Chd8 (chromodomain helicase DNA binding protein 8) - Rat Genome Database

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Gene: Chd8 (chromodomain helicase DNA binding protein 8) Rattus norvegicus
Analyze
Symbol: Chd8
Name: chromodomain helicase DNA binding protein 8
RGD ID: 620696
Description: Enables armadillo repeat domain binding activity and beta-catenin binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Located in nucleus. Part of protein-containing complex. Orthologous to human CHD8 (chromodomain helicase DNA binding protein 8); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-dependent helicase CHD8; axis duplication inhibitor; beta-catenin binding protein; CHD-8; chromodomain-helicase-DNA-binding protein 8; duplin; Loc65027
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Chd8em1Mcwi  
Genetic Models: LE-Chd8em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,379,285 - 27,438,959 (-)NCBIGRCr8
mRatBN7.21524,905,789 - 24,965,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,905,789 - 24,951,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,678,019 - 27,716,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,632,597 - 28,671,160 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,885,536 - 26,924,098 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,612,932 - 28,672,574 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,612,932 - 28,672,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,423,198 - 32,482,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,642,767 - 27,704,443 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,684,891 - 27,696,816 (-)NCBI
Celera1525,209,591 - 25,269,314 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
MLL1 complex  (IBA,IEA,ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
protein-containing complex  (IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. Kobayashi M, etal., J Biol Chem. 2002 Feb 22;277(8):5816-22. Epub 2001 Dec 13.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation. Sakamoto I, etal., J Biol Chem 2000 Oct 20;275(42):32871-8.
11. Suppression of STAT3 activity by Duplin, which is a negative regulator of the Wnt signal. Yamashina K, etal., J Biochem. 2006 Feb;139(2):305-14.
Additional References at PubMed
PMID:15367660   PMID:15960975   PMID:17938208   PMID:18378692   PMID:19151705   PMID:20453063   PMID:22083958   PMID:23071553   PMID:24998929   PMID:25294932   PMID:27602517   PMID:29920279  


Genomics

Comparative Map Data
Chd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,379,285 - 27,438,959 (-)NCBIGRCr8
mRatBN7.21524,905,789 - 24,965,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,905,789 - 24,951,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,678,019 - 27,716,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,632,597 - 28,671,160 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,885,536 - 26,924,098 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,612,932 - 28,672,574 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,612,932 - 28,672,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,423,198 - 32,482,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,642,767 - 27,704,443 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,684,891 - 27,696,816 (-)NCBI
Celera1525,209,591 - 25,269,314 (-)NCBICelera
Cytogenetic Map15p14NCBI
CHD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,385,199 - 21,456,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,385,194 - 21,456,126 (-)EnsemblGRCh38hg38GRCh38
GRCh371421,853,358 - 21,924,282 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,923,198 - 20,975,244 (-)NCBINCBI36Build 36hg18NCBI36
Celera141,718,849 - 1,770,858 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,973,207 - 2,025,186 (-)NCBIHuRef
CHM1_11421,855,022 - 21,906,934 (-)NCBICHM1_1
T2T-CHM13v2.01415,582,676 - 15,653,513 (-)NCBIT2T-CHM13v2.0
Chd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,435,608 - 52,495,499 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,435,608 - 52,495,237 (-)EnsemblGRCm39 Ensembl
GRCm381452,198,151 - 52,258,042 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,198,151 - 52,257,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371452,817,826 - 52,857,247 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361451,120,096 - 51,159,523 (-)NCBIMGSCv36mm8
Celera1449,182,118 - 49,221,458 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.84NCBI
Chd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555502,115,649 - 2,175,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555502,115,649 - 2,175,687 (-)NCBIChiLan1.0ChiLan1.0
CHD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,840,472 - 22,911,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11422,056,959 - 22,128,117 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,202,847 - 2,274,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11420,281,422 - 20,326,361 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1420,281,422 - 20,326,361 (-)Ensemblpanpan1.1panPan2
CHD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,430,601 - 18,492,564 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,431,019 - 18,491,920 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,915,263 - 18,977,048 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,689,452 - 18,730,186 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,689,459 - 18,736,281 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,371,825 - 18,433,622 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,427,678 - 18,489,656 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,556,498 - 18,618,517 (-)NCBIUU_Cfam_GSD_1.0
Chd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,636,869 - 32,698,700 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880546,236 - 608,080 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936880546,250 - 608,061 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl777,719,582 - 77,780,146 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1777,719,476 - 77,780,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,061,334 - 83,121,484 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,856,434 - 21,924,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,856,263 - 21,924,787 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,505,797 - 24,574,122 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,411,629 - 7,474,526 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,411,629 - 7,475,111 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chd8
156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000022593
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
WI-14045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,905,800 - 24,905,927 (+)MAPPERmRatBN7.2
Rnor_6.01528,612,942 - 28,613,068NCBIRnor6.0
Rnor_5.01532,423,209 - 32,423,335UniSTSRnor5.0
RGSC_v3.41527,642,777 - 27,642,903UniSTSRGSC3.4
Celera1525,209,601 - 25,209,727UniSTS
Cytogenetic Map15p14UniSTS
BF393768  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,911,588 - 24,911,757 (+)MAPPERmRatBN7.2
Rnor_6.01528,618,729 - 28,618,897NCBIRnor6.0
Rnor_5.01532,428,996 - 32,429,164UniSTSRnor5.0
RGSC_v3.41527,648,564 - 27,648,732UniSTSRGSC3.4
Celera1525,215,388 - 25,215,556UniSTS
Cytogenetic Map15p14UniSTS
RH135273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,912,875 - 24,913,080 (+)MAPPERmRatBN7.2
Rnor_6.01528,620,016 - 28,620,220NCBIRnor6.0
Rnor_5.01532,430,283 - 32,430,487UniSTSRnor5.0
RGSC_v3.41527,649,851 - 27,650,055UniSTSRGSC3.4
Celera1525,216,675 - 25,216,879UniSTS
Cytogenetic Map15p14UniSTS


Genetic Models
This gene Chd8 is modified in the following models/strains:
LE-Chd8em1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 40 24 19 24 4 4 74 35 39 11 4
Low 12 17 17 17 4 7 2 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022593   ⟹   ENSRNOP00000022593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,905,789 - 24,944,357 (-)Ensembl
Rnor_6.0 Ensembl1528,612,932 - 28,672,530 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087722   ⟹   ENSRNOP00000071948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,905,789 - 24,944,357 (-)Ensembl
Rnor_6.0 Ensembl1528,612,954 - 28,672,569 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096813   ⟹   ENSRNOP00000096922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,932,068 - 24,951,285 (-)Ensembl
RefSeq Acc Id: NM_001347661   ⟹   NP_001334590
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,285 - 27,417,851 (-)NCBI
mRatBN7.21524,905,789 - 24,944,357 (-)NCBI
RefSeq Acc Id: XM_006251908   ⟹   XP_006251970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,438,958 (-)NCBI
mRatBN7.21524,905,791 - 24,965,461 (-)NCBI
Rnor_6.01528,612,932 - 28,672,573 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251909   ⟹   XP_006251971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,424,841 (-)NCBI
mRatBN7.21524,906,090 - 24,951,409 (-)NCBI
Rnor_6.01528,613,292 - 28,659,222 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251910   ⟹   XP_006251972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,425,578 (-)NCBI
mRatBN7.21524,906,090 - 24,951,174 (-)NCBI
Rnor_6.01528,613,292 - 28,658,369 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251912   ⟹   XP_006251974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,438,958 (-)NCBI
mRatBN7.21524,905,791 - 24,965,461 (-)NCBI
Rnor_6.01528,612,932 - 28,672,574 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093643   ⟹   XP_038949571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,388,807 - 27,438,959 (-)NCBI
mRatBN7.21524,915,312 - 24,965,461 (-)NCBI
RefSeq Acc Id: XM_063274617   ⟹   XP_063130687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,438,958 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006251974   ⟸   XM_006251912
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251970   ⟸   XM_006251908
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R557 (UniProtKB/TrEMBL),   A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251971   ⟸   XM_006251909
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R557 (UniProtKB/TrEMBL),   A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251972   ⟸   XM_006251910
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R557 (UniProtKB/TrEMBL),   A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071948   ⟸   ENSRNOT00000087722
RefSeq Acc Id: ENSRNOP00000022593   ⟸   ENSRNOT00000022593
RefSeq Acc Id: NP_001334590   ⟸   NM_001347661
- UniProtKB: Q9JIX5 (UniProtKB/Swiss-Prot),   A0A8L2QBK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949571   ⟸   XM_039093643
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000096922   ⟸   ENSRNOT00000096813
RefSeq Acc Id: XP_063130687   ⟸   XM_063274617
- Peptide Label: isoform X2
Protein Domains
Chromo   Helicase ATP-binding   Helicase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIX5-F1-model_v2 AlphaFold Q9JIX5 1-2581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699637
Promoter ID:EPDNEW_R10161
Type:initiation region
Name:Chd8_1
Description:chromodomain helicase DNA binding protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,672,509 - 28,672,569EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620696 AgrOrtholog
BioCyc Gene G2FUF-13983 BioCyc
Ensembl Genes ENSRNOG00000025011 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022593.7 UniProtKB/TrEMBL
  ENSRNOT00000087722.2 UniProtKB/TrEMBL
  ENSRNOT00000096813.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.5.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10810 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRK_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRK_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHD8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo/chromo_shadow_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNF2-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNF2/RAD54-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNF2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65027 UniProtKB/Swiss-Prot
NCBI Gene 65027 ENTREZGENE
PANTHER CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9 UniProtKB/TrEMBL
  DNA HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNF2-rel_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Chd8 PhenoGen
PROSITE CHROMO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025011 RatGTEx
SMART BRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF160481 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QBK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R557 ENTREZGENE, UniProtKB/TrEMBL
  A6KEG8_RAT UniProtKB/TrEMBL
  CHD8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Chd8  chromodomain helicase DNA binding protein 8  Loc65027  beta-catenin binding protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc65027  beta-catenin binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus  
gene_process involved in inhibition of beta-catenin-dependent Tcf activation and axis formation