Parg (poly (ADP-ribose) glycohydrolase) - Rat Genome Database

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Gene: Parg (poly (ADP-ribose) glycohydrolase) Rattus norvegicus
Analyze
Symbol: Parg
Name: poly (ADP-ribose) glycohydrolase
RGD ID: 620387
Description: Enables chromatin binding activity and poly(ADP-ribose) glycohydrolase activity. Involved in positive regulation of DNA repair. Located in chromatin. Used to study brain infarction. Biomarker of borna disease. Orthologous to human PARG (poly(ADP-ribose) glycohydrolase); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: poly(ADP-ribose) glycohydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,442,696 - 7,550,585 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl167,442,726 - 7,550,584 (+)EnsemblGRCr8
mRatBN7.2167,436,429 - 7,544,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,436,476 - 7,544,273 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx167,449,157 - 7,556,848 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,594,015 - 8,701,707 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,447,229 - 7,555,053 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,350,168 - 8,457,999 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,350,326 - 8,457,996 (+)Ensemblrn6Rnor6.0
Rnor_5.0168,267,358 - 8,375,030 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4167,689,492 - 7,798,104 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,654,675 - 7,762,172 (-)NCBICelera
RGSC_v3.1167,689,489 - 7,798,102 (+)NCBI
Cytogenetic Map16p16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methylmercury chloride  (ISO)
myricetin  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rosmarinic acid  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
streptozocin  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
topotecan  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA)
cytoplasm  (IBA)
cytosol  (ISO)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion. Cuzzocrea S, etal., FASEB J. 2005 Apr;19(6):558-66. doi: 10.1096/fj.04-3117com.
3. Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors. Di Meglio S, etal., Biochim Biophys Acta. 2004 May 28;1692(1):35-44.
4. Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells. Di Meglio S, etal., Mol Cell Biochem. 2003 Jun;248(1-2):85-91.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat. Lu XC, etal., Brain Res. 2003 Jul 18;978(1-2):99-103.
7. Active poly(ADPribose) metabolism in DNAase- and salt-resistant rat testis chromatin with high transcriptional activity/competence. Mennella MR, etal., J Cell Biochem 2003 Jul 1;89(4):688-97.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Poly(ADPribosyl)ation system in rat germinal cells at different stages of differentiation. Quesada P, etal., Exp Cell Res. 1996 Jul 10;226(1):183-90.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection. Williams BL, etal., J Virol. 2008 Feb;82(4):1748-58. Epub 2007 Dec 5.
Additional References at PubMed
PMID:9074616   PMID:10502684   PMID:15282315   PMID:15450800   PMID:22609859   PMID:23474714   PMID:27257257  


Genomics

Comparative Map Data
Parg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,442,696 - 7,550,585 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl167,442,726 - 7,550,584 (+)EnsemblGRCr8
mRatBN7.2167,436,429 - 7,544,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,436,476 - 7,544,273 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx167,449,157 - 7,556,848 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,594,015 - 8,701,707 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,447,229 - 7,555,053 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,350,168 - 8,457,999 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,350,326 - 8,457,996 (+)Ensemblrn6Rnor6.0
Rnor_5.0168,267,358 - 8,375,030 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4167,689,492 - 7,798,104 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,654,675 - 7,762,172 (-)NCBICelera
RGSC_v3.1167,689,489 - 7,798,102 (+)NCBI
Cytogenetic Map16p16NCBI
PARG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381049,818,279 - 49,942,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1049,815,137 - 49,970,203 (-)Ensemblhg38GRCh38
GRCh371051,026,325 - 51,371,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361051,293,430 - 51,377,668 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341051,293,590 - 51,377,669NCBI
Celera1044,612,906 - 44,656,296 (-)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1045,291,110 - 45,327,535 (-)NCBIHuRef
HuRef1045,722,307 - 45,739,745 (+)NCBIHuRef
CHM1_11051,308,371 - 51,646,597 (-)NCBICHM1_1
T2T-CHM13v2.01050,667,926 - 50,791,669 (-)NCBIT2T-CHM13v2.0
Parg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,923,900 - 32,020,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,923,906 - 32,019,507 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381432,201,930 - 32,298,714 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,201,949 - 32,297,550 (+)Ensemblmm10GRCm38
MGSCv371433,015,157 - 33,110,736 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361431,031,229 - 31,126,229 (+)NCBIMGSCv36mm8
Celera1428,460,805 - 28,556,220 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
Parg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556435,027 - 535,941 (+)Ensembl
ChiLan1.0NW_004955556435,264 - 539,935 (+)NCBIChiLan1.0ChiLan1.0
PARG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2862,090,878 - 62,220,671 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11062,096,198 - 62,225,992 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01044,290,391 - 44,420,184 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PARG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,651,698 - 1,767,210 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,652,670 - 1,766,895 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha281,882,923 - 2,001,730 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0281,825,421 - 1,944,576 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,751,095 - 1,944,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,622,593 - 1,741,672 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,659,545 - 1,778,554 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,791,590 - 1,910,710 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Parg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,225,199 - 79,338,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728428,028 - 541,530 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936728428,028 - 538,413 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,338,510 - 90,480,989 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11490,338,599 - 90,481,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,258,045 - 98,357,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,867,776 - 42,006,845 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl941,869,061 - 42,005,789 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660481,609,622 - 1,746,936 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462492854,874 - 186,353 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462492854,610 - 188,948 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Parg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1137,892,380 - 8,003,750 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Parg
636 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:74
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000027071
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16423421216278352Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16423421216278352Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421216061395Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
631524Bp75Blood pressure QTL 750.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)161177108157035Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16423433317730812Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Rat107  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8167,528,619 - 7,528,748 (+)Marker Load Pipeline
mRatBN7.2167,522,339 - 7,522,468 (+)MAPPERmRatBN7.2
Rnor_6.0168,435,922 - 8,436,050NCBIRnor6.0
Rnor_5.0168,352,953 - 8,353,081UniSTSRnor5.0
RGSC_v3.4167,776,142 - 7,776,270UniSTSRGSC3.4
RGSC_v3.4167,776,021 - 7,776,427RGDRGSC3.4
Celera167,676,482 - 7,676,610UniSTS
RGSC_v3.1167,776,140 - 7,776,268RGD
RH 3.4 Map1665.2RGD
RH 3.4 Map1665.2UniSTS
RH 2.0 Map1612.2RGD
SHRSP x BN Map162.32RGD
Cytogenetic Map16pUniSTS
D16Chm58  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,538,912 - 7,539,111 (+)MAPPERmRatBN7.2
Rnor_6.0168,452,558 - 8,452,756NCBIRnor6.0
Rnor_5.0168,369,589 - 8,369,787UniSTSRnor5.0
RGSC_v3.4167,792,746 - 7,792,944UniSTSRGSC3.4
Celera167,659,835 - 7,660,033UniSTS
Cytogenetic Map16pUniSTS
RH128636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,543,996 - 7,544,176 (+)MAPPERmRatBN7.2
Rnor_6.0168,457,720 - 8,457,899NCBIRnor6.0
Rnor_5.0168,374,751 - 8,374,930UniSTSRnor5.0
RGSC_v3.4167,797,828 - 7,798,007UniSTSRGSC3.4
Celera167,654,772 - 7,654,951UniSTS
RH 3.4 Map1665.3UniSTS
Cytogenetic Map16pUniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027071   ⟹   ENSRNOP00000027071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,442,731 - 7,550,584 (+)Ensembl
mRatBN7.2 Ensembl167,436,599 - 7,544,273 (+)Ensembl
Rnor_6.0 Ensembl168,350,326 - 8,457,996 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093772   ⟹   ENSRNOP00000089571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,442,731 - 7,550,576 (+)Ensembl
mRatBN7.2 Ensembl167,436,476 - 7,544,259 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000140507   ⟹   ENSRNOP00000101487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,442,731 - 7,530,758 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153712   ⟹   ENSRNOP00000110536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,442,726 - 7,550,584 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159558   ⟹   ENSRNOP00000107925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,442,731 - 7,550,576 (+)Ensembl
RefSeq Acc Id: NM_031339   ⟹   NP_112629
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,442,878 - 7,550,582 (+)NCBI
mRatBN7.2167,436,599 - 7,544,273 (+)NCBI
Rnor_6.0168,350,326 - 8,457,996 (+)NCBI
Rnor_5.0168,267,358 - 8,375,030 (+)NCBI
RGSC_v3.4167,689,492 - 7,798,104 (+)RGD
Celera167,654,675 - 7,762,172 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252669   ⟹   XP_006252731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,449,038 - 7,550,585 (+)NCBI
mRatBN7.2167,436,875 - 7,544,276 (+)NCBI
Rnor_6.0168,356,487 - 8,457,999 (+)NCBI
Rnor_5.0168,267,358 - 8,375,030 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600258   ⟹   XP_017455747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,442,696 - 7,550,585 (+)NCBI
mRatBN7.2167,436,429 - 7,544,276 (+)NCBI
Rnor_6.0168,350,168 - 8,457,999 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094861   ⟹   XP_038950789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,443,008 - 7,550,585 (+)NCBI
mRatBN7.2167,436,456 - 7,544,276 (+)NCBI
RefSeq Acc Id: XM_039094863   ⟹   XP_038950791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,443,008 - 7,484,794 (+)NCBI
mRatBN7.2167,436,455 - 7,461,405 (+)NCBI
RefSeq Acc Id: XR_005494674
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,443,008 - 7,523,620 (+)NCBI
mRatBN7.2167,436,455 - 7,517,340 (+)NCBI
RefSeq Acc Id: NP_112629   ⟸   NM_031339
- UniProtKB: Q9QYM2 (UniProtKB/Swiss-Prot),   G3V8M8 (UniProtKB/TrEMBL),   A6KFW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252731   ⟸   XM_006252669
- Peptide Label: isoform X3
- UniProtKB: Q9QYM2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455747   ⟸   XM_017600258
- Peptide Label: isoform X2
- UniProtKB: Q9QYM2 (UniProtKB/Swiss-Prot),   A6KFW4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027071   ⟸   ENSRNOT00000027071
RefSeq Acc Id: XP_038950791   ⟸   XM_039094863
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950789   ⟸   XM_039094861
- Peptide Label: isoform X1
- UniProtKB: Q9QYM2 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000089571   ⟸   ENSRNOT00000093772
Ensembl Acc Id: ENSRNOP00000101487   ⟸   ENSRNOT00000140507
Ensembl Acc Id: ENSRNOP00000107925   ⟸   ENSRNOT00000159558
Ensembl Acc Id: ENSRNOP00000110536   ⟸   ENSRNOT00000153712
Protein Domains
PARG catalytic Macro   PARG helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYM2-F1-model_v2 AlphaFold Q9QYM2 1-972 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620387 AgrOrtholog
BioCyc Gene G2FUF-12113 BioCyc
Ensembl Genes ENSRNOG00000019978 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027071 ENTREZGENE
  ENSRNOT00000093772 ENTREZGENE
  ENSRNOT00000153712 ENTREZGENE
InterPro PARG_cat UniProtKB/Swiss-Prot
  PARG_helical UniProtKB/Swiss-Prot
  Poly_GlycHdrlase UniProtKB/Swiss-Prot
KEGG Report rno:83507 UniProtKB/Swiss-Prot
NCBI Gene 83507 ENTREZGENE
PANTHER POLY(ADP-RIBOSE) GLYCOHYDROLASE UniProtKB/Swiss-Prot
  PTHR12837 UniProtKB/Swiss-Prot
Pfam PARG_cat UniProtKB/Swiss-Prot
  PARG_cat_N UniProtKB/Swiss-Prot
PharmGKB PARG RGD
PhenoGen Parg PhenoGen
RatGTEx ENSRNOG00000019978 RatGTEx
UniProt A0A8I6AC28_RAT UniProtKB/TrEMBL
  A0ABK0L8W9_RAT UniProtKB/TrEMBL
  A0ABK0LW15_RAT UniProtKB/TrEMBL
  A0ABK0M0A1_RAT UniProtKB/TrEMBL
  A6KFW3 ENTREZGENE, UniProtKB/TrEMBL
  A6KFW4 ENTREZGENE, UniProtKB/TrEMBL
  G3V8M8 ENTREZGENE, UniProtKB/TrEMBL
  PARG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Parg  poly (ADP-ribose) glycohydrolase    poly(ADP-ribose) glycohydrolase  Name updated 1299863 APPROVED
2002-08-07 Parg        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization associated with actively transcribing chromatin 724638
gene_process may mediate DNA repair and transcriptionand cellular transport 724638