Sox5 (SRY-box transcription factor 5) - Rat Genome Database

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Pathways
Gene: Sox5 (SRY-box transcription factor 5) Rattus norvegicus
Analyze
Symbol: Sox5
Name: SRY-box transcription factor 5
RGD ID: 620471
Description: Enables cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cartilage development; cellular response to transforming growth factor beta stimulus; and positive regulation of cell differentiation. Predicted to act upstream of or within several processes, including negative regulation of DNA-templated transcription; neurogenesis; and regulation of timing of neuron differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human SOX5 (SRY-box transcription factor 5); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Sox5l1; SRY (sex determining region Y)-box 5; SRY box 5; SRY-box containing gene 5; SRY-box containing gene 5-like 1; transcription factor SOX-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84178,512,272 - 179,467,686 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4178,512,272 - 178,938,495 (-)EnsemblGRCr8
mRatBN7.24176,781,375 - 177,736,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4176,785,892 - 177,736,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4183,088,517 - 183,461,996 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04178,872,831 - 179,246,322 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04177,493,406 - 177,866,892 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04178,062,267 - 179,031,991 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4178,066,165 - 178,441,547 (-)Ensemblrn6Rnor6.0
Rnor_5.04242,266,295 - 243,221,217 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44181,558,995 - 181,931,117 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4165,313,274 - 165,629,808 (-)NCBICelera
RGSC_v3.14181,825,983 - 182,011,429 (-)NCBI
Cytogenetic Map4q44NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
chromium(6+)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
glyphosate  (EXP)
leflunomide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Liu CF and Lefebvre V, Nucleic Acids Res. 2015 Sep 30;43(17):8183-203. doi: 10.1093/nar/gkv688. Epub 2015 Jul 6.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Smits P and Lefebvre V, Development 2003 Mar;130(6):1135-48.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9755172   PMID:15634692   PMID:17084361   PMID:18215621   PMID:20668334   PMID:20940257   PMID:21073445   PMID:21401405   PMID:22344693   PMID:23946438   PMID:24854956   PMID:26345464  
PMID:26525805  


Genomics

Comparative Map Data
Sox5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84178,512,272 - 179,467,686 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4178,512,272 - 178,938,495 (-)EnsemblGRCr8
mRatBN7.24176,781,375 - 177,736,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4176,785,892 - 177,736,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4183,088,517 - 183,461,996 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04178,872,831 - 179,246,322 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04177,493,406 - 177,866,892 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04178,062,267 - 179,031,991 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4178,066,165 - 178,441,547 (-)Ensemblrn6Rnor6.0
Rnor_5.04242,266,295 - 243,221,217 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44181,558,995 - 181,931,117 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4165,313,274 - 165,629,808 (-)NCBICelera
RGSC_v3.14181,825,983 - 182,011,429 (-)NCBI
Cytogenetic Map4q44NCBI
SOX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,529,504 - 24,562,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1223,529,504 - 24,562,544 (-)Ensemblhg38GRCh38
GRCh371223,682,438 - 24,715,425 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361223,576,498 - 24,606,647 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1228,833,198 - 29,862,278 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1223,452,599 - 24,484,456 (-)NCBIHuRef
CHM1_11223,650,324 - 24,680,623 (-)NCBICHM1_1
T2T-CHM13v2.01223,401,301 - 24,433,529 (-)NCBIT2T-CHM13v2.0
Sox5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396143,774,151 - 144,728,008 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6143,774,151 - 144,727,703 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386143,828,425 - 144,782,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6143,828,425 - 144,781,977 (-)Ensemblmm10GRCm38
MGSCv376143,781,349 - 144,158,078 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366143,790,051 - 144,166,639 (-)NCBIMGSCv36mm8
Celera6146,885,590 - 147,265,302 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map676.14NCBI
Sox5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541318,831,931 - 19,204,217 (-)Ensembl
ChiLan1.0NW_00495541318,831,931 - 19,676,371 (-)NCBIChiLan1.0ChiLan1.0
SOX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21072,253,383 - 73,284,141 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11272,249,780 - 73,280,539 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01262,361,631 - 62,780,805 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11264,973,019 - 65,391,500 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1264,971,818 - 65,388,694 (+)EnsemblpanPan2panpan1.1
SOX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12722,857,661 - 23,855,709 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2723,452,985 - 23,851,380 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2722,515,990 - 23,511,350 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02723,058,695 - 24,061,457 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2723,059,559 - 24,061,452 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12722,871,574 - 23,867,072 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02722,890,892 - 23,887,914 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02722,685,794 - 23,683,255 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sox5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494584,725,370 - 85,677,233 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365483,213,466 - 3,599,425 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365483,213,305 - 3,599,876 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl549,504,551 - 50,161,558 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1549,159,950 - 50,166,463 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2553,008,491 - 53,806,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11123,298,622 - 24,131,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1123,303,325 - 23,715,492 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606910,803,456 - 11,833,677 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sox5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475214,985,942 - 15,378,465 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475214,986,146 - 15,382,687 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sox5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v161,576,650 - 1,945,796 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sox5
5929 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:90
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000020729
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4176806581181925369Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
D9Rat28  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84178,704,201 - 178,704,525 (+)Marker Load Pipeline
mRatBN7.24176,973,326 - 176,973,650 (+)MAPPERmRatBN7.2
Rnor_6.04178,253,454 - 178,253,777NCBIRnor6.0
Rnor_5.04242,456,468 - 242,456,791UniSTSRnor5.0
RGSC_v3.44181,645,676 - 181,646,000RGDRGSC3.4
RGSC_v3.44181,645,677 - 181,646,000UniSTSRGSC3.4
Celera4165,498,972 - 165,499,295UniSTS
RGSC_v3.14181,890,801 - 181,891,124RGD
RH 3.4 Map41062.3RGD
RH 3.4 Map41062.3UniSTS
Cytogenetic Map4q44UniSTS
D4Got154  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84178,682,210 - 178,682,366 (+)Marker Load Pipeline
mRatBN7.24176,951,334 - 176,951,490 (+)MAPPERmRatBN7.2
Rnor_6.04178,231,463 - 178,231,618NCBIRnor6.0
Rnor_5.04242,434,477 - 242,434,632UniSTSRnor5.0
RGSC_v3.44181,623,685 - 181,623,841RGDRGSC3.4
RGSC_v3.44181,623,686 - 181,623,841UniSTSRGSC3.4
Celera4165,476,979 - 165,477,134UniSTS
RGSC_v3.14181,868,810 - 181,868,965RGD
RH 3.4 Map41013.5RGD
RH 3.4 Map41013.5UniSTS
RH 2.0 Map41105.3RGD
Cytogenetic Map4q44UniSTS
BE108803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24176,860,248 - 176,860,432 (+)MAPPERmRatBN7.2
Rnor_6.04178,141,125 - 178,141,308NCBIRnor6.0
Rnor_5.04242,344,099 - 242,344,282UniSTSRnor5.0
RGSC_v3.44180,472,699 - 180,472,882UniSTSRGSC3.4
Celera4165,387,487 - 165,387,670UniSTS
RH 3.4 Map41057.9UniSTS
Cytogenetic Map4q44UniSTS
RH134712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24176,786,011 - 176,786,169 (+)MAPPERmRatBN7.2
Rnor_6.04178,066,907 - 178,067,064NCBIRnor6.0
Rnor_5.04242,270,935 - 242,271,092UniSTSRnor5.0
RGSC_v3.44180,399,064 - 180,399,221UniSTSRGSC3.4
Celera4165,313,400 - 165,313,557UniSTS
RH 3.4 Map41057.9UniSTS
Cytogenetic Map4q44UniSTS
Sox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24176,786,012 - 176,786,632 (+)MAPPERmRatBN7.2
Rnor_6.04178,066,908 - 178,067,527NCBIRnor6.0
Rnor_5.04242,270,936 - 242,271,555UniSTSRnor5.0
RGSC_v3.44180,399,065 - 180,399,684UniSTSRGSC3.4
Celera4165,313,401 - 165,314,020UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 162 91 90 59 84 59 6 346 183 11 141 80 92 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB073719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020729   ⟹   ENSRNOP00000020729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4178,512,272 - 178,890,449 (-)Ensembl
mRatBN7.2 Ensembl4176,785,892 - 177,736,852 (-)Ensembl
Rnor_6.0 Ensembl4178,067,051 - 178,168,690 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000055542   ⟹   ENSRNOP00000052404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4178,512,272 - 178,890,449 (-)Ensembl
mRatBN7.2 Ensembl4176,785,892 - 177,159,525 (-)Ensembl
Rnor_6.0 Ensembl4178,066,787 - 178,441,547 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087434   ⟹   ENSRNOP00000073853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4178,512,272 - 178,938,495 (-)Ensembl
mRatBN7.2 Ensembl4176,785,892 - 177,208,076 (-)Ensembl
Rnor_6.0 Ensembl4178,066,165 - 178,441,547 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096663   ⟹   ENSRNOP00000079278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4178,512,272 - 178,890,486 (-)Ensembl
mRatBN7.2 Ensembl4176,785,892 - 177,736,852 (-)Ensembl
RefSeq Acc Id: NM_001014060   ⟹   NP_001014082
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,512,272 - 178,624,633 (-)NCBI
mRatBN7.24176,781,379 - 176,893,750 (-)NCBI
RefSeq Acc Id: NM_001271267   ⟹   NP_001258196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,512,272 - 178,890,449 (-)NCBI
mRatBN7.24176,781,379 - 177,159,575 (-)NCBI
Rnor_6.04178,066,781 - 178,441,547 (-)NCBI
Rnor_5.04242,266,295 - 243,221,217 (-)NCBI
Celera4165,313,274 - 165,629,808 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001415821   ⟹   NP_001402750
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,512,272 - 178,890,449 (-)NCBI
mRatBN7.24176,781,379 - 177,159,575 (-)NCBI
RefSeq Acc Id: NM_001415822   ⟹   NP_001402751
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,512,272 - 178,890,449 (-)NCBI
mRatBN7.24176,781,379 - 177,159,575 (-)NCBI
RefSeq Acc Id: NM_001415823   ⟹   NP_001402752
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,512,272 - 178,890,449 (-)NCBI
mRatBN7.24176,781,379 - 177,159,575 (-)NCBI
RefSeq Acc Id: XM_006237604   ⟹   XP_006237666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 178,890,462 (-)NCBI
mRatBN7.24176,781,375 - 177,159,576 (-)NCBI
Rnor_6.04178,062,267 - 178,441,601 (-)NCBI
Rnor_5.04242,266,295 - 243,221,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763349   ⟹   XP_008761571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 178,890,515 (-)NCBI
mRatBN7.24176,781,375 - 177,159,641 (-)NCBI
Rnor_6.04178,062,267 - 178,441,669 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592402   ⟹   XP_017447891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 179,467,686 (-)NCBI
mRatBN7.24176,781,375 - 177,736,833 (-)NCBI
Rnor_6.04178,062,267 - 179,031,991 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592410   ⟹   XP_017447899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 178,624,704 (-)NCBI
mRatBN7.24176,781,715 - 176,893,809 (-)NCBI
Rnor_6.04178,062,267 - 178,174,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106952   ⟹   XP_038962880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 178,968,048 (-)NCBI
mRatBN7.24176,781,375 - 177,237,409 (-)NCBI
RefSeq Acc Id: XM_039106953   ⟹   XP_038962881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 179,467,681 (-)NCBI
mRatBN7.24176,781,375 - 177,736,833 (-)NCBI
RefSeq Acc Id: XM_063285440   ⟹   XP_063141510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 179,278,245 (-)NCBI
RefSeq Acc Id: XM_063285441   ⟹   XP_063141511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 178,890,462 (-)NCBI
RefSeq Acc Id: XM_063285442   ⟹   XP_063141512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 178,624,677 (-)NCBI
RefSeq Acc Id: XM_063285443   ⟹   XP_063141513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84178,516,865 - 178,624,624 (-)NCBI
RefSeq Acc Id: NP_001258196   ⟸   NM_001271267
- Peptide Label: isoform 2
- UniProtKB: F1LQN4 (UniProtKB/Swiss-Prot),   Q5U1X4 (UniProtKB/Swiss-Prot),   F1M8W4 (UniProtKB/TrEMBL),   A6IMY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237666   ⟸   XM_006237604
- Peptide Label: isoform X1
- UniProtKB: A6IMY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761571   ⟸   XM_008763349
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZMP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447891   ⟸   XM_017592402
- Peptide Label: isoform X3
- UniProtKB: A6IMY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447899   ⟸   XM_017592410
- Peptide Label: isoform X7
- Sequence:
Ensembl Acc Id: ENSRNOP00000052404   ⟸   ENSRNOT00000055542
Ensembl Acc Id: ENSRNOP00000073853   ⟸   ENSRNOT00000087434
Ensembl Acc Id: ENSRNOP00000020729   ⟸   ENSRNOT00000020729
RefSeq Acc Id: XP_038962881   ⟸   XM_039106953
- Peptide Label: isoform X3
- UniProtKB: A6IMY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962880   ⟸   XM_039106952
- Peptide Label: isoform X2
- UniProtKB: A6IMY0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079278   ⟸   ENSRNOT00000096663
RefSeq Acc Id: NP_001402751   ⟸   NM_001415822
- Peptide Label: isoform 4
- UniProtKB: A0A8L2QAC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402752   ⟸   NM_001415823
- Peptide Label: isoform 5
- UniProtKB: A0A8I5ZMP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402750   ⟸   NM_001415821
- Peptide Label: isoform 3
- UniProtKB: A0A8L2QAC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001014082   ⟸   NM_001014060
- Peptide Label: isoform 1
RefSeq Acc Id: XP_063141510   ⟸   XM_063285440
- Peptide Label: isoform X3
- UniProtKB: A6IMY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141511   ⟸   XM_063285441
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QAC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141512   ⟸   XM_063285442
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063141513   ⟸   XM_063285443
- Peptide Label: isoform X8
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8W4-F1-model_v2 AlphaFold F1M8W4 1-763 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620471 AgrOrtholog
BioCyc Gene G2FUF-42476 BioCyc
Ensembl Genes ENSRNOG00000027869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020729 ENTREZGENE
  ENSRNOT00000055542 ENTREZGENE
  ENSRNOT00000055542.4 UniProtKB/Swiss-Prot
  ENSRNOT00000087434 ENTREZGENE
  ENSRNOT00000096663 ENTREZGENE
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7131922 IMAGE-MGC_LOAD
InterPro HMG_box_dom UniProtKB/Swiss-Prot
  HMG_box_dom_sf UniProtKB/Swiss-Prot
  SOX/SOX-like_TF UniProtKB/Swiss-Prot
KEGG Report rno:140587 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105885 IMAGE-MGC_LOAD
NCBI Gene 140587 ENTREZGENE
PANTHER FI18025P1 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR SOX-5 UniProtKB/Swiss-Prot
Pfam HMG_box UniProtKB/Swiss-Prot
PhenoGen Sox5 PhenoGen
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027869 RatGTEx
SMART HMG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot
UniProt A0A0G2K6K9_RAT UniProtKB/TrEMBL
  A0A8I5ZMP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QAC4 ENTREZGENE, UniProtKB/TrEMBL
  A6IMY0 ENTREZGENE, UniProtKB/TrEMBL
  F1LQN4 ENTREZGENE
  F1M8W4 ENTREZGENE
  Q5U1X4 ENTREZGENE
  SOX5_RAT UniProtKB/Swiss-Prot
UniProt Secondary F1LQN4 UniProtKB/Swiss-Prot
  Q5U1X4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Sox5  SRY-box transcription factor 5  Sox5  SRY box 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Sox5  SRY box 5  Sox5  SRY (sex determining region Y)-box 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Sox5  SRY (sex determining region Y)-box 5  Sox5l1  SRY-box containing gene 5-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Sox5l1  SRY-box containing gene 5-like 1  Sox5  SRY (sex determining region Y)-box 5  Data merged from RGD:1359322 737654 PROVISIONAL
2010-04-20 Sox5  SRY (sex determining region Y)-box 5  LOC312831  similar to SRY (sex determining region Y)-box 5 isoform a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC312831  similar to SRY (sex determining region Y)-box 5 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-08 Sox5  SRY-box containing gene 5    SRY (sex determining region Y)-box 5  Name updated 1299863 APPROVED
2002-08-07 Sox5  SRY (sex determining region Y)-box 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference