Mlxipl (MLX interacting protein-like) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mlxipl (MLX interacting protein-like) Rattus norvegicus
Analyze
Symbol: Mlxipl (Ensembl: AABR07035839.1)
Name: MLX interacting protein-like
RGD ID: 620400
Description: Enables DNA-binding transcription factor activity; protein kinase binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; fatty acid homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nucleus. Biomarker of end stage renal disease; kidney disease; metabolic dysfunction-associated steatohepatitis; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human MLXIPL (MLX interacting protein like); PARTICIPATES IN glycolysis/gluconeogenesis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHd14; carbohydrate-responsive element-binding protein; ChREBP; class D basic helix-loop-helix protein 14; MLX interactor; MLX-interacting protein-like; Wbscr14; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosome region 14 homolog; Williams-Beuren syndrome chromosome region 14 homolog (human); WS basic-helix-loop-helix leucine zipper protein; WS-bHLH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,178,158 - 27,213,675 (-)NCBIGRCr8
mRatBN7.21221,541,608 - 21,577,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,683,529 - 22,719,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,295,853 - 23,331,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,362,318 - 22,398,011 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,590,645 - 24,619,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01226,588,220 - 26,620,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1223,305,691 - 23,340,439 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatcoronary artery disease susceptibilityISOMLXIPL (Homo sapiens)401794582DNA:SNP:cds: G771C and Q241H (rs381231)RGD 
MlxiplRatcoronary artery disease susceptibilityISOMLXIPL (Homo sapiens)401794581DNA:SNP:cds: C771G and H241QRGD 
MlxiplRatcoronary artery disease susceptibilityISOMLXIPL (Homo sapiens)401794579DNA:SNPs and haplotypes: (rs3812316) (human)RGD 
MlxiplRatCoronary Disease susceptibilityISOMLXIPL (Homo sapiens)401799677DNA:SNP: (rs35493868) and in younger than 55 years of ageRGD 
MlxiplRatend stage renal disease amelioratesIEP 2326081 RGD 
MlxiplRatHypertriglyceridemia treatmentIEP 329955565 RGD 
MlxiplRatHypertriglyceridemia susceptibilityISOMLXIPL (Homo sapiens)401794577DNA:SNPs and haplotypes: (rs17145738) (human)RGD 
MlxiplRatInsulin Resistance treatmentIEP 329955565 RGD 
MlxiplRatkidney disease  IEP 401824613associated with hypertension and protein:increased expression:kidney (rat)RGD 
MlxiplRatmetabolic dysfunction-associated steatohepatitis treatmentIEP 401799674 RGD 
MlxiplRatmetabolic dysfunction-associated steatotic liver disease treatmentIEP 329955565 RGD 
MlxiplRatMetabolic Syndrome amelioratesIEP 401799622 RGD 
MlxiplRatmyocardial infarction susceptibilityISOMLXIPL (Homo sapiens)401799621DNA:SNP:cd: C771G and p.Q241H (rs3812316) (human)RGD 
MlxiplRattype 2 diabetes mellitus  IEP 401799626protein:increased expression:liver (rat)RGD 
1 to 14 of 14 rows
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatautism spectrum disorder  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21658581 more ...
MlxiplRatautistic disorder  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
MlxiplRatintestinal volvulus  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIALClinVarPMID:25741868
MlxiplRatmyoepithelioma  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: Myoepithelial tumorClinVar 
MlxiplRatNeurodevelopmental Disorders  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
MlxiplRatpleomorphic xanthoastrocytoma  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
MlxiplRatschizophrenia  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
MlxiplRatVolvulus Of Midgut  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: Volvulus of midgutClinVarPMID:25741868
MlxiplRatWilliams-Beuren syndrome  ISOMLXIPL (Homo sapiens)8554872ClinVar Annotator: match by term: Williams syndromeClinVarPMID:25741868 and PMID:28492532
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatend stage renal disease  ISOMLXIPL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19878707
MlxiplRathepatocellular carcinoma  ISOMLXIPL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21147110
MlxiplRatWilliams-Beuren syndrome  ISOMLXIPL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatirritable bowel syndrome  ISSMlxipl (Mus musculus)13592920 MouseDO 

1 to 20 of 186 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MLXIPL mRNA]CTDPMID:31150632
MlxiplRat(+/-)-Aegeline multiple interactionsISOMlxipl (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNACTDPMID:28843594
MlxiplRat(aminooxy)acetic acid multiple interactionsISOMlxipl (Mus musculus)6480464[Aminooxyacetic Acid co-treated with Xylitol] results in increased expression of MLXIPL mRNA alternative formCTDPMID:31974165
MlxiplRat(RS)-coclaurine multiple interactionsISOMlxipl (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNACTDPMID:28843594
MlxiplRat(RS)-norcoclaurine multiple interactionsISOMlxipl (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNACTDPMID:28843594
MlxiplRat(S)-coclaurine multiple interactionsISOMlxipl (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNACTDPMID:28843594
MlxiplRat1,2-dimethylhydrazine decreases expressionISOMlxipl (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of MLXIPL mRNACTDPMID:22206623
MlxiplRat17alpha-ethynylestradiol affects expressionISOMlxipl (Mus musculus)6480464Ethinyl Estradiol affects the expression of MLXIPL mRNACTDPMID:17555576
MlxiplRat17alpha-ethynylestradiol decreases expressionISOMlxipl (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of MLXIPL mRNACTDPMID:17942748
MlxiplRat17beta-estradiol multiple interactionsISOMLXIPL (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of MLXIPL mRNACTDPMID:30165855
MlxiplRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of MLXIPL mRNACTDPMID:32145629 and PMID:35192832
MlxiplRat17beta-estradiol decreases expressionISOMlxipl (Mus musculus)6480464Estradiol results in decreased expression of MLXIPL mRNACTDPMID:39298647
MlxiplRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMlxipl (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MLXIPL mRNACTDPMID:17942748
MlxiplRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMLXIPL (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of MLXIPL mRNACTDPMID:29704546
MlxiplRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMlxipl (Mus musculus)6480464Dietary Fats promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of MLXIPL mRNA] and Tetrachlorodibenzodioxin inhibits the reaction [Dietary Fats results in increased expression of MLXIPL mRNA]CTDPMID:27713108
MlxiplRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMlxipl (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MLXIPL mRNACTDPMID:26377647
MlxiplRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMlxipl (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MLXIPL mRNACTDPMID:26290441 more ...
MlxiplRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOMlxipl (Mus musculus)64804642 more ...CTDPMID:38648751
MlxiplRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOMLXIPL (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MLXIPL mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MLXIPL mRNACTDPMID:28628672
MlxiplRat4,4'-diaminodiphenylmethane increases expressionISOMlxipl (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of MLXIPL mRNACTDPMID:18648102

1 to 20 of 186 rows

Biological Process
1 to 20 of 44 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatcellular response to glucose stimulus involved_inIDA 8554541PMID:20025850BHF-UCL 
MlxiplRatenergy homeostasis involved_inIMP 634534PMID:11724780UniProt 
MlxiplRatfatty acid homeostasis involved_inIMP 634534PMID:11724780UniProt 
MlxiplRatglucose homeostasis involved_inISOMlxipl (Mus musculus)1624291 PMID:15118080RGDPMID:15118080
MlxiplRatglucose homeostasis involved_inIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatglucose mediated signaling pathway involved_inISOMlxipl (Mus musculus)1624291 PMID:18591247RGDPMID:18591247
MlxiplRatglucose mediated signaling pathway involved_inIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatlipid biosynthetic process involved_inIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatlipid biosynthetic process involved_inISOMLXIPL (Homo sapiens)1624291 PMID:21084751RGDPMID:21084751
MlxiplRatnegative regulation of DNA-templated transcription involved_inIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatnegative regulation of DNA-templated transcription involved_inISOMlxipl (Mus musculus)1624291 PMID:11230181RGDPMID:11230181
MlxiplRatnegative regulation of oxidative phosphorylation involved_inIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatnegative regulation of oxidative phosphorylation involved_inISOMLXIPL (Homo sapiens)1624291 PMID:19995986RGDPMID:19995986
MlxiplRatnegative regulation of signal transduction by p53 class mediator involved_inISOMLXIPL (Homo sapiens)1624291 PMID:19995986RGDPMID:19995986
MlxiplRatnegative regulation of signal transduction by p53 class mediator involved_inIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOMlxipl (Mus musculus)1624291 PMID:11230181RGDPMID:11230181
MlxiplRatnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatpositive regulation of cell population proliferation involved_inIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatpositive regulation of cell population proliferation involved_inISOMLXIPL (Homo sapiens)1624291 PMID:19995986RGDPMID:19995986
MlxiplRatpositive regulation of DNA-templated transcription involved_inISOMlxipl (Mus musculus)1624291 PMID:15163635RGDPMID:15163635
1 to 20 of 44 rows

Cellular Component
1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatchromatin is_active_inISOMLXIPL (Homo sapiens)1624291 PMID:21084751RGDPMID:21084751
MlxiplRatchromatin is_active_inIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatcytoplasm located_inISOMlxipl (Mus musculus)1624291 PMID:15163635RGDPMID:15163635
MlxiplRatcytoplasm located_inIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatcytosol located_inIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatcytosol located_inTAS 1600115Reactome:R-RNO-164113ReactomeReactome:R-RNO-164113
MlxiplRatcytosol located_inIDA 8554541PMID:20025850BHF-UCL 
MlxiplRatcytosol located_inISOMLXIPL (Homo sapiens) more ...1624291 RGDGO_REF:0000052
MlxiplRatnucleoplasm located_inTAS 1600115Reactome:R-RNO-164087ReactomeReactome:R-RNO-164087
MlxiplRatnucleoplasm is_active_inISOMlxipl (Mus musculus)1624291 PMID:18606808RGDPMID:18606808
MlxiplRatnucleoplasm is_active_inIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatnucleoplasm located_inISOMLXIPL (Homo sapiens) more ...1624291 RGDGO_REF:0000052
MlxiplRatnucleoplasm located_inIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatnucleoplasm located_inTAS 1600115Reactome:R-RNO-164129ReactomeReactome:R-RNO-164129
MlxiplRatnucleoplasm located_inTAS 1600115Reactome:R-RNO-164132ReactomeReactome:R-RNO-164132
MlxiplRatnucleus located_inISOMlxipl (Mus musculus)1624291 PMID:15163635RGDPMID:15163635
MlxiplRatnucleus located_inIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatnucleus is_active_inIBAFB:FBgn0001994 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
MlxiplRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
MlxiplRatnucleus located_inIDA 8554541PMID:20025850BHF-UCL 
1 to 20 of 24 rows

Molecular Function
1 to 20 of 34 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatcarbohydrate response element binding enablesNAS 8554541PMID:20025850BHF-UCL 
MlxiplRatDNA binding enablesIDA 634534PMID:11724780UniProt 
MlxiplRatDNA binding contributes_toIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatDNA binding contributes_toISOMlxipl (Mus musculus)1624291 PMID:11230181RGDPMID:11230181
MlxiplRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
MlxiplRatDNA-binding transcription activator activity enablesISOMLXIPL (Homo sapiens)1624291 PMID:21084751RGDPMID:21084751
MlxiplRatDNA-binding transcription activator activity enablesIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOMlxipl (Mus musculus)1624291MGI:1339639 more ...RGDPMID:15496471 more ...
MlxiplRatDNA-binding transcription factor activity  IDA 634534 RGD 
MlxiplRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN000761437 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
MlxiplRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOMlxipl (Mus musculus)1624291 PMID:18606808RGDPMID:18606808
MlxiplRatDNA-binding transcription factor binding enablesISOMLXIPL (Homo sapiens)1624291 PMID:21084751RGDPMID:21084751
MlxiplRatDNA-binding transcription factor binding enablesIEAUniProtKB:Q9NP71 and ensembl:ENSP000003208861600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOMlxipl (Mus musculus)1624291 PMID:11230181RGDPMID:11230181
MlxiplRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q99MZ3 and ensembl:ENSMUSP000000055071600115GO_REF:0000107EnsemblGO_REF:0000107
MlxiplRatprotein binding enablesIPIUniProtKB:Q80U968554541PMID:20025850BHF-UCL 
MlxiplRatprotein binding enablesISOMlxipl (Mus musculus)1624291UniProtKB:Q6P069 more ...RGDPMID:15163635 and PMID:22338092
MlxiplRatprotein binding enablesIPIUniProtKB:P319468554541PMID:20025850BHF-UCL 
1 to 20 of 34 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MlxiplRatglycolysis/gluconeogenesis pathway  IDA 634534 RGD 

1 to 20 of 22 rows
#
Reference Title
Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
3. WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog. de Luis O, etal., Eur J Hum Genet. 2000 Mar;8(3):215-22.
4. Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Fukasawa M, etal., Biochem Biophys Res Commun. 2010 Jan 8;391(2):1166-9. doi: 10.1016/j.bbrc.2009.11.115. Epub 2009 Dec 17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study. Ghasemi A, etal., Anatol J Cardiol. 2015 Jan;15(1):8-12. doi: 10.5152/akd.2014.5135. Epub 2014 Feb 10.
7. ChREBP gene polymorphisms are associated with coronary artery disease in Han population of Hubei province. Guo S, etal., Clin Chim Acta. 2011 Sep 18;412(19-20):1854-60. doi: 10.1016/j.cca.2011.06.024. Epub 2011 Jun 25.
8. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
9. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. Kawaguchi T, etal., J Biol Chem 2002 Feb 8;277(6):3829-35.
10. Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. Li H, etal., Biol Pharm Bull. 2017;40(5):650-657. doi: 10.1248/bpb.b16-00942.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial. Ortega-Azorín C, etal., Circ Cardiovasc Genet. 2014 Feb;7(1):49-58. doi: 10.1161/CIRCGENETICS.113.000301. Epub 2014 Jan 21.
13. G771C Polymorphism in the MLXIPL Gene Is Associated with a Risk of Coronary Artery Disease in the Chinese: A Case-Control Study. Pan LA, etal., Cardiology. 2009;114(3):174-8. doi: 10.1159/000226610. Epub 2009 Jul 2.
14. A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. Ram R, etal., Clin Genet. 2017 Mar;91(3):371-378. doi: 10.1111/cge.12859. Epub 2017 Jan 30.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Beneficial effects of cherry consumption as a dietary intervention for metabolic, hepatic and vascular complications in type 2 diabetic rats. Van der Werf R, etal., Cardiovasc Diabetol. 2018 Jul 20;17(1):104. doi: 10.1186/s12933-018-0744-6.
18. The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma. Volpe CM, etal., J Am Coll Surg. 1995 Jul;181(1):56-64.
19. Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats. Wang D, etal., Sci Rep. 2017 Aug 29;7(1):9793. doi: 10.1038/s41598-017-09470-0.
20. Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease. Wu N, etal., Anatol J Cardiol. 2018 Jun;19(6):360-367. doi: 10.14744/AnatolJCardiol.2018.23682.
1 to 20 of 22 rows
PMID:11230181   PMID:12684532   PMID:15118080   PMID:15163635   PMID:15664996   PMID:16885160   PMID:17341548   PMID:17418800   PMID:18215143   PMID:18436566   PMID:18591247   PMID:18602890  
PMID:18606808   PMID:18765640   PMID:19406844   PMID:19660458   PMID:19682972   PMID:19995986   PMID:20382893   PMID:21282101   PMID:21665952   PMID:21856285   PMID:22198437   PMID:22214556  
PMID:22466288   PMID:22760788   PMID:23257733   PMID:23803610   PMID:23918932   PMID:24616092   PMID:26384380   PMID:26984404   PMID:27345365   PMID:27545881   PMID:27900263   PMID:27989594  
PMID:28027934   PMID:31505737   PMID:32518215   PMID:38042369   PMID:39300600  



Mlxipl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,178,158 - 27,213,675 (-)NCBIGRCr8
mRatBN7.21221,541,608 - 21,577,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,683,529 - 22,719,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,295,853 - 23,331,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,362,318 - 22,398,011 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,590,645 - 24,619,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01226,588,220 - 26,620,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1223,305,691 - 23,340,439 (-)NCBICelera
Cytogenetic Map12q12NCBI
MLXIPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,593,202 - 73,647,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl773,593,194 - 73,624,543 (-)EnsemblGRCh38hg38GRCh38
GRCh37773,007,532 - 73,038,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,645,460 - 72,676,806 (-)NCBINCBI36Build 36hg18NCBI36
Build 34772,452,174 - 72,483,521NCBI
Celera768,485,730 - 68,517,088 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef768,888,586 - 68,920,882 (-)NCBIHuRef
CHM1_1773,153,232 - 73,184,532 (-)NCBICHM1_1
T2T-CHM13v2.0774,794,073 - 74,848,925 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,340,596 - 72,371,942 (-)NCBI
Mlxipl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,118,744 - 135,168,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,118,744 - 135,167,236 (+)EnsemblGRCm39 Ensembl
GRCm385135,089,890 - 135,139,768 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,089,890 - 135,138,382 (+)EnsemblGRCm38mm10GRCm38
MGSCv375135,582,783 - 135,613,792 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,391,540 - 135,426,429 (+)NCBIMGSCv36mm8
Celera5132,118,107 - 132,149,116 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.0NCBI
Mlxipl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,096,531 - 14,117,269 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,096,530 - 14,116,687 (+)NCBIChiLan1.0ChiLan1.0
MLXIPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,254,158 - 91,308,364 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,541,661 - 139,572,996 (+)NCBINHGRI_mPanPan1
PanPan1.1780,745,765 - 80,776,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,745,765 - 80,776,153 (-)Ensemblpanpan1.1panPan2
MLXIPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,617,398 - 6,652,201 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,633,231 - 6,652,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,314,804 - 8,349,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,448,811 - 6,467,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,448,825 - 6,467,255 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,421,940 - 6,456,726 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,369,681 - 6,404,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,533,405 - 6,568,214 (+)NCBIUU_Cfam_GSD_1.0
Mlxipl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,163,797 - 131,197,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,839,105 - 2,857,002 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,839,105 - 2,856,997 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLXIPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,898,670 - 10,934,048 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,898,675 - 10,934,257 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,598,366 - 10,632,610 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MLXIPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,442,520 - 9,465,772 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660707,011,875 - 7,045,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mlxipl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,168,238 - 14,187,264 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,150,425 - 14,187,687 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Mlxipl
220 total Variants

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:75
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000074230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat

1 to 10 of 54 rows
BI277291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,543,682 - 21,543,897 (+)MAPPERmRatBN7.2
Rnor_6.01224,590,762 - 24,590,976NCBIRnor6.0
Rnor_5.01226,588,337 - 26,588,551UniSTSRnor5.0
Celera1223,305,808 - 23,306,022UniSTS
RH 3.4 Map12341.51UniSTS
Wbscr14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,544,143 - 21,545,203 (+)MAPPERmRatBN7.2
Rnor_6.01224,591,223 - 24,592,282NCBIRnor6.0
Rnor_5.01226,588,798 - 26,589,857UniSTSRnor5.0
Celera1223,306,269 - 23,307,328UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 31 34 30 18 6 18 6 58 24 19 10 19 12



Ensembl Acc Id: ENSRNOT00000071067   ⟹   ENSRNOP00000093059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)Ensembl
Rnor_6.0 Ensembl1224,591,199 - 24,619,607 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074230   ⟹   ENSRNOP00000090385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,543,576 - 21,577,112 (-)Ensembl
Rnor_6.0 Ensembl1224,590,645 - 24,600,065 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1224,606,260 - 24,619,639 (-)Ensembl
RefSeq Acc Id: NM_001393706   ⟹   NP_001380635
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,213,660 (-)NCBI
mRatBN7.21221,541,608 - 21,577,116 (-)NCBI
RefSeq Acc Id: NM_133552   ⟹   NP_598236
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,213,656 (-)NCBI
mRatBN7.21221,541,608 - 21,577,112 (-)NCBI
Rnor_6.01224,590,645 - 24,619,639 (-)NCBI
Rnor_5.01226,588,220 - 26,620,779 (-)NCBI
Celera1223,305,691 - 23,340,439 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089043   ⟹   XP_038944971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,206,487 (-)NCBI
mRatBN7.21221,542,964 - 21,569,900 (-)NCBI
RefSeq Acc Id: XM_039089044   ⟹   XP_038944972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,191,643 (-)NCBI
mRatBN7.21221,542,964 - 21,555,070 (-)NCBI
RefSeq Acc Id: XM_063271027   ⟹   XP_063127097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,178,158 - 27,191,643 (-)NCBI
RefSeq Acc Id: XM_063271028   ⟹   XP_063127098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,183,925 - 27,213,675 (-)NCBI
RefSeq Acc Id: XR_005491593
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,183,826 - 27,213,675 (-)NCBI
mRatBN7.21221,547,276 - 21,577,120 (-)NCBI
RefSeq Acc Id: XR_005491594
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,183,823 - 27,213,675 (-)NCBI
mRatBN7.21221,547,273 - 21,577,120 (-)NCBI
RefSeq Acc Id: NP_598236   ⟸   NM_133552
- Peptide Label: isoform 2
- UniProtKB: Q8VIP2 (UniProtKB/Swiss-Prot),   A6J0E8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038944971   ⟸   XM_039089043
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944972   ⟸   XM_039089044
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000090385   ⟸   ENSRNOT00000074230
Ensembl Acc Id: ENSRNOP00000093059   ⟸   ENSRNOT00000071067
bHLH

Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIP2-F1-model_v2 AlphaFold Q8VIP2 1-865 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19607 BioCyc
Ensembl Genes ENSRNOG00000046171 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071067 ENTREZGENE
  ENSRNOT00000074230 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Max-like/E-box_TFs UniProtKB/Swiss-Prot
KEGG Report rno:171078 UniProtKB/Swiss-Prot
NCBI Gene 171078 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
  CARBOHYDRATE-RESPONSIVE ELEMENT-BINDING PROTEIN UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Mlxipl PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046171 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A0A8I6ADP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKH5_RAT UniProtKB/TrEMBL
  A6J0E8 ENTREZGENE, UniProtKB/TrEMBL
  C7C5T1 ENTREZGENE, UniProtKB/TrEMBL
  MLXPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-08-15 Mlxipl  MLX interacting protein-like  Wbscr14  Williams-Beuren syndrome chromosome region 14 homolog (human)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-07-08 Wbscr14  Williams-Beuren syndrome chromosome region 14 homolog (human)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Wbscr14  Williams-Beuren syndrome chromosome region 14 homolog (human)      Symbol and Name status set to provisional 70820 PROVISIONAL