Zfp111 (zinc finger protein 111) - Rat Genome Database

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Gene: Zfp111 (zinc finger protein 111) Rattus norvegicus
Analyze
Symbol: Zfp111
Name: zinc finger protein 111
RGD ID: 620595
Description: Predicted to enable DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human ZNF226 (zinc finger protein 226); INTERACTS WITH 2,4-dinitrotoluene; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: rKr2; zinc finger protein 227
RGD Orthologs
Human
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,890,816 - 88,902,183 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,890,622 - 88,897,494 (-)EnsemblGRCr8
mRatBN7.2179,762,897 - 79,774,274 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,762,782 - 79,775,608 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,156,059 - 85,167,290 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,706,352 - 93,717,575 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,911,870 - 86,923,101 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,035,686 - 81,046,934 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,035,972 - 81,043,340 (-)Ensemblrn6Rnor6.0
Rnor_5.0182,300,361 - 82,311,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,416,956 - 79,428,180 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,217,720 - 74,228,944 (-)NCBICelera
RGSC_v3.1179,495,066 - 79,506,291 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. A new Cys2/His2 zinc finger gene, rKr2, is expressed in differentiated rat oligodendrocytes and encodes a protein with a functional repressor domain. Pott U, etal., J Neurochem 1995 Nov;65(5):1955-66.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:26246563  


Genomics

Comparative Map Data
Zfp111
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,890,816 - 88,902,183 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,890,622 - 88,897,494 (-)EnsemblGRCr8
mRatBN7.2179,762,897 - 79,774,274 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,762,782 - 79,775,608 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,156,059 - 85,167,290 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,706,352 - 93,717,575 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,911,870 - 86,923,101 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,035,686 - 81,046,934 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,035,972 - 81,043,340 (-)Ensemblrn6Rnor6.0
Rnor_5.0182,300,361 - 82,311,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,416,956 - 79,428,180 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,217,720 - 74,228,944 (-)NCBICelera
RGSC_v3.1179,495,066 - 79,506,291 (-)NCBI
Cytogenetic Map1q21NCBI
ZNF226
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,165,100 - 44,199,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,165,073 - 44,178,381 (+)Ensemblhg38GRCh38
GRCh371944,669,253 - 44,681,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361949,361,089 - 49,373,678 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341949,361,147 - 49,373,676NCBI
Celera1941,473,314 - 41,485,931 (+)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1941,101,354 - 41,113,971 (+)NCBIHuRef
CHM1_11944,671,041 - 44,683,649 (+)NCBICHM1_1
T2T-CHM13v2.01946,987,958 - 47,000,543 (+)NCBIT2T-CHM13v2.0
ZNF235
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22050,452,900 - 50,474,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,313,444 - 52,346,435 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,241,063 - 41,262,655 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11949,847,808 - 49,866,576 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1949,798,325 - 49,866,576 (-)EnsemblpanPan2panpan1.1
ZNF235
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,011,558 - 111,036,136 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,955,986 - 111,146,182 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1110,493,119 - 110,515,488 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01111,586,041 - 111,608,415 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,511,194 - 111,608,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,215,942 - 111,238,235 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,848,175 - 110,870,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,728,230 - 111,750,559 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ZNF226
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1637,653,562 - 37,665,805 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607317,202,656 - 17,215,085 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp111
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000051473
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 57 59 6 320 157 11 142 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000051473   ⟹   ENSRNOP00000046964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,890,622 - 88,897,494 (-)Ensembl
mRatBN7.2 Ensembl179,762,782 - 79,774,260 (-)Ensembl
Rnor_6.0 Ensembl181,035,972 - 81,043,340 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115762   ⟹   ENSRNOP00000082073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,762,782 - 79,775,608 (-)Ensembl
RefSeq Acc Id: NM_133323   ⟹   NP_579857
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,890,840 - 88,902,064 (-)NCBI
mRatBN7.2179,762,921 - 79,774,146 (-)NCBI
Rnor_6.0181,035,710 - 81,046,934 (-)NCBI
Rnor_5.0182,300,361 - 82,311,775 (-)NCBI
RGSC_v3.4179,416,956 - 79,428,180 (-)RGD
Celera174,217,720 - 74,228,944 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084722   ⟹   XP_038940650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,890,816 - 88,902,183 (-)NCBI
mRatBN7.2179,762,897 - 79,774,274 (-)NCBI
RefSeq Acc Id: XM_063272638   ⟹   XP_063128708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,890,816 - 88,902,178 (-)NCBI
Protein Sequences
Protein RefSeqs NP_579857 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940650 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128708 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB60512 (Get FASTA)   NCBI Sequence Viewer  
  EDM08115 (Get FASTA)   NCBI Sequence Viewer  
  EDM08116 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046964
  ENSRNOP00000046964.7
RefSeq Acc Id: NP_579857   ⟸   NM_133323
- UniProtKB: Q62788 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046964   ⟸   ENSRNOT00000051473
RefSeq Acc Id: XP_038940650   ⟸   XM_039084722
- Peptide Label: isoform X1
- UniProtKB: G3V9G6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082073   ⟸   ENSRNOT00000115762
RefSeq Acc Id: XP_063128708   ⟸   XM_063272638
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G8Y2 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9G6-F1-model_v2 AlphaFold G3V9G6 1-744 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620595 AgrOrtholog
BioCyc Gene G2FUF-60472 BioCyc
Ensembl Genes ENSRNOG00000024376 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051473 ENTREZGENE
  ENSRNOT00000051473.7 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Krueppel_C2H2_ZnFinger UniProtKB/TrEMBL
  Snail/Krueppel_Znf UniProtKB/TrEMBL
  Znf-C2H2_11 UniProtKB/TrEMBL
  Znf_C2H2-type UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:170849 UniProtKB/TrEMBL
NCBI Gene 170849 ENTREZGENE
PANTHER GENE, 32687-RELATED UniProtKB/TrEMBL
  IP01015P-RELATED UniProtKB/TrEMBL
  RIKEN CDNA 6720489N17 GENE-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN ZFP2 UniProtKB/TrEMBL
  ZNF44 PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_11 UniProtKB/TrEMBL
PhenoGen Zfp111 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024376 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6G8Y2 ENTREZGENE
  A6J8W8_RAT UniProtKB/TrEMBL
  A6J8W9_RAT UniProtKB/TrEMBL
  G3V9G6 ENTREZGENE, UniProtKB/TrEMBL
  Q62788 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Zfp111  zinc finger protein 111      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Zfp111  zinc finger protein 111      Symbol and Name status set to provisional 70820 PROVISIONAL