Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ncoa6 | Rat | endometriosis | | ISO | NCOA6 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:22138541 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ncoa6 | Rat | endometriosis | | ISO | NCOA6 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:22138541 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| # | Reference Title | Reference Citation |
| 1. | Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. | Antonson P, etal., Mol Cell Biol 2003 Feb;23(4):1260-8. |
| 2. | Trbp regulates heart function through microRNA-mediated Sox6 repression. | Ding J, etal., Nat Genet. 2015 Jul;47(7):776-83. doi: 10.1038/ng.3324. Epub 2015 Jun 1. |
| 3. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 4. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 5. | Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. | Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57. |
| 6. | Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. | Ko L, etal., Proc Natl Acad Sci U S A 2000 May 23;97(11):6212-7. |
| 7. | A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. | Lee SK, etal., J Biol Chem. 1999 Nov 26;274(48):34283-93. |
| 8. | Expression and localization of RAP250 mRNA in rat ovary: possible implications in follicular development and ovulation. | Liu DL, etal., Endocrine. 2002 Jul;18(2):173-8. |
| 9. | A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. | Mahajan MA and Samuels HH, Mol Cell Biol 2000 Jul;20(14):5048-63. |
| 10. | NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. | Mahajan MA, etal., Mol Cell Biol 2002 Oct;22(19):6883-94. |
| 11. | Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling. | Mahajan MA, etal., Mol Endocrinol. 2007 Aug;21(8):1822-34. Epub 2007 May 29. |
| 12. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 13. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 14. | GOA pipeline | RGD automated data pipeline |
| 15. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 16. | The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. | Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100. |
| 17. | Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. | Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41. |
| 18. | MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction. | Tony H, etal., Mediators Inflamm. 2015;2015:479123. doi: 10.1155/2015/479123. Epub 2015 Nov 25. |
| 19. | Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. | Yeom SY, etal., Mol Cell Biol. 2006 Jun;26(12):4553-63. |
| PMID:10681503 | PMID:10788465 | PMID:11302752 | PMID:11443112 | PMID:12039952 | PMID:12368298 | PMID:12446761 | PMID:17021013 | PMID:17500065 | PMID:21700703 | PMID:22311984 | PMID:23341457 |
| PMID:29263199 |
| Ncoa6 (Rattus norvegicus - Norway rat) |
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| NCOA6 (Homo sapiens - human) |
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| Ncoa6 (Mus musculus - house mouse) |
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| Ncoa6 (Chinchilla lanigera - long-tailed chinchilla) |
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| NCOA6 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| NCOA6 (Canis lupus familiaris - dog) |
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| Ncoa6 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| NCOA6 (Sus scrofa - pig) |
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| NCOA6 (Chlorocebus sabaeus - green monkey) |
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| Ncoa6 (Heterocephalus glaber - naked mole-rat) |
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| Ncoa6 (Rattus rattus - black rat) |
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Variants in Ncoa6
289 total Variants
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| The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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| 16 | 12 | 67 | 165 | 91 | 90 | 59 | 92 | 59 | 6 | 356 | 192 | 11 | 144 | 81 | 92 | 31 | 17 | 17 |
| RefSeq Transcripts | NM_001276714 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| NM_001429659 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006235296 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008762295 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008762296 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008762297 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008762298 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008762299 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039104103 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039104104 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039104105 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039104106 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039104107 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063282996 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063282997 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XR_005501749 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XR_591737 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AC123188 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AF176351 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF228043 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH474050 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JAXUCZ010000003 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| Ensembl Acc Id: | ENSRNOT00000024714 ⟹ ENSRNOP00000024714 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000114206 ⟹ ENSRNOP00000093567 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000118396 ⟹ ENSRNOP00000097352 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001276714 ⟹ NP_001263643 | ||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_006235296 ⟹ XP_006235358 | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_008762295 ⟹ XP_008760517 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_039104103 ⟹ XP_038960031 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039104104 ⟹ XP_038960032 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039104105 ⟹ XP_038960033 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039104106 ⟹ XP_038960034 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039104107 ⟹ XP_038960035 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_063282996 ⟹ XP_063139066 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_063282997 ⟹ XP_063139067 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XR_005501749 | ||||||||||||
| Type: | NON-CODING | ||||||||||||
| Position: |
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| Protein RefSeqs | NP_001263643 | (Get FASTA) | NCBI Sequence Viewer |
| NP_001416588 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006235358 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008760517 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038960031 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038960032 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038960033 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038960034 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038960035 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063139066 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063139067 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAF71830 | (Get FASTA) | NCBI Sequence Viewer |
| AAF76422 | (Get FASTA) | NCBI Sequence Viewer | |
| EDL85918 | (Get FASTA) | NCBI Sequence Viewer | |
| Ensembl Protein | ENSRNOP00000024714 | ||
| ENSRNOP00000093567 | |||
| ENSRNOP00000097352 | |||
| GenBank Protein | Q9JLI4 | (Get FASTA) | NCBI Sequence Viewer |
| RefSeq Acc Id: | NP_001263643 ⟸ NM_001276714 |
| - UniProtKB: | G3V8C9 (UniProtKB/TrEMBL), A6KI36 (UniProtKB/TrEMBL), A0A8I6AHU2 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_006235358 ⟸ XM_006235296 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
| RefSeq Acc Id: | XP_008760517 ⟸ XM_008762295 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | G3V8C9 (UniProtKB/TrEMBL), A6KI36 (UniProtKB/TrEMBL), A0A8I6AHU2 (UniProtKB/TrEMBL) |
| - Sequence: |
| Ensembl Acc Id: | ENSRNOP00000024714 ⟸ ENSRNOT00000024714 |
| RefSeq Acc Id: | XP_038960033 ⟸ XM_039104105 |
| - Peptide Label: | isoform X4 |
| - UniProtKB: | A0A8I6AHU2 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038960032 ⟸ XM_039104104 |
| - Peptide Label: | isoform X3 |
| - UniProtKB: | A0A8I6AHU2 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_038960035 ⟸ XM_039104107 |
| - Peptide Label: | isoform X6 |
| RefSeq Acc Id: | XP_038960034 ⟸ XM_039104106 |
| - Peptide Label: | isoform X5 |
| RefSeq Acc Id: | XP_038960031 ⟸ XM_039104103 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | A0A8I6AHU2 (UniProtKB/TrEMBL) |
| Ensembl Acc Id: | ENSRNOP00000093567 ⟸ ENSRNOT00000114206 |
| Ensembl Acc Id: | ENSRNOP00000097352 ⟸ ENSRNOT00000118396 |
| RefSeq Acc Id: | XP_063139067 ⟸ XM_063282997 |
| - Peptide Label: | isoform X8 |
| RefSeq Acc Id: | XP_063139066 ⟸ XM_063282996 |
| - Peptide Label: | isoform X7 |
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-Q9JLI4-F1-model_v2 | AlphaFold | Q9JLI4 | 1-418 | view protein structure |
| eQTL | View at Phenogen | |
| WGCNA | View at Phenogen | |
| Tissue/Strain Expression | View at Phenogen |
| Database | Acc Id | Source(s) |
| AGR Gene | RGD:620111 | AgrOrtholog |
| BioCyc Gene | G2FUF-47137 | BioCyc |
| Ensembl Genes | ENSRNOG00000018288 | Ensembl, ENTREZGENE |
| Ensembl Transcript | ENSRNOT00000024714 | ENTREZGENE |
| ENSRNOT00000114206 | ENTREZGENE | |
| ENSRNOT00000118396 | ENTREZGENE | |
| InterPro | NCOA6 | UniProtKB/Swiss-Prot |
| NCBI Gene | 116464 | ENTREZGENE |
| PANTHER | NUCLEAR RECEPTOR COACTIVATOR 6 | UniProtKB/Swiss-Prot |
| PTHR15690 | UniProtKB/Swiss-Prot | |
| PhenoGen | Ncoa6 | PhenoGen |
| RatGTEx | ENSRNOG00000018288 | RatGTEx |
| UniProt | A0A8I6AHU2 | ENTREZGENE, UniProtKB/TrEMBL |
| A0A8I6ARE2 | ENTREZGENE, UniProtKB/TrEMBL | |
| A6KI36 | ENTREZGENE, UniProtKB/TrEMBL | |
| G3V8C9 | ENTREZGENE, UniProtKB/TrEMBL | |
| NCOA6_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
| UniProt Secondary | Q9JIH6 | UniProtKB/Swiss-Prot |
| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-02-26 | Ncoa6 | nuclear receptor coactivator 6 | Symbol and Name status set to approved | 625702 | APPROVED | ||
| 2002-08-07 | Ncoa6 | nuclear receptor coactivator 6 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
| Note Type | Note | Reference |
|---|---|---|
| gene_domains | contains a LXXLL motif | 633379 |
| gene_protein | 2063 amino acid residues | 633379 |