Ncoa6 (nuclear receptor coactivator 6) - Rat Genome Database

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Pathways
Gene: Ncoa6 (nuclear receptor coactivator 6) Rattus norvegicus
Analyze
Symbol: Ncoa6
Name: nuclear receptor coactivator 6
RGD ID: 620111
Description: Enables several functions, including identical protein binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in ovarian follicle development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6); PARTICIPATES IN estrogen signaling pathway; glucocorticoid signaling pathway; retinoic acid signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activating signal cointegrator 2; Aib3; amplified in breast cancer protein 3; ASC-2; cancer-amplified transcriptional coactivator ASC-2; NRC; nuclear receptor coactivator RAP250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; RAP250; thyroid hormone receptor binding protein; thyroid hormone receptor-binding protein; Trbp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,351,062 - 164,422,079 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,351,062 - 164,421,991 (-)EnsemblGRCr8
mRatBN7.23143,890,896 - 143,961,916 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,757,713 - 147,797,978 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,374,984 - 156,415,249 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,114,516 - 154,154,781 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,919,317 - 150,990,391 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)Ensemblrn6Rnor6.0
Rnor_5.03157,287,434 - 157,358,499 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43145,886,874 - 145,957,928 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,616,753 - 142,657,466 (-)NCBICelera
RGSC_v3.13145,808,879 - 145,815,141 (-)NCBI
Cytogenetic Map3q41-q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Antonson P, etal., Mol Cell Biol 2003 Feb;23(4):1260-8.
2. Trbp regulates heart function through microRNA-mediated Sox6 repression. Ding J, etal., Nat Genet. 2015 Jul;47(7):776-83. doi: 10.1038/ng.3324. Epub 2015 Jun 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
6. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Ko L, etal., Proc Natl Acad Sci U S A 2000 May 23;97(11):6212-7.
7. A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. Lee SK, etal., J Biol Chem. 1999 Nov 26;274(48):34283-93.
8. Expression and localization of RAP250 mRNA in rat ovary: possible implications in follicular development and ovulation. Liu DL, etal., Endocrine. 2002 Jul;18(2):173-8.
9. A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mahajan MA and Samuels HH, Mol Cell Biol 2000 Jul;20(14):5048-63.
10. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. Mahajan MA, etal., Mol Cell Biol 2002 Oct;22(19):6883-94.
11. Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling. Mahajan MA, etal., Mol Endocrinol. 2007 Aug;21(8):1822-34. Epub 2007 May 29.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
17. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41.
18. MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction. Tony H, etal., Mediators Inflamm. 2015;2015:479123. doi: 10.1155/2015/479123. Epub 2015 Nov 25.
19. Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. Yeom SY, etal., Mol Cell Biol. 2006 Jun;26(12):4553-63.
Additional References at PubMed
PMID:10681503   PMID:10788465   PMID:11302752   PMID:11443112   PMID:12039952   PMID:12368298   PMID:12446761   PMID:17021013   PMID:17500065   PMID:21700703   PMID:22311984   PMID:23341457  
PMID:29263199  


Genomics

Comparative Map Data
Ncoa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,351,062 - 164,422,079 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3164,351,062 - 164,421,991 (-)EnsemblGRCr8
mRatBN7.23143,890,896 - 143,961,916 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3147,757,713 - 147,797,978 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,374,984 - 156,415,249 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,114,516 - 154,154,781 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,919,317 - 150,990,391 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)Ensemblrn6Rnor6.0
Rnor_5.03157,287,434 - 157,358,499 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43145,886,874 - 145,957,928 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3142,616,753 - 142,657,466 (-)NCBICelera
RGSC_v3.13145,808,879 - 145,815,141 (-)NCBI
Cytogenetic Map3q41-q42NCBI
NCOA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,714,774 - 34,825,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,689,097 - 34,825,739 (-)Ensemblhg38GRCh38
GRCh372033,302,578 - 33,413,454 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,766,239 - 32,877,094 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342032,766,238 - 32,877,094NCBI
Celera2030,051,663 - 30,162,529 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,081,569 - 30,192,220 (-)NCBIHuRef
CHM1_12033,204,060 - 33,314,823 (-)NCBICHM1_1
T2T-CHM13v2.02036,435,437 - 36,546,294 (-)NCBIT2T-CHM13v2.0
Ncoa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,232,585 - 155,315,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,232,576 - 155,315,814 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382155,390,656 - 155,473,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,390,656 - 155,473,894 (-)Ensemblmm10GRCm38
MGSCv372155,216,401 - 155,266,519 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362155,082,112 - 155,129,567 (-)NCBIMGSCv36mm8
Celera2161,323,189 - 161,373,222 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
Ncoa6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,564,037 - 26,632,675 (+)Ensembl
ChiLan1.0NW_00495542226,564,535 - 26,639,516 (+)NCBIChiLan1.0ChiLan1.0
NCOA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,448,796 - 40,559,276 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,441,963 - 40,552,376 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,044,339 - 31,154,798 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,170,583 - 32,247,167 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,170,583 - 32,247,167 (-)EnsemblpanPan2panpan1.1
NCOA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,802,360 - 23,877,986 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,802,351 - 23,866,792 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2423,447,946 - 23,539,033 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02424,493,126 - 24,584,695 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,493,113 - 24,581,564 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,780,970 - 23,872,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,876,107 - 23,967,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,314,983 - 24,406,060 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ncoa6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,766,751 - 172,862,411 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,906,485 - 5,982,268 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,905,905 - 5,982,824 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1738,114,291 - 38,221,901 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11738,114,284 - 38,221,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,309,959 - 43,393,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1239,013,364 - 39,129,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,013,232 - 39,129,658 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605087,702,887 - 87,819,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248424,570,758 - 4,665,517 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ncoa6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15134,737,917 - 134,809,695 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ncoa6
289 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:107
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000024714, ENSRNOT00000074304
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001276714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_591737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF176351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024714   ⟹   ENSRNOP00000024714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,351,062 - 164,402,702 (-)Ensembl
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)Ensembl
Rnor_6.0 Ensembl3150,919,317 - 150,960,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114206   ⟹   ENSRNOP00000093567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,351,062 - 164,421,991 (-)Ensembl
mRatBN7.2 Ensembl3143,894,869 - 143,952,268 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118396   ⟹   ENSRNOP00000097352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3164,351,062 - 164,402,702 (-)Ensembl
mRatBN7.2 Ensembl3143,890,896 - 143,952,268 (-)Ensembl
RefSeq Acc Id: NM_001276714   ⟹   NP_001263643
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,391,775 (-)NCBI
mRatBN7.23143,890,896 - 143,931,612 (-)NCBI
Rnor_6.03150,919,317 - 150,960,030 (-)NCBI
Rnor_5.03157,287,434 - 157,358,499 (-)NCBI
Celera3142,616,753 - 142,657,466 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235296   ⟹   XP_006235358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
Rnor_6.03150,919,317 - 150,990,391 (-)NCBI
Rnor_5.03157,287,434 - 157,358,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762295   ⟹   XP_008760517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,076 (-)NCBI
mRatBN7.23143,890,930 - 143,961,916 (-)NCBI
Rnor_6.03150,919,317 - 150,990,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104103   ⟹   XP_038960031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104104   ⟹   XP_038960032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104105   ⟹   XP_038960033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104106   ⟹   XP_038960034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_039104107   ⟹   XP_038960035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
mRatBN7.23143,890,896 - 143,961,914 (-)NCBI
RefSeq Acc Id: XM_063282996   ⟹   XP_063139066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
RefSeq Acc Id: XM_063282997   ⟹   XP_063139067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,351,062 - 164,422,079 (-)NCBI
RefSeq Acc Id: XR_005501749
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83164,359,011 - 164,422,079 (-)NCBI
mRatBN7.23143,898,839 - 143,961,914 (-)NCBI
RefSeq Acc Id: NP_001263643   ⟸   NM_001276714
- UniProtKB: G3V8C9 (UniProtKB/TrEMBL),   A6KI36 (UniProtKB/TrEMBL),   A0A8I6AHU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235358   ⟸   XM_006235296
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008760517   ⟸   XM_008762295
- Peptide Label: isoform X1
- UniProtKB: G3V8C9 (UniProtKB/TrEMBL),   A6KI36 (UniProtKB/TrEMBL),   A0A8I6AHU2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024714   ⟸   ENSRNOT00000024714
RefSeq Acc Id: XP_038960033   ⟸   XM_039104105
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AHU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960032   ⟸   XM_039104104
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AHU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960035   ⟸   XM_039104107
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038960034   ⟸   XM_039104106
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038960031   ⟸   XM_039104103
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093567   ⟸   ENSRNOT00000114206
Ensembl Acc Id: ENSRNOP00000097352   ⟸   ENSRNOT00000118396
RefSeq Acc Id: XP_063139067   ⟸   XM_063282997
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063139066   ⟸   XM_063282996
- Peptide Label: isoform X7
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLI4-F1-model_v2 AlphaFold Q9JLI4 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620111 AgrOrtholog
BioCyc Gene G2FUF-47137 BioCyc
Ensembl Genes ENSRNOG00000018288 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024714 ENTREZGENE
  ENSRNOT00000114206 ENTREZGENE
  ENSRNOT00000118396 ENTREZGENE
InterPro NCOA6 UniProtKB/Swiss-Prot
NCBI Gene 116464 ENTREZGENE
PANTHER NUCLEAR RECEPTOR COACTIVATOR 6 UniProtKB/Swiss-Prot
  PTHR15690 UniProtKB/Swiss-Prot
PhenoGen Ncoa6 PhenoGen
RatGTEx ENSRNOG00000018288 RatGTEx
UniProt A0A8I6AHU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARE2 ENTREZGENE, UniProtKB/TrEMBL
  A6KI36 ENTREZGENE, UniProtKB/TrEMBL
  G3V8C9 ENTREZGENE, UniProtKB/TrEMBL
  NCOA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9JIH6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ncoa6  nuclear receptor coactivator 6      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ncoa6  nuclear receptor coactivator 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a LXXLL motif 633379
gene_protein 2063 amino acid residues 633379