAGGGATAAATAGGGACTTTGCTTAGGCCAAGGCAAGAGCGGAAGTGG
GGCAAGTCAGTCCTGCAGTTGTCAATCCTACTCCCCACCTCACTAGGGCATACATATACTATTT
TACTTTTTTAAAATCATAAACGGCAGGAGAACAGATTTGGTTAGTTTAGAAGAAGAGAAAAAGC
TCTATAAATATAAATATATATTCCTGTATTTTTATTTAATAATTTATAAATGCCAAGTTCATTT
GACTTTTATTTTTGTGTAATATGTAATGGTCGTATTAAAAATAAACAAATAAAGCCCAGAAATT
TAATGAGAAGTA

hide sequence

RefSeq Acc Id:

XM_063274606 ⟹ XP_063130676

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	32,326,686 - 32,337,834 (+)	NCBI

RefSeq Acc Id:

XM_063274607 ⟹ XP_063130677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	32,326,686 - 32,337,834 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_068622	(Get FASTA)	NCBI Sequence Viewer
	XP_017455282	(Get FASTA)	NCBI Sequence Viewer
	XP_063130676	(Get FASTA)	NCBI Sequence Viewer
	XP_063130677	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC64200	(Get FASTA)	NCBI Sequence Viewer
	AAH74021	(Get FASTA)	NCBI Sequence Viewer
	AAO64468	(Get FASTA)	NCBI Sequence Viewer
	AAO64469	(Get FASTA)	NCBI Sequence Viewer
	AAO64470	(Get FASTA)	NCBI Sequence Viewer
	EDM14197	(Get FASTA)	NCBI Sequence Viewer
	EDM14198	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020409.3

RefSeq Acc Id:	NP_068622 ⟸ NM_021850
- UniProtKB:	O88996 (UniProtKB/TrEMBL), F7ELB1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDL AAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVT YLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFAS K hide sequence

RefSeq Acc Id:	XP_017455282 ⟸ XM_017599793
- Peptide Label:	isoform X1
- UniProtKB:	Q7TS60 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLFGLCQYFSYIYVSLSSLPLSAARMATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPA ADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVF GAALCAESVNKEMEPLVGQVQDWMVTYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGN WASVRTVLTGAVALGALVTVGAFFASK hide sequence

RefSeq Acc Id:

ENSRNOP00000020409 ⟸ ENSRNOT00000020409

RefSeq Acc Id:	XP_063130676 ⟸ XM_063274606
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063130677 ⟸ XM_063274607
- Peptide Label:	isoform X3

Protein Domains

Apoptosis regulator Bcl-2 family BH4

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88996-F1-model_v2	AlphaFold	O88996	1-193	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699661

Promoter ID:

EPDNEW_R10184

Type:

multiple initiation site

Name:

Bcl2l2_1

Description:

Bcl2-like 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	33,544,343 - 33,544,403	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620717	AgrOrtholog
BIND	133989
	133990
BioCyc Gene	G2FUF-13770	BioCyc
Ensembl Genes	ENSRNOG00000015732	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020409.5	UniProtKB/TrEMBL
Gene3D-CATH	1.10.437.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7105621	IMAGE-MGC_LOAD
InterPro	Apop_reg_BclW	UniProtKB/TrEMBL
	Bcl-2_BH1-3	UniProtKB/TrEMBL
	BCL2_apoptsis	UniProtKB/TrEMBL
	Bcl2_BH1_motif_CS	UniProtKB/TrEMBL
	Bcl2_BH2_motif_CS	UniProtKB/TrEMBL
	Bcl2_BH4	UniProtKB/TrEMBL
	Bcl2_BH4_motif_CS	UniProtKB/TrEMBL
	Blc2-like_sf	UniProtKB/TrEMBL
	Blc2_fam	UniProtKB/TrEMBL
KEGG Report	rno:60434	UniProtKB/TrEMBL
MGC_CLONE	MGC:91704	IMAGE-MGC_LOAD
NCBI Gene	60434	ENTREZGENE
PANTHER	BCL-2-LIKE PROTEIN 2	UniProtKB/TrEMBL
	PTHR11256	UniProtKB/TrEMBL
Pfam	Bcl-2	UniProtKB/TrEMBL
	BH4	UniProtKB/TrEMBL
PhenoGen	Bcl2l2	PhenoGen
PRINTS	APOPREGBCLW	UniProtKB/TrEMBL
	BCL2FAMILY	UniProtKB/TrEMBL
PROSITE	BCL2_FAMILY	UniProtKB/TrEMBL
	BH1	UniProtKB/TrEMBL
	BH2	UniProtKB/TrEMBL
	BH4_1	UniProtKB/TrEMBL
	BH4_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015732	RatGTEx
SMART	BCL	UniProtKB/TrEMBL
	BH4	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56854	UniProtKB/TrEMBL
UniProt	F7ELB1	ENTREZGENE, UniProtKB/TrEMBL
	O88996	ENTREZGENE, UniProtKB/TrEMBL
	Q7TS60	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Bcl2l2	Bcl2-like 2		Bcl-w protein	Name updated	1299863	APPROVED
2002-08-07	Bcl2l2	Bcl-w protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_product	member of the Bcl-2 family of anti-apoptotic proteins	632001

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

RGD Manual Annotations