Cox5a (cytochrome c oxidase subunit 5A) - Rat Genome Database

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Gene: Cox5a (cytochrome c oxidase subunit 5A) Rattus norvegicus
Analyze
Symbol: Cox5a (Ensembl: LOC100361008)
Name: cytochrome c oxidase subunit 5A (Ensembl:Cytochrome c oxidase subunit 5A, mitochondrial-like)
RGD ID: 620607
Description: Enables cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytochrome c oxidase polypeptide Va; cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase, subunit Va
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,818,284 - 66,829,691 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,818,196 - 66,830,279 (+)EnsemblGRCr8
mRatBN7.2857,922,374 - 57,933,781 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,922,290 - 57,933,781 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx124,621,194 - 4,621,793 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0125,244,830 - 5,245,429 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,597,297 - 59,608,688 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,298,358 - 62,309,765 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,298,358 - 62,309,765 (+)Ensemblrn6Rnor6.0
Rnor_5.0862,075,344 - 62,087,001 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,264,971 - 61,276,380 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera857,388,557 - 57,399,970 (+)NCBICelera
RGSC_v3.1861,284,024 - 61,295,434 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atrazine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Brodifacoum  (EXP)
cadmium acetate  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
fenvalerate  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
leflunomide  (EXP)
limonene  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
maneb  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
microcystin RR  (ISO)
minocycline  (ISO)
Mitoquinone  (EXP)
neomycin  (EXP)
nitrates  (ISO)
nobiletin  (ISO)
osimertinib  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pinosylvin  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trans-pinosylvin  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleotide sequence of cDNA encoding subunit Va from rat heart cytochrome c oxidase. Droste M, etal., Nucleic Acids Res 1989 Jun 12;17(11):4375.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform. Schagger H, etal., Eur J Biochem 1995 May 15;230(1):235-41.
Additional References at PubMed
PMID:12865426   PMID:14645204   PMID:14651853   PMID:17634366   PMID:18408135   PMID:18614015   PMID:19393246   PMID:19837698   PMID:22792342   PMID:23376485   PMID:25436770   PMID:29476059  
PMID:30030519   PMID:31536960   PMID:32349668   PMID:34518647   PMID:35352799  


Genomics

Comparative Map Data
Cox5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,818,284 - 66,829,691 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl866,818,196 - 66,830,279 (+)EnsemblGRCr8
mRatBN7.2857,922,374 - 57,933,781 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,922,290 - 57,933,781 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx124,621,194 - 4,621,793 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0125,244,830 - 5,245,429 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,597,297 - 59,608,688 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,298,358 - 62,309,765 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,298,358 - 62,309,765 (+)Ensemblrn6Rnor6.0
Rnor_5.0862,075,344 - 62,087,001 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4861,264,971 - 61,276,380 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera857,388,557 - 57,399,970 (+)NCBICelera
RGSC_v3.1861,284,024 - 61,295,434 (+)NCBI
Cytogenetic Map8q24NCBI
COX5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,919,791 - 74,938,073 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,919,791 - 74,939,351 (-)Ensemblhg38GRCh38
GRCh371575,212,132 - 75,230,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,999,672 - 73,017,425 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341572,999,671 - 73,017,425NCBI
Celera1552,162,990 - 52,180,882 (-)NCBICelera
Cytogenetic Map15q24.2NCBI
HuRef1552,009,425 - 52,027,208 (-)NCBIHuRef
CHM1_11575,331,219 - 75,349,083 (-)NCBICHM1_1
T2T-CHM13v2.01572,789,676 - 72,807,970 (-)NCBIT2T-CHM13v2.0
Cox5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,423,012 - 57,439,710 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,428,557 - 57,439,709 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38957,517,328 - 57,532,427 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,521,274 - 57,532,426 (+)Ensemblmm10GRCm38
MGSCv37957,369,039 - 57,380,234 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36957,319,443 - 57,330,561 (+)NCBIMGSCv36mm8
Celera954,756,801 - 54,768,000 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.05NCBI
LOC102005653
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,035,815 - 3,051,507 (+)Ensembl
ChiLan1.0NW_0049554503,036,387 - 3,049,121 (+)NCBIChiLan1.0ChiLan1.0
LOC100988094
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,145,956 - 64,164,031 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,309,656 - 68,327,659 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,860,721 - 53,878,699 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,481,320 - 73,512,497 (-)NCBIPanPan1.1PanPan1.1panPan2
COX5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,955,203 - 37,968,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,905,827 - 37,968,111 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3037,887,182 - 37,899,343 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03038,159,602 - 38,172,380 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,159,602 - 38,172,380 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,112,293 - 38,125,260 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,158,708 - 38,171,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,394,282 - 38,407,115 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101971648
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640116,026,575 - 116,039,276 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,872,842 - 33,887,400 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,874,638 - 33,887,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,622,964 - 58,644,021 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1758,622,969 - 58,644,024 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,311,916 - 63,332,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COX5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,533,410 - 8,551,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl268,533,453 - 8,552,280 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048133,097,621 - 133,131,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101714403
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624894107,034 - 121,020 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624894107,464 - 120,365 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116908089
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1851,407,773 - 51,419,455 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cox5a
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:16
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000025525
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
AA959768  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2857,930,207 - 57,931,520 (+)MAPPERmRatBN7.2
mRatBN7.2313,804,219 - 13,804,383 (+)MAPPERmRatBN7.2
Rnor_6.039,096,228 - 9,096,391NCBIRnor6.0
Rnor_6.0862,306,192 - 62,307,504NCBIRnor6.0
Rnor_5.0862,083,428 - 62,084,740UniSTSRnor5.0
Rnor_5.0314,461,006 - 14,461,169UniSTSRnor5.0
RGSC_v3.4861,272,807 - 61,274,119UniSTSRGSC3.4
RGSC_v3.439,575,824 - 9,575,987UniSTSRGSC3.4
Celera38,569,559 - 8,569,722UniSTS
Celera857,396,397 - 57,397,709UniSTS
Cytogenetic Map8q24UniSTS
UniSTS:141382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,803,968 - 13,804,115 (+)MAPPERmRatBN7.2
mRatBN7.2857,932,932 - 57,933,698 (+)MAPPERmRatBN7.2
Rnor_6.0862,308,917 - 62,309,682NCBIRnor6.0
Rnor_6.039,095,977 - 9,096,123NCBIRnor6.0
Rnor_5.0862,086,153 - 62,086,918UniSTSRnor5.0
Rnor_5.0314,460,755 - 14,460,901UniSTSRnor5.0
RGSC_v3.4861,275,532 - 61,276,297UniSTSRGSC3.4
RGSC_v3.439,575,573 - 9,575,719UniSTSRGSC3.4
Celera38,569,308 - 8,569,454UniSTS
Celera857,399,122 - 57,399,887UniSTS
Cytogenetic Map8q24UniSTS
RH134568  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,803,967 - 13,804,181 (+)MAPPERmRatBN7.2
Rnor_6.039,095,976 - 9,096,189NCBIRnor6.0
Rnor_5.0314,460,754 - 14,460,967UniSTSRnor5.0
RGSC_v3.439,575,572 - 9,575,785UniSTSRGSC3.4
Celera38,569,307 - 8,569,520UniSTS
Cytogenetic Map8q24UniSTS
Cox5a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2857,930,234 - 57,931,589 (+)MAPPERmRatBN7.2
Rnor_6.0862,306,219 - 62,307,573NCBIRnor6.0
Rnor_5.0862,083,455 - 62,084,809UniSTSRnor5.0
Celera857,396,424 - 57,397,778UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025525   ⟹   ENSRNOP00000025525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl866,825,950 - 66,830,279 (+)Ensembl
mRatBN7.2 Ensembl857,922,540 - 57,933,781 (+)Ensembl
Rnor_6.0 Ensembl862,298,358 - 62,309,765 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101188   ⟹   ENSRNOP00000097463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl866,818,196 - 66,830,279 (+)Ensembl
mRatBN7.2 Ensembl857,922,290 - 57,932,078 (+)Ensembl
RefSeq Acc Id: NM_145783   ⟹   NP_665726
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,818,284 - 66,829,691 (+)NCBI
mRatBN7.2857,922,374 - 57,933,781 (+)NCBI
Rnor_6.0862,298,358 - 62,309,765 (+)NCBI
Rnor_5.0862,075,344 - 62,087,001 (+)NCBI
RGSC_v3.4861,264,971 - 61,276,380 (+)RGD
Celera857,388,557 - 57,399,970 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_665726 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA33134 (Get FASTA)   NCBI Sequence Viewer  
  EDL95628 (Get FASTA)   NCBI Sequence Viewer  
  EDL95629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000097463
GenBank Protein P11240 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_665726   ⟸   NM_145783
- Peptide Label: precursor
- UniProtKB: P11240 (UniProtKB/Swiss-Prot),   A6J4V5 (UniProtKB/TrEMBL),   A0A8L2QDJ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025525   ⟸   ENSRNOT00000025525
Ensembl Acc Id: ENSRNOP00000097463   ⟸   ENSRNOT00000101188

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11240-F1-model_v2 AlphaFold P11240 1-146 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696012
Promoter ID:EPDNEW_R6536
Type:initiation region
Name:Cox5a_1
Description:cytochrome c oxidase subunit 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,298,334 - 62,298,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620607 AgrOrtholog
BioCyc Gene G2FUF-30308 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000018816 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000101188 ENTREZGENE
Gene3D-CATH 1.25.40.40 UniProtKB/Swiss-Prot
InterPro Cyt_c_oxidase_su5A/6 UniProtKB/Swiss-Prot
  Cyt_c_oxidase_su5A/6_sf UniProtKB/Swiss-Prot
KEGG Report rno:252934 UniProtKB/Swiss-Prot
NCBI Gene 252934 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR14200 UniProtKB/Swiss-Prot
Pfam COX5A UniProtKB/Swiss-Prot
PhenoGen Cox5a PhenoGen
RatGTEx ENSRNOG00000018816 RatGTEx
Superfamily-SCOP SSF48479 UniProtKB/Swiss-Prot
UniProt A0A8I6GM29_RAT UniProtKB/TrEMBL
  A0A8L2QDJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6J4V5 ENTREZGENE, UniProtKB/TrEMBL
  A6J4V6_RAT UniProtKB/TrEMBL
  COX5A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Cox5a  cytochrome c oxidase subunit 5A  Cox5a  cytochrome c oxidase, subunit Va  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cox5a  cytochrome c oxidase, subunit Va      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cox5a  cytochrome c oxidase, subunit Va      Symbol and Name status set to provisional 70820 PROVISIONAL