Sfxn3 (sideroflexin 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sfxn3 (sideroflexin 3) Rattus norvegicus
Analyze
Symbol: Sfxn3
Name: sideroflexin 3
RGD ID: 620716
Description: Predicted to enable L-serine transmembrane transporter activity. Predicted to be involved in serine import into mitochondrion. Located in mitochondrial membrane. Orthologous to human SFXN3 (sideroflexin 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Loc65042; sideroflexin-3; SLC64A3; solute carrier family 64 member 3; TCC; tricarboxylate carrier; tricarboxylate carrier-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Rf1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,856,935 - 253,866,219 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1253,856,882 - 253,887,542 (+)EnsemblGRCr8
mRatBN7.21243,907,958 - 243,917,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,907,751 - 243,917,073 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1252,056,395 - 252,064,673 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,754,272 - 258,762,548 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01251,406,450 - 251,414,785 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,796,671 - 264,805,159 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,796,812 - 264,805,157 (+)Ensemblrn6Rnor6.0
Rnor_5.01272,238,265 - 272,247,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41250,113,685 - 250,122,002 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1239,719,856 - 239,728,172 (+)NCBICelera
RGSC_v3.11250,374,253 - 250,382,570 (+)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain. Miyake S, etal., Brain Res Mol Brain Res 2002 Apr 30;100(1-2):67-73.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. Roles of CTPL/Sfxn3 and Sfxn family members in pancreatic islet. Yoshikumi Y, etal., J Cell Biochem. 2005 Aug 15;95(6):1157-68.
Additional References at PubMed
PMID:1299286   PMID:18614015   PMID:21700703   PMID:29476059   PMID:30442778   PMID:31177362  


Genomics

Comparative Map Data
Sfxn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,856,935 - 253,866,219 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1253,856,882 - 253,887,542 (+)EnsemblGRCr8
mRatBN7.21243,907,958 - 243,917,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,907,751 - 243,917,073 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1252,056,395 - 252,064,673 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,754,272 - 258,762,548 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01251,406,450 - 251,414,785 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,796,671 - 264,805,159 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,796,812 - 264,805,157 (+)Ensemblrn6Rnor6.0
Rnor_5.01272,238,265 - 272,247,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41250,113,685 - 250,122,002 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1239,719,856 - 239,728,172 (+)NCBICelera
RGSC_v3.11250,374,253 - 250,382,570 (+)NCBI
Cytogenetic Map1q54NCBI
SFXN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,031,234 - 101,041,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10101,031,229 - 101,041,244 (+)Ensemblhg38GRCh38
GRCh3710102,790,991 - 102,800,998 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,780,986 - 102,790,988 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410102,780,985 - 102,790,987NCBI
Celera1096,528,732 - 96,538,734 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1096,420,512 - 96,430,563 (+)NCBIHuRef
CHM1_110103,075,229 - 103,085,231 (+)NCBICHM1_1
T2T-CHM13v2.010101,914,634 - 101,924,642 (+)NCBIT2T-CHM13v2.0
Sfxn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,036,015 - 45,044,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,035,942 - 45,044,822 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381945,046,773 - 45,056,383 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,047,503 - 45,056,383 (+)Ensemblmm10GRCm38
MGSCv371945,122,066 - 45,130,873 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361945,100,985 - 45,109,693 (+)NCBIMGSCv36mm8
Celera1945,818,428 - 45,827,234 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.26NCBI
Sfxn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554859,157,657 - 9,165,243 (-)Ensembl
ChiLan1.0NW_0049554859,157,657 - 9,165,243 (-)NCBIChiLan1.0ChiLan1.0
SFXN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,916,308 - 112,926,311 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,922,232 - 112,931,631 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01097,632,562 - 97,642,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,108,356 - 101,116,876 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,109,287 - 101,116,396 (+)EnsemblpanPan2panpan1.1
SFXN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,712,846 - 13,720,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,712,891 - 13,718,926 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2813,882,071 - 13,889,728 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02814,180,680 - 14,188,348 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,180,940 - 14,188,348 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12813,726,422 - 13,734,072 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,767,713 - 13,775,364 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,899,688 - 13,907,367 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sfxn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,047,540 - 33,057,167 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,650,244 - 4,659,551 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366004,650,765 - 4,659,641 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFXN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,111,569 - 112,119,162 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114112,111,483 - 112,119,166 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214121,769,174 - 121,770,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFXN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,049,167 - 94,057,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl994,051,515 - 94,058,561 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604855,100,818 - 55,109,841 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfxn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624831625,489 - 633,298 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624831624,788 - 633,306 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sfxn3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1244,553,168 - 44,561,618 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sfxn3
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:209
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000021171
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Rat81  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,914,732 - 243,914,901 (+)MAPPERmRatBN7.2
Rnor_6.01264,802,828 - 264,802,994NCBIRnor6.0
Rnor_5.01272,245,217 - 272,245,383UniSTSRnor5.0
RGSC_v3.41250,119,666 - 250,119,874RGDRGSC3.4
RGSC_v3.41250,119,672 - 250,119,838UniSTSRGSC3.4
Celera1239,725,843 - 239,726,008UniSTS
RGSC_v3.11250,380,235 - 250,380,443RGD
SHRSP x BN Map1139.1099RGD
SHRSP x BN Map1139.1099UniSTS
FHH x ACI Map1129.1499RGD
Cytogenetic Map1q54UniSTS
D1Rat453  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81253,863,888 - 253,864,018 (+)Marker Load Pipeline
mRatBN7.21243,914,732 - 243,914,864 (+)MAPPERmRatBN7.2
Rnor_6.01264,802,828 - 264,802,957NCBIRnor6.0
Rnor_5.01272,245,217 - 272,245,346UniSTSRnor5.0
RGSC_v3.41250,119,672 - 250,119,801UniSTSRGSC3.4
RGSC_v3.41250,119,671 - 250,119,801RGDRGSC3.4
Celera1239,725,843 - 239,725,971UniSTS
SHRSP x BN Map1139.09UniSTS
SHRSP x BN Map1139.09RGD
Cytogenetic Map1q54UniSTS
D1Rat374  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81253,863,893 - 253,864,089 (+)Marker Load Pipeline
mRatBN7.21243,914,737 - 243,914,935 (+)MAPPERmRatBN7.2
Rnor_6.01264,802,833 - 264,803,028NCBIRnor6.0
Rnor_5.01272,245,222 - 272,245,417UniSTSRnor5.0
RGSC_v3.41250,119,676 - 250,119,870RGDRGSC3.4
RGSC_v3.41250,119,677 - 250,119,872UniSTSRGSC3.4
Celera1239,725,848 - 239,726,042UniSTS
RGSC_v3.11250,380,245 - 250,380,439RGD
SHRSP x BN Map1139.09RGD
SHRSP x BN Map1139.09UniSTS
Cytogenetic Map1q54UniSTS
D1Rat375  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81253,863,903 - 253,864,018 (+)Marker Load Pipeline
mRatBN7.21243,914,747 - 243,914,864 (+)MAPPERmRatBN7.2
Rnor_6.01264,802,843 - 264,802,957NCBIRnor6.0
Rnor_5.01272,245,232 - 272,245,346UniSTSRnor5.0
RGSC_v3.41250,119,687 - 250,119,801UniSTSRGSC3.4
RGSC_v3.41250,119,686 - 250,119,801RGDRGSC3.4
Celera1239,725,858 - 239,725,971UniSTS
RGSC_v3.11250,380,256 - 250,380,370RGD
RH 3.4 Map11622.91UniSTS
RH 3.4 Map11622.91RGD
RH 2.0 Map11223.7RGD
SHRSP x BN Map1139.09RGD
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021171   ⟹   ENSRNOP00000021171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,866,222 (+)Ensembl
mRatBN7.2 Ensembl1243,908,703 - 243,917,059 (+)Ensembl
Rnor_6.0 Ensembl1264,796,812 - 264,805,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096811   ⟹   ENSRNOP00000084659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,866,222 (+)Ensembl
mRatBN7.2 Ensembl1243,907,751 - 243,917,065 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098685   ⟹   ENSRNOP00000078124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,866,222 (+)Ensembl
mRatBN7.2 Ensembl1243,908,867 - 243,917,063 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100653   ⟹   ENSRNOP00000089193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,866,222 (+)Ensembl
mRatBN7.2 Ensembl1243,908,707 - 243,917,073 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105996   ⟹   ENSRNOP00000083890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,856,882 - 253,866,222 (+)Ensembl
mRatBN7.2 Ensembl1243,908,683 - 243,917,065 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124342   ⟹   ENSRNOP00000103673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,864,736 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128043   ⟹   ENSRNOP00000102519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,878,771 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136486   ⟹   ENSRNOP00000109953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,887,542 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000148126   ⟹   ENSRNOP00000108267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,864,736 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151363   ⟹   ENSRNOP00000107418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1253,858,073 - 253,864,816 (+)Ensembl
RefSeq Acc Id: NM_022948   ⟹   NP_075237
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,857,902 - 253,866,219 (+)NCBI
mRatBN7.21243,908,742 - 243,917,065 (+)NCBI
Rnor_6.01264,796,841 - 264,805,158 (+)NCBI
Rnor_5.01272,238,265 - 272,247,550 (+)NCBI
RGSC_v3.41250,113,685 - 250,122,002 (+)RGD
Celera1239,719,856 - 239,728,172 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231565   ⟹   XP_006231627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,857,711 - 253,866,219 (+)NCBI
mRatBN7.21243,908,552 - 243,917,065 (+)NCBI
Rnor_6.01264,796,671 - 264,805,159 (+)NCBI
Rnor_5.01272,238,265 - 272,247,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231566   ⟹   XP_006231628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,859,129 - 253,866,219 (+)NCBI
mRatBN7.21243,909,961 - 243,917,065 (+)NCBI
Rnor_6.01264,798,097 - 264,805,159 (+)NCBI
Rnor_5.01272,238,265 - 272,247,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760451   ⟹   XP_008758673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,858,402 - 253,866,219 (+)NCBI
mRatBN7.21243,909,249 - 243,917,065 (+)NCBI
Rnor_6.01264,797,371 - 264,805,159 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089867   ⟹   XP_038945795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,856,935 - 253,866,219 (+)NCBI
mRatBN7.21243,907,958 - 243,917,065 (+)NCBI
RefSeq Acc Id: XM_063272891   ⟹   XP_063128961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,857,863 - 253,866,219 (+)NCBI
RefSeq Acc Id: NP_075237   ⟸   NM_022948
- UniProtKB: G3V804 (UniProtKB/Swiss-Prot),   Q9JHY2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231627   ⟸   XM_006231565
- Peptide Label: isoform X2
- UniProtKB: Q9JHY2 (UniProtKB/Swiss-Prot),   G3V804 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231628   ⟸   XM_006231566
- Peptide Label: isoform X2
- UniProtKB: Q9JHY2 (UniProtKB/Swiss-Prot),   G3V804 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758673   ⟸   XM_008760451
- Peptide Label: isoform X2
- UniProtKB: Q9JHY2 (UniProtKB/Swiss-Prot),   G3V804 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021171   ⟸   ENSRNOT00000021171
RefSeq Acc Id: XP_038945795   ⟸   XM_039089867
- Peptide Label: isoform X1
- UniProtKB: Q9JHY2 (UniProtKB/Swiss-Prot),   G3V804 (UniProtKB/Swiss-Prot),   A0A8I6A2F4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078124   ⟸   ENSRNOT00000098685
Ensembl Acc Id: ENSRNOP00000089193   ⟸   ENSRNOT00000100653
Ensembl Acc Id: ENSRNOP00000083890   ⟸   ENSRNOT00000105996
Ensembl Acc Id: ENSRNOP00000084659   ⟸   ENSRNOT00000096811
RefSeq Acc Id: XP_063128961   ⟸   XM_063272891
- Peptide Label: isoform X2
- UniProtKB: Q9JHY2 (UniProtKB/Swiss-Prot),   G3V804 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000108267   ⟸   ENSRNOT00000148126
Ensembl Acc Id: ENSRNOP00000107418   ⟸   ENSRNOT00000151363
Ensembl Acc Id: ENSRNOP00000102519   ⟸   ENSRNOT00000128043
Ensembl Acc Id: ENSRNOP00000103673   ⟸   ENSRNOT00000124342
Ensembl Acc Id: ENSRNOP00000109953   ⟸   ENSRNOT00000136486

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHY2-F1-model_v2 AlphaFold Q9JHY2 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690947
Promoter ID:EPDNEW_R1472
Type:initiation region
Name:Sfxn3_1
Description:sideroflexin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01264,796,966 - 264,797,026EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620716 AgrOrtholog
BioCyc Gene G2FUF-55567 BioCyc
Ensembl Genes ENSRNOG00000015442 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021171 ENTREZGENE
  ENSRNOT00000105996 ENTREZGENE
IMAGE_CLONE IMAGE:5597953 IMAGE-MGC_LOAD
InterPro Mtc UniProtKB/Swiss-Prot
KEGG Report rno:65042 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72434 IMAGE-MGC_LOAD
NCBI Gene 65042 ENTREZGENE
PANTHER PTHR11153 UniProtKB/Swiss-Prot
  SIDEROFLEXIN-3 UniProtKB/Swiss-Prot
Pfam Mtc UniProtKB/Swiss-Prot
PhenoGen Sfxn3 PhenoGen
RatGTEx ENSRNOG00000015442 RatGTEx
UniProt A0A8I5ZKG3_RAT UniProtKB/TrEMBL
  A0A8I5ZY86_RAT UniProtKB/TrEMBL
  A0A8I6A2F4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AC71_RAT UniProtKB/TrEMBL
  A0A8W1ATD7_RAT UniProtKB/TrEMBL
  A0ABK0L3B7_RAT UniProtKB/TrEMBL
  A0ABK0LMC7_RAT UniProtKB/TrEMBL
  A0ABK0LQK8_RAT UniProtKB/TrEMBL
  A0ABK0LST4_RAT UniProtKB/TrEMBL
  A0ABK0LWK3_RAT UniProtKB/TrEMBL
  G3V804 ENTREZGENE
  Q6P6T0_RAT UniProtKB/TrEMBL
  Q9JHY2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3V804 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Sfxn3  sideroflexin 3  Loc65042  tricarboxylate carrier-like protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc65042  tricarboxylate carrier-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues examined with highest levels in brain, kidney, and liver 1299286