Dnase1l3 (deoxyribonuclease 1L3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dnase1l3 (deoxyribonuclease 1L3) Rattus norvegicus
Analyze
Symbol: Dnase1l3
Name: deoxyribonuclease 1L3
RGD ID: 620669
Description: Enables DNA binding activity and DNA endonuclease activity. Predicted to be involved in several processes, including apoptotic DNA fragmentation; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1L3); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyribonuclease 1-like 3; deoxyribonuclease gamma; deoxyribonuclease gamma-like; deoxyribonuclease I-like 3; DNase gamma; DNase I-like 3; DNaseY; LOC103690049; MGC108624
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,351,683 - 19,378,536 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1519,352,493 - 19,378,531 (+)EnsemblGRCr8
mRatBN7.21516,922,335 - 16,948,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,922,335 - 16,948,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1519,097,088 - 19,122,996 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,055,563 - 20,081,473 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,310,474 - 18,336,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,710,492 - 18,736,476 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,710,492 - 18,736,473 (+)Ensemblrn6Rnor6.0
Rnor_5.01521,913,671 - 21,925,373 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01522,676,702 - 22,702,930 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41518,909,363 - 18,935,347 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1516,878,636 - 16,904,597 (+)NCBICelera
RGSC_v3.11518,909,362 - 18,935,344 (+)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
Echimidine  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fructose  (ISO)
glucose  (ISO)
glyphosate  (ISO)
Heliotrine  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
Tesaglitazar  (EXP)
testosterone undecanoate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum  (IEA,ISO)
extracellular region  (IEA)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Host DNases prevent vascular occlusion by neutrophil extracellular traps. Jiménez-Alcázar M, etal., Science. 2017 Dec 1;358(6367):1202-1206. doi: 10.1126/science.aam8897.
4. DNaseY: a rat DNaseI-like gene coding for a constitutively expressed chromatin-bound endonuclease. Liu QY, etal., Biochemistry 1998 Jul 14;37(28):10134-43.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase gamma. Shiokawa D and Tanuma S, Biochem J 1998 Jun 15;332 ( Pt 3):713-20.
12. Identification of an endonuclease responsible for apoptosis in rat thymocytes. Shiokawa D, etal., Eur J Biochem 1994 Nov 15;226(1):23-30.
Additional References at PubMed
PMID:9307016   PMID:9328279   PMID:12050166   PMID:12477932   PMID:15118903   PMID:15167901   PMID:15489334   PMID:23229555  


Genomics

Comparative Map Data
Dnase1l3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,351,683 - 19,378,536 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1519,352,493 - 19,378,531 (+)EnsemblGRCr8
mRatBN7.21516,922,335 - 16,948,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,922,335 - 16,948,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1519,097,088 - 19,122,996 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,055,563 - 20,081,473 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,310,474 - 18,336,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,710,492 - 18,736,476 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,710,492 - 18,736,473 (+)Ensemblrn6Rnor6.0
Rnor_5.01521,913,671 - 21,925,373 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01522,676,702 - 22,702,930 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41518,909,363 - 18,935,347 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1516,878,636 - 16,904,597 (+)NCBICelera
RGSC_v3.11518,909,362 - 18,935,344 (+)NCBI
Cytogenetic Map15p14NCBI
DNASE1L3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,192,257 - 58,210,972 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,192,257 - 58,214,697 (-)Ensemblhg38GRCh38
GRCh37358,177,984 - 58,196,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36358,153,394 - 58,175,438 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34358,153,393 - 58,175,438NCBI
Celera358,192,880 - 58,214,912 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,275,239 - 58,293,591 (-)NCBIHuRef
CHM1_1358,128,540 - 58,147,077 (-)NCBICHM1_1
T2T-CHM13v2.0358,232,673 - 58,251,379 (-)NCBIT2T-CHM13v2.0
Dnase1l3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,475,014 - 14,504,586 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,475,200 - 14,505,240 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38147,965,187 - 7,994,760 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl147,964,533 - 7,994,573 (-)Ensemblmm10GRCm38
MGSCv37148,797,701 - 8,826,696 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36146,757,066 - 6,786,061 (-)NCBIMGSCv36mm8
Celera143,588,560 - 3,617,542 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.67NCBI
Dnase1l3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554307,867,109 - 7,892,079 (-)Ensembl
ChiLan1.0NW_0049554307,867,172 - 7,892,079 (-)NCBIChiLan1.0ChiLan1.0
DNASE1L3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2258,162,226 - 58,181,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1358,167,000 - 58,186,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0358,127,491 - 58,146,177 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,542,243 - 59,560,363 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,542,243 - 59,560,363 (-)EnsemblpanPan2panpan1.1
DNASE1L3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,350,138 - 32,379,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,358,110 - 32,379,245 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2032,279,076 - 32,308,726 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02032,622,923 - 32,652,898 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,631,042 - 32,653,137 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,078,710 - 32,108,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,434,957 - 32,464,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,607,074 - 32,636,716 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnase1l3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118175,291,652 - 175,356,649 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364738,430,231 - 8,457,469 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364738,430,235 - 8,495,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE1L3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,958,387 - 39,975,946 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11339,958,384 - 39,976,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,927,674 - 43,932,404 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNASE1L3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,487,767 - 19,496,019 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,487,596 - 19,496,129 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041147,331,166 - 147,373,602 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnase1l3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821849,434 - 871,609 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624821845,631 - 871,156 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dnase1l3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11278,401,656 - 78,427,080 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnase1l3
164 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:31
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000012532
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat

Markers in Region
RH130735  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81519,378,256 - 19,378,439 (+)Marker Load Pipeline
mRatBN7.21516,948,041 - 16,948,225 (+)MAPPERmRatBN7.2
Rnor_6.01518,736,196 - 18,736,379NCBIRnor6.0
Rnor_6.01517,944,832 - 17,945,015NCBIRnor6.0
Rnor_5.01521,925,089 - 21,925,272UniSTSRnor5.0
Rnor_5.01522,702,650 - 22,702,833UniSTSRnor5.0
RGSC_v3.41518,935,067 - 18,935,250UniSTSRGSC3.4
Celera1516,904,317 - 16,904,500UniSTS
RH 3.4 Map15139.0UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 35 112 91 90 59 56 59 6 273 124 11 83 66 87 31 4 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF039852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012532   ⟹   ENSRNOP00000012532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1519,352,493 - 19,378,531 (+)Ensembl
mRatBN7.2 Ensembl1516,922,335 - 16,948,317 (+)Ensembl
Rnor_6.0 Ensembl1518,710,492 - 18,736,473 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090768   ⟹   ENSRNOP00000081557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,922,335 - 16,948,315 (+)Ensembl
RefSeq Acc Id: NM_053907   ⟹   NP_446359
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,352,552 - 19,378,536 (+)NCBI
mRatBN7.21516,922,335 - 16,948,322 (+)NCBI
Rnor_6.01518,710,492 - 18,736,476 (+)NCBI
Rnor_5.01522,676,702 - 22,702,930 (+)NCBI
RGSC_v3.41518,909,363 - 18,935,347 (+)RGD
Celera1516,878,636 - 16,904,597 (+)RGD
Sequence:
RefSeq Acc Id: XM_063273913   ⟹   XP_063129983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,351,683 - 19,378,536 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446359 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC28937 (Get FASTA)   NCBI Sequence Viewer  
  AAC40134 (Get FASTA)   NCBI Sequence Viewer  
  AAH88122 (Get FASTA)   NCBI Sequence Viewer  
  EDL94170 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012532
  ENSRNOP00000012532.2
GenBank Protein O89107 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446359   ⟸   NM_053907
- Peptide Label: precursor
- UniProtKB: O89107 (UniProtKB/Swiss-Prot),   A6K0C3 (UniProtKB/TrEMBL),   A0A8I5ZSG6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012532   ⟸   ENSRNOT00000012532
Ensembl Acc Id: ENSRNOP00000081557   ⟸   ENSRNOT00000090768
RefSeq Acc Id: XP_063129983   ⟸   XM_063273913
- Peptide Label: isoform X1
- UniProtKB: O89107 (UniProtKB/Swiss-Prot),   A0A8I5ZSG6 (UniProtKB/TrEMBL),   A6K0C3 (UniProtKB/TrEMBL)
Protein Domains
Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89107-F1-model_v2 AlphaFold O89107 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699592
Promoter ID:EPDNEW_R10115
Type:multiple initiation site
Name:Dnase1l3_2
Description:deoxyribonuclease 1-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10116  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01518,710,477 - 18,710,537EPDNEW
RGD ID:13699593
Promoter ID:EPDNEW_R10116
Type:multiple initiation site
Name:Dnase1l3_1
Description:deoxyribonuclease 1-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10115  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01518,710,665 - 18,710,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620669 AgrOrtholog
BioCyc Gene G2FUF-14284 BioCyc
Ensembl Genes ENSRNOG00000009291 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012532 ENTREZGENE
  ENSRNOT00000012532.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7325326 IMAGE-MGC_LOAD
InterPro Deoxyribonuclease-1_AS UniProtKB/Swiss-Prot
  DNase_I UniProtKB/Swiss-Prot
  DNASE_I_2 UniProtKB/Swiss-Prot
  Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot
KEGG Report rno:116687 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108624 IMAGE-MGC_LOAD
NCBI Gene 116687 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE UniProtKB/Swiss-Prot
  DEOXYRIBONUCLEASE GAMMA UniProtKB/Swiss-Prot
Pfam Exo_endo_phos UniProtKB/Swiss-Prot
PhenoGen Dnase1l3 PhenoGen
PIRSF DNase_I_euk UniProtKB/Swiss-Prot
PRINTS DNASEI UniProtKB/Swiss-Prot
PROSITE DNASE_I_1 UniProtKB/Swiss-Prot
  DNASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009291 RatGTEx
SMART DNaseIc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56219 UniProtKB/Swiss-Prot
UniProt A0A8I5ZSG6 ENTREZGENE
  A6K0C3 ENTREZGENE, UniProtKB/TrEMBL
  DNSL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-29 Dnase1l3  deoxyribonuclease 1L3  Dnase1l3  deoxyribonuclease 1-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Dnase1l3  deoxyribonuclease 1-like 3  LOC103690049  deoxyribonuclease gamma-like  Data merged from RGD:9371112 737654 PROVISIONAL
2014-08-25 LOC103690049  deoxyribonuclease gamma-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-22 Dnase1l3  deoxyribonuclease 1-like 3  Dnase1l3  deoxyribonuclease I-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dnase1l3  deoxyribonuclease I-like 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dnase1l3  deoxyribonuclease I-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL