Advanced Search (OLGA)

Gene: Pth2r (parathyroid hormone 2 receptor) Rattus norvegicus

Analyze

Symbol:

Pth2r

Name:

parathyroid hormone 2 receptor

RGD ID:

620612

Description:

Enables parathyroid hormone receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and positive regulation of cold-induced thermogenesis. Predicted to be active in plasma membrane. Orthologous to human PTH2R (parathyroid hormone 2 receptor); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; atrazine.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

parathyroid hormone receptor 2; PTH2 receptor; Pthr2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTH2R (parathyroid hormone 2 receptor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Pth2r (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pth2r (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTH2R (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PTH2R (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pth2r (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PTH2R (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PTH2R (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pth2r (parathyroid hormone 2 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PTH2R (parathyroid hormone 2 receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pth2r (parathyroid hormone 2 receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pth2r (parathyroid hormone 2 receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-4h4.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pdfr-1	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pth2r	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	74,199,785 - 74,304,326 (+)	NCBI		GRCr8
mRatBN7.2	9	66,706,050 - 66,810,601 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	66,706,050 - 66,810,036 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	75,224,757 - 75,332,486 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	80,347,604 - 80,450,942 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	78,763,893 - 78,864,581 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	72,052,966 - 72,158,343 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	72,052,966 - 72,157,773 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	70,414,061 - 70,518,866 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	63,942,380 - 64,049,405 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	64,089,361 - 64,196,387 (+)	NCBI
Celera	9	64,101,423 - 64,205,579 (+)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

primary pulmonary hypertension (ISO)

syndromic intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carmustine (EXP)

CGP 52608 (ISO)

decabromodiphenyl ether (EXP)

fipronil (ISO)

fulvestrant (ISO)

methotrexate (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

N-nitrosodiethylamine (EXP)

permethrin (EXP)

pirinixic acid (ISO)

progesterone (ISO)

sodium arsenite (ISO)

tioguanine (EXP)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IBA)

cell surface receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

positive regulation of cold-induced thermogenesis (ISO,ISS)

Cellular Component

plasma membrane (IBA,IEA)

Molecular Function

G protein-coupled peptide receptor activity (IBA)

G protein-coupled receptor activity (IEA)

parathyroid hormone receptor activity (IBA,IDA)

peptide hormone binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation.	Dimitrov EL, etal., J Neurosci. 2011 Dec 7;31(49):18166-79. doi: 10.1523/JNEUROSCI.2619-11.2011.
2.	Transcript expression of the tuberoinfundibular peptide (TIP)39/PTH2 receptor system and non-PTH1 receptor-mediated tonic effects of TIP39 and other PTH2 receptor ligands in renal vessels.	Eichinger A, etal., Endocrinology 2002 Aug;143(8):3036-43.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Regions in rat and human parathyroid hormone (PTH) 2 receptors controlling receptor interaction with PTH and with antagonist ligands.	Goold CP, etal., J Pharmacol Exp Ther 2001 Nov;299(2):678-90.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat.	Usdin TB, etal., Endocrinology 1996 Oct;137(10):4285-97.

Additional References at PubMed

PMID:14988434	PMID:15670850	PMID:15677763

Genomics

Comparative Map Data

Pth2r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	74,199,785 - 74,304,326 (+)	NCBI		GRCr8
mRatBN7.2	9	66,706,050 - 66,810,601 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	66,706,050 - 66,810,036 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	75,224,757 - 75,332,486 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	80,347,604 - 80,450,942 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	78,763,893 - 78,864,581 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	72,052,966 - 72,158,343 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	72,052,966 - 72,157,773 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	70,414,061 - 70,518,866 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	63,942,380 - 64,049,405 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	64,089,361 - 64,196,387 (+)	NCBI
Celera	9	64,101,423 - 64,205,579 (+)	NCBI		Celera
Cytogenetic Map	9	q32	NCBI

PTH2R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	208,359,692 - 208,494,506 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	208,359,714 - 208,854,503 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	209,224,416 - 209,359,231 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	208,979,801 - 209,067,476 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	209,097,061 - 209,184,736	NCBI
Celera	2	203,039,476 - 203,127,142 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI
HuRef	2	201,071,685 - 201,206,321 (+)	NCBI		HuRef
CHM1_1	2	209,230,414 - 209,365,040 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	208,839,502 - 208,974,285 (+)	NCBI		T2T-CHM13v2.0

Pth2r
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	65,317,921 - 65,428,784 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	65,321,215 - 65,428,403 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	65,280,282 - 65,389,625 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	65,282,056 - 65,389,244 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	65,357,831 - 65,435,818 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	65,245,872 - 65,323,086 (+)	NCBI		MGSCv36	mm8
Celera	1	65,801,872 - 65,880,183 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	33.05	NCBI

Pth2r
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	6,584,627 - 6,715,337 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	6,584,627 - 6,674,990 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTH2R
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	110,969,434 - 111,112,053 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	110,984,410 - 111,128,225 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	95,598,732 - 95,746,699 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	213,722,389 - 213,866,526 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	213,769,735 - 213,866,519 (+)	Ensembl	panpan1.1		panPan2

PTH2R
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	16,656,573 - 16,758,313 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	16,678,002 - 16,734,220 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	17,539,128 - 17,640,540 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	16,592,184 - 16,694,239 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	16,592,037 - 16,669,677 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	16,566,302 - 16,646,147 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	16,509,816 - 16,612,231 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	16,519,218 - 16,621,171 (+)	NCBI		UU_Cfam_GSD_1.0

Pth2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	165,022,023 - 165,113,964 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936950	114,317 - 204,718 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936950	114,265 - 181,948 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTH2R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	111,509,531 - 111,598,829 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	111,509,496 - 111,598,308 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	123,124,761 - 123,185,921 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTH2R
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	94,146,254 - 94,284,056 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	94,216,493 - 94,283,743 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	105,066,687 - 105,176,926 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pth2r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	7,501,225 - 7,627,503 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624765	7,500,586 - 7,627,440 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pth2r
772 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	30
Count of miRNA genes:	28
Interacting mature miRNAs:	29
Transcripts:	ENSRNOT00000021099
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	62072275	96470995	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	62072275	96470995	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
5	6	100	30	25	16	6	16	63	19	93	23	44	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U55836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021099 ⟹ ENSRNOP00000021099

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	66,706,050 - 66,810,036 (+)	Ensembl
Rnor_6.0 Ensembl	9	72,052,966 - 72,157,773 (+)	Ensembl

RefSeq Acc Id:

NM_031089 ⟹ NP_112351

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	74,199,785 - 74,304,326 (+)	NCBI
mRatBN7.2	9	66,706,050 - 66,810,601 (+)	NCBI
Rnor_6.0	9	72,052,966 - 72,157,771 (+)	NCBI
Rnor_5.0	9	70,414,061 - 70,518,866 (-)	NCBI
RGSC_v3.4	9	63,942,380 - 64,049,405 (+)	RGD
Celera	9	64,101,423 - 64,205,579 (+)	RGD

Sequence:

show sequence

CCCCCTCCCGCAGCTGTCCTCTGTAGAAGGCGGGACCACCCAGAGCCCTCAGGACCGGGATTCC
CAGRCTCCGGGCGCAGGCAGCCAGACCCCCGAGAGTCCTGGTTGTGCCTCCAGCTGCCCAGCGG
CGCCTCGCTCCCCATCACAAGTTTGGTCCATACTGGATAAGTAAGCTAGTCTGGGATACCGACT
GCTTGTGCCTTAGGAGGGTTTGGACATGCCCTGGCTGGAAGCTTTACCCTACATCTGTGGATGG
CTGATTCTCCGTAGCTGTCTCCTGGTTGGAGCGCAGCTGGATTCTGATGGCACCATCACTATAG
AGGAGCAGATTGTTCTTGTTATGAAGGCTAAAATGCAATGTGAACTCAACATCACAGCTCAGTT
CCAAGAAGGAGAGGGCAATTGCTTCCCAGAATGGGATGGACTCATTTGTTGGCCTAGAGGAACG
GCGGGGAAAACGTCAGCTATGCCCTGTCCTTCATATGTTTATGATTTCAATCACAAAGGAGTTG
CTTTCCGGCACTGCACTCCCAAYGGAACGTGGGATTTTATTCATGGCTCAAATAAAACCTGGGC
TAACTATTCAGACTGCTTTCTGCAGCCTGATATCAACATAGGAAAGCAAGAGTTCTTTGAAAAC
CTCTACATCCTGTACACTGTCGGCTATTCCATCTCTTTTGGCTCCTTGGCAGTAGCCATTCTCA
TCATTGGCTATTTCAGGCGGTTGCATTGCACTAGGAACTATATCCACTTGCATTTGTTTGTGTC
CTTCATGCTGAGAGCCAYGAGCATCTTTGTCAAGGACAGAGTAGCCCAGGCTCACCTGGGAGTA
GAGGCACTGCAGTCTCTGGTGATGCAGGGTGACCTTCAGAACTTCATTGGAGGACCATCTGTGG
ACAAATCTCAGTATGTGGGGTGCAAGATCGCTGTCGTGATGTTTATTTATTTCTTGGCTACAAA
CTATTATTGGATCCTGGTGGAAGGGCTCTACCTGCATAACTTAATCTTTGTGTCTTTCTTTTCT
GACACCAAATACCTGTGGGGCTTCATCTTGATAGGCTGGGGATTTCCAGCGGTATTTGTTGTGG
CCTGGGCAGTAGCACGAGCCACTCTGGCGGATACCAGGTGTTGGGAACTTAGTGCTGGAGACAG
GTGGATTTACCMGGMTCCAATCTTGGCGGCTATTGGGCTGAATTTTATTCTGTTCCTGAATACA
GTTAGAGTTCTTGCTACYAAAATTTGGGAGACCAATGCTGTTGGGCATGACATGAGAAAGCAGT
ACAGGAAACTGGCTAAGTCAACGCTGGTCCTGGTGCTGGTGTTTGGTGTGCATTACATCGTGTT
CATCTGCCAGCCGCACTCCTTCTCGGGGCTCTGGTGGGAGATCCGCATGCACTGCGAGCTCTTC
TTCAACTCCTTCCAGGGATTCTTCGTGTCTATTGTCTATTGCTACTGCAACGGAGAGGTACAGG
CTGAGGTGAAGAAGACCTGGACTCGTTGGAATCTGTCCATCGACTGGAAAAAGGCGCCGCCTTG
TGGCGGCCACAGGTACGGCTCGGTGCTCACCACTGTCACACACAGCACCAGCAGCCAGTCACAG
ATGGGACCAAGCACACGCCTGGTGCTCATCTCTAGCAAACCCGCCAAGACTGCCTGCAGACAGA
TCGACAGTCATGTGACTCTACCTGGCTACGTCTGGAGTAGTTCTGAGCAGGACTGTCAACCACA
ATCTACCCCGGAGGAGACTAAAAAAGGTCATGGGCGACAGGAAGATGATAGTCCAGTGGGGGAG
TCTTCCAGGCCAGTAGCATTCACCATAGACACGGAAGGATGCAAGGGAGAATCCCACCCTATCT
GAATCACCATTTGCAGCTCTTGTGGATTGGCGGATCTGGCTGTGTGGGAGGACCTAAGTTGGAA
GACTGGAATTCTGAAATAAGGCGTCGCTTAAACATTTCCAGTTTCTATGAGTGGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_112351	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52849	(Get FASTA)	NCBI Sequence Viewer
	EDL98857	(Get FASTA)	NCBI Sequence Viewer
	EDL98858	(Get FASTA)	NCBI Sequence Viewer
	EDL98859	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021099.1
GenBank Protein	P70555	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_112351 ⟸ NM_031089
- Peptide Label:	precursor
- UniProtKB:	P70555 (UniProtKB/Swiss-Prot), G3V800 (UniProtKB/TrEMBL), A6IPK1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPWLEALPYICGWLILRSCLLVGAQLDSDGTITIEEQIVLVMKAKMQCELNITAQFQEGEGNCF PEWDGLICWPRGTAGKTSAMPCPSYVYDFNHKGVAFRHCTPNGTWDFIHGSNKTWANYSDCFLQ PDINIGKQEFFENLYILYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHLHLFVSFMLRAXSI FVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEG LYLHNLIFVSFFSDTKYLWGFILIGWGFPAVFVVAWAVARATLADTRCWELSAGDRWIYXXPIL AAIGLNFILFLNTVRVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFICQPHSFS GLWWEIRMHCELFFNSFQGFFVSIVYCYCNGEVQAEVKKTWTRWNLSIDWKKAPPCGGHRYGSV LTTVTHSTSSQSQMGPSTRLVLISSKPAKTACRQIDSHVTLPGYVWSSSEQDCQPQSTPEETKK GHGRQEDDSPVGESSRPVAFTIDTEGCKGESHPI hide sequence

Ensembl Acc Id:

ENSRNOP00000021099 ⟸ ENSRNOT00000021099

Protein Domains

G-protein coupled receptors family 2 profile

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620612	AgrOrtholog
BioCyc Gene	G2FUF-27298	BioCyc
Ensembl Genes	ENSRNOG00000015259	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021099.3	UniProtKB/TrEMBL
Gene3D-CATH	4.10.1240.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracell_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracellular_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81753	UniProtKB/Swiss-Prot
NCBI Gene	81753	ENTREZGENE
PANTHER	PARATHYROID HORMONE 2 RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDF RECEPTOR-LIKE PROTEIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pth2r	PhenoGen
PRINTS	GPCRSECRETIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015259	RatGTEx
SMART	HormR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF111418	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6IPK1	ENTREZGENE, UniProtKB/TrEMBL
	G3V800	ENTREZGENE, UniProtKB/TrEMBL
	P70555	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-17	Pth2r	parathyroid hormone 2 receptor	Pthr2	parathyroid hormone receptor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Pthr2	parathyroid hormone receptor 2			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Pthr2	parathyroid hormone receptor 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in neuronal tissues, pancreas, peripheral endocrine cells and throughout the cardiovascular system including vascular smooth muscle and endothelium	625719
gene_expression	mRNA expressed in renal vessels	625719
gene_product	member of the secretin/calcitonin family of receptors	625719
gene_regulation	activated by the neuropeptide tuberoinfundibular peptide (TIP39)	737643
gene_regulation	activation by PTH is weaker than PTH activation of the human PTH2 receptor	737643

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar