Apaf1 (apoptotic peptidase activating factor 1) - Rat Genome Database

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Gene: Apaf1 (apoptotic peptidase activating factor 1) Rattus norvegicus
Analyze
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
RGD ID: 620575
Description: Enables heat shock protein binding activity and identical protein binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; cellular response to transforming growth factor beta stimulus; and response to hypoxia. Located in cytoplasm. Part of apoptosome. Biomarker of brain ischemia; colon cancer; middle cerebral artery infarction; and muscular atrophy. Orthologous to human APAF1 (apoptotic peptidase activating factor 1); PARTICIPATES IN intrinsic apoptotic pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apaf-1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,381,392 - 27,466,772 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl727,381,855 - 27,466,772 (-)EnsemblGRCr8
mRatBN7.2725,494,143 - 25,579,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,494,609 - 25,579,540 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx727,489,053 - 27,573,980 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,651,444 - 29,736,367 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,428,845 - 29,513,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,699,309 - 31,784,192 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,699,885 - 31,784,192 (-)Ensemblrn6Rnor6.0
Rnor_5.0731,791,073 - 31,872,984 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4727,932,908 - 28,020,533 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera722,620,761 - 22,706,298 (-)NCBICelera
RGSC_v3.1727,953,178 - 28,040,804 (-)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-D  (ISO)
2,4-dinitrophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-Methoxyflavone  (ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP)
apigenin  (EXP,ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
azadirachtin A  (ISO)
bafilomycin A1  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
butachlor  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carvacrol  (EXP)
casticin  (ISO)
ceric oxide  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (ISO)
chrysin  (EXP)
cimetidine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
colistin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
endosulfan  (EXP,ISO)
epichlorohydrin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
flavone  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glucaric acid  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (ISO)
isoflurane  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
leptomycin B  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
melittin  (EXP,ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
morin  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nicotinamide  (ISO)
nobiletin  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentobarbital  (EXP)
perfluorononanoic acid  (ISO)
peroxynitrous acid  (EXP)
Pf-06840003  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (ISO)
propofol  (EXP)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
safrole  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sinapic acid  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
syringic acid  (EXP)
tanespimycin  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vemurafenib  (ISO)
vinclozolin  (EXP)
WIN 55212-2  (ISO)
zearalenone  (ISO)
zebularine  (ISO)
zinc oxide  (ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apoptosome  (IDA,IEA,ISO)
cytoplasm  (IDA,IEA)
cytosol  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Baker DJ and Hepple RT, Exp Gerontol. 2006 Nov;41(11):1149-56. Epub 2006 Oct 6.
2. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
3. Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations. Choi SA, etal., FEBS Lett. 2006 Oct 2;580(22):5275-82. Epub 2006 Sep 11.
4. Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. Chong ZZ, etal., J Cereb Blood Flow Metab 2003 Mar;23(3):320-30.
5. Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance. Corvaro M, etal., Cancer Biol Ther. 2007 Feb;6(2):209-17. Epub 2007 Feb 25.
6. Comparison of combined antioxidants and thymoquinone in the prevention of testis ischemia - reperfusion injury. Erol B, etal., Andrology. 2017 Jan;5(1):119-124. doi: 10.1111/andr.12268. Epub 2016 Oct 16.
7. The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats. Erol B, etal., Kaohsiung J Med Sci. 2015 Sep;31(9):454-62. doi: 10.1016/j.kjms.2015.06.005. Epub 2015 Jul 22.
8. Transforming growth factor-beta(1) induces apoptosis in rat FaO hepatoma cells via cytochrome c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex. Freathy C, etal., Hepatology. 2000 Oct;32(4 Pt 1):750-60.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death. Henshall DC, etal., Cell Death Differ. 2001 Dec;8(12):1169-81.
12. Apaf-1 deficiency and neural tube closure defects are found in fog mice. Honarpour N, etal., Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9683-7.
13. Immunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Kawamoto Y, etal., Brain Res. 2014 Jul 7;1571:39-48. doi: 10.1016/j.brainres.2014.05.007. Epub 2014 May 13.
14. p53- and Bax-mediated apoptosis in injured rat spinal cord. Kotipatruni RR, etal., Neurochem Res. 2011 Nov;36(11):2063-74. doi: 10.1007/s11064-011-0530-2. Epub 2011 Jul 7.
15. MiR-484 promotes non-small-cell lung cancer (NSCLC) progression through inhibiting Apaf-1 associated with the suppression of apoptosis. Li T, etal., Biomed Pharmacother. 2017 Dec;96:153-164. doi: 10.1016/j.biopha.2017.09.102. Epub 2017 Oct 2.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease. Mochizuki H, etal., Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10918-23. doi: 10.1073/pnas.191107398. Epub 2001 Sep 4.
18. Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors. Mondragon L, etal., J Med Chem. 2008 Feb 14;51(3):521-9. Epub 2008 Jan 16.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
21. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. Orzáez M, etal., PLoS One. 2014 Oct 20;9(10):e110979. doi: 10.1371/journal.pone.0110979. eCollection 2014.
22. Alteration of apoptotic protease-activating factor-1 (APAF-1)-dependent apoptotic pathway during development of rat brain and liver. Ota K, etal., J Biochem (Tokyo) 2002 Jan;131(1):131-5.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathway. Saini MK, etal., Nutr Cancer. 2012 Apr;64(3):409-18. doi: 10.1080/01635581.2012.655402. Epub 2012 Feb 27.
27. Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. Siniscalco D, etal., Pharmacol Res. 2008 Mar;57(3):223-33. Epub 2008 Feb 2.
28. MicroRNA-17-mediated down-regulation of apoptotic protease activating factor 1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes. Song S, etal., Biochem Biophys Res Commun. 2015 Sep 18;465(2):299-304. doi: 10.1016/j.bbrc.2015.08.028. Epub 2015 Aug 8.
29. Expression of Cyt-c-Mediated Mitochondrial Apoptosis-Related Proteins in Rat Renal Proximal Tubules during Development. Song XF, etal., Nephron. 2017;135(1):77-86. doi: 10.1159/000450585. Epub 2016 Sep 24.
30. Identification of the apoptosis activation cascade induced in mammary carcinomas by energy restriction. Thompson HJ, etal., Cancer Res. 2004 Feb 15;64(4):1541-5.
31. Jun kinase delays caspase-9 activation by interaction with the apoptosome. Tran TH, etal., J Biol Chem. 2007 Jul 13;282(28):20340-50. Epub 2007 May 4.
32. Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. Udayanga KG, etal., Histol Histopathol. 2011 Jul;26(7):811-20. doi: 10.14670/HH-26.811.
33. Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis. Wright KM, etal., J Cell Biol. 2004 Oct 25;167(2):303-13.
34. Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. Xu XH, etal., Acta Pharmacol Sin. 2007 Aug;28(8):1097-104.
35. Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. Yagmurdur H, etal., Acta Anaesthesiol Scand. 2008 Mar;52(3):350-7. Epub 2008 Jan 16.
36. Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. Yakovlev AG, etal., J Neurosci. 2001 Oct 1;21(19):7439-46.
37. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Yoshida H, etal., Cell 1998 Sep 18;94(6):739-50.
38. Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Zhang S, etal., Neurochem Int. 2013 Nov;63(5):522-32. doi: 10.1016/j.neuint.2013.08.008. Epub 2013 Sep 4.
39. Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. Zhang Z, etal., Exp Eye Res. 2012 Jan;94(1):98-108. Epub 2011 Nov 28.
Additional References at PubMed
PMID:9216040   PMID:9267021   PMID:9753320   PMID:10830166   PMID:11821383   PMID:15271982   PMID:15703386   PMID:15776018   PMID:15877105   PMID:15907471   PMID:16183742   PMID:16207793  
PMID:16375719   PMID:16407291   PMID:19056867   PMID:21827945   PMID:27443636   PMID:27580417   PMID:31212066   PMID:34304702  


Genomics

Comparative Map Data
Apaf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,381,392 - 27,466,772 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl727,381,855 - 27,466,772 (-)EnsemblGRCr8
mRatBN7.2725,494,143 - 25,579,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,494,609 - 25,579,540 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx727,489,053 - 27,573,980 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,651,444 - 29,736,367 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,428,845 - 29,513,775 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,699,309 - 31,784,192 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,699,885 - 31,784,192 (-)Ensemblrn6Rnor6.0
Rnor_5.0731,791,073 - 31,872,984 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4727,932,908 - 28,020,533 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera722,620,761 - 22,706,298 (-)NCBICelera
RGSC_v3.1727,953,178 - 28,040,804 (-)NCBI
Cytogenetic Map7q13NCBI
APAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381298,645,290 - 98,735,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1298,645,149 - 98,735,433 (+)Ensemblhg38GRCh38
GRCh371299,039,068 - 99,129,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361297,563,209 - 97,653,342 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341297,541,545 - 97,631,678NCBI
Celera1298,703,974 - 98,794,106 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1296,100,029 - 96,190,306 (+)NCBIHuRef
CHM1_11299,004,024 - 99,094,151 (+)NCBICHM1_1
T2T-CHM13v2.01298,618,230 - 98,708,377 (+)NCBIT2T-CHM13v2.0
Apaf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391090,825,173 - 90,918,688 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1090,825,173 - 90,918,632 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1090,989,311 - 91,082,770 (-)Ensemblmm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBIMGSCv36mm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.47NCBI
Apaf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540534,623,267 - 34,693,677 (+)Ensembl
ChiLan1.0NW_00495540534,619,780 - 34,693,616 (+)NCBIChiLan1.0ChiLan1.0
APAF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,637,622 - 99,726,946 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)EnsemblpanPan2panpan1.1
APAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11538,026,893 - 38,160,842 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1538,028,132 - 38,114,987 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1538,408,276 - 38,554,051 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01538,689,945 - 38,835,971 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1538,689,948 - 38,780,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,961,882 - 38,107,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01538,054,503 - 38,200,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01538,328,187 - 38,474,238 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apaf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494521,806,281 - 21,891,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649214,816,623 - 14,902,132 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649214,818,561 - 14,902,231 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl585,166,628 - 85,258,364 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1585,166,616 - 85,258,751 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2589,443,106 - 89,580,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11193,942,137 - 94,024,728 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1193,942,103 - 94,024,457 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037151,034,383 - 151,120,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apaf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247508,837,037 - 8,938,009 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247508,835,521 - 8,940,957 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Apaf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11170,071,689 - 170,158,638 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apaf1
798 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:90
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000010869
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010869   ⟹   ENSRNOP00000010869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl727,381,855 - 27,466,772 (-)Ensembl
mRatBN7.2 Ensembl725,494,609 - 25,579,540 (-)Ensembl
Rnor_6.0 Ensembl731,699,885 - 31,784,192 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115920   ⟹   ENSRNOP00000081242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl727,381,855 - 27,466,772 (-)Ensembl
mRatBN7.2 Ensembl725,494,609 - 25,579,540 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145233   ⟹   ENSRNOP00000099450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl727,381,855 - 27,466,772 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145298   ⟹   ENSRNOP00000108270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl727,383,860 - 27,466,772 (-)Ensembl
RefSeq Acc Id: NM_023979   ⟹   NP_076469
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,381,842 - 27,466,772 (-)NCBI
mRatBN7.2725,494,596 - 25,579,540 (-)NCBI
Rnor_6.0731,699,872 - 31,784,192 (-)NCBI
Rnor_5.0731,791,073 - 31,872,984 (-)NCBI
RGSC_v3.4727,932,908 - 28,020,533 (-)RGD
Celera722,620,761 - 22,706,298 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765263   ⟹   XP_008763485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,381,392 - 27,462,546 (-)NCBI
mRatBN7.2725,494,143 - 25,575,368 (-)NCBI
Rnor_6.0731,699,309 - 31,770,327 (-)NCBI
Sequence:
RefSeq Acc Id: NP_076469   ⟸   NM_023979
- UniProtKB: Q9EPV5 (UniProtKB/Swiss-Prot),   A6IFU7 (UniProtKB/TrEMBL),   Q8VI66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763485   ⟸   XM_008765263
- Peptide Label: isoform X1
- UniProtKB: A6IFU6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010869   ⟸   ENSRNOT00000010869
Ensembl Acc Id: ENSRNOP00000081242   ⟸   ENSRNOT00000115920
Ensembl Acc Id: ENSRNOP00000099450   ⟸   ENSRNOT00000145233
Ensembl Acc Id: ENSRNOP00000108270   ⟸   ENSRNOT00000145298
Protein Domains
CARD   NB-ARC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPV5-F1-model_v2 AlphaFold Q9EPV5 1-1249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695139
Promoter ID:EPDNEW_R5664
Type:multiple initiation site
Name:Apaf1_1
Description:apoptotic peptidase activating factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0731,784,141 - 31,784,201EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620575 AgrOrtholog
BioCyc Gene G2FUF-34469 BioCyc
Ensembl Genes ENSRNOG00000008022 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010869 ENTREZGENE
  ENSRNOT00000010869.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  1.10.533.10 UniProtKB/Swiss-Prot
  1.10.8.430 UniProtKB/Swiss-Prot
  1.25.40.370 UniProtKB/Swiss-Prot
  2.130.10.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro Apaf-1 UniProtKB/Swiss-Prot
  APAF1_C UniProtKB/Swiss-Prot
  APAF1_CARD_dom UniProtKB/Swiss-Prot
  APAF1_WHD UniProtKB/Swiss-Prot
  Apaf_helical UniProtKB/Swiss-Prot
  CARD UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot
  NB-ARC UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_CS UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:78963 UniProtKB/Swiss-Prot
NCBI Gene 78963 ENTREZGENE
PANTHER APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/Swiss-Prot
  APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/Swiss-Prot
Pfam APAF-1-like_WHD UniProtKB/Swiss-Prot
  APAF1_C UniProtKB/Swiss-Prot
  CARD UniProtKB/Swiss-Prot
  NB-ARC UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot
PhenoGen Apaf1 PhenoGen
PIRSF Apop_pept_activating-1 UniProtKB/Swiss-Prot
PRINTS DISEASERSIST UniProtKB/Swiss-Prot
  GPROTEINBRPT UniProtKB/Swiss-Prot
PROSITE CARD UniProtKB/Swiss-Prot
  WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008022 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF50978 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6G5N4_RAT UniProtKB/TrEMBL
  A0ABK0LF43_RAT UniProtKB/TrEMBL
  A0ABK0LQY4_RAT UniProtKB/TrEMBL
  A6IFU1_RAT UniProtKB/TrEMBL
  A6IFU2_RAT UniProtKB/TrEMBL
  A6IFU4_RAT UniProtKB/TrEMBL
  A6IFU6 ENTREZGENE, UniProtKB/TrEMBL
  A6IFU7 ENTREZGENE, UniProtKB/TrEMBL
  APAF_RAT UniProtKB/Swiss-Prot
  Q8VI66 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPV5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Apaf1  apoptotic peptidase activating factor 1    apoptotic protease activating factor 1  Name updated 1299863 APPROVED
2002-08-07 Apaf1  apoptotic protease activating factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression suppressed within 4 weeks after birth in brain tissue 1299279