Srgn (serglycin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Srgn (serglycin) Rattus norvegicus
Analyze
Symbol: Srgn
Name: serglycin
RGD ID: 619969
Description: Enables collagen binding activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; negative regulation of bone mineralization; and protein localization to secretory granule. Located in Golgi membrane and zymogen granule. Orthologous to human SRGN (serglycin); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chondroitin sulfate proteoglycan core protein; cytolytic granule proteoglycan core protein; PG19 core protein; Pgsg; proteoglycan 10K core protein; proteoglycan peptide core protein; secretory granule proteoglycan core protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,985,508 - 31,022,296 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2030,985,508 - 31,000,327 (-)EnsemblGRCr8
mRatBN7.22030,442,810 - 30,479,549 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,442,813 - 30,457,406 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2031,453,724 - 31,468,322 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02030,844,629 - 30,859,227 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02031,581,369 - 31,595,957 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02032,120,317 - 32,158,071 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,120,320 - 32,139,789 (-)Ensemblrn6Rnor6.0
Rnor_5.02033,908,571 - 33,942,620 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42029,746,729 - 29,761,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2031,862,885 - 31,877,472 (-)NCBICelera
RGSC_v3.12029,760,531 - 29,774,872 (-)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ferric oxide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue. Avraham S, etal., J Biol Chem 1988 May 25;263(15):7292-6.
2. Serglycin proteoglycan is sorted into zymogen granules of rat pancreatic acinar cells. Biederbick A, etal., Eur J Cell Biol. 2003 Jan;82(1):19-29.
3. Identification from cDNA of the precursor form of a chondroitin sulfate proteoglycan core protein. Bourdon MA, etal., J Biol Chem 1986 Sep 25;261(27):12534-7.
4. Molecular cloning and sequence analysis of a chondroitin sulfate proteoglycan cDNA. Bourdon MA, etal., Proc Natl Acad Sci U S A 1985 Mar;82(5):1321-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Decreased serglycin proteoglycan size is associated with the platelet alpha granule storage defect in Wistar Furth hereditary macrothrombocytopenic rats. Serglycin binding affinity to type I collagen is unaltered. Schick BP, etal., J Cell Physiol. 1997 Jul;172(1):87-93.
Additional References at PubMed
PMID:2352541   PMID:11154222   PMID:11911826   PMID:12477932   PMID:15136585   PMID:15231821   PMID:15489334   PMID:16046402   PMID:16807245   PMID:16870619   PMID:17010166   PMID:17081126  
PMID:19766573   PMID:27453502  


Genomics

Comparative Map Data
Srgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,985,508 - 31,022,296 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2030,985,508 - 31,000,327 (-)EnsemblGRCr8
mRatBN7.22030,442,810 - 30,479,549 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,442,813 - 30,457,406 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2031,453,724 - 31,468,322 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02030,844,629 - 30,859,227 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02031,581,369 - 31,595,957 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02032,120,317 - 32,158,071 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,120,320 - 32,139,789 (-)Ensemblrn6Rnor6.0
Rnor_5.02033,908,571 - 33,942,620 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42029,746,729 - 29,761,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2031,862,885 - 31,877,472 (-)NCBICelera
RGSC_v3.12029,760,531 - 29,774,872 (-)NCBI
Cytogenetic Map20q11NCBI
SRGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381069,087,603 - 69,104,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1069,088,103 - 69,104,811 (+)Ensemblhg38GRCh38
GRCh371070,847,359 - 70,864,567 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361070,517,834 - 70,534,573 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341070,517,833 - 70,534,571NCBI
Celera1064,123,664 - 64,140,417 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1064,847,942 - 64,864,694 (+)NCBIHuRef
CHM1_11071,129,576 - 71,146,327 (+)NCBICHM1_1
T2T-CHM13v2.01069,925,937 - 69,973,238 (+)NCBIT2T-CHM13v2.0
Srgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,329,612 - 62,363,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,329,612 - 62,363,230 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381062,493,833 - 62,527,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,493,833 - 62,527,451 (-)Ensemblmm10GRCm38
MGSCv371061,957,176 - 61,970,503 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361061,889,785 - 61,903,112 (-)NCBIMGSCv36mm8
Celera1063,596,893 - 63,610,808 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.42NCBI
Srgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543721,951,732 - 21,965,581 (-)Ensembl
ChiLan1.0NW_00495543721,954,837 - 21,966,552 (-)NCBIChiLan1.0ChiLan1.0
SRGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2881,234,083 - 81,251,316 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11081,239,404 - 81,256,637 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01065,554,873 - 65,572,108 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11068,089,349 - 68,106,261 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1068,089,392 - 68,106,250 (+)EnsemblpanPan2panpan1.1
SRGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1420,230,713 - 20,244,952 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl420,230,743 - 20,244,474 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha420,360,979 - 20,375,208 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0420,503,127 - 20,517,366 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,503,157 - 20,517,696 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1420,403,602 - 20,418,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,606,545 - 20,620,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0420,949,982 - 20,964,223 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721360,826,392 - 60,839,986 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365219,319,114 - 9,332,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1472,183,363 - 72,199,250 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11472,183,368 - 72,199,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21478,197,805 - 78,215,931 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,217,836 - 62,235,110 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl962,217,525 - 62,235,238 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604822,958,463 - 22,975,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247543,401,480 - 3,411,488 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247543,379,651 - 3,412,175 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Srgn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11828,323,067 - 28,343,154 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srgn
603 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:48
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000000443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
RH127524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,442,835 - 30,443,037 (+)MAPPERmRatBN7.2
Rnor_6.02032,120,343 - 32,120,544NCBIRnor6.0
Rnor_5.02033,908,597 - 33,908,798UniSTSRnor5.0
RGSC_v3.42029,746,755 - 29,746,956UniSTSRGSC3.4
Celera2031,862,911 - 31,863,112UniSTS
Cytogenetic Map20q11UniSTS
RH140911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,443,300 - 30,443,482 (+)MAPPERmRatBN7.2
Rnor_6.02032,120,808 - 32,120,989NCBIRnor6.0
Rnor_5.02033,909,062 - 33,909,243UniSTSRnor5.0
RGSC_v3.42029,747,220 - 29,747,401UniSTSRGSC3.4
Celera2031,863,376 - 31,863,557UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000000443   ⟹   ENSRNOP00000000443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,985,508 - 31,000,327 (-)Ensembl
mRatBN7.2 Ensembl2030,442,813 - 30,457,406 (-)Ensembl
Rnor_6.0 Ensembl2032,120,320 - 32,133,431 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078140   ⟹   ENSRNOP00000073486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2032,120,661 - 32,139,789 (-)Ensembl
RefSeq Acc Id: NM_020074   ⟹   NP_064459
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,985,508 - 31,000,103 (-)NCBI
mRatBN7.22030,442,810 - 30,457,406 (-)NCBI
Rnor_6.02032,120,317 - 32,133,431 (-)NCBI
Rnor_5.02033,908,571 - 33,942,620 (-)NCBI
RGSC_v3.42029,746,729 - 29,761,072 (-)RGD
Celera2031,862,885 - 31,877,472 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256484   ⟹   XP_006256546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,985,851 - 31,022,296 (-)NCBI
mRatBN7.22030,442,810 - 30,479,549 (-)NCBI
Rnor_6.02032,120,637 - 32,158,071 (-)NCBI
Rnor_5.02033,908,571 - 33,942,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099046   ⟹   XP_038954974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,985,851 - 31,000,299 (-)NCBI
mRatBN7.22030,442,810 - 30,457,602 (-)NCBI
RefSeq Acc Id: NP_064459   ⟸   NM_020074
- Peptide Label: precursor
- UniProtKB: P04917 (UniProtKB/Swiss-Prot),   A6K451 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256546   ⟸   XM_006256484
- Peptide Label: isoform X2
- UniProtKB: P04917 (UniProtKB/Swiss-Prot),   A6K451 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000443   ⟸   ENSRNOT00000000443
Ensembl Acc Id: ENSRNOP00000073486   ⟸   ENSRNOT00000078140
RefSeq Acc Id: XP_038954974   ⟸   XM_039099046
- Peptide Label: isoform X1
- UniProtKB: A6K450 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04917-F1-model_v2 AlphaFold P04917 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701614
Promoter ID:EPDNEW_R12138
Type:multiple initiation site
Name:Srgn_1
Description:serglycin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02032,133,450 - 32,133,510EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619969 AgrOrtholog
BioCyc Gene G2FUF-3689 BioCyc
Ensembl Genes ENSRNOG00000000394 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000443 ENTREZGENE
  ENSRNOT00000000443.6 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7384101 IMAGE-MGC_LOAD
InterPro Serglycin UniProtKB/Swiss-Prot
KEGG Report rno:56782 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108702 IMAGE-MGC_LOAD
NCBI Gene 56782 ENTREZGENE
PANTHER SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN UniProtKB/Swiss-Prot
  SERGLYCIN UniProtKB/Swiss-Prot
Pfam Serglycin UniProtKB/Swiss-Prot
PharmGKB PRG1 RGD
PhenoGen Srgn PhenoGen
RatGTEx ENSRNOG00000000394 RatGTEx
UniProt A6K450 ENTREZGENE, UniProtKB/TrEMBL
  A6K451 ENTREZGENE, UniProtKB/TrEMBL
  P04917 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Srgn  serglycin  Pgsg  proteoglycan peptide core protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Pgsg  proteoglycan peptide core protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 179 amino acids 633721