Chrm5 (cholinergic receptor, muscarinic 5) - Rat Genome Database

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Gene: Chrm5 (cholinergic receptor, muscarinic 5) Rattus norvegicus
Analyze
Symbol: Chrm5
Name: cholinergic receptor, muscarinic 5
RGD ID: 620027
Description: Enables G protein-coupled acetylcholine receptor activity. Involved in regulation of phosphatidylinositol dephosphorylation. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in cannabis dependence and nicotine dependence. Orthologous to human CHRM5 (cholinergic receptor muscarinic 5); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alcohol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: muscarinic acetylcholine receptor M5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83119,739,229 - 119,791,630 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3119,735,975 - 119,792,166 (-)EnsemblGRCr8
mRatBN7.2399,284,846 - 99,337,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,284,846 - 99,337,252 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3102,911,743 - 102,964,081 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03111,510,739 - 111,563,079 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03109,207,281 - 109,259,678 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,966,451 - 104,018,815 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,966,451 - 104,018,861 (-)Ensemblrn6Rnor6.0
Rnor_5.03110,560,292 - 110,632,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4398,326,809 - 98,378,531 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera398,270,221 - 98,321,572 (-)NCBICelera
RGSC_v3.1398,223,400 - 98,274,959 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults. Anney RJ, etal., BMC Genet. 2007 Jul 3;8:46. doi: 10.1186/1471-2156-8-46.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Molecular cloning and expression of a fifth muscarinic acetylcholine receptor. Liao CF, etal., J Biol Chem 1989 May 5;264(13):7328-37.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
10. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. Tseng J, etal., Hear Res 2002 Dec;174(1-2):86-92.
11. Muscarinic M4 and M5 receptors in the ventral subiculum differentially modulate alcohol seeking versus consumption in male alcohol-preferring rats. Walker LC, etal., Br J Pharmacol. 2021 Sep;178(18):3730-3746. doi: 10.1111/bph.15513. Epub 2021 Jun 3.
Additional References at PubMed
PMID:2380182   PMID:3272174   PMID:11756520   PMID:18246091   PMID:18443764   PMID:19160866   PMID:22095037   PMID:23504804   PMID:24866457  


Genomics

Comparative Map Data
Chrm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83119,739,229 - 119,791,630 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3119,735,975 - 119,792,166 (-)EnsemblGRCr8
mRatBN7.2399,284,846 - 99,337,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,284,846 - 99,337,252 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3102,911,743 - 102,964,081 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03111,510,739 - 111,563,079 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03109,207,281 - 109,259,678 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,966,451 - 104,018,815 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,966,451 - 104,018,861 (-)Ensemblrn6Rnor6.0
Rnor_5.03110,560,292 - 110,632,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4398,326,809 - 98,378,531 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera398,270,221 - 98,321,572 (-)NCBICelera
RGSC_v3.1398,223,400 - 98,274,959 (-)NCBI
Cytogenetic Map3q35NCBI
CHRM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381533,968,497 - 34,067,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1533,968,497 - 34,067,458 (+)Ensemblhg38GRCh38
GRCh371534,260,698 - 34,359,659 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,097,720 - 32,144,579 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341532,097,719 - 32,144,579NCBI
Celera1511,064,121 - 11,160,334 (+)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1511,124,408 - 11,221,244 (+)NCBIHuRef
CHM1_11534,379,045 - 34,475,247 (+)NCBICHM1_1
T2T-CHM13v2.01531,766,653 - 31,865,649 (+)NCBIT2T-CHM13v2.0
Chrm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392112,306,055 - 112,365,487 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2112,309,516 - 112,311,114 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382112,478,733 - 112,536,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2112,479,171 - 112,480,769 (-)Ensemblmm10GRCm38
MGSCv372112,319,229 - 112,320,974 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362112,280,010 - 112,281,608 (-)NCBIMGSCv36mm8
Celera2113,630,348 - 113,632,093 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map257.02NCBI
Chrm5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955416526,755 - 528,353 (-)Ensembl
ChiLan1.0NW_004955416526,718 - 528,353 (-)NCBIChiLan1.0ChiLan1.0
CHRM5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21622,744,555 - 22,849,360 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11527,473,497 - 27,568,780 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01512,478,656 - 12,575,512 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11531,315,839 - 31,408,563 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,406,198 - 31,407,796 (+)EnsemblpanPan2panpan1.1
CHRM5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.130988,764 - 1,074,599 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl30990,208 - 991,806 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha301,033,732 - 1,118,973 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0301,086,979 - 1,172,509 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl301,088,172 - 1,089,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1301,033,678 - 1,119,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0301,132,741 - 1,218,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0301,260,343 - 1,345,796 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chrm5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864079,539,375 - 79,618,606 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366732,608,003 - 2,609,624 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366732,607,906 - 2,610,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl780,427,360 - 80,428,963 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1780,423,768 - 80,429,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2786,417,799 - 86,503,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRM5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12648,842,021 - 48,940,962 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,842,779 - 48,844,377 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604892,061,214 - 92,063,631 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrm5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624804255,505 - 257,103 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624804252,437 - 334,457 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Chrm5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1590,805,745 - 90,857,550 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chrm5
390 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:106
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000008387
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)3116582412122654872Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Got55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2399,300,139 - 99,300,344 (+)MAPPERmRatBN7.2
Rnor_6.03103,981,744 - 103,981,948NCBIRnor6.0
Rnor_5.03110,575,585 - 110,575,789UniSTSRnor5.0
RGSC_v3.4398,342,016 - 98,342,325RGDRGSC3.4
RGSC_v3.4398,342,103 - 98,342,307UniSTSRGSC3.4
Celera398,285,514 - 98,285,718UniSTS
RGSC_v3.1398,238,531 - 98,238,735RGD
RH 3.4 Map3857.1RGD
RH 3.4 Map3857.1UniSTS
Cytogenetic Map3q34UniSTS
PMC61174P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2399,285,763 - 99,285,993 (+)MAPPERmRatBN7.2
Rnor_6.03103,967,369 - 103,967,598NCBIRnor6.0
Rnor_5.03110,561,210 - 110,561,439UniSTSRnor5.0
RGSC_v3.4398,327,727 - 98,327,956UniSTSRGSC3.4
Celera398,271,139 - 98,271,368UniSTS
Cytogenetic Map3q34UniSTS
Chrm5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2399,285,375 - 99,286,294 (+)MAPPERmRatBN7.2
Rnor_6.03103,966,981 - 103,967,899NCBIRnor6.0
Rnor_5.03110,560,822 - 110,561,740UniSTSRnor5.0
Celera398,270,751 - 98,271,669UniSTS
Cytogenetic Map3q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
3 10 62 105 36 36 17 40 17 3 164 112 1 98 24 49 19 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000008387   ⟹   ENSRNOP00000008387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3119,735,975 - 119,792,166 (-)Ensembl
mRatBN7.2 Ensembl399,284,846 - 99,337,252 (-)Ensembl
Rnor_6.0 Ensembl3103,966,451 - 104,018,861 (-)Ensembl
RefSeq Acc Id: NM_017362   ⟹   NP_059058
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83119,739,229 - 119,791,630 (-)NCBI
mRatBN7.2399,284,846 - 99,337,252 (-)NCBI
Rnor_6.03103,966,451 - 104,018,815 (-)NCBI
Rnor_5.03110,560,292 - 110,632,938 (-)NCBI
RGSC_v3.4398,326,809 - 98,378,531 (-)RGD
Celera398,270,221 - 98,321,572 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_059058 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40658 (Get FASTA)   NCBI Sequence Viewer  
  AAA41572 (Get FASTA)   NCBI Sequence Viewer  
  EDL79805 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008387
  ENSRNOP00000008387.4
GenBank Protein P08911 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059058   ⟸   NM_017362
- UniProtKB: P08911 (UniProtKB/Swiss-Prot),   A6HP54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008387   ⟸   ENSRNOT00000008387
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08911-F1-model_v2 AlphaFold P08911 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620027 AgrOrtholog
BioCyc Gene G2FUF-48385 BioCyc
Ensembl Genes ENSRNOG00000006397 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008387 ENTREZGENE
  ENSRNOT00000008387.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Musac_Ach_M5_rcpt UniProtKB/Swiss-Prot
  Musac_Ach_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:53949 UniProtKB/Swiss-Prot
NCBI Gene 53949 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  MUSCARINIC ACETYLCHOLINE RECEPTOR M5 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB CHRM5 RGD
PhenoGen Chrm5 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MUSCARINICR UniProtKB/Swiss-Prot
  MUSCRINICM5R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006397 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HP54 ENTREZGENE, UniProtKB/TrEMBL
  ACM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Chrm5  cholinergic receptor, muscarinic 5    muscarinic acetylcholine receptor M5  Name updated 1299863 APPROVED
2002-08-07 Chrm5  muscarinic acetylcholine receptor M5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 531 amino acids 724743