Aox1 (aldehyde oxidase 1) - Rat Genome Database

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Gene: Aox1 (aldehyde oxidase 1) Rattus norvegicus
Analyze
Symbol: Aox1
Name: aldehyde oxidase 1
RGD ID: 620528
Description: Enables aldehyde oxidase activity. Predicted to be involved in NAD+ catabolic process and xenobiotic metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human AOX1 (aldehyde oxidase 1); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde oxidase; aldehyde oxidase (female form); azaheterocycle hydroxylase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,073,831 - 67,152,980 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,073,821 - 67,152,980 (+)EnsemblGRCr8
mRatBN7.2959,579,621 - 59,658,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,579,649 - 59,658,770 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,079,746 - 68,155,526 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,195,659 - 73,271,431 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,513,768 - 71,589,528 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0964,929,682 - 65,007,872 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl964,929,721 - 65,007,870 (+)Ensemblrn6Rnor6.0
Rnor_5.0964,726,609 - 64,804,786 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4956,693,698 - 56,774,115 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,025,110 - 57,102,310 (+)NCBICelera
RGSC_v3.1956,840,679 - 56,921,097 (+)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,4-dioxane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
Bufotalin  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
dibenzofurans  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ferric oxide  (EXP)
fipronil  (EXP)
flutamide  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
galactose  (ISO)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
lanthanum trichloride  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP,ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
succimer  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungstate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zaleplon  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. Aliciguzel Y, etal., J Lab Clin Med 2003 Sep;142(3):172-7.
2. Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis. Berger R, etal., Somat Cell Mol Genet 1995 Mar;21(2):121-31.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Xanthine oxidase and aldehyde oxidase: a simple procedure for the simultaneous purification from rat liver. Maia L and Mira L, Arch Biochem Biophys 2002 Apr 1;400(1):48-53.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1). Differences in redox status may distinguish male and female forms of hepatic APX. Wright RM, etal., J Biol Chem 1999 Feb 5;274(6):3878-86.
Additional References at PubMed
PMID:518535   PMID:6372555   PMID:10190983   PMID:10377246   PMID:17639027   PMID:18098066   PMID:19056867   PMID:19401776   PMID:19801639   PMID:20444863   PMID:20700607   PMID:22031625  
PMID:22231435   PMID:22279051   PMID:22522748   PMID:22705828   PMID:22996261   PMID:23462233   PMID:23857892   PMID:25537183   PMID:26322824   PMID:26842593  


Genomics

Comparative Map Data
Aox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,073,831 - 67,152,980 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,073,821 - 67,152,980 (+)EnsemblGRCr8
mRatBN7.2959,579,621 - 59,658,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,579,649 - 59,658,770 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,079,746 - 68,155,526 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,195,659 - 73,271,431 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,513,768 - 71,589,528 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0964,929,682 - 65,007,872 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl964,929,721 - 65,007,870 (+)Ensemblrn6Rnor6.0
Rnor_5.0964,726,609 - 64,804,786 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4956,693,698 - 56,774,115 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,025,110 - 57,102,310 (+)NCBICelera
RGSC_v3.1956,840,679 - 56,921,097 (+)NCBI
Cytogenetic Map9q31NCBI
AOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382200,586,014 - 200,682,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2200,585,864 - 200,677,064 (+)Ensemblhg38GRCh38
GRCh372201,450,737 - 201,536,218 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,158,976 - 201,244,463 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342201,276,043 - 201,361,720NCBI
Celera2195,205,613 - 195,291,094 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,302,067 - 193,387,763 (+)NCBIHuRef
CHM1_12201,456,717 - 201,542,113 (+)NCBICHM1_1
T2T-CHM13v2.02201,069,494 - 201,165,683 (+)NCBIT2T-CHM13v2.0
Aox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,068,963 - 58,145,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,069,090 - 58,145,572 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38158,029,809 - 58,106,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,029,931 - 58,106,413 (+)Ensemblmm10GRCm38
MGSCv37158,086,813 - 58,163,254 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36157,974,550 - 58,050,959 (+)NCBIMGSCv36mm8
Celera158,543,669 - 58,620,236 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map128.86NCBI
Aox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403828,066 - 872,218 (-)Ensembl
ChiLan1.0NW_004955403827,538 - 875,856 (-)NCBIChiLan1.0ChiLan1.0
AOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213103,208,614 - 103,294,161 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B103,223,614 - 103,309,164 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B87,839,376 - 87,924,823 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B205,996,604 - 206,083,897 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B205,996,604 - 206,083,897 (+)EnsemblpanPan2panpan1.1
AOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1379,912,731 - 9,992,322 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl379,913,675 - 9,992,319 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3710,799,110 - 10,877,517 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0379,818,121 - 9,897,733 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl379,819,065 - 9,897,732 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1379,800,648 - 9,879,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0379,778,952 - 9,857,094 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0379,772,362 - 9,850,965 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303157,695,152 - 157,763,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936825263,081 - 332,622 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936825263,725 - 332,424 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,157,527 - 104,236,006 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115104,157,748 - 104,234,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215115,429,739 - 115,506,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Aox1
829 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:21
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000068633
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
AW533952  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8967,109,096 - 67,109,257 (+)Marker Load Pipeline
mRatBN7.2959,614,886 - 59,615,047 (+)MAPPERmRatBN7.2
Rnor_6.0964,965,031 - 64,965,191NCBIRnor6.0
Rnor_5.0964,761,947 - 64,762,107UniSTSRnor5.0
RGSC_v3.4956,729,520 - 56,729,680UniSTSRGSC3.4
Celera957,060,263 - 57,060,423UniSTS
RH 3.4 Map9483.3UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 151 91 90 59 40 59 6 297 140 11 130 75 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000068633   ⟹   ENSRNOP00000059651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,087,989 - 67,152,980 (+)Ensembl
mRatBN7.2 Ensembl959,593,781 - 59,658,770 (+)Ensembl
Rnor_6.0 Ensembl964,929,721 - 65,007,870 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl964,986,555 - 64,987,451 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl964,981,112 - 64,981,636 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102452   ⟹   ENSRNOP00000077590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,073,821 - 67,152,980 (+)Ensembl
mRatBN7.2 Ensembl959,579,649 - 59,658,770 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171389   ⟹   ENSRNOP00000100414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,091,547 - 67,152,980 (+)Ensembl
RefSeq Acc Id: NM_019363   ⟹   NP_062236
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,073,891 - 67,152,980 (+)NCBI
mRatBN7.2959,579,681 - 59,658,772 (+)NCBI
Rnor_6.0964,929,721 - 65,007,870 (+)NCBI
Rnor_5.0964,726,609 - 64,804,786 (+)NCBI
RGSC_v3.4956,693,698 - 56,774,115 (+)RGD
Celera957,025,110 - 57,102,310 (+)RGD
Sequence:
RefSeq Acc Id: XM_039084139   ⟹   XP_038940067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,088,376 - 67,152,980 (+)NCBI
mRatBN7.2959,597,366 - 59,658,772 (+)NCBI
RefSeq Acc Id: XR_594396
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,073,831 - 67,151,099 (+)NCBI
mRatBN7.2959,579,621 - 59,658,772 (+)NCBI
Rnor_6.0964,929,682 - 65,007,872 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062236 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940067 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD16999 (Get FASTA)   NCBI Sequence Viewer  
  AAD17000 (Get FASTA)   NCBI Sequence Viewer  
  EDL99010 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059651
  ENSRNOP00000100414
GenBank Protein Q9Z0U5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062236   ⟸   NM_019363
- UniProtKB: Q9Z0U5 (UniProtKB/Swiss-Prot),   Q9R240 (UniProtKB/Swiss-Prot),   A6IP50 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059651   ⟸   ENSRNOT00000068633
RefSeq Acc Id: XP_038940067   ⟸   XM_039084139
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y9M0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077590   ⟸   ENSRNOT00000102452
Ensembl Acc Id: ENSRNOP00000100414   ⟸   ENSRNOT00000171389
Protein Domains
2Fe-2S ferredoxin-type   FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0U5-F1-model_v2 AlphaFold Q9Z0U5 1-1333 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696682
Promoter ID:EPDNEW_R7207
Type:multiple initiation site
Name:Aox1_1
Description:aldehyde oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0964,929,696 - 64,929,756EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620528 AgrOrtholog
BioCyc Gene G2FUF-27464 BioCyc
Ensembl Genes ENSRNOG00000015354 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000068633 ENTREZGENE
  ENSRNOT00000171389 ENTREZGENE
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot
  3.30.43.10 UniProtKB/Swiss-Prot
  3.30.465.10 UniProtKB/Swiss-Prot
  [2Fe-2S]-binding domain UniProtKB/Swiss-Prot
  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead UniProtKB/Swiss-Prot
  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain UniProtKB/Swiss-Prot
  CO dehydrogenase flavoprotein, C-terminal domain UniProtKB/Swiss-Prot
InterPro 2Fe-2S-bd UniProtKB/Swiss-Prot
  2Fe-2S-bd_dom_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot
  2Fe2S_fd_BS UniProtKB/Swiss-Prot
  Ald_Oxase/Xan_DH_a/b UniProtKB/Swiss-Prot
  Ald_Oxase/Xan_DH_a/b_sf UniProtKB/Swiss-Prot
  Ald_Oxase/xanthine_DH UniProtKB/Swiss-Prot
  Aldehyde_oxidase UniProtKB/Swiss-Prot
  AldOxase/xan_DH_MoCoBD2 UniProtKB/Swiss-Prot
  AldOxase/xan_DH_Mopterin-bd UniProtKB/Swiss-Prot
  AldOxase/xan_DH_Mopterin-bd_sf UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot
  CO_DH_flav_C UniProtKB/Swiss-Prot
  CO_DH_flav_C_dom_sf UniProtKB/Swiss-Prot
  FAD-bd_PCMH UniProtKB/Swiss-Prot
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot
  Mopterin_DH_FAD-bd UniProtKB/Swiss-Prot
  OxRdtase_Mopterin_BS UniProtKB/Swiss-Prot
KEGG Report rno:54349 UniProtKB/Swiss-Prot
NCBI Gene 54349 ENTREZGENE
PANTHER XANTHINE DEHYDROGENASE UniProtKB/Swiss-Prot
  XANTHINE DEHYDROGENASE UniProtKB/Swiss-Prot
Pfam Ald_Xan_dh_C UniProtKB/Swiss-Prot
  Ald_Xan_dh_C2 UniProtKB/Swiss-Prot
  CO_deh_flav_C UniProtKB/Swiss-Prot
  FAD_binding_5 UniProtKB/Swiss-Prot
  Fer2 UniProtKB/Swiss-Prot
  Fer2_2 UniProtKB/Swiss-Prot
  MoCoBD_2 UniProtKB/Swiss-Prot
PharmGKB AOX1 RGD
PhenoGen Aox1 PhenoGen
PIRSF Xanthine_DH UniProtKB/Swiss-Prot
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot
  2FE2S_FER_2 UniProtKB/Swiss-Prot
  FAD_PCMH UniProtKB/Swiss-Prot
  MOLYBDOPTERIN_EUK UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015354 RatGTEx
SMART Ald_Xan_dh_C UniProtKB/Swiss-Prot
  CO_deh_flav_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47741 UniProtKB/Swiss-Prot
  SSF54292 UniProtKB/Swiss-Prot
  SSF54665 UniProtKB/Swiss-Prot
  SSF55447 UniProtKB/Swiss-Prot
  SSF56003 UniProtKB/Swiss-Prot
  SSF56176 UniProtKB/Swiss-Prot
UniProt A0A8I5Y9M0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L6H9_RAT UniProtKB/TrEMBL
  A6IP50 ENTREZGENE, UniProtKB/TrEMBL
  AOXA_RAT UniProtKB/Swiss-Prot
  F1LRQ1_RAT UniProtKB/TrEMBL
  Q9R240 ENTREZGENE
  Q9Z0U5 ENTREZGENE
UniProt Secondary Q9R240 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Aox1  aldehyde oxidase 1    aldehyde oxidase  Name updated 1299863 APPROVED
2002-08-07 Aox1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 150 kDa 632256
gene_protein kinetic differences exist between male and female rat liver and caused by differences in redox state 632256