Abcg8 (ATP binding cassette subfamily G member 8) - Rat Genome Database

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Gene: Abcg8 (ATP binding cassette subfamily G member 8) Rattus norvegicus
Analyze
Symbol: Abcg8
Name: ATP binding cassette subfamily G member 8
RGD ID: 620300
Description: Predicted to enable ATPase-coupled transmembrane transporter activity and protein heterodimerization activity. Predicted to contribute to ATP binding activity; ATP hydrolysis activity; and cholesterol transfer activity. Involved in several processes, including cholesterol homeostasis; response to muscle activity; and triglyceride homeostasis. Predicted to be located in apical plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex and receptor complex. Predicted to be active in plasma membrane. Biomarker of cholestasis and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; obesity; sitosterolemia; and sitosterolemia 1. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP-binding cassette, subfamily G (WHITE), member 8; sterolin 2; sterolin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,698,448 - 15,717,730 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl615,698,448 - 15,717,730 (-)EnsemblGRCr8
mRatBN7.269,945,629 - 9,964,912 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,945,629 - 9,964,912 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx610,234,054 - 10,253,474 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,543,447 - 10,562,866 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,065,072 - 10,084,536 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,961,413 - 7,980,708 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,961,413 - 7,980,708 (+)Ensemblrn6Rnor6.0
Rnor_5.067,897,005 - 7,916,593 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.468,064,631 - 8,083,271 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera69,667,270 - 9,686,500 (-)NCBICelera
RGSC_v3.168,064,630 - 8,083,271 (+)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7-ketocholesterol  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
aristolochic acid A  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
aztreonam  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bosentan  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholate  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
corn oil  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
diethylstilbestrol  (EXP)
difenoconazole  (ISO)
diosgenin  (EXP,ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
Evodiamine  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
fipronil  (EXP,ISO)
fonofos  (ISO)
fumonisin B1  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
leflunomide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methidathion  (ISO)
metronidazole  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP,ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
psoralen  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium citrate  (EXP)
spironolactone  (EXP)
stigmasterol  (ISO)
streptozocin  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
tianeptine  (EXP)
toluene  (EXP)
triolein  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Berge KE, etal., Science 2000 Dec 1;290(5497):1771-5.
2. Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes. Bloks VW, etal., Diabetologia 2004 Jan;47(1):104-12. Epub 2003 Nov 14.
3. ATP-binding cassette transporter G8 gene as a determinant of apolipoprotein B-100 kinetics in overweight men. Chan DC, etal., Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2188-91. Epub 2004 Aug 26.
4. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
5. An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. Côté I, etal., Eur J Nutr. 2013 Aug;52(5):1523-32. doi: 10.1007/s00394-012-0459-5. Epub 2012 Nov 2.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. Hoekstra M, etal., J Hepatol. 2005 Mar;42(3):400-7.
8. Response of obligate heterozygotes for phytosterolemia to a low-fat diet and to a plant sterol ester dietary challenge. Kwiterovich PO Jr, etal., J Lipid Res. 2003 Jun;44(6):1143-55. Epub 2003 Apr 1.
9. The different effect of pioglitazone as compared to insulin on expression of hepatic and intestinal genes regulating post-prandial lipoproteins in diabetes. Lally S, etal., Atherosclerosis. 2006 Nov 14;.
10. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Lu K, etal., Am J Hum Genet 2001 Aug;69(2):278-90.
11. Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. Macias RI, etal., Life Sci. 2006 Aug 1;79(10):1014-9. Epub 2006 May 20.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects. Miwa K, etal., Clin Sci (Lond). 2005 Aug;109(2):183-8.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. Repa JJ, etal., J Biol Chem 2002 May 24;277(21):18793-800. Epub 2002 Mar 18.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
Additional References at PubMed
PMID:12208867   PMID:12783625   PMID:14504269   PMID:15040800   PMID:16867993   PMID:16870176   PMID:16893193   PMID:18395092   PMID:20413720   PMID:25912874   PMID:27144356  


Genomics

Comparative Map Data
Abcg8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,698,448 - 15,717,730 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl615,698,448 - 15,717,730 (-)EnsemblGRCr8
mRatBN7.269,945,629 - 9,964,912 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,945,629 - 9,964,912 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx610,234,054 - 10,253,474 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,543,447 - 10,562,866 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,065,072 - 10,084,536 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,961,413 - 7,980,708 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,961,413 - 7,980,708 (+)Ensemblrn6Rnor6.0
Rnor_5.067,897,005 - 7,916,593 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.468,064,631 - 8,083,271 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera69,667,270 - 9,686,500 (-)NCBICelera
RGSC_v3.168,064,630 - 8,083,271 (+)NCBI
Cytogenetic Map6q12NCBI
ABCG8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38243,838,971 - 43,882,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl243,831,942 - 43,882,988 (+)Ensemblhg38GRCh38
GRCh37244,066,110 - 44,110,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36243,919,607 - 43,959,109 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34243,977,753 - 44,017,255NCBI
Celera243,904,835 - 43,944,326 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef243,802,799 - 43,841,930 (+)NCBIHuRef
CHM1_1243,995,502 - 44,035,021 (+)NCBICHM1_1
T2T-CHM13v2.0243,844,302 - 43,888,321 (+)NCBIT2T-CHM13v2.0
Abcg8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,983,730 - 85,007,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1784,983,730 - 85,007,761 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381784,676,302 - 84,700,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,676,302 - 84,700,333 (+)Ensemblmm10GRCm38
MGSCv371785,082,471 - 85,099,673 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361784,591,457 - 84,608,659 (+)NCBIMGSCv36mm8
Celera1789,050,583 - 89,068,069 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.02NCBI
Abcg8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,982,307 - 11,009,116 (+)Ensembl
ChiLan1.0NW_00495544110,982,307 - 11,004,789 (+)NCBIChiLan1.0ChiLan1.0
ABCG8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,530,935 - 82,585,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,536,896 - 82,589,287 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A43,922,787 - 43,966,678 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A44,771,247 - 44,905,375 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A44,771,247 - 44,904,830 (+)EnsemblpanPan2panpan1.1
ABCG8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,300,142 - 46,319,592 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,300,165 - 46,319,229 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1046,161,869 - 46,181,385 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01047,178,745 - 47,198,241 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,178,832 - 47,197,878 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11046,887,146 - 46,906,668 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,176,806 - 47,196,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,360,439 - 47,379,994 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcg8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,645,685 - 36,664,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365088,074,674 - 8,093,550 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365088,074,697 - 8,093,424 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCG8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,596,531 - 96,616,229 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1396,596,975 - 96,616,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,751,981 - 102,768,385 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,389,817 - 63,420,048 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,390,433 - 63,413,906 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604548,472,611 - 48,497,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcg8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,310,917 - 25,329,595 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473825,310,740 - 25,330,097 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Abcg8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v178,208,242 - 8,224,441 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abcg8
161 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1914
Count of miRNA genes:309
Interacting mature miRNAs:411
Transcripts:ENSRNOT00000007638, ENSRNOT00000061871
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
D6Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.269,957,483 - 9,957,643 (-)MAPPERmRatBN7.2
Rnor_6.067,968,682 - 7,968,841NCBIRnor6.0
Rnor_5.067,904,274 - 7,904,433UniSTSRnor5.0
RGSC_v3.468,071,899 - 8,072,059RGDRGSC3.4
RGSC_v3.468,071,900 - 8,072,059UniSTSRGSC3.4
Celera69,679,058 - 9,679,231UniSTS
RGSC_v3.168,071,899 - 8,072,059RGD
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 8 22 89 84 81 57 35 57 6 193 72 74 50 69 24 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000007638   ⟹   ENSRNOP00000007638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,698,448 - 15,717,730 (-)Ensembl
mRatBN7.2 Ensembl69,945,629 - 9,964,912 (-)Ensembl
Rnor_6.0 Ensembl67,961,413 - 7,980,708 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061871   ⟹   ENSRNOP00000058587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl615,698,448 - 15,717,730 (-)Ensembl
mRatBN7.2 Ensembl69,945,629 - 9,964,912 (-)Ensembl
Rnor_6.0 Ensembl67,961,523 - 7,978,008 (+)Ensembl
RefSeq Acc Id: NM_130414   ⟹   NP_569098
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8615,698,448 - 15,717,730 (-)NCBI
mRatBN7.269,945,629 - 9,964,912 (-)NCBI
Rnor_6.067,961,413 - 7,980,708 (+)NCBI
Rnor_5.067,897,005 - 7,916,593 (+)NCBI
RGSC_v3.468,064,631 - 8,083,271 (+)RGD
Celera69,667,270 - 9,686,500 (-)RGD
Sequence:
RefSeq Acc Id: NP_569098   ⟸   NM_130414
- UniProtKB: Q923R7 (UniProtKB/Swiss-Prot),   Q8CIQ5 (UniProtKB/Swiss-Prot),   P58428 (UniProtKB/Swiss-Prot),   A6H9I7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007638   ⟸   ENSRNOT00000007638
Ensembl Acc Id: ENSRNOP00000058587   ⟸   ENSRNOT00000061871
Protein Domains
ABC transmembrane type-2   ABC transporter   ABC-2 type transporter transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P58428-F1-model_v2 AlphaFold P58428 1-694 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694376
Promoter ID:EPDNEW_R4901
Type:single initiation site
Name:Abcg8_1
Description:ATP binding cassette subfamily G member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.067,961,451 - 7,961,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620300 AgrOrtholog
BioCyc Gene G2FUF-38645 BioCyc
Ensembl Genes ENSRNOG00000005420 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007638 ENTREZGENE
  ENSRNOT00000007638.8 UniProtKB/Swiss-Prot
  ENSRNOT00000061871.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro ABC_2_trans UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABCG_dom UniProtKB/Swiss-Prot
  ABCG_transporters UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:155192 UniProtKB/Swiss-Prot
NCBI Gene 155192 ENTREZGENE
PANTHER ABC TRANSPORTER G FAMILY MEMBER 28 UniProtKB/Swiss-Prot
  ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 8 UniProtKB/Swiss-Prot
Pfam ABC2_membrane UniProtKB/Swiss-Prot
  ABC2_membrane_7 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PhenoGen Abcg8 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005420 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8A1U9B9_RAT UniProtKB/TrEMBL
  A6H9I7 ENTREZGENE, UniProtKB/TrEMBL
  A6H9I8_RAT UniProtKB/TrEMBL
  ABCG8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CIQ5 ENTREZGENE
  Q923R7 ENTREZGENE
UniProt Secondary Q8CIQ5 UniProtKB/Swiss-Prot
  Q923R7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcg8  ATP binding cassette subfamily G member 8  Abcg8  ATP-binding cassette, subfamily G (WHITE), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcg8  ATP-binding cassette, subfamily G (WHITE), member 8  Abcg8  ATP-binding cassette, sub-family G (WHITE), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Abcg8  ATP-binding cassette, sub-family G (WHITE), member 8      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Abcg8  ATP-binding cassette, sub-family G (WHITE), member 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease human gene mutated in some patients with sitosterolemia 631968
gene_process may play a role in sterol catabolism and transport