Chd8 (chromodomain helicase DNA binding protein 8) - Rat Genome Database

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Pathways
Gene: Chd8 (chromodomain helicase DNA binding protein 8) Rattus norvegicus
Analyze
Symbol: Chd8
Name: chromodomain helicase DNA binding protein 8
RGD ID: 620696
Description: Enables armadillo repeat domain binding activity and beta-catenin binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Located in nucleus. Part of protein-containing complex. Orthologous to human CHD8 (chromodomain helicase DNA binding protein 8); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-dependent helicase CHD8; axis duplication inhibitor; beta-catenin binding protein; CHD-8; chromodomain-helicase-DNA-binding protein 8; duplin; Loc65027
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Chd8em1Mcwi
Genetic Models: LE-Chd8em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,379,285 - 27,438,959 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1527,379,285 - 27,417,851 (-)EnsemblGRCr8
mRatBN7.21524,905,789 - 24,965,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,905,789 - 24,951,285 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,678,019 - 27,716,742 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,632,597 - 28,671,160 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,885,536 - 26,924,098 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,612,932 - 28,672,574 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,612,932 - 28,672,569 (-)Ensemblrn6Rnor6.0
Rnor_5.01532,423,198 - 32,482,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,642,767 - 27,704,443 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1525,209,591 - 25,269,314 (-)NCBICelera
RGSC_v3.11527,684,891 - 27,696,816 (-)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
MLL1 complex  (IBA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. Kobayashi M, etal., J Biol Chem. 2002 Feb 22;277(8):5816-22. Epub 2001 Dec 13.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation. Sakamoto I, etal., J Biol Chem 2000 Oct 20;275(42):32871-8.
11. Suppression of STAT3 activity by Duplin, which is a negative regulator of the Wnt signal. Yamashina K, etal., J Biochem. 2006 Feb;139(2):305-14.
Additional References at PubMed
PMID:15367660   PMID:15960975   PMID:17938208   PMID:18378692   PMID:19151705   PMID:20453063   PMID:22083958   PMID:23071553   PMID:24998929   PMID:25294932   PMID:27602517   PMID:29920279  


Genomics

Comparative Map Data
Chd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,379,285 - 27,438,959 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1527,379,285 - 27,417,851 (-)EnsemblGRCr8
mRatBN7.21524,905,789 - 24,965,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,905,789 - 24,951,285 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,678,019 - 27,716,742 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,632,597 - 28,671,160 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,885,536 - 26,924,098 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,612,932 - 28,672,574 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,612,932 - 28,672,569 (-)Ensemblrn6Rnor6.0
Rnor_5.01532,423,198 - 32,482,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,642,767 - 27,704,443 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1525,209,591 - 25,269,314 (-)NCBICelera
RGSC_v3.11527,684,891 - 27,696,816 (-)NCBI
Cytogenetic Map15p14NCBI
CHD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,385,199 - 21,456,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,385,194 - 21,456,126 (-)Ensemblhg38GRCh38
GRCh371421,853,358 - 21,924,282 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,923,198 - 20,975,244 (-)NCBIBuild 36Build 36hg18NCBI36
Celera141,718,849 - 1,770,858 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,973,207 - 2,025,186 (-)NCBIHuRef
CHM1_11421,855,022 - 21,906,934 (-)NCBICHM1_1
T2T-CHM13v2.01415,582,676 - 15,653,513 (-)NCBIT2T-CHM13v2.0
Chd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,435,608 - 52,495,499 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,435,608 - 52,495,237 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381452,198,151 - 52,258,042 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,198,151 - 52,257,780 (-)Ensemblmm10GRCm38
MGSCv371452,817,826 - 52,857,247 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361451,120,096 - 51,159,523 (-)NCBIMGSCv36mm8
Celera1449,182,118 - 49,221,458 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.84NCBI
Chd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555502,115,649 - 2,175,181 (-)Ensembl
ChiLan1.0NW_0049555502,115,649 - 2,175,687 (-)NCBIChiLan1.0ChiLan1.0
CHD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,840,472 - 22,911,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11422,056,959 - 22,128,117 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,202,847 - 2,274,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11420,281,422 - 20,326,361 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1420,281,422 - 20,326,361 (-)EnsemblpanPan2panpan1.1
CHD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,430,601 - 18,492,564 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,431,019 - 18,491,920 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1518,915,263 - 18,977,048 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01518,689,452 - 18,730,186 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,689,459 - 18,736,281 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,371,825 - 18,433,622 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,427,678 - 18,489,656 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,556,498 - 18,618,517 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,636,869 - 32,698,700 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880546,236 - 608,080 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936880546,250 - 608,061 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl777,719,582 - 77,780,146 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1777,719,476 - 77,780,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,061,334 - 83,121,484 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,856,434 - 21,924,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,856,263 - 21,924,787 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605924,505,797 - 24,574,122 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,411,629 - 7,474,526 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248257,411,629 - 7,475,111 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Chd8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11271,633,621 - 71,692,242 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chd8
653 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000022593
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
WI-14045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,905,800 - 24,905,927 (+)MAPPERmRatBN7.2
Rnor_6.01528,612,942 - 28,613,068NCBIRnor6.0
Rnor_5.01532,423,209 - 32,423,335UniSTSRnor5.0
RGSC_v3.41527,642,777 - 27,642,903UniSTSRGSC3.4
Celera1525,209,601 - 25,209,727UniSTS
Cytogenetic Map15p14UniSTS
BF393768  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,911,588 - 24,911,757 (+)MAPPERmRatBN7.2
Rnor_6.01528,618,729 - 28,618,897NCBIRnor6.0
Rnor_5.01532,428,996 - 32,429,164UniSTSRnor5.0
RGSC_v3.41527,648,564 - 27,648,732UniSTSRGSC3.4
Celera1525,215,388 - 25,215,556UniSTS
Cytogenetic Map15p14UniSTS
RH135273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,912,875 - 24,913,080 (+)MAPPERmRatBN7.2
Rnor_6.01528,620,016 - 28,620,220NCBIRnor6.0
Rnor_5.01532,430,283 - 32,430,487UniSTSRnor5.0
RGSC_v3.41527,649,851 - 27,650,055UniSTSRGSC3.4
Celera1525,216,675 - 25,216,879UniSTS
Cytogenetic Map15p14UniSTS


Genetic Models
This gene Chd8 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022593   ⟹   ENSRNOP00000022593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1527,379,285 - 27,417,851 (-)Ensembl
mRatBN7.2 Ensembl1524,905,789 - 24,944,357 (-)Ensembl
Rnor_6.0 Ensembl1528,612,932 - 28,672,530 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087722   ⟹   ENSRNOP00000071948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1527,379,285 - 27,417,851 (-)Ensembl
mRatBN7.2 Ensembl1524,905,789 - 24,944,357 (-)Ensembl
Rnor_6.0 Ensembl1528,612,954 - 28,672,569 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096813   ⟹   ENSRNOP00000096922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,932,068 - 24,951,285 (-)Ensembl
RefSeq Acc Id: NM_001347661   ⟹   NP_001334590
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,285 - 27,417,851 (-)NCBI
mRatBN7.21524,905,789 - 24,944,357 (-)NCBI
RefSeq Acc Id: XM_006251908   ⟹   XP_006251970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,438,958 (-)NCBI
mRatBN7.21524,905,791 - 24,965,461 (-)NCBI
Rnor_6.01528,612,932 - 28,672,573 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251909   ⟹   XP_006251971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,424,841 (-)NCBI
mRatBN7.21524,906,090 - 24,951,409 (-)NCBI
Rnor_6.01528,613,292 - 28,659,222 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251910   ⟹   XP_006251972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,425,578 (-)NCBI
mRatBN7.21524,906,090 - 24,951,174 (-)NCBI
Rnor_6.01528,613,292 - 28,658,369 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251912   ⟹   XP_006251974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,438,958 (-)NCBI
mRatBN7.21524,905,791 - 24,965,461 (-)NCBI
Rnor_6.01528,612,932 - 28,672,574 (-)NCBI
Rnor_5.01532,423,198 - 32,482,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093643   ⟹   XP_038949571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,388,807 - 27,438,959 (-)NCBI
mRatBN7.21524,915,312 - 24,965,461 (-)NCBI
RefSeq Acc Id: XM_063274617   ⟹   XP_063130687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,379,288 - 27,438,958 (-)NCBI
RefSeq Acc Id: XP_006251974   ⟸   XM_006251912
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251970   ⟸   XM_006251908
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R557 (UniProtKB/TrEMBL),   A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251971   ⟸   XM_006251909
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R557 (UniProtKB/TrEMBL),   A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251972   ⟸   XM_006251910
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R557 (UniProtKB/TrEMBL),   A0A8L2QBK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071948   ⟸   ENSRNOT00000087722
Ensembl Acc Id: ENSRNOP00000022593   ⟸   ENSRNOT00000022593
RefSeq Acc Id: NP_001334590   ⟸   NM_001347661
- UniProtKB: Q9JIX5 (UniProtKB/Swiss-Prot),   A0A8L2QBK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949571   ⟸   XM_039093643
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000096922   ⟸   ENSRNOT00000096813
RefSeq Acc Id: XP_063130687   ⟸   XM_063274617
- Peptide Label: isoform X2
- UniProtKB: Q9JIX5 (UniProtKB/Swiss-Prot),   A0A8L2QBK0 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIX5-F1-model_v2 AlphaFold Q9JIX5 1-2581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699637
Promoter ID:EPDNEW_R10161
Type:initiation region
Name:Chd8_1
Description:chromodomain helicase DNA binding protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,672,509 - 28,672,569EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620696 AgrOrtholog
BioCyc Gene G2FUF-13983 BioCyc
Ensembl Genes ENSRNOG00000025011 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022593 ENTREZGENE
  ENSRNOT00000087722 ENTREZGENE
  ENSRNOT00000096813.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
  3.40.5.120 UniProtKB/Swiss-Prot
  3.40.50.10810 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro BRK_domain UniProtKB/Swiss-Prot
  BRK_sf UniProtKB/Swiss-Prot
  CHD UniProtKB/Swiss-Prot
  CHD8 UniProtKB/Swiss-Prot
  Chromo-like_dom_sf UniProtKB/Swiss-Prot
  Chromo/chromo_shadow_dom UniProtKB/Swiss-Prot
  Chromo_domain UniProtKB/Swiss-Prot
  Helicase_ATP-bd UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  HTH_CHD6-9 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  SNF2-like_sf UniProtKB/Swiss-Prot
  SNF2/RAD54-like_C UniProtKB/Swiss-Prot
  SNF2_N UniProtKB/Swiss-Prot
KEGG Report rno:65027 UniProtKB/Swiss-Prot
NCBI Gene 65027 ENTREZGENE
PANTHER CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9 UniProtKB/Swiss-Prot
  CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9 UniProtKB/Swiss-Prot
Pfam BRK UniProtKB/Swiss-Prot
  Chromo UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  HTH_CHD8_8th UniProtKB/Swiss-Prot
  SNF2_N UniProtKB/Swiss-Prot
PhenoGen Chd8 PhenoGen
PROSITE CHROMO_2 UniProtKB/Swiss-Prot
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot
  HELICASE_CTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025011 RatGTEx
SMART BRK UniProtKB/Swiss-Prot
  CHROMO UniProtKB/Swiss-Prot
  DEXDc UniProtKB/Swiss-Prot
  HELICc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF160481 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF54160 UniProtKB/Swiss-Prot
UniProt A0A8L2QBK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R557 ENTREZGENE, UniProtKB/TrEMBL
  A6KEG8_RAT UniProtKB/TrEMBL
  CHD8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Chd8  chromodomain helicase DNA binding protein 8  Loc65027  beta-catenin binding protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc65027  beta-catenin binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus  
gene_process involved in inhibition of beta-catenin-dependent Tcf activation and axis formation