Mlxipl (MLX interacting protein-like) - Rat Genome Database

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Gene: Mlxipl (MLX interacting protein-like) Rattus norvegicus
Analyze
Symbol: Mlxipl (Ensembl: AABR07035839.1)
Name: MLX interacting protein-like
RGD ID: 620400
Description: Enables DNA-binding transcription factor activity; protein kinase binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; fatty acid homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nucleus. Biomarker of end stage renal disease; kidney disease; metabolic dysfunction-associated steatohepatitis; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human MLXIPL (MLX interacting protein like); PARTICIPATES IN glycolysis/gluconeogenesis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHd14; carbohydrate-responsive element-binding protein; ChREBP; class D basic helix-loop-helix protein 14; MLX interactor; MLX-interacting protein-like; Wbscr14; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosome region 14 homolog; Williams-Beuren syndrome chromosome region 14 homolog (human); WS basic-helix-loop-helix leucine zipper protein; WS-bHLH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,178,158 - 27,213,675 (-)NCBIGRCr8
mRatBN7.21221,541,608 - 21,577,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,683,529 - 22,719,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,295,853 - 23,331,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,362,318 - 22,398,011 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,590,645 - 24,619,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01226,588,220 - 26,620,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1223,305,691 - 23,340,439 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+/-)-Aegeline  (ISO)
(aminooxy)acetic acid  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
amiodarone  (ISO)
amitrole  (EXP)
arsenite(3-)  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cetirizine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
difenoconazole  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenthion  (ISO)
Fexofenadine hydrochloride  (ISO)
fludioxonil  (ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
L-methionine  (ISO)
methimazole  (EXP)
monosodium L-glutamate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
nefazodone  (EXP)
nicotinamide  (EXP)
nicotinic acid  (EXP)
nordihydroguaiaretic acid  (EXP)
Nutlin-3  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
paxilline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
pirinixic acid  (EXP,ISO)
propamocarb  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
salvianolic acid B  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
xylitol  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (ISO)
cytosol  (IDA,IEA,ISO,TAS)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IDA,IEA,ISO)
transcription regulator complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
3. WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog. de Luis O, etal., Eur J Hum Genet. 2000 Mar;8(3):215-22.
4. Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Fukasawa M, etal., Biochem Biophys Res Commun. 2010 Jan 8;391(2):1166-9. doi: 10.1016/j.bbrc.2009.11.115. Epub 2009 Dec 17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study. Ghasemi A, etal., Anatol J Cardiol. 2015 Jan;15(1):8-12. doi: 10.5152/akd.2014.5135. Epub 2014 Feb 10.
7. ChREBP gene polymorphisms are associated with coronary artery disease in Han population of Hubei province. Guo S, etal., Clin Chim Acta. 2011 Sep 18;412(19-20):1854-60. doi: 10.1016/j.cca.2011.06.024. Epub 2011 Jun 25.
8. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
9. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. Kawaguchi T, etal., J Biol Chem 2002 Feb 8;277(6):3829-35.
10. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial. Ortega-Azorín C, etal., Circ Cardiovasc Genet. 2014 Feb;7(1):49-58. doi: 10.1161/CIRCGENETICS.113.000301. Epub 2014 Jan 21.
13. G771C Polymorphism in the MLXIPL Gene Is Associated with a Risk of Coronary Artery Disease in the Chinese: A Case-Control Study. Pan LA, etal., Cardiology. 2009;114(3):174-8. doi: 10.1159/000226610. Epub 2009 Jul 2.
14. A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. Ram R, etal., Clin Genet. 2017 Mar;91(3):371-378. doi: 10.1111/cge.12859. Epub 2017 Jan 30.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Beneficial effects of cherry consumption as a dietary intervention for metabolic, hepatic and vascular complications in type 2 diabetic rats. Van der Werf R, etal., Cardiovasc Diabetol. 2018 Jul 20;17(1):104. doi: 10.1186/s12933-018-0744-6.
18. The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma. Volpe CM, etal., J Am Coll Surg. 1995 Jul;181(1):56-64.
19. Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats. Wang D, etal., Sci Rep. 2017 Aug 29;7(1):9793. doi: 10.1038/s41598-017-09470-0.
20. Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease. Wu N, etal., Anatol J Cardiol. 2018 Jun;19(6):360-367. doi: 10.14744/AnatolJCardiol.2018.23682.
21. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Yamashita H, etal., Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9116-21. Epub 2001 Jul 24.
22. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:11230181   PMID:12684532   PMID:15118080   PMID:15163635   PMID:15664996   PMID:16885160   PMID:17341548   PMID:17418800   PMID:18215143   PMID:18436566   PMID:18591247   PMID:18602890  
PMID:18606808   PMID:18765640   PMID:19406844   PMID:19660458   PMID:19682972   PMID:19995986   PMID:20382893   PMID:21282101   PMID:21665952   PMID:21856285   PMID:22198437   PMID:22214556  
PMID:22466288   PMID:22760788   PMID:23257733   PMID:23803610   PMID:23918932   PMID:24616092   PMID:26384380   PMID:26984404   PMID:27345365   PMID:27545881   PMID:27900263   PMID:27989594  
PMID:28027934   PMID:31505737   PMID:32518215   PMID:38042369  


Genomics

Comparative Map Data
Mlxipl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,178,158 - 27,213,675 (-)NCBIGRCr8
mRatBN7.21221,541,608 - 21,577,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,683,529 - 22,719,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,295,853 - 23,331,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,362,318 - 22,398,011 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,590,645 - 24,619,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01226,588,220 - 26,620,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1223,305,691 - 23,340,439 (-)NCBICelera
Cytogenetic Map12q12NCBI
MLXIPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,593,202 - 73,647,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl773,593,194 - 73,624,543 (-)EnsemblGRCh38hg38GRCh38
GRCh37773,007,532 - 73,038,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,645,460 - 72,676,806 (-)NCBINCBI36Build 36hg18NCBI36
Build 34772,452,174 - 72,483,521NCBI
Celera768,485,730 - 68,517,088 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef768,888,586 - 68,920,882 (-)NCBIHuRef
CHM1_1773,153,232 - 73,184,532 (-)NCBICHM1_1
T2T-CHM13v2.0774,794,073 - 74,848,925 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,340,596 - 72,371,942 (-)NCBI
Mlxipl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,118,744 - 135,168,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,118,744 - 135,167,236 (+)EnsemblGRCm39 Ensembl
GRCm385135,089,890 - 135,139,768 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,089,890 - 135,138,382 (+)EnsemblGRCm38mm10GRCm38
MGSCv375135,582,783 - 135,613,792 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,391,540 - 135,426,429 (+)NCBIMGSCv36mm8
Celera5132,118,107 - 132,149,116 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.0NCBI
Mlxipl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,096,531 - 14,117,269 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,096,530 - 14,116,687 (+)NCBIChiLan1.0ChiLan1.0
MLXIPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,254,158 - 91,308,364 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,541,661 - 139,572,996 (+)NCBINHGRI_mPanPan1
PanPan1.1780,745,765 - 80,776,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,745,765 - 80,776,153 (-)Ensemblpanpan1.1panPan2
MLXIPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,617,398 - 6,652,201 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,633,231 - 6,652,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,314,804 - 8,349,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,448,811 - 6,467,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,448,825 - 6,467,255 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,421,940 - 6,456,726 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,369,681 - 6,404,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,533,405 - 6,568,214 (+)NCBIUU_Cfam_GSD_1.0
Mlxipl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,163,797 - 131,197,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,839,105 - 2,857,002 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,839,105 - 2,856,997 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLXIPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,898,670 - 10,934,048 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,898,675 - 10,934,257 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,598,366 - 10,632,610 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MLXIPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,442,520 - 9,465,772 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660707,011,875 - 7,045,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mlxipl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,168,238 - 14,187,264 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,150,425 - 14,187,687 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mlxipl
220 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:75
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000074230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
BI277291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,543,682 - 21,543,897 (+)MAPPERmRatBN7.2
Rnor_6.01224,590,762 - 24,590,976NCBIRnor6.0
Rnor_5.01226,588,337 - 26,588,551UniSTSRnor5.0
Celera1223,305,808 - 23,306,022UniSTS
RH 3.4 Map12341.51UniSTS
Wbscr14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,544,143 - 21,545,203 (+)MAPPERmRatBN7.2
Rnor_6.01224,591,223 - 24,592,282NCBIRnor6.0
Rnor_5.01226,588,798 - 26,589,857UniSTSRnor5.0
Celera1223,306,269 - 23,307,328UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 31 34 30 18 6 18 6 58 24 19 10 19 12

Sequence


Ensembl Acc Id: ENSRNOT00000071067   ⟹   ENSRNOP00000093059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)Ensembl
Rnor_6.0 Ensembl1224,591,199 - 24,619,607 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074230   ⟹   ENSRNOP00000090385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)Ensembl
Rnor_6.0 Ensembl1224,590,645 - 24,600,065 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1224,606,260 - 24,619,639 (-)Ensembl
RefSeq Acc Id: NM_001393706   ⟹   NP_001380635
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,213,660 (-)NCBI
mRatBN7.21221,541,608 - 21,577,116 (-)NCBI
RefSeq Acc Id: NM_133552   ⟹   NP_598236
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,213,656 (-)NCBI
mRatBN7.21221,541,608 - 21,577,112 (-)NCBI
Rnor_6.01224,590,645 - 24,619,639 (-)NCBI
Rnor_5.01226,588,220 - 26,620,779 (-)NCBI
Celera1223,305,691 - 23,340,439 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089043   ⟹   XP_038944971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,206,487 (-)NCBI
mRatBN7.21221,542,964 - 21,569,900 (-)NCBI
RefSeq Acc Id: XM_039089044   ⟹   XP_038944972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,191,643 (-)NCBI
mRatBN7.21221,542,964 - 21,555,070 (-)NCBI
RefSeq Acc Id: XM_063271027   ⟹   XP_063127097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,191,643 (-)NCBI
RefSeq Acc Id: XM_063271028   ⟹   XP_063127098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,183,925 - 27,213,675 (-)NCBI
RefSeq Acc Id: XR_005491593
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,183,826 - 27,213,675 (-)NCBI
mRatBN7.21221,547,276 - 21,577,120 (-)NCBI
RefSeq Acc Id: XR_005491594
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,183,823 - 27,213,675 (-)NCBI
mRatBN7.21221,547,273 - 21,577,120 (-)NCBI
RefSeq Acc Id: NP_598236   ⟸   NM_133552
- Peptide Label: isoform 2
- UniProtKB: Q8VIP2 (UniProtKB/Swiss-Prot),   A6J0E8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038944971   ⟸   XM_039089043
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944972   ⟸   XM_039089044
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000090385   ⟸   ENSRNOT00000074230
Ensembl Acc Id: ENSRNOP00000093059   ⟸   ENSRNOT00000071067
RefSeq Acc Id: NP_001380635   ⟸   NM_001393706
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ADP9 (UniProtKB/TrEMBL),   C7C5T1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127097   ⟸   XM_063271027
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127098   ⟸   XM_063271028
- Peptide Label: isoform X4
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIP2-F1-model_v2 AlphaFold Q8VIP2 1-865 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620400 AgrOrtholog
BioCyc Gene G2FUF-19607 BioCyc
Ensembl Genes ENSRNOG00000046171 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071067.3 UniProtKB/TrEMBL
  ENSRNOT00000074230.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171078 UniProtKB/Swiss-Prot
NCBI Gene 171078 ENTREZGENE
PANTHER CARBOHYDRATE-RESPONSIVE ELEMENT-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN MAX MYC-ASSOCIATED FACTOR X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mlxipl PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046171 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ADP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKH5_RAT UniProtKB/TrEMBL
  A6J0E8 ENTREZGENE, UniProtKB/TrEMBL
  C7C5T1 ENTREZGENE, UniProtKB/TrEMBL
  MLXPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-08-15 Mlxipl  MLX interacting protein-like  Wbscr14  Williams-Beuren syndrome chromosome region 14 homolog (human)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-07-08 Wbscr14  Williams-Beuren syndrome chromosome region 14 homolog (human)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Wbscr14  Williams-Beuren syndrome chromosome region 14 homolog (human)      Symbol and Name status set to provisional 70820 PROVISIONAL