Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pdha2 | Rat | spermatogenic failure 70 | | ISO | PDHA2 (Homo sapiens) | 7240710 | | OMIM | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pdha2 | Rat | spermatogenic failure 70 | | ISO | PDHA2 (Homo sapiens) | 7240710 | | OMIM | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| # | Reference Title | Reference Citation |
| 1. | Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes. | Fitzgerald J, etal., Biochim Biophys Acta 1992 May 7;1131(1):83-90. |
| 2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 3. | KEGG: Kyoto Encyclopedia of Genes and Genomes | KEGG |
| 4. | Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. | Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5. |
| 5. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. | Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. | Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7. |
| 8. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 9. | GOA pipeline | RGD automated data pipeline |
| 10. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| PMID:7916643 | PMID:12477932 | PMID:15489334 | PMID:16436377 | PMID:18614015 | PMID:21630459 |
| Pdha2 (Rattus norvegicus - Norway rat) |
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| PDHA2 (Homo sapiens - human) |
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| Pdha2 (Mus musculus - house mouse) |
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| Pdha2 (Chinchilla lanigera - long-tailed chinchilla) |
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| PDHA2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PDHA2 (Canis lupus familiaris - dog) |
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| Pdha2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PDHA2 (Sus scrofa - pig) |
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| PDHA2 (Chlorocebus sabaeus - green monkey) |
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| Pdha2 (Heterocephalus glaber - naked mole-rat) |
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| Pdha2 (Rattus rattus - black rat) |
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Variants in Pdha2
11 total Variants
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| The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
| RW2 |
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appendage
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | 8 | 6 | 7 | 3 | 5 | 3 | 17 | 8 | 6 | 3 | 42 | 4 |
| RefSeq Transcripts | NM_053994 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| GenBank Nucleotide | BC078757 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| CH473952 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JAXUCZ010000002 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| Ensembl Acc Id: | ENSRNOT00000021719 ⟹ ENSRNOP00000071767 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000123491 ⟹ ENSRNOP00000101469 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000128650 ⟹ ENSRNOP00000108975 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000147417 ⟹ ENSRNOP00000111897 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000155332 ⟹ ENSRNOP00000099534 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000164505 ⟹ ENSRNOP00000105458 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Ensembl Acc Id: | ENSRNOT00000166183 ⟹ ENSRNOP00000099911 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_053994 ⟹ NP_446446 | ||||||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||||||
| Position: |
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| Sequence: |
| Protein RefSeqs | NP_446446 | (Get FASTA) | NCBI Sequence Viewer |
| GenBank Protein | AAH78757 | (Get FASTA) | NCBI Sequence Viewer |
| EDL82338 | (Get FASTA) | NCBI Sequence Viewer | |
| Ensembl Protein | ENSRNOP00000099911 | ||
| GenBank Protein | Q06437 | (Get FASTA) | NCBI Sequence Viewer |
| RefSeq Acc Id: | NP_446446 ⟸ NM_053994 |
| - Peptide Label: | precursor |
| - UniProtKB: | Q06437 (UniProtKB/Swiss-Prot), A6HW52 (UniProtKB/TrEMBL) |
| - Sequence: |
| Ensembl Acc Id: | ENSRNOP00000071767 ⟸ ENSRNOT00000021719 |
| Ensembl Acc Id: | ENSRNOP00000099911 ⟸ ENSRNOT00000166183 |
| Ensembl Acc Id: | ENSRNOP00000099534 ⟸ ENSRNOT00000155332 |
| Ensembl Acc Id: | ENSRNOP00000101469 ⟸ ENSRNOT00000123491 |
| Ensembl Acc Id: | ENSRNOP00000108975 ⟸ ENSRNOT00000128650 |
| Ensembl Acc Id: | ENSRNOP00000105458 ⟸ ENSRNOT00000164505 |
| Ensembl Acc Id: | ENSRNOP00000111897 ⟸ ENSRNOT00000147417 |
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-Q06437-F1-model_v2 | AlphaFold | Q06437 | 1-391 | view protein structure |
| eQTL | View at Phenogen | |
| WGCNA | View at Phenogen | |
| Tissue/Strain Expression | View at Phenogen |
| RGD ID: | 13691792 | ||||||||
| Promoter ID: | EPDNEW_R2316 | ||||||||
| Type: | multiple initiation site | ||||||||
| Name: | Pdha2_1 | ||||||||
| Description: | pyruvate dehydrogenase E1 alpha 2 subunit | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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| Database | Acc Id | Source(s) |
| AGR Gene | RGD:620095 | AgrOrtholog |
| BioCyc Gene | G2FUF-51004 | BioCyc |
| Ensembl Genes | ENSRNOG00000016223 | Ensembl |
| ENSRNOG00000077743 | Ensembl, ENTREZGENE | |
| Ensembl Transcript | ENSRNOT00000166183 | ENTREZGENE |
| Gene3D-CATH | 3.40.50.970 | UniProtKB/Swiss-Prot |
| IMAGE_CLONE | IMAGE:7113421 | IMAGE-MGC_LOAD |
| InterPro | DH_E1 | UniProtKB/Swiss-Prot |
| PDH_E1_Alpha_Subunit | UniProtKB/Swiss-Prot | |
| Pyrv_DH_E1_asu_subgrp-y | UniProtKB/Swiss-Prot | |
| THDP-binding | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:117098 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93262 | IMAGE-MGC_LOAD |
| NCBI Gene | 117098 | ENTREZGENE |
| PANTHER | PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL | UniProtKB/Swiss-Prot |
| PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR | UniProtKB/Swiss-Prot | |
| Pfam | E1_dh | UniProtKB/Swiss-Prot |
| PhenoGen | Pdha2 | PhenoGen |
| RatGTEx | ENSRNOG00000016223 | RatGTEx |
| ENSRNOG00000077743 | RatGTEx | |
| Superfamily-SCOP | SSF52518 | UniProtKB/Swiss-Prot |
| UniProt | A6HW52 | ENTREZGENE, UniProtKB/TrEMBL |
| ODPAT_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2019-12-06 | Pdha2 | pyruvate dehydrogenase E1 subunit alpha 2 | Pdha2 | pyruvate dehydrogenase E1 alpha 2 subunit | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2017-08-23 | Pdha2 | pyruvate dehydrogenase E1 alpha 2 subunit | Pdha2 | pyruvate dehydrogenase alpha 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2017-06-20 | Pdha2 | pyruvate dehydrogenase alpha 2 | Pdha2 | pyruvate dehydrogenase (lipoamide) alpha 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2016-08-29 | Pdha2 | pyruvate dehydrogenase (lipoamide) alpha 2 | Pdha2 | pyruvate dehydrogenase E1 alpha 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2015-06-08 | Pdha2 | pyruvate dehydrogenase E1 alpha 2 | Pdha2 | pyruvate dehydrogenase (lipoamide) alpha 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2009-02-26 | Pdha2 | pyruvate dehydrogenase (lipoamide) alpha 2 | Pdha2 | pyruvate dehydrogenase E1 alpha 2 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2004-12-03 | Pdha2 | pyruvate dehydrogenase E1 alpha 2 | Pdhal | pyruvate dehydrogenase E1 alpha-like | Symbol and Name updated | 1299863 | APPROVED |
| 2002-08-07 | Pdhal | pyruvate dehydrogenase E1 alpha-like | Symbol and Name status set to provisional | 70820 | PROVISIONAL |